Browsing HMS Scholarly Articles by Title
Now showing items 6970-6989 of 17922
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Genome-wide association study identifies 48 common genetic variants associated with handedness
(Springer Science and Business Media LLC, 2020-09-28)Handedness, a consistent asymmetry in skill or use of the hands, has been studied extensively because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using ... -
Genome-wide association study identifies 74 loci associated with educational attainment
(2016)Summary Educational attainment (EA) is strongly influenced by social and other environmental factors, but genetic factors are also estimated to account for at least 20% of the variation across individuals1. We report the ... -
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2
(Nature Publishing Group, 2009)Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk1. We performed a genome wide association study (GWAS) to identify common ovarian ... -
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India
(American Diabetes Association, 2013)We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico ... -
A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population
(BioMed Central, 2014)Background: Uric acid (UA) is a complex phenotype influenced by both genetic and environmental factors as well as their interactions. Current genome-wide association studies (GWASs) have identified a variety of genetic ... -
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
(2015)Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide ... -
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
(2014)We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 ... -
A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
(Public Library of Science, 2008)We conducted a multi-stage genome-wide association study of natural hair color in more than 10,000 men and women of European ancestry from the United States and Australia. An initial analysis of 528,173 single nucleotide ... -
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
(Public Library of Science, 2012)Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their ... -
Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma
(Public Library of Science, 2015)Background: Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, ... -
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
(BioMed Central, 2015)Background: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ... -
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder
(Nature Publishing Group, 2016)Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relatively homogeneous ... -
Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
(Public Library of Science, 2015)Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically ... -
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
(Nature Publishing Group, 2010)Ovarian cancer (OC) accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance OC susceptibility genes, we conducted a genome-wide association study (GWAS) of 507,094 SNPs in ... -
Genome-wide Association Study Identifies Two Susceptibility Loci for Osteosarcoma
(2013)Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. In order to better understand the genetic etiology of osteosarcoma, we performed a multi-stage genome-wide association study (GWAS) ... -
Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children
(Public Library of Science, 2009)Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in ... -
Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS
(2014)Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning. The OCD Collaborative ... -
A genome-wide association study of anorexia nervosa
(2013)Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome wide association study (GWAS) have yielded significant and ... -
Genome-wide association study of antisocial personality disorder
(Nature Publishing Group, 2016)The pathophysiology of antisocial personality disorder (ASPD) remains unclear. Although the most consistent biological finding is reduced grey matter volume in the frontal cortex, about 50% of the total liability to ... -
Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension
(Public Library of Science, 2010)Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension. ...