Browsing HMS Scholarly Articles by Title

Now showing items 6284-6303 of 17922

    • Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer 

      Saunders, Edward J.; Dadaev, Tokhir; Leongamornlert, Daniel A.; Jugurnauth-Little, Sarah; Tymrakiewicz, Malgorzata; Wiklund, Fredrik; Al Olama, Ali Amin; Benlloch, Sara; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Giles, Graham G.; Severi, Gianluca; Gronberg, Henrik; Aly, Markus; Haiman, Christopher A.; Schumacher, Fredrick; Henderson, Brian E.; Lindstrom, Sara; Kraft, Peter; Hunter, David J.; Gapstur, Susan; Chanock, Stephen; Berndt, Sonja I.; Albanes, Demetrius; Andriole, Gerald; Schleutker, Johanna; Weischer, Maren; Nordestgaard, Børge G.; Canzian, Federico; Campa, Daniele; Riboli, Elio; Key, Tim J.; Travis, Ruth C.; Ingles, Sue A.; John, Esther M.; Hayes, Richard B.; Pharoah, Paul; Khaw, Kay-Tee; Stanford, Janet L.; Ostrander, Elaine A.; Signorello, Lisa B.; Thibodeau, Stephen N.; Schaid, Daniel; Maier, Christiane; Kibel, Adam S.; Cybulski, Cezary; Cannon-Albright, Lisa; Brenner, Hermann; Park, Jong Y.; Kaneva, Radka; Batra, Jyotsna; Clements, Judith A.; Teixeira, Manuel R.; Xu, Jianfeng; Mikropoulos, Christos; Goh, Chee; Govindasami, Koveela; Guy, Michelle; Wilkinson, Rosemary A.; Sawyer, Emma J.; Morgan, Angela; Easton, Douglas F.; Muir, Ken; Eeles, Rosalind A.; Kote-Jarai, Zsofia (Public Library of Science, 2014)
      The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the ...

    • Fine-tuning of macrophage activation using synthetic rocaglate derivatives 

      Bhattacharya, Bidisha; Chatterjee, Sujoy; Devine, William G.; Kobzik, Lester; Beeler, Aaron B.; Porco, John A.; Kramnik, Igor (Nature Publishing Group, 2016)
      Drug-resistant bacteria represent a significant global threat. Given the dearth of new antibiotics, host-directed therapies (HDTs) are especially desirable. As IFN-gamma (IFNγ) plays a central role in host resistance to ...

    • Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease 

      Aytan, Nurgul; Choi, Ji-Kyung; Carreras, Isabel; Brinkmann, Volker; Kowall, Neil W.; Jenkins, Bruce G.; Dedeoglu, Alpaslan (Nature Publishing Group, 2016)
      Sphingosine 1-phosphate (SP1) receptors may be attractive targets for modulation of inflammatory processes in neurodegenerative diseases. Recently fingolimod, a functional S1P1 receptor antagonist, was introduced for ...

    • Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling 

      Szepanowski, Fabian; Derksen, Angelika; Steiner, Irina; Meyer zu Hörste, Gerd; Daldrup, Thomas; Hartung, Hans-Peter; Kieseier, Bernd C. (BioMed Central, 2016)
      Background: The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a broad range of physiological functions. Targeting the S1P1 receptor on lymphocytes ...

    • Firefighters and On-duty Deaths From Coronary Heart Disease: A Case Control Study 

      Kales, Stefanos Nicholas; Soteriades, Elpidoforos S.; Christoudias, Stavros G; Christiani, David C. (BioMed Central, 2003)
      Background: Coronary heart disease (CHD) is responsible for 45% of on-duty deaths among United States firefighters. We sought to identify occupational and personal risk factors associated with on-duty CHD death. Methods: ...

    • The First 500 Registrations to the Research Registry®: Advancing Registration of Under-Registered Study Types 

      Agha, Riaz; Fowler, Alexander J.; Limb, Christopher; Al Omran, Yasser; Sagoo, Harkiran; Koshy, Kiron; Jafree, Daniyal J.; Anwar, Mohammed Omer; McCullogh, Peter; Orgill, Dennis Paul (Frontiers Media S.A., 2016)
      Introduction: The Declaration of Helsinki 2013 encourages the registration of all research studies involving human participants. However, emphasis has been placed on prospective clinical trials, and it is estimated that ...

    • The First International Mini-Symposium on Methionine Restriction and Lifespan 

      Ables, Gene P.; Brown-Borg, Holly M.; Buffenstein, Rochelle; Church, Christopher D.; Elshorbagy, Amany K.; Gladyshev, Vadim N.; Huang, Tsang-hai; Miller, Richard A.; Mitchell, James R.; Richie, John P.; Rogina, Blanka; Stipanuk, Martha H.; Orentreich, David S.; Orentreich, Norman (Frontiers Media S.A., 2014)
      It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et ...

    • The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy 

      McKee, Ann C.; Cairns, Nigel J.; Dickson, Dennis W.; Folkerth, Rebecca D.; Dirk Keene, C.; Litvan, Irene; Perl, Daniel P.; Stein, Thor D.; Vonsattel, Jean-Paul; Stewart, William; Tripodis, Yorghos; Crary, John F.; Bieniek, Kevin F.; Dams-O’Connor, Kristen; Alvarez, Victor E.; Gordon, Wayne A. (Springer Berlin Heidelberg, 2015)
      Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE ...

    • First Results From the IllustrisTNG Simulations: Matter and Galaxy Clustering 

      Springel, Volker; Pakmor, Rüdiger; Pillepich, Annalisa; Weinberger, Rainer; Nelson, Dylan; Hernquist, Lars; Vogelsberger, Mark; Genel, Shy; Torrey, Paul; Marinacci, Federico; Naiman, Jill (Oxford University Press (OUP), 2017-12-22)
      Hydrodynamical simulations of galaxy formation have now reached sufficient volume to make precision predictions for clustering on cosmologically relevant scales. Here, we use our new IllustrisTNG simulations to study the ...

    • First translational ‘Think Tank’ on cerebrovascular disease, cognitive impairment and dementia 

      Barone, Frank C.; Gustafson, Deborah; Crystal, Howard A.; Moreno, Herman; Adamski, Mateusz G.; Arai, Ken; Baird, Alison E.; Balucani, Clotilde; Brickman, Adam M.; Cechetto, David; Gorelick, Philip; Biessels, Geert Jan; Kiliaan, Amanda; Launer, Lenore; Schneider, Julie; Sorond, Farzaneh A.; Whitmer, Rachel; Wright, Clinton; Zhang, Zheng Gang (BioMed Central, 2016)
      Abstract and introduction to the workshop As the human population continues to age, an increasing number of people will exhibit significant deficits in cognitive function and dementia. It is now recognized that cerebrovascular, ...

    • First-Episode of Synthetic Cannabinoid-Induced Psychosis in a Young Adult, Successfully Managed with Hospitalization and Risperidone 

      Roberto, Aaron J.; Lorenzo, Aileen; Li, Kevin J.; Young, Jonathan; Mohan, Abhishek; Pinnaka, Subhash; Lapidus, Kyle A. B. (Hindawi Publishing Corporation, 2016)
      Synthetic cannabinoids- (SCs-) induced psychosis is a growing public health concern. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case ...

    • First-Episode Schizophrenic Psychosis Differs From First-Episode Affective Psychosis and Controls in P300 Amplitude Over Left Temporal Lobe 

      Salisbury, Dean F.; Shenton, Martha Elizabeth; Sherwood, Andrea R.; Fischer, Iris A.; Yurgelun-Todd, Deborah; Tohen, Mauricio; McCarley, Robert William (American Medical Association (AMA), 1998)
      Background: Schizophrenia is associated with central (sagittal) midline reductions of the P300 cognitive event-related potential and topographic asymmetry of P300, with reduced left temporal voltage. This P300 asymmetry ...

    • A First-Generation Multi-Functional Cytokine for Simultaneous Optical Tracking and Tumor Therapy 

      Hingtgen, Shawn; Kasmieh, Randa; Elbayly, Elizabeth; Nesterenko, Irina; Figueiredo, Jose-Luiz; Dash, Rupesh; Sarkar, Devanand; Hall, David; Kozakov, Dima; Vajda, Sandor; Fisher, Paul B.; Shah, Khalid A. (Public Library of Science, 2012)
      Creating new molecules that simultaneously enhance tumor cell killing and permit diagnostic tracking is vital to overcoming the limitations rendering current therapeutic regimens for terminal cancers ineffective. Accordingly, ...

    • First-principles simulations of ionic molecular solids: The phase transitions inK2SeO4 

      Lu, Hsiao-ming; Hardy, J. R. (American Physical Society (APS), 1990)
      We present a new approach to first-principles simulations of the statics and dynamics of ionic molecular crystals. It is shown that the new method gives very realistic simulations of the phase transitions in K2Se04 and ...

    • First-principles study of phase transitions inKNO3 

      Lu, Hsiao-ming; Hardy, J. R. (American Physical Society (APS), 1991)
      We report a first-principles simulation study of phase transitions in KNO3, using our recently developed method for treating ionic molecular solids. With the interionic potentials calculated from ab initio electron charge ...

    • First-principles study of the lattice dynamics ofK2SO4 

      Liu, D.; Lu, Hsiao-ming; Ullman, F. G.; Hardy, J. R. (American Physical Society (APS), 1991)
      Using a newly developed first-principles approach to simulations of ionic molecular crystals, we performed static relaxation, molecular-dynamics simulation, and lattice-dynamics calculations, and measurements of the Raman ...

    • First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus 

      Thadhani, Ravi Ishwar; Powe, Camille Elise; Tjoa, May Lee; Khankin, Eliyahu; Ye, Jun; Ecker, Jeffrey Lawrence; Schneyer, Alan; Karumanchi, Subbian Ananth (American Diabetes Association, 2009)
      Objective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent ...

    • First-Trimester Urine Concentrations of Phthalate Metabolites and Phenols and Placenta miRNA Expression in a Cohort of U.S. Women 

      LaRocca, Jessica; Binder, Alexandra M.; McElrath, Thomas F.; Michels, Karin B. (National Institute of Environmental Health Sciences, 2015)
      Background: There is increasing concern that early-life exposure to endocrine-disrupting chemicals (EDCs) can influence the risk of disease development. Phthalates and phenols are two classes of suspected EDCs that are ...

    • Fiscal difficulties of cities, the labor market, and health care 

      Hsu, John; Newhouse, Joseph; Overhage, Lindsay Nicole; Zuvekas, Samuel (Cambridge University Press (CUP), 2018-12-19)
      We investigated labor force and health outcomes in cities experiencing fiscal difficulties to assess how those difficulties might impact their employees. We matched 23 cities with bond downgrades and 31 cities with stable ...

    • FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution 

      Eames, B Frank; DeLaurier, April; Ullmann, Bonnie; Huycke, Tyler R; Nichols, James T; Dowd, John; McFadden, Marcie; Sasaki, Mark M; Kimmel, Charles B (BioMed Central, 2013)
      Background: The vertebrate craniofacial skeleton may exhibit anatomical complexity and diversity, but its genesis and evolution can be understood through careful dissection of developmental programs at cellular resolution. ...