Now showing items 594-613 of 17917

    • Alloimmunity and Tolerance in Corneal Transplantation 

      Amouzegar, Afsaneh; Chauhan, Sunil Kumar; Dana, Reza (The American Association of Immunologists, 2016)
      Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection still remains the major cause of corneal allograft ...
    • Allorecognition by T Lymphocytes and Allograft Rejection 

      Marino, Jose; Paster, Joshua; Benichou, Gilles (Frontiers Media S.A., 2016)
      Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants. Allospecific T cells become activated ...
    • Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors 

      Singh, Parmit; Li, Wen; Bedwell, Gregory J.; Fadel, Hind J.; Poeschla, Eric M.; Engelman, Alan N. (MDPI, 2022-08)
      Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human ...
    • Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation 

      Jurado, Kellie; Wang, Hao; Slaughter, Alison; Feng, Lei; Kessl, Jacques; Koh, Yasuhiro; Wang, Weifeng; Ballandras-Colas, Allison; Patel, Pratiq; Fuchs, James; Kvaratskhelia, Mamuka; Engelman, Alan (National Academy of Sciences, 2013)
      Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage the IN dimer interface at the binding site for the ...
    • Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation 

      Staus, Dean P; Strachan, Ryan T; Manglik, Aashish; Pani, Biswaranjan; Kahsai, Alem W; Kim, Tae Hun; Wingler, Laura M; Ahn, Seungkirl; Chatterjee, Arnab; Masoudi, Ali; Kruse, Andrew C; Pardon, Els; Steyaert, Jan; Weis, William I; Prosser, R. Scott; Kobilka, Brian K; Costa, Tommaso; Lefkowitz, Robert J (2016)
      G-protein coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. Ligand binding to an extracellular orthosteric pocket propagates ...
    • Almost Efficient Estimation of Relative Risk Regression 

      Fitzmaurice, Garrett; Lipsitz, Stuart; Arriaga, Alex; Sinha, Debajyoti; Greenberg, Caprice; Gawande, Atul (2014)
      Relative risks (RRs) are often considered the preferred measures of association in prospective studies, especially when the binary outcome of interest is common. In particular, many researchers regard RRs to be more ...
    • Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking 

      Barthel, Steven R.; Wiese, Georg K.; Cho, Jaehyung; Opperman, Matthew J.; Hays, Danielle L.; Siddiqui, Javed; Pienta, Kenneth J.; Furie, Bruce; Dimitroff, Charles J. (National Academy of Sciences, 2009)
      How cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, yet essential step in metastasis. We postulate that the metastatic process involves discrete adhesive interactions between ...
    • The alpha angle as a predictor of contralateral slipped capital femoral epiphysis 

      Boyle, Matthew J.; Lirola, Jose F.; Hogue, Grant D.; Yen, Yi-Meng; Millis, Michael B.; Kim, Young-Jo (Springer Berlin Heidelberg, 2016)
      Purpose Contralateral hip involvement in slipped capital femoral epiphysis (SCFE) is common. Femoral head−neck asphericity, as measured by an elevated alpha angle, has not previously been assessed with respect to SCFE risk. ...
    • Alpha-CTLA-4 mAb-associated Panenteritis: A Histologic and Immunohistochemical Analysis 

      Oble, Darryl A.; Mino-Kenudson, Mari; Goldsmith, Jeffrey David; Hodi, Frank Stephen; Seliem, Rania M.; Dranoff, Glenn; Mihm, Martin Charles; Hasserjian, Robert Paul; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. ...
    • Alpha-synuclein in cutaneous small nerve fibers 

      Siepmann, Timo; Illigens, Ben Min-Woo; Barlinn, Kristian (Dove Medical Press, 2016)
      Despite progression in the development of pharmacological therapy, treatment of alpha synucleinopathies, such as Parkinson’s disease (PD) and some atypical parkinsonism syndromes, is still challenging. To date, our knowledge ...
    • ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP 

      Sun, Shuying; Ling, Shuo-Chien; Qiu, Jinsong; Albuquerque, Claudio P.; Zhou, Yu; Tokunaga, Seiya; Li, Hairi; Qiu, Haiyan; Bui, Anh; Yeo, Gene W.; Huang, Eric J.; Eggan, Kevin; Zhou, Huilin; Fu, Xiang-Dong; Lagier-Tourenne, Clotilde; Cleveland, Don W. (2015)
      The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to ...
    • Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease 

      Uchino, Yuichi; Mauris, Jerome; Woodward, Ashley Morgan; Dieckow, Julia; Amparo, Francisco; Dana, Reza; Mantelli, Flavio; Argueso, Pablo (Elsevier BV, 2015)
      Purpose To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease. Design Observational case series with a comparison group. Methods Tear washes and ...
    • Alteration of Innate Immunity by Donor IL-6 Deficiency in a Presensitized Heart Transplant Model 

      Ge, Fangmin; Yuan, Shunzong; Su, Lida; Shen, Zhonghua; He, Aibin; Huang, Tao; Gong, Weihua (Public Library of Science, 2013)
      Engraftment of IL-6 deficient donor into wild-type recipient could significantly improve allograft survival through T cell lineage particularly regulatory T cells (Tregs) in non-sensitized transplant host. However, its ...
    • ALTERATION OF THE EPHA2/EPHRIN-A SIGNALING AXIS IN PSORIATIC EPIDERMIS 

      Gordon, Kristin; Kochkodan, James J.; Blatt, Hanz; Lin, Samantha Y.; Kaplan, Nihal; Johnston, Andrew; Swindell, William R.; Hoover, Paul; Schlosser, Bethanee J.; Elder, James T.; Gudjonsson, Johann E.; Getsios, Spiro (2012)
      EphA2 is a receptor tyrosine kinase (RTK) that triggers keratinocyte differentiation upon activation and subsequently down-regulation by ephrin-A1 ligand. The objective for this study was to determine if the EphA2/ephrin-A1 ...
    • Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia 

      Francis, Alan N; Seidman, Larry Joel; Jabbar, Gul A.; Mesholam-Gately, Raquelle; Thermenos, Heidi Wencel; Juelich, Richard; Proal, Ashley; Shenton, Martha Elizabeth; Kubicki, Marek R.; Mathew, Ian; Keshavan, Matcheri S; DeLisi, Lynn E (Elsevier BV, 2012)
      Introduction—Neuroanatomical and cognitive alterations typical of schizophrenia (SZ) patients are observed to a lesser extent in their adolescent and adult first-degree relatives, likely reflecting neurodevelopmental ...
    • Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment 

      Licata, Stephanie C.; Shinday, Nina M.; Huizenga, Megan N.; Darnell, Shayna B.; Sangrey, Gavin R.; Rudolph, Uwe; Rowlett, James K.; Sadri-Vakili, Ghazaleh (Public Library of Science, 2013)
      Benzodiazepines (BZs) are safe drugs for treating anxiety, sleep, and seizure disorders, but their use also results in unwanted effects including memory impairment, abuse, and dependence. The present study aimed to reveal ...
    • Alterations in Corneal Stromal Dendritic Cell Phenotype and Distribution in Inflammation 

      Hamrah, Pedram; Liu, Ying; Zhang, Qiang; Dana, Reza (American Medical Association (AMA), 2003)
      Background The normal corneal stroma is endowed with large numbers of resident dendritic cells (DCs). The purpose of this study was to examine the phenotype and distribution of these cells in inflammation. Methods ...
    • Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate-Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity 

      Lei, Shulei; Zavala-Flores, Laura; Garcia-Garcia, Aracely; Nandakumar, Renu; Huang, Yuting; Madayiputhiya, Nandakumar; Stanton, Robert C.; Dodds, Eric D.; Powers, Robert; Franco, Rodrigo (American Chemical Society, 2014)
      Parkinson’s disease (PD) is a multifactorial disorder with a complex etiology including genetic risk factors, environmental exposures, and aging. While energy failure and oxidative stress have largely been associated with ...
    • Alterations in gray matter volume due to unilateral hearing loss 

      Wang, Xingchao; Xu, Pengfei; Li, Peng; Wang, Zhenmin; Zhao, Fu; Gao, Zhixian; Xu, Lei; Luo, Yue-jia; Fan, Jin; Liu, Pinan (Nature Publishing Group, 2016)
      Although extensive research on neural plasticity resulting from hearing deprivation has been conducted, the direct influence of compromised audition on the auditory cortex and the potential impact of long durations of ...
    • Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia 

      Gascon, Eduardo; Lynch, Kelleen; Ruan, Hongyu; Almeida, Sandra; Verheyden, Jamie; Seeley, William W.; Dickson, Dennis W.; Petrucelli, Leonard; Sun, Danqiong; Jiao, Jian; Zhou, Hongru; Jakovcevski, Mira; Akbarian, Schahram; Yao, Wei-Dong; Gao, Fen-Biao (2014)
      Many neurodegenerative diseases, such as frontotemporal dementia (FTD), are associated with behavioral deficits, but the anatomical and molecular bases remain poorly understood. Here we show that forebrain-specific expression ...