Browsing HMS Scholarly Articles by Title
Now showing items 5880-5899 of 17922
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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc
(American Society for Biochemistry & Molecular Biology (ASBMB), 2000-05-08)Abeta binds Zn(2+), Cu(2+), and Fe(3+) in vitro, and these metals are markedly elevated in the neocortex and especially enriched in amyloid plaque deposits of individuals with Alzheimer's disease (AD). Zn(2+) precipitates ... -
An Evidence-Based Comparison of Operational Criteria for the Presence of Sarcopenia
(Oxford University Press, 2014)Background. Several consensus groups have previously published operational criteria for sarcopenia, incorporating lean mass with strength and/or physical performance. The purpose of this manuscript is to describe the ... -
Evidence-based decision support for pediatric rheumatology reduces diagnostic errors
(BioMed Central, 2016)Background: The number of trained specialists world-wide is insufficient to serve all children with pediatric rheumatologic disorders, even in the countries with robust medical resources. We evaluated the potential of ... -
Evidence-based endoscopic management of Barrett’s esophagus
(Oxford University Press, 2014)Barrett’s esophagus (BE) develops as a consequence of chronic esophageal acid exposure, and is the major risk factor for esophageal adenocarcinoma (EAC). The practices of endoscopic screening for—and surveillance of—BE, ... -
An Evidence-Based Guide to Writing Grant Proposals for Clinical Research
(American College of Physicians, 2005)The competition for funds to conduct clinical research is intense, and only a minority of grant proposals receive funding. In particular, funding for patient-oriented research lags behind that allocated for basic science ... -
Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine
(Ovid Technologies (Wolters Kluwer Health), 2014)Objective: To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs). Methods: Systematic review and practice recommendation ... -
Evidence-based guideline: Assessment and management of psychiatric disorders in individuals with MS: Report of the Guideline Development Subcommittee of the American Academy of Neurology
(Ovid Technologies (Wolters Kluwer Health), 2013)Objective: To make evidence-based recommendations for screening, diagnosing, and treating psychiatric disorders in individuals with multiple sclerosis (MS). Methods: We reviewed the literature (1950 to August 2011) and ... -
Evidence-Based Psychosocial Treatments for Self-Injurious Thoughts and Behaviors in Youth
(Informa UK Limited, 2014)The purpose of this study was to review the current evidence base of psychosocial treatments for suicidal and nonsuicidal self-injurious thoughts and behaviors (SITBs) in youth. We reviewed major scientific databases ... -
An Evidence-Based Review of Alternating Electric Fields Therapy for Malignant Gliomas
(Springer US, 2015)Opinion statement Glioblastoma is a deadly disease and even aggressive neurosurgical resection followed by radiation and chemotherapy only extends patient survival to a median of 1.5 years. The challenge in treating this ... -
An Evil Backstage Manipulator: Psychological Factors Correlated with Health-Related Quality of Life in Chinese Patients with Crohn's Disease
(Hindawi Publishing Corporation, 2013)Health-related quality of life (HRQoL) is recommended as one of essential parameters to evaluate treatment effect and clinical outcome in patients with Crohn's disease (CD). Recent studies reported that psychological factors ... -
Evoked itch perception is associated with changes in functional brain connectivity
(Elsevier, 2014)Chronic itch, a highly debilitating condition, has received relatively little attention in the neuroimaging literature. Recent studies suggest that brain regions supporting itch in chronic itch patients encompass sensorimotor ... -
Evoked Pain Analgesia in Chronic Pelvic Pain Patients Using Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation
(Oxford University Press (OUP), 2012)Objective Previous Vagus Nerve Stimulation (VNS) studies have demonstrated anti-nociceptive effects, and recent non-invasive approaches; termed transcutaneous-VNS, or t-VNS, have utilized stimulation of the auricular ... -
Evolution and Current Role of Autologous Chondrocyte Implantation for Treatment of Articular Cartilage Defects in the Football (Soccer) Player
(SAGE Publications, 2012)Background: Autologous chondrocyte implantation (ACI) continues to technically evolve, but how the technical innovations affect the ability to participate in high-impact sports such as football is unknown. Methods: Clinical ... -
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection
(National Academy of Sciences, 2006)Primate tripartite motif 5 alpha (TRIM5 alpha) proteins mediate innate intracellular resistance to retroviruses. In humans, TRIMS is located in a paralogous cluster that includes TRIM6, TRIM34, and TRIM22. Although TRIM6 ... -
Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys
(Public Library of Science, 2008)The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family is ... -
The evolution of cooperation within the gut microbiota
(2016)Cooperative phenotypes are considered central to the functioning of microbial communities in many contexts, including communication via quorum sensing, biofilm formation, antibiotic resistance, and pathogenesis1-5. The ... -
Evolution of coreceptor utilization to escape CCR5 antagonist therapy
(2016)The HIV-1 envelope interacts with coreceptors CCR5 and CXCR4 in a dynamic, multi-step process, its molecular details not clearly delineated. Use of CCR5 antagonists results in tropism shift and therapeutic failure. Here ... -
The evolution of corneal and refractive surgery with the femtosecond laser
(BioMed Central, 2015)The use of femtosecond lasers has created an evolution in modern corneal and refractive surgery. With accuracy, safety, and repeatability, eye surgeons can utilize the femtosecond laser in almost all anterior refractive ... -
Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal
(Public Library of Science, 2015)Background: The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis ... -
Evolution of Highly Polymorphic T Cell Populations in Siblings with the Wiskott-Aldrich Syndrome
(Public Library of Science, 2008)Population level evolutionary processes can occur within a single organism when the germ line contains a mutation that confers a cost at the level of the cell. Here we describe how multiple compensatory mutations arose ...