Browsing HMS Scholarly Articles by Title
Now showing items 7223-7242 of 17918
-
Glycogen Synthase Kinase3 Beta Phosphorylates Serine 33 of p53 and Activates p53's Transcriptional Activity
(BioMed Central, 2001)Background: The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth arrest and apoptosis. p53 activation is regulated by ... -
Glycogene Expression in Conjunctiva of Patients with Dry Eye: Downregulation of Notch Signaling
(Association for Research in Vision and Ophthalmology (ARVO), 2009)purpose. Glycoconjugates regulate a variety of biological events in mucosal surfaces, such as differentiation of postmitotic epithelial cells and maintenance of the wet-surfaced phenotype. This study aimed to identify the ... -
Glycolytic regulation of cell rearrangement in angiogenesis
(Nature Publishing Group, 2016)During vessel sprouting, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip position. We recently identified a key role for the glycolytic activator PFKFB3 in vessel sprouting by ... -
Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin In Vitro and In Vivo
(2015)Blockade of P-selectin/PSGL-1 interactions holds significant potential for treatment of disorders of innate immunity, thrombosis, and cancer. Current inhibitors remain limited due to low binding affinity or by the recognized ... -
Glycopeptidolipid Acetylation Affects Sliding Motility and Biofilm Formation in Mycobacterium smegmatis
(American Society for Microbiology, 2001)The absence of glycopeptidolipids (GPLs) abolishes the ability of mycobacteria both to slide over the surface of motility plates and to form biofilms on polyvinyl chloride. In a screen for biofilm-defective mutants of ... -
Glypican 4, a Membrane Binding Protein for Bactericidal/Permeability-Increasing Protein Signaling Pathways in Retinal Pigment Epithelial Cells
(Association for Research in Vision and Ophthalmology (ARVO), 2007)Purpose. Originally identified as a lipopolysaccharide binding protein with Gram-negative bactericidal activity in the leukocytes, bactericidal/permeability-increasing protein (BPI) has been shown to induce various effects ... -
GlyTouCan 1.0 – The international glycan structure repository
(Oxford University Press, 2016)Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the ‘face’ of cells, whereby other biomolecules and viruses interact. The structure of ... -
GNAS mutations in primary mucinous and non-mucinous lung adenocarcinomas
(Springer Science and Business Media LLC, 2017-08-04)GNAS mutations have been described in mucinous and non-mucinous epithelial neoplasms of the appendix, pancreas, and colon, with hotspot GNAS mutations found in up to two-thirds of pancreatic intraductal papillary mucinous ... -
Goals in Geriatric Assessment: Are We Measuring the Right Outcomes?
(Oxford University Press (OUP), 2000)Previous evaluative studies of outpatient geriatric assessment have focused on a limited set of outcomes related to functioning, health services utilization, and costs. The purpose of this study was to identify important ... -
GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images
(BioMed Central, 2014)Molecular analysis has revealed extensive intra-tumor heterogeneity in human cancer samples, but cannot identify cell-to-cell variations within the tissue microenvironment. In contrast, in situ analysis can identify genetic ... -
Golgicide A Reveals Essential Roles for GBF1 in Golgi Assembly and Function
(Nature Publishing Group, 2009)ADP-ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs) which ... -
The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity
(Nature Publishing Group, 2016)The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of ... -
Good Outcome Rate of 35% in IV-tPA-Treated Patients With Computed Tomography Angiography Confirmed Severe Anterior Circulation Occlusive Stroke
(Ovid Technologies (Wolters Kluwer Health), 2013)BACKGROUND AND PURPOSE: To determine the effect of intravenous tissue plasminogen activator (IV-tPA) on outcomes in patients with severe major anterior circulation ischemic stroke. METHODS: Prospectively, 649 patients ... -
Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Actuators
(Nature Publishing Group, 2016)Google Glass is a recently designed wearable device capable of displaying information in a smartphone-like hands-free format by wireless communication. The Glass also provides convenient control over remote devices, primarily ... -
Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate
(Public Library of Science, 2015)As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as ... -
A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition
(Public Library of Science, 2013)The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing ... -
GpnmbR150X Allele Must Be Present in Bone Marrow Derived Cells to Mediate DBA/2J Glaucoma
(BioMed Central, 2008)Background: The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice ... -
The GPR 55 agonist, L-α-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis
(John Wiley & Sons, Ltd, 2015)Background and Purpose Highly vascularized ovarian carcinoma secretes the putative endocannabinoid and GPR55 agonist, L-α-lysophosphatidylinositol (LPI), into the circulation. We aimed to assess the involvement of this ... -
GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development
(Public Library of Science, 2013)Loss of function mutations in GPR56, which encodes a G protein-coupled receptor, cause a specific human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Studies from BFPP postmortem brain tissue ... -
GPU Based Real-Time Instrument Tracking with Three-Dimensional Ultrasound
(Elsevier BV, 2007-10)Real-time three-dimensional ultrasound enables new intra-cardiac surgical procedures, but the distorted appearance of instruments in ultrasound poses a challenge to surgeons. This paper presents a detection technique that ...