Browsing HMS Scholarly Articles by Title

Now showing items 5452-5471 of 17922

    • Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using Magnetic Resonance Imaging 

      Meredith, Dennis S; Losina, Elena; Neumann, Gesa; Yoshioka, Hiroshi; Lang, Philipp K; Katz, Jeffrey Neil (Springer Science and Business Media LLC, 2009-10-29)
      Background: In this cross-sectional study, we conducted a comprehensive assessment of all articular elements that could be measured using knee MRI. We assessed the association of pathological change in multiple articular ...

    • Empirical Evidence for the Effect of Airline Travel on Inter-Regional Influenza Spread in the United States 

      Wolfe, Cecily J; Galvani, Alison; Brownstein, John Samuel; Mandl, Kenneth David (Public Library of Science, 2006)
      Background: The influence of air travel on influenza spread has been the subject of numerous investigations using simulation, but very little empirical evidence has been provided. Understanding the role of airline travel ...

    • Empirically Establishing Blood Glucose Targets to Achieve HbA1c Goals 

      Wei, Nancy; Zheng, Hui; Nathan, David M. (American Diabetes Association, 2014)
      OBJECTIVE To determine the average fasting, postprandial, and bedtime self-monitored blood glucose (SMBG) concentrations associated with specified HbA1c levels using data from the A1c-Derived Average Glucose (ADAG) study. ...

    • Empowering the Digital Therapeutic Relationship: Virtual Clinics for Digital Health Interventions 

      Torous, John; Hsin, Honor (Nature, 2018)
      As “digital phenotyping” and monitoring technologies begin to unleash the potential of data insights for mental health care, we propose here a complementary concept of the “digital therapeutic relationship” to unleash the ...

    • EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children 

      Namjou, Bahram; Keddache, Mehdi; Marsolo, Keith; Wagner, Michael; Lingren, Todd; Cobb, Beth; Perry, Cassandra; Kennebeck, Stephanie; Holm, Ingrid A.; Li, Rongling; Crimmins, Nancy A.; Martin, Lisa; Solti, Imre; Kohane, Isaac S.; Harley, John B. (Frontiers Media S.A., 2013)
      Common variations at the loci harboring the fat mass and obesity gene (FTO), MC4R, and TMEM18 are consistently reported as being associated with obesity and body mass index (BMI) especially in adult population. In order ...

    • EMSAR: estimation of transcript abundance from RNA-seq data by mappability-based segmentation and reclustering 

      Lee, Soohyun; Seo, Chae Hwa; Alver, Burak Han; Lee, Sanghyuk; Park, Peter J. (BioMed Central, 2015)
      Background: RNA-seq has been widely used for genome-wide expression profiling. RNA-seq data typically consists of tens of millions of short sequenced reads from different transcripts. However, due to sequence similarity ...

    • EMT and tumor metastasis 

      Heerboth, Sarah; Housman, Genevieve; Leary, Meghan; Longacre, Mckenna; Byler, Shannon; Lapinska, Karolina; Willbanks, Amber; Sarkar, Sibaji (Springer Berlin Heidelberg, 2015)
      EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and ...

    • En bloc esophageal mucosectomy for concentric circumferential mucosal resection (with video) 

      Willingham, Field F.; Gee, Denise W.; Sylla, Patricia; Lauwers, Gregory Y.; Rattner, David William; Brugge, William Robert (Elsevier BV, 2009)
      Background: With conventional EMR, specimens are fragmented, metaplasia may be left behind, and invasive lesions could be missed because of incomplete sampling. Concentric subtotal esophageal mucosectomy would address these ...

    • Enabling automated magnetic resonance imaging-based targeting assessment during dipole field navigation 

      Latulippe, Maxime; Felfoul, Ouajdi; Dupont, Pierre E; Martel, Sylvain (AIP Publishing, 2016)
      The magnetic navigation of drugs in the vascular network promises to increase the efficacy and reduce the secondary toxicity of cancer treatments by targeting tumors directly. Recently, dipole field navigation (DFN) was ...

    • Enabling multiplexed testing of pooled donor cells through whole-genome sequencing 

      Chan, Yingleong; Chan, Ying Kai; Goodman, Daniel B.; Guo, Xiaoge; Chavez, Alejandro; Lim, Elaine T.; Church, George M. (BioMed Central, 2018)
      We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes ...

    • Encapsulated stem cells for cancer therapy 

      Shah, Khalid (Landes Bioscience, 2013)
      Stem cells have inherent tumor‑trophic migratory properties and can serve as vehicles for delivering effective, targeted therapy to isolated tumors and metastatic disease, making them promising anti‑cancer agents. Encapsulation ...

    • The Encephalomyocarditis Virus 

      Carocci, Margot; Bakkali-Kassimi, Labib (Landes Bioscience, 2012)
      The encephalomyocarditis virus (EMCV) is a small non-enveloped single-strand RNA virus, the causative agent of not only myocarditis and encephalitis, but also neurological diseases, reproductive disorders and diabetes in ...

    • Encoding Cortical Dynamics in Sparse Features 

      Khan, Sheraz; Lefèvre, Julien; Baillet, Sylvain; Michmizos, Konstantinos P.; Ganesan, Santosh; Kitzbichler, Manfred G.; Zetino, Manuel; Hämäläinen, Matti S.; Papadelis, Christos; Kenet, Tal (Frontiers Media S.A., 2014)
      Distributed cortical solutions of magnetoencephalography (MEG) and electroencephalography (EEG) exhibit complex spatial and temporal dynamics. The extraction of patterns of interest and dynamic features from these cortical ...

    • Encoding visual information in retinal ganglion cells with prosthetic stimulation 

      Freeman, Daniel K; Rizzo, Joseph F; Fried, Shelley (IOP Publishing, 2011-05-18)
      Retinal prostheses aim to restore functional vision to those blinded by outer retinal diseases using electric stimulation of surviving retinal neurons. The ability to replicate the spatiotemporal pattern of ganglion cell ...

    • End-of-Life Care for Older Patients With Ovarian Cancer Is Intensive Despite High Rates of Hospice Use 

      Wright, A. A.; Hatfield, Laura Anne; Earle, C. C.; Keating, Nancy Lynn (American Society of Clinical Oncology (ASCO), 2014)
      Purpose: To date, few studies have examined end-of-life care for patients with ovarian cancer. One study documented increased hospice use among older patients with ovarian cancer from 2000 to 2005. We sought to determine ...

    • Endobiont Viruses Sensed by the Human Host – Beyond Conventional Antiparasitic Therapy 

      Fichorova, Raina N.; Lee, Yujin; Yamamoto, Hidemi; Takagi, Yuko; Hayes, Gary R.; Goodman, Russell P.; Chepa-Lotrea, Xenia; Buck, Olivia R.; Murray, Ryan; Kula, Tomasz; Beach, David H.; Singh, Bibhuti N.; Nibert, Max L. (Public Library of Science, 2012)
      Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted to the human genitourinary tract, infects globally ∼250 ...

    • Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment 

      McKay, Tina B; Hjortdal, Jesper; Sejersen, Henrik; Asara, John M; Wu, Jennifer; Karamichos, Dimitrios (Nature Publishing Group, 2016)
      Hormones play a critical role in regulating tissue function by promoting cell survival, proliferation, and differentiation. Our study explores the influence of endocrine function in regulating metabolism and inflammatory ...

    • The Endocrine Tumor Summit 2008: Appraising Therapeutic Approaches for Acromegaly and Carcinoid Syndrome 

      Klibanski, Anne; Melmed, Shlomo; Clemmons, David R.; Colao, Annamaria; Cunningham, Regina S.; Molitch, Mark E.; Vinik, Aaron I.; Adelman, Daphne T.; Liebert, Karen J. P. (Springer US, 2009)
      The Endocrine Tumor Summit convened in December 2008 to address 6 statements prepared by panel members that reflect important questions in the treatment of acromegaly and carcinoid syndrome. Data pertinent to each of the ...

    • Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine 

      Bajic, Dusica; Soiza-Reilly, Mariano; Spalding, Allegra L.; Berde, Charles B.; Commons, Kathryn G. (Public Library of Science, 2015)
      Neuroplasticity in the mesolimbic dopaminergic system is critical for behavioral adaptations associated with opioid reward and addiction. These processes may be influenced by cholinergic transmission arising from the ...

    • Endogenous Levels of Circulating Androgens and Risk of Crohn's Disease and Ulcerative Colitis Among Women: A Nested Case–Control Study from the Nurses' Health Study Cohorts 

      Khalili, Hamed; Ananthakrishnan, Ashwin N.; Konijeti, Gauree G.; Higuchi, Leslie M.; Fuchs, Charles S.; Richter, James M.; Tworoger, Shelley S.; Hankinson, Susan E.; Chan, Andrew T. (Lippincott Williams & Wilkins, 2015)
      Background: Androgens, which are known to be altered by exogenous hormone use, have recently been linked to alterations of the gut microbiome and mucosal immune function. No study has evaluated the association between ...