Now showing items 511-530 of 17917

    • Age-related differences in the automatic processing of single letters 

      Daffner, Kirk R.; Alperin, Brittany R.; Mott, Katherine K.; Holcomb, Phillip J. (Ovid Technologies (Wolters Kluwer Health), 2014)
      Older adults exhibit diminished ability to inhibit the processing of visual stimuli that are supposed to be ignored. The extent to which age-related changes in early visual processing contribute to impairments in selective ...
    • Age-Related Macular Degeneration and the Incidence of Cardiovascular Disease: A Systematic Review and Meta-Analysis 

      Wu, Juan; Uchino, Miki; Sastry, Srinivas M.; Schaumberg, Debra A. (Public Library of Science, 2014)
      Importance Research has indicated some shared pathogenic mechanisms between age-related macular degeneration (AMD) and cardiovascular disease (CVD). However, results from prior epidemiologic studies have been inconsistent ...
    • Age-Related Patterns in Clinical Presentations and Gluten-Related Issues Among Children and Adolescents With Celiac Disease 

      Tanpowpong, Pornthep; Broder-Fingert, Sarabeth; Katz, Aubrey J.; Camargo, Carlos Arturo (Nature Publishing Group, 2012)
      OBJECTIVES: Celiac disease (CD) is common and often cited as an “iceberg” phenomenon (i.e., an assumed large number of undiagnosed cases). Recently, atypical or asymptomatic manifestations are becoming more commonly described ...
    • Age-related striatal BOLD changes without changes in behavioral loss aversion 

      Viswanathan, Vijay; Lee, Sang; Gilman, Jodi M.; Kim, Byoung Woo; Lee, Nick; Chamberlain, Laura; Livengood, Sherri L.; Raman, Kalyan; Lee, Myung Joo; Kuster, Jake; Stern, Daniel B.; Calder, Bobby; Mulhern, Frank J.; Blood, Anne J.; Breiter, Hans C. (Frontiers Media S.A., 2015)
      Loss aversion (LA), the idea that negative valuations have a higher psychological impact than positive ones, is considered an important variable in consumer research. The literature on aging and behavior suggests older ...
    • The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis 

      Singh, Gitanjali M.; Danaei, Goodarz; Farzadfar, Farshad; Stevens, Gretchen A.; Woodward, Mark; Wormser, David; Kaptoge, Stephen; Whitlock, Gary; Qiao, Qing; Lewington, Sarah; Di Angelantonio, Emanuele; vander Hoorn, Stephen; Lawes, Carlene M. M.; Ali, Mohammed K.; Mozaffarian, Dariush; Ezzati, Majid (Public Library of Science, 2013)
      Background: The effects of systolic blood pressure (SBP), serum total cholesterol (TC), fasting plasma glucose (FPG), and body mass index (BMI) on the risk of cardiovascular diseases (CVD) have been established in ...
    • The aged niche disrupts muscle stem cell quiescence 

      Chakkalakal, Joe V.; Jones, Kieran M.; Basson, M. Albert; Brack, Andrew Stephen (2012)
      SUMMARY The niche is a conserved regulator of stem cell quiescence and function. During aging, stem cell function declines. To what extent and by which means age-related changes within the niche contribute to this phenomenon ...
    • An Agenda for Closing Resource Gaps in Global Mental Health: Innovation, Capacity Building, and Partnerships 

      Becker, Anne Edith; Kleinman, Arthur Michael (Informa Healthcare, 2012)
    • Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results 

      Senders, Joeky T.; Muskens, Ivo S.; Schnoor, Rosalie; Karhade, Aditya V.; Cote, David J.; Smith, Timothy R.; Broekman, Marike L. D. (Springer Vienna, 2016)
      Background: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all ...
    • Aggressive Regimens for Multidrug-Resistant Tuberculosis Decrease All-Cause Mortality 

      Mitnick, Carole Diane; Franke, Molly Forrest; Rich, Michael Leonard; Alcantara Viru, Felix A.; Appleton, Sasha C.; Atwood, Sidney S.; Bayona, Jaime N.; Bonilla, Cesar A.; Chalco, Katiuska; Fraser, Hamish S. F.; Furin, Jennifer J.; Guerra, Dalia; Hurtado, Rocio M.; Joseph, Keith; Llaro, Karim; Mestanza, Lorena; Mukherjee, Joia S.; Muñoz, Maribel; Palacios, Eda; Sanchez, Epifanio; Seung, Kwonjune J.; Shin, Sonya S.; Sloutsky, Alexander; Tolman, Arielle W.; Becerra, Mercedes C. (Public Library of Science, 2013)
      Rationale: A better understanding of the composition of optimal treatment regimens for multidrug-resistant tuberculosis (MDR-TB) is essential for expanding universal access to effective treatment and for developing new ...
    • Aggressive therapy for patients with non-small cell lung carcinoma and synchronous brain-only oligometastatic disease is associated with long-term survival 

      Gray, Phillip; Mak, Raymond Heungwing; Yeap, Beow Yong; Cryer, Sarah K.; Pinnell, Nancy E.; Christianson, Laura W.; Sher, David J.; Arvold, Nils; Baldini, Elizabeth Healey; Chen, Aileen Betty; Kozono, David Eiichi; Swanson, Scott James; Jackman, David M; Alexander, Brian Michael (Elsevier BV, 2014)
      Objectives: Optimal therapy for patients with non-small cell lung carcinoma (NSCLC) presenting with synchronous brain-only oligometastases (SBO) is not well defined. We sought to analyze the effect of differing therapeutic ...
    • Aging and emotional expressions: is there a positivity bias during dynamic emotion recognition? 

      Di Domenico, Alberto; Palumbo, Rocco; Mammarella, Nicola; Fairfield, Beth (Frontiers Media S.A., 2015)
      In this study, we investigated whether age-related differences in emotion regulation priorities influence online dynamic emotional facial discrimination. A group of 40 younger and a group of 40 older adults were invited ...
    • Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context 

      Christensen, Brock C.; Marsit, Carmen J.; Zheng, Shichun; Wrensch, Margaret R.; Wiemels, Joseph L.; Nelson, Heather H.; Karagas, Margaret R.; Padbury, James F.; Yeh, Ru-Fang; Wiencke, John K.; Kelsey, Karl T.; Houseman, Eugene Andres; Bueno, Raphael; Sugarbaker, David John (Public Library of Science, 2009)
      Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human ...
    • The Aging Kidney: Increased Susceptibility to Nephrotoxicity 

      Wang, Xinhui; Bonventre, Joseph V.; Parrish, Alan R. (MDPI, 2014)
      Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data ...
    • Aging Syndrome Genes and Premature Coronary Artery Disease 

      Low, Adrian F; O'Donnell, Christopher Joseph; Kathiresan, Sekar; Everett, Brendan Murphy; Chae, Claudia Un-Yong; Shaw, Stanley Yang; Ellinor, Patrick Thomas; MacRae, Calum A (BioMed Central, 2005)
      Background: Vascular disease is a feature of aging, and coronary vascular events are a major source of morbidity and mortality in rare premature aging syndromes. One such syndrome is caused by mutations in the lamin A/C ...
    • Aging, brain disease, and reserve: Implications for delirium 

      Jones, Richard Norman; Fong, Tamara G; Metzger, Eran Daniel; Tulebaev, Samir Raisovich; Yang, Frances Margaret; Alsop, David C.; Marcantonio, Edward Ralph; Cupples, L; Gottlieb, Gary L.; Inouye, Sharon (2010)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Aging, Brain Disease, and Reserve: Implications for Delirium 

      Jones, Richard; Fong, Tamara; Metzger, Eran; Tulebaev, Samir; Yang, Frances; Alsop, David; Marcantonio, Edward; Cupples, L Adrienne; Gottlieb, Gary; Inouye, Sharon (Elsevier BV, 2010-02)
      Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. ...
    • Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells 

      Rimmelé, Pauline; Bigarella, Carolina L.; Liang, Raymond; Izac, Brigitte; Dieguez-Gonzalez, Rebeca; Barbet, Gaetan; Donovan, Michael; Brugnara, Carlo; Blander, Julie M.; Sinclair, David A.; Ghaffari, Saghi (Elsevier, 2014)
      Summary Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and compromised immune competence in the elderly. Mechanisms ...
    • Aging: Past, Present and Future 

      Blagosklonny, Mikhail V.; Campisi, Judith; Sinclair, David Andrew (Impact Journals LLC, 2009)
      In his Foundation series, published in the 1950’s, Isaac Asimov imagined Civilization capable of colonizing the entire Universe. This feat is unlikely to occur. Strikingly, Asimov referred to a 70-old man as an old ...
    • Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes 

      Gladyshev, Vadim N. (John Wiley and Sons Inc., 2016)
      Summary Different theories posit that aging is caused by molecular damage, genetic programs, continued development, hyperfunction, antagonistic pleiotropy alleles, mutations, trade‐offs, incomplete repair, etc. Here, I ...
    • Agnogene Deletion in a Novel Pathogenic JC Virus Isolate Impairs VP1 Expression and Virion Production 

      Ellis, Laura C.; Norton, Elizabeth; Dang, Xin; Koralnik, Igor J. (Public Library of Science, 2013)
      Infection of glial cells by the human polyomavirus JC (JCV) causes progressive multifocal leukoencephalopathy (PML). JCV Encephalopathy (JCVE) is a newly identified disease characterized by JCV infection of cortical pyramidal ...