Browsing HMS Scholarly Articles by Title
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GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers
(Public Library of Science, 2012)Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel susceptibility loci associated ... -
GWAS in IMIDs
(BioMed Central, 2010) -
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
(2013)Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in ... -
A GWAS Study on Liver Function Test Using eMERGE Network Participants
(Public Library of Science, 2015)Introduction: Liver enzyme levels and total serum bilirubin are under genetic control and in recent years genome-wide population-based association studies have identified different susceptibility loci for these traits. We ... -
Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis
(American Society for Microbiology, 2016)Molecular diagnostics that rapidly and accurately predict resistance to fluoroquinolone drugs and especially later-generation agents promise to improve treatment outcomes for patients with multidrug-resistant tuberculosis ... -
Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis
(2012)Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and ... -
H+ Transport Is an Integral Function of the Mitochondrial ADP/ATP Carrier
(Springer Science and Business Media LLC, 2019-07)The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP. In addition, it has been ... -
H2A.Z Landscapes and Dual Modifications in Pluripotent and Multipotent Stem Cells Underlie Complex Genome Regulatory Functions
(BioMed Central, 2012)Background: The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. ... -
H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents
(Nature Publishing Group, 2013)The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form of ROS produced during I/R, causes inflammation, ... -
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
(Springer Science and Business Media LLC, 2023-07-17)The epigenetic mechanisms that maintain differentiated cell states remain largely unexplored. Here, we employed histone mutants to uncover a crucial role for H3K36-methylation in the maintenance of cell identities across ... -
H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression
(Springer Science and Business Media LLC, 2018-11-19)Epigenetic regulators are attractive anticancer targets, but the promise of therapeutic strategies inhibiting some of these factors has not been proven in vivo or taken into account tumor cell heterogeneity. Here we show ... -
Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men12
(American Society for Nutrition, 2016)Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk, which fruits are most beneficial and what key constituents are responsible are unclear. Habitual intakes of flavonoids, specifically ... -
Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts12
(American Society for Nutrition, 2016)Background: Flavonoids inhibit the growth of colon cancer cells in vitro. In a secondary analysis of a randomized controlled trial, the Polyp Prevention Trial, a higher intake of one subclass, flavonols, was statistically ... -
The HAC1 Gene from Pichia Pastoris: Characterization and Effect of its Overexpression on the Production of Secreted, Surface Displayed and Membrane Proteins
(BioMed Central, 2010)Background: The unfolded protein response (UPR) in eukaryotes upregulates factors that restore ER homeostasis upon protein folding stress and in yeast is activated by a non-conventional splicing of the HAC1 mRNA. The spliced ... -
Haematological Safety of Perinatal Zidovudine in Pregnant HIV-1–Infected Women in Thailand: Secondary Analysis of a Randomized Trial
(Public Library of Science, 2007)Objectives: To respond to the primary safety objective of the Perinatal HIV Prevention Trial 1 (PHPT-1) by studying the evolution of haematological parameters according to zidovudine exposure duration in HIV-1−infected ... -
Haematopoietic stem cells require a highly regulated protein synthesis rate
(2014)Many aspects of cellular physiology remain unstudied in somatic stem cells. For example, there are almost no data on protein synthesis in any somatic stem cell. We found that the amount of protein synthesized per hour in ... -
Hair follicle melanocyte cells as a renewable source of melanocytes for culture and transplantation
(2008)Objective: Advances in melanocyte culture techniques have not yet led to reliable clinical methods for treating hypopigmentation disorders. We hypothesized that melanocytes harvested from plucked hair follicles may provide ... -
Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water
(National Institute of Environmental Health Sciences, 2006)Background: Neurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Québec (Canada) where ... -
Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells
(Springer Nature, 2019-07-31)The skin is a multi-layered organ equipped with appendages (i.e. follicles and glands) critical for regulating bodily fluid retention and temperature, guarding against external stresses, and mediating touch and pain ... -
Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice
(Public Library of Science, 2016)Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled ...