Browsing HMS Scholarly Articles by Title

Now showing items 5919-5938 of 17922

    • The Evolving Roles of the Medical Journal 

      Podolsky, Scott Harris; Greene, Jeremy Alan; Jones, David Shumway (New England Journal of Medicine (NEJM/MMS), 2012)

    • Ex Vivo Adenovirus-Mediated Gene Transfer to Corneal Graft Endothelial Cells in Mice 

      Qian, Ying; Leong, Fee-Lai; Kazlauskas, Andrius; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2004)
      purpose. Genetic modulation of donor tissue before corneal transplantation may have the potential to modulate alloimmunity and/or to prevent corneal endothelial cell death. This study was conducted to optimize adenovirus-mediated ...

    • Ex Vivo and in Vivo Stable Isotope Labelling of Central Carbon Metabolism and Related Pathways With Analysis by LC–MS/MS 

      Yuan, Min; Kremer, Daniel M.; Huang, He; Breitkopf, Susanne B.; Ben-Sahra, Issam; Manning, Brendan; Lyssiotis, Costas A.; Asara, John (Springer Science and Business Media LLC, 2019-02)
      Targeted tandem mass spectrometry (LC–MS/MS) has been extremely useful for profiling small molecules extracted from biological sources, such as cells, bodily fluids and tissues. Here, we present a protocol for analysing ...

    • Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells 

      Sharei, Armon; Trifonova, Radiana; Jhunjhunwala, Siddharth; Hartoularos, George C.; Eyerman, Alexandra T.; Lytton-Jean, Abigail; Angin, Mathieu; Sharma, Siddhartha; Poceviciute, Roberta; Mao, Shirley; Heimann, Megan; Liu, Sophia; Talkar, Tanya; Khan, Omar F.; Addo, Marylyn; von Andrian, Ulrich H.; Anderson, Daniel G.; Langer, Robert; Lieberman, Judy; Jensen, Klavs F. (Public Library of Science, 2015)
      Intracellular delivery of biomolecules, such as proteins and siRNAs, into primary immune cells, especially resting lymphocytes, is a challenge. Here we describe the design and testing of microfluidic intracellular delivery ...

    • Ex Vivo Expansion of Human CD8+ T Cells Using Autologous CD4+ T Cell Help 

      Butler, Marcus O.; Imataki, Osamu; Yamashita, Yoshihiro; Tanaka, Makito; Ansén, Sascha; Berezovskaya, Alla; Metzler, Genita; Milstein, Matthew I.; Mooney, Mary M.; Murray, Andrew P.; Mano, Hiroyuki; Nadler, Lee Marshall; Hirano, Naoto (Public Library of Science, 2012)
      Background: Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis of human CD4+ T cell help is largely lacking. Our goal was to elucidate the ...

    • The ExAC browser: displaying reference data information from over 60 000 exomes 

      Karczewski, Konrad J.; Weisburd, Ben; Thomas, Brett; Solomonson, Matthew; Ruderfer, Douglas M.; Kavanagh, David; Hamamsy, Tymor; Lek, Monkol; Samocha, Kaitlin E.; Cummings, Beryl B.; Birnbaum, Daniel; Daly, Mark J.; MacArthur, Daniel G. (Oxford University Press, 2017)
      Worldwide, hundreds of thousands of humans have had their genomes or exomes sequenced, and access to the resulting data sets can provide valuable information for variant interpretation and understanding gene function. Here, ...

    • Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells 

      Bouma, Gerben; Carter, Natalie A; Recher, Mike; Malinova, Dessislava; Adriani, Marsilio; Notarangelo, Luigi D; Burns, Siobhan O; Mauri, Claudia; Thrasher, Adrian J (BlackWell Publishing Ltd, 2014)
      Patients deficient in the cytoskeletal regulator Wiskott–Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing ...

    • Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse environment challenge in subjects with a history of dry eye and ocular allergy 

      Gomes, Paulo J; Ousler, George W; Welch, Donna L; Smith, Lisa M; Coderre, Jeffrey; Abelson, Mark B (Dove Medical Press, 2013)
      Background: The goal of this study was to assess the effect of a controlled adverse environment (CAE) challenge on subjects with both allergic conjunctivitis and dry eye. Methods: Thirty-three subjects were screened and ...

    • Examining Product Risk in Context. Market Withdrawal of Zomepirac as a Case Study 

      Ross-Degnan, Dennis; Soumerai, Stephen Bertram; Fortress, Eric E. (American Medical Association (AMA), 1993)
      Objective. —To examine changes in the prescribing of analgesics after the market entry and subsequent withdrawal of zomepirac sodium, a nonsteroidal anti-inflammatory drug (NSAID), following repeated reports of zomepirac-related ...

    • Examining the Interface Between Substance Misuse and Intimate Partner Violence 

      Stuart, Gregory L.; O’Farrell, Timothy J.; Leonard, Kenneth; Moore, Todd M.; Temple, Jeff R.; Ramsey, Susan E.; Stout, Robert L.; Kahler, Christopher W.; Bucossi, Meggan M.; Andersen, Shawna M.; Recupero, Patricia R.; Walsh, Zach; Schonbrun, Yael Chatav; Strong, David R.; Rothman, Emily F.; Rhatigan, Deborah L.; Monti, Peter M. (Libertas Academica, 2009)
      There is considerable theoretical and empirical support for a link between substance misuse and perpetration and victimization of intimate partner violence. This review briefly summarizes this literature and highlights ...

    • Excellent clinical outcomes and retention in care for adults with HIV-associated Kaposi sarcoma treated with systemic chemotherapy and integrated antiretroviral therapy in rural Malawi 

      Herce, Michael E; Kalanga, Noel; Wroe, Emily B; Keck, James W; Chingoli, Felix; Tengatenga, Listern; Gopal, Satish; Phiri, Atupere; Mailosi, Bright; Bazile, Junior; Beste, Jason A; Elmore, Shekinah N; Crocker, Jonathan T; Rigodon, Jonas (International AIDS Society, 2015)
      Introduction: HIV-associated Kaposi sarcoma (HIV-KS) is the most common cancer in Malawi. In 2008, the non-governmental organization, Partners In Health, and the Ministry of Health established the Neno Kaposi Sarcoma Clinic ...

    • Exceptional Molecular and Coreceptor-requirement Properties of Molecular Clones Isolated from an Human Immunodeficiency Virus Type-1 Subtype C Infection 

      Dash, Prasanta K; Mangaiarkarasi, Asokan; Mahendarkar, Aruna V; Roshan, Padmanabhan; Anand, Krishnamurthy Kumar; Mahadevan, Anita; Satishchandra, Parthasarathy; Shankar, Susarla K; Prasad, Vinayaka R; Ranga, Udaykumar; Siddappa, Nagadenahalli B. (BioMed Central, 2008)
      Background: The pathogenic significance of coreceptor switch in the viral infection of HIV-1 is not completely understood. This situation is more complex in subtype C infection where coreceptor switch is either absent or ...

    • Excess cancer incidence among workers exposed to fluoride 

      Grandjean, Philippe; Olsen, JH; Juel, K (Nordic Association of Occupational Safety and Health, 1993)

    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans 

      Parikh, Samir Mukund; Mammoto, Tadanori; Schultz, Aylit; Yuan, Hai-Tao; Christiani, David C.; Karumanchi, Subbian Ananth; Sukhatme, Vikas Pandurang (Public Library of Science, 2006)
      Background: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS ...

    • Excess cost of non-remission among outpatients with major depressive disorder 

      Woo, Jong-Min; Jeon, Hong Jin; Kim, Hyo-Jin; Lee, Kwang-Hun; Lee, Chang Uk; Noh, Jai Sung; Lee, Chang Hwa; Hong, Jin Pyo (BioMed Central, 2014)
      Background: The purpose of this study was to assess the economic benefit of achieving remission among outpatients with major depressive disorder (MDD) who are currently employed in Korea. Methods: Cross-sectional observational ...

    • Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus 

      Shim, Joon W.; Sandlund, Johanna; Hameed, Mustafa Q.; Blazer-Yost, Bonnie; Zhou, Feng C.; Klagsbrun, Michael; Madsen, Joseph R. (Nature Publishing Group, 2016)
      Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence ...

    • Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection 

      Lenz, Tobias L.; Spirin, Victor; Jordan, Daniel M.; Sunyaev, Shamil R. (Oxford University Press, 2016)
      Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are ...

    • Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation 

      Sheets, Lavinia (Nature Publishing Group, 2017)
      Accumulation of excess glutamate plays a central role in eliciting the pathological events that follow intensely loud noise exposures and ischemia-reperfusion injury. Glutamate excitotoxicity has been characterized in ...

    • Excessive diagnostic testing in acute kidney injury 

      Leaf, David E.; Srivastava, Anand; Zeng, Xiaoxi; McMahon, Gearoid M.; Croy, Heather E.; Mendu, Mallika L.; Kachalia, Allen; Waikar, Sushrut S. (BioMed Central, 2016)
      Background: The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated. Methods: We characterized the frequency of ...

    • Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset 

      Pasternak, Ofer; Westin, Carl-Fredrik; Bouix, Sylvain; Seidman, Larry Joel; Goldstein, Jill M.; Woo, Tsung-Ung Wilson; Petryshen, Tracey Lynn; Mesholam-Gately, Raquelle; McCarley, Robert William; Kikinis, Ron; Shenton, Martha Elizabeth; Kubicki, Marek R. (Society for Neuroscience, 2012)
      Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. ...