Now showing items 554-573 of 17917

    • Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma 

      Planaguma, Anna; Kazani, Shamsah; Marigowda, Gautham; Haworth, Oliver; Mariani, Thomas J.; Israel, Elliot; Bleecker, Eugene R.; Curran-Everett, Douglas; Erzurum, Serpil C.; Calhoun, William J.; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Jarjour, Nizar N.; Busse, William W.; Wenzel, Sally E.; Levy, Bruce (American Thoracic Society, 2008-09-15)
      Rationale: Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A4 (LXA4) is an arachidonic acid–derived mediator that serves as an agonist for resolution of ...
    • AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair 

      Cha, Jong-Ho; Wee, Hee-Jun; Seo, Ji Hae; Ahn, Bum Ju; Park, Ji-Hyeon; Yang, Jun-Mo; Lee, Sae-Won; Kim, Eun Hee; Lee, Ok-Hee; Heo, Ji Hoe; Lee, Hyo-Jong; Gelman, Irwin H.; Arai, Ken; Lo, Eng H.; Kim, Kyu-Won (Public Library of Science, 2014)
      The repair process after CNS injury shows a well-organized cascade of three distinct stages: inflammation, new tissue formation, and remodeling. In the new tissue formation stage, various cells migrate and form the fibrotic ...
    • AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation 

      Herter, Jan M.; Grabie, Nir; Cullere, Xavier; Azcutia, Veronica; Rosetti, Florencia; Bennett, Paul; Herter-Sprie, Grit S.; Elyaman, Wassim; Luscinskas, Francis W.; Lichtman, Andrew H.; Mayadas, Tanya N. (Nature Publishing Group, 2015)
      The mechanisms driving T cell homing to lymph nodes and migration to tissue are well described but little is known about factors that affect T cell egress from tissues. Here, we generate mice with a T cell-specific deletion ...
    • Akt Finds its New Path to Regulate Cell Cycle Through Modulating Skp2 Activity and its Destruction by APC/Cdh1 

      Gao, Daming; Inuzuka, Hiroyuki; Tseng, Alan; Wei, Wenyi (BioMed Central, 2009)
      Skp2 over-expression has been observed in many human cancers. However, the mechanisms underlying elevated Skp2 expression have remained elusive. We recently reported that Akt1, but not Akt2, directly controls Skp2 stability ...
    • AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions 

      Guo, Jianping; Dai, Xiangpeng; Laurent, Benoit; Zheng, Nana; Gan, Wenjian; Zhang, Jian; Guo, Ailan; Yuan, Min; Liu, Pengda; Asara, John M.; Toker, Alex; Shi, Yang; Pandolfi, Pier Paolo; Wei, Wenyi (Springer Science and Business Media LLC, 2019-01-28)
      Aberrant activation of Akt disturbs proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand upstream signaling pathways governing Akt activation. Here, we report that ...
    • Akt Promotes Endocardial-Mesenchyme Transition 

      Meadows, Kafi Najuma; Iyer, Seema; Stevens, Mark V.; Wang, Duanning; Shechter, Sharon; Perruzzi, Carole; Camenisch, Todd D.; Benjamin, Laura E. (BioMed Central, 2009)
      Endothelial to mesenchyme transition (EndMT) can be observed during the formation of endocardial cushions from the endocardium, the endothelial lining of the atrioventricular canal (AVC), of the developing heart at embryonic ...
    • Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis 

      McNamara, Colleen R.; Ahuja, Ruchita; Osafo-Addo, Awo D.; Barrows, Douglas; Kettenbach, Arminja; Skidan, Igor; Teng, Xin; Cuny, Gregory Douglas; Gerber, Scott; Degterev, Alexei (Public Library of Science, 2013)
      Necroptosis is a regulated form of necrotic cell death that has been implicated in the pathogenesis of various diseases including intestinal inflammation and systemic inflammatory response syndrome (SIRS). In this work, ...
    • Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells 

      Ding, Yahui; Gao, Huier; Zhang, Yu; Li, Ye; Vasdev, Neil; Gao, Yingdai; Chen, Yue; Zhang, Quan (BioMed Central, 2016)
      Background: The poor outcomes for patients diagnosed with acute myeloid leukemia (AML) are largely attributed to leukemia stem cells (LSCs) which are difficult to eliminate with conventional therapy and responsible for ...
    • Albuminuria, Cerebrovascular Disease and Cortical Atrophy: among Cognitively Normal Elderly Individuals 

      Cho, Eun Bin; Shin, Hee-Young; Park, Sang Eon; Chun, Phillip; Jang, Hye Ryoun; Yang, Jin-ju; Kim, Hee Jin; Kim, Yeo Jin; Jung, Na-Yeon; Lee, Jin San; Lee, Juyoun; Jang, Young Kyoung; Jang, Eun Young; Kang, Mira; Lee, Jong-Min; Kim, Changsoo; Min, Ju-Hong; Ryu, Seungho; Na, Duk L.; Seo, Sang Won (Nature Publishing Group, 2016)
      We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution ...
    • Alcohol Affects the Brain's Resting-State Network in Social Drinkers 

      Lithari, Chrysa; Klados, Manousos A.; Pappas, Costas; Albani, Maria; Kapoukranidou, Dorothea; Kovatsi, Leda; Bamidis, Panagiotis D.; Papadelis, Christos (Public Library of Science, 2012)
      Acute alcohol intake is known to enhance inhibition through facilitation of GABAA receptors, which are present in 40% of the synapses all over the brain. Evidence suggests that enhanced GABAergic transmission leads to ...
    • Alcohol and Difficulty Conceiving in the SUN Cohort: A Nested Case-Control Study 

      Lopez-del Burgo, Cristina; Gea, Alfredo; de Irala, Jokin; Martínez-González, Miguel A.; Chavarro, Jorge E.; Toledo, Estefania (MDPI, 2015)
      The role of alcohol on fertility remains unclear. We aimed to investigate the association between alcohol and specific alcoholic beverages consumption and the risk of difficulty getting pregnant. We used a case-control ...
    • Alcohol Consumption, Mediating Biomarkers, and Risk of Type 2 Diabetes Among Middle-Aged Women 

      Beulens, Joline W.J.; Rimm, Eric B.; Hu, Frank B.; Hendriks, Henk F.J.; Mukamal, Ken J. (American Diabetes Association, 2008)
      OBJECTIVE—The purpose of this study was to investigate whether adiponectin concentrations and biomarkers of inflammation, endothelial dysfunction, and insulin resistance mediate the association between alcohol consumption ...
    • Alcohol Consumption, Physical Activity, and Chronic Disease Risk Factors: A Population-based Cross-sectional Survey 

      Mukamal, Ken J.; Ding, Eric L.; Djoussé, Luc (BioMed Central, 2006)
      Background: Whether the association of alcohol consumption and cardiovascular disease is the product of confounding and the degree to which this concern applies to other behaviors are unclear. Methods: Using the 2003 ...
    • Alcohol Intake and Mortality among Women with Invasive Breast Cancer 

      Harris, Holly Ruth; Bergkvist, L; Wolk, A (Nature Publishing Group, 2012)
      Background: Alcohol intake has consistently been associated with increased breast cancer incidence in epidemiological studies. However, the relation between alcohol and survival after breast cancer diagnosis is less clear. ...
    • Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk 

      Liu, Ying; Colditz, Graham A.; Rosner, Bernard; Berkey, Catherine S.; Collins, Laura C.; Schnitt, Stuart J.; Connolly, James L.; Chen, Wendy Y.; Willett, Walter C.; Tamimi, Rulla M. (Oxford University Press, 2013)
      Background: Adult alcohol consumption during the previous year is related to breast cancer risk. Breast tissue is particularly susceptible to carcinogens between menarche and first full-term pregnancy. No study has ...
    • Alcohol Policies and Alcoholic Cirrhosis Mortality in the United States 

      Hadland, Scott E.; Xuan, Ziming; Blanchette, Jason G.; Heeren, Timothy C.; Swahn, Monica H.; Naimi, Timothy S. (Centers for Disease Control and Prevention, 2015)
      Introduction: Stronger alcohol policies predict decreased alcohol consumption and binge drinking in the United States. We examined the relationship between the strength of states’ alcohol policies and alcoholic cirrhosis ...
    • Alcohol use and HIV serostatus of partner predict high-risk sexual behavior among patients receiving antiretroviral therapy in South Western Uganda 

      Bajunirwe, Francis; Bangsberg, David Roy; Sethi, Ajay K (BioMed Central, 2013)
      Background: Antiretroviral treatment restores the physical and immunological function for patients with HIV/AIDS and the return of sexual desire. The frequency and correlates of sexual activity among patients receiving ART ...
    • Alcohol, Hospital Discharge, and Socioeconomic Risk Factors for Default from Multidrug Resistant Tuberculosis Treatment in Rural South Africa: A Retrospective Cohort Study 

      Kendall, Emily A.; Theron, Danie; Franke, Molly F.; van Helden, Paul; Victor, Thomas C.; Murray, Megan B.; Warren, Robin M.; Jacobson, Karen R. (Public Library of Science, 2013)
      Background: Default from multidrug-resistant tuberculosis (MDR-TB) treatment remains a major barrier to cure and epidemic control. We sought to identify patient risk factors for default from MDR-TB treatment and high-risk ...
    • Alcohol-Induced Delay of Viability Loss in Stationary-Phase Cultures of Escherichia coli 

      Vulić, Marin; Kolter, Roberto (American Society for Microbiology, 2002)
      During prolonged incubation in stationary phase Escherichia coli undergoes starvation-induced differentiation, resulting in highly resistant cells. In rich medium with high amino acid content further incubation of cultures ...
    • Alfalfa Mosaic Virus Coat Protein Bridges Rna and Rna-dependent Rna Polymerase in Vitro 

      Reichert, Vienna L.; Choi, Mehee; Petrillo, Jessica E.; Gehrke, Lee (SAGE Publications, 2007)
      Alfalfa mosaic virus (AMV) RNA replication requires the viral coat protein (CP). AMV CP is an integral component of the viral replicase; moreover, it binds to the viral RNA 3'-termini and induces the formation of multiple ...