Browsing HMS Scholarly Articles by Title

Now showing items 528-547 of 17920

    • Aging: Past, Present and Future 

      Blagosklonny, Mikhail V.; Campisi, Judith; Sinclair, David Andrew (Impact Journals LLC, 2009)
      In his Foundation series, published in the 1950’s, Isaac Asimov imagined Civilization capable of colonizing the entire Universe. This feat is unlikely to occur. Strikingly, Asimov referred to a 70-old man as an old ...

    • Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes 

      Gladyshev, Vadim N. (John Wiley and Sons Inc., 2016)
      Summary Different theories posit that aging is caused by molecular damage, genetic programs, continued development, hyperfunction, antagonistic pleiotropy alleles, mutations, trade‐offs, incomplete repair, etc. Here, I ...

    • Agnogene Deletion in a Novel Pathogenic JC Virus Isolate Impairs VP1 Expression and Virion Production 

      Ellis, Laura C.; Norton, Elizabeth; Dang, Xin; Koralnik, Igor J. (Public Library of Science, 2013)
      Infection of glial cells by the human polyomavirus JC (JCV) causes progressive multifocal leukoencephalopathy (PML). JCV Encephalopathy (JCVE) is a newly identified disease characterized by JCV infection of cortical pyramidal ...

    • Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors 

      Chang, Hung; Yanachkov, Ivan B.; Michelson, Alan D; Li, YouFu; Barnard, M.R.; Wright, George E.; Frelinger, Andrew Lawrence (Elsevier BV, 2010)
      INTRODUCTION: Diadenosine 5',5'''-P(1),P(4)- tetraphosphate (Ap(4)A) is stored in platelet dense granules, but its effects on platelet function are not well understood. METHODS AND RESULTS: We examined the effects of Ap(4)A ...

    • AGuIX nanoparticles as a promising platform for image-guided radiation therapy 

      Detappe, Alexandre; Kunjachan, Sijumon; Rottmann, Joerg; Robar, James; Tsiamas, Panagiotis; Korideck, Houari; Tillement, Olivier; Berbeco, Ross (Springer Vienna, 2015)
      AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the uptake of ...

    • AI-based pathology predicts origins for cancers of unknown primary 

      Lu, Ming Y.; Chen, Tiffany Y.; Williamson, Drew F.K.; Zhao, Melissa; Shady, Maha; Lipkova, Jana; Mahmood, Faisal (Springer Science and Business Media LLC, 2021-05-05)

    • An AICD-based functional screen to identify APP metabolism regulators 

      Zhang, Can; Khandelwal, Preeti J; Chakraborty, Ranjita; Cuellar, Trinna L; Sarangi, Srikant; Patel, Shyam A; Cosentino, Christopher P; O'Connor, Michael; Lee, Jeremy C; Tanzi, Rudolph Emile; Saunders, Aleister J (BioMed Central, 2007)
      Background: A central event in Alzheimer's disease (AD) is the regulated intramembraneous proteolysis of the β-amyloid precursor protein (APP), to generate the β-amyloid (Aβ) peptide and the APP intracellular domain (AICD). ...

    • AIDA and UCP1 Snuggle Up to Prevent Hypothermia 

      Mills, Evanna; Xiao, Haopeng; Chouchani, Edward (Springer Science and Business Media LLC, 2021-03-09)
      In response to cold stress, mammals release norepinephrine from the sympathetic nervous system to elevate thermogenesis in brown adipose tissue (BAT) in order to maintain body temperature. This study reveals that the protein ...

    • AIF Downregulation and Its Interaction with STK3 in Renal Cell Carcinoma 

      Xu, Shengqiang; Wu, Hongjin; Nie, Huan; Yue, Lei; Jiang, Huadong; Xiao, Sheng; Li, Yu (Public Library of Science, 2014)
      Apoptosis-inducing factor (AIF) plays a crucial role in caspase-independent programmed cell death by triggering chromatin condensation and DNA fragmentation. Therefore, it might be involved in cell homeostasis and tumor ...

    • AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs 

      Parsons, William H; Kolar, Matthew J; Kamat, Siddhesh S; Cognetta, Armand B; Hulce, Jonathan J; Saez, Enrique; Kahn, Barbara B; Saghatelian, Alan; Cravatt, Benjamin F (2016)
      Enzyme classes may contain outlier members that share mechanistic, but not sequence or structural relatedness with more common representatives. The functional annotation of such exceptional proteins can be challenging. ...

    • Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease. 

      Janssen, Nicole A H; Schwartz, Joel David; Zanobetti, Antonella; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2002)
      Studies on acute effects of particulate matter (PM) air pollution show significant variability in exposure-effect relations among cities. Recent studies have shown an influence of ventilation on personal/indoor-outdoor ...

    • Air Pollution and ST-Segment Depression in Elderly Subjects 

      MacCallum, Gail; Canner, Marina J.; Gold, Diane R.; Litonjua, Augusto Ampil; Zanobetti, Antonella; Coull, Brent Andrew; Schwartz, Joel David; Verrier, Richard Leonard; Nearing, Bruce David; Suh MacIntosh, Helen H.; Stone, Peter Howard (National Institue of Environmental Health Sciences, 2005)
      Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated ...

    • Air pollution attributable postneonatal infant mortality in U.S. metropolitan areas: a risk assessment study 

      Kaiser, Reinhard; Romieu, Isabelle; Medina, Sylvia; Schwartz, Joel David; Krzyzanowski, Michal; Künzli, Nino (BioMed Central, 2004)
      Background: The impact of outdoor air pollution on infant mortality has not been quantified. Methods: Based on exposure-response functions from a U.S. cohort study, we assessed the attributable risk of postneonatal infant ...

    • Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort 

      Fleisch, Abby F.; Gold, Diane R.; Rifas-Shiman, Sheryl L.; Koutrakis, Petros; Schwartz, Joel D.; Kloog, Itai; Melly, Steven; Coull, Brent A.; Zanobetti, Antonella; Gillman, Matthew W.; Oken, Emily (National Institute of Environmental Health Sciences, 2014)
      Background: Exposure to fine particulate matter (PM with diameter ≤ 2.5 μm; PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied. Methods: We studied ...

    • Air pollution exposure and gestational diabetes mellitus among pregnant women in Massachusetts: a cohort study 

      Fleisch, Abby F.; Kloog, Itai; Luttmann-Gibson, Heike; Gold, Diane R.; Oken, Emily; Schwartz, Joel D. (BioMed Central, 2016)
      Background: Rodent and human studies suggest an association between air pollution exposure and type 2 diabetes mellitus, but the extent to which air pollution is associated with gestational diabetes mellitus (GDM) is less ...

    • Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study 

      Baccarelli, Andrea A; Zheng, Yinan; Zhang, Xiao; Chang, Dou; Liu, Lei; Wolf, Katherine Rose; Zhang, Zhou; McCracken, John P; Díaz, Anaité; Bertazzi, Pier Alberto; Schwartz, Joel; Wang, Sheng; Kang, Choong-Min; Koutrakis, Petros; Hou, Lifang (BioMed Central, 2014)
      Background: Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to ...

    • Air Pollution Exposures During Adulthood and Risk of Endometriosis in the Nurses’ Health Study II 

      Mahalingaiah, Shruthi; Hart, Jaime E.; Laden, Francine; Aschengrau, Ann; Missmer, Stacey A. (National Institute of Environmental Health Sciences, 2013)
      Background: Particulate matter and proximity to large roadways may promote disease mechanisms, including systemic inflammation, hormonal alteration, and vascular proliferation, that may contribute to the development and ...

    • Air Pollution, Smoking, and Plasma Homocysteine 

      Baccarelli, Andrea; Zanobetti, Antonella; Martinelli, Ida; Grillo, Paolo; Hou, Lifang; Lanzani, Guido; Mannucci, Pier Mannuccio; Bertazzi, Pier Alberto; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2006)
      Background: Mild hyperhomocysteinemia is independently associated with an increased risk of cardiovascular disease. Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, ...

    • Air Travel and the Spread of Influenza: Authors' Reply 

      Brownstein, John Samuel; Mandl, Kenneth David; Wolfe, Cecily J (Public Library of Science, 2006)

    • Air-Stimulated ATP Release from Keratinocytes Occurs through Connexin Hemichannels 

      Barr, Travis P; Albrecht, Phillip J.; Hou, Quanzhi; Mongin, Alexander A.; Strichartz, Gary Richard; Rice, Frank L. (Public Library of Science, 2013)
      Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis. In this study, we analyzed ATP ...