Browsing HMS Scholarly Articles by Title
Now showing items 5570-5589 of 17922
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Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations
(Wolters Kluwer, 2016)Abstract There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in ... -
The Enterococcus faecalis fsrB Gene, a Key Component of the fsr Quorum-Sensing System, Is Associated with Virulence in the Rabbit Endophthalmitis Model
(American Society for Microbiology, 2002)We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had ... -
Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila
(Elsevier BV, 2014-10-09)Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory ... -
Entry Is a Rate-Limiting Step for Viral Infection in a Drosophila Melanogaster Model of Pathogenesis
(Springer Nature, 2004-01)The identification of host factors that control susceptibility to infection has been hampered by a lack of amenable genetic systems. We established an in vivo model to determine the host factors that control pathogenesis ... -
Environment and Obesity in the National Children's Study
(National Institute of Environmental Health Sciences, 2008)Objective: In this review we describe the approach taken by the National Children’s Study (NCS), a 21-year prospective study of 100,000 American children, to understanding the role of environmental factors in the development ... -
Environment-Wide Association Study of Blood Pressure in the National Health and Nutrition Examination Survey (1999–2012)
(Nature Publishing Group, 2016)Identifying environmental exposures associated with blood pressure is a priority. Recently, we proposed the environment-wide association study to search for and replicate environmental factors associated with phenotypes. ... -
Environmental and Occupational Exposures in Immigrant Health
(Libertas Academica, 2008)Immigrants comprise vulnerable populations that are frequently exposed to a multitude of environmental and occupational hazards. The historical context behind state and federal legislation has helped to foster an environment ... -
Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment
(National Institute of Environmental Health Sciences, 2015)Background: Investigators measuring exposure biomarkers in urine typically adjust for creatinine to account for dilution-dependent sample variation in urine concentrations. Similarly, it is standard to adjust for serum ... -
Environmental conditioning in the control of macrophage thrombospondin-1 production
(Nature Publishing Group, 2012)Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate. Macrophages are a source of TSP-1, ... -
Environmental Exposure to Polychlorinated Biphenyls and p,p´-DDE and Sperm Sex-Chromosome Disomy
(National Institute of Environmental Health Sciences, 2012)Background: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention. Objectives: We evaluated the association of polychlorinated ... -
Environmental Mold and Mycotoxin Exposures Elicit Specific Cytokine and Chemokine Responses
(Public Library of Science, 2015)Background: Molds can cause respiratory symptoms and asthma. We sought to use isolated peripheral blood mononuclear cells (PBMCs) to understand changes in cytokine and chemokine levels in response to mold and mycotoxin ... -
Environmental Organochlorines and Semen Quality: Results of a Pilot Study
(National Institute of Environmental Health Sciences, 2002)There have been numerous studies that suggest that sperm concentrations (sperm counts) are declining in men. However, other studies suggest that sperm counts are not declining or may be increasing in some areas. Although ... -
Environmental Stress-Dependent Effects of Deletions Encompassing Hsp70Ba on Canalization and Quantitative Trait Asymmetry in Drosophila melanogaster
(Public Library of Science, 2011)Hsp70 genes may influence the expression of wing abnormalities in Drosophila melanogaster but their effects on variability in quantitative characters and developmental instability are unclear. In this study, we focused on ... -
Environmental Susceptibility of the Sperm Epigenome During Windows of Male Germ Cell Development
(Springer International Publishing, 2015)Male germ cells require multiple epigenetic reprogramming events during their lifespan to achieve reproductive capacity. An emerging body of compelling data demonstrates that environmental exposures can be embodied within ... -
Environmental tobacco smoke, indoor allergens, and childhood asthma.
(2000)Both environmental tobacco smoke and indoor allergens can exacerbate already established childhood albeit primarily through quite disparate mechanisms. In infancy and childhood, environmental tobacco smoke (ETS) exposure ... -
Environmental transmission of Mycobacterium ulcerans drives dynamics of Buruli ulcer in endemic regions of Cameroon
(Nature Publishing Group, 2015)Buruli Ulcer is a devastating skin disease caused by the pathogen Mycobacterium ulcerans. Emergence and distribution of Buruli ulcer cases is clearly linked to aquatic ecosystems, but the specific route of transmission of ... -
Enzalutamide in European and North American men participating in the AFFIRM trial
(John Wiley & Sons Ltd, 2014)Objective: To explore any differences in efficacy and safety outcomes between European (EU) (n = 684) and North American (NA) (n = 395) patients in the AFFIRM trial (NCT00974311). Patients and Methods Phase III, double-blind, ... -
Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
(American Chemical Society, 2014)Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate ... -
Enzymatic Relay Mechanism Stimulates Cyclic GMP Synthesis in Rod Photoresponse: Biochemical and Physiological Study in Guanylyl Cyclase Activating Protein 1 Knockout Mice
(Public Library of Science, 2012)Regulation of cGMP synthesis by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) in rod and cone photoreceptors by calcium-sensitive guanylyl cyclase activating proteins (GCAP1 and GCAP2) is one of the key ...