Browsing HMS Scholarly Articles by Title

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    • Hospital Readmission in General Medicine Patients: A Prediction Model 

      Hasan, Omar; Meltzer, David O.; Shaykevich, Shimon A.; Bell, Chaim M.; Kaboli, Peter J.; Auerbach, Andrew; Wetterneck, Tosha B.; Arora, Vineet M.; Zhang, James; Schnipper, Jeffrey Lawrence (Springer-Verlag, 2009)
      Background: Previous studies of hospital readmission have focused on specific conditions or populations and generated complex prediction models. Objective: To identify predictors of early hospital readmission in a diverse ...

    • Hospital Surgical Volume, Utilization, Costs and Outcomes of Retroperitoneal Lymph Node Dissection for Testis Cancer 

      Yu, Hua-yin; Hevelone, Nathanael D.; Patel, Sunil; Lipsitz, Stuart Roger; Hu, Jim C. (Hindawi Publishing Corporation, 2012)
      Objectives: Retroperitoneal lymph node dissection (RPLND) outcomes for testis cancer originate mostly from single-center series. We characterized population-based utilization, costs, and outcomes and assessed whether higher ...

    • Hospital Variation in Premature Clopidogrel Discontinuation After Drug‐Eluting Stent Placement in the Veterans Affairs (VA) Healthcare System 

      Vigen, Rebecca; Maddox, Thomas M.; O'Donnell, Colin I.; Grunwald, Gary K.; Bhatt, Deepak L.; Tsai, Thomas T.; Rumsfeld, John S.; Ho, P. Michael (John Wiley and Sons Inc., 2016)
      Background: Premature clopidogrel discontinuation after drug‐eluting stent placement is associated with adverse outcomes. Little is known about patient and hospital factors associated with premature discontinuation or ...

    • Hospitalized Patients at High Risk for Obstructive Sleep Apnea Have More Rapid Response System Events and Intervention Is Associated with Reduced Events 

      Sharma, Sunil; Chowdhury, Anindita; Tang, Lili; Willes, Leslee; Glynn, Brian; Quan, Stuart F. (Public Library of Science, 2016)
      Background: Rapid response system (RRS) is a safety tool designed for early detection and intervention of a deteriorating patient on the general floor in the hospital. Obstructive sleep apnea (OSA) has been associated with ...

    • Host and Bacterial Proteins That Repress Recruitment of LC3 to Shigella Early during Infection 

      Baxt, Leigh A.; Goldberg, Marcia B. (Public Library of Science, 2014)
      Shigella spp. are intracytosolic gram-negative pathogens that cause disease by invasion and spread through the colonic mucosa, utilizing host cytoskeletal components to form propulsive actin tails. We have previously ...

    • Host and viral determinants for MxB restriction of HIV-1 infection 

      Matreyek, Kenneth A; Wang, Weifeng; Serrao, Erik; Singh, Parmit Kumar; Levin, Henry L; Engelman, Alan (BioMed Central, 2014)
      Background: Interferon-induced cellular proteins play important roles in the host response against viral infection. The Mx family of dynamin-like GTPases, which include MxA and MxB, target a wide variety of viruses. Despite ...

    • Host Cell Nucleolin Is Required to Maintain the Architecture of Human Cytomegalovirus Replication Compartments 

      Strang, Blair L.; Boulant, Steeve; Kirchhausen, Tomas; Coen, Donald M. (American Society for Microbiology, 2012)
      Drastic reorganization of the nucleus is a hallmark of herpesvirus replication. This reorganization includes the formation of viral replication compartments, the subnuclear structures in which the viral DNA genome is ...

    • Host Genetics Predict Clinical Deterioration in HCV-Related Cirrhosis 

      King, Lindsay Y.; Johnson, Kara B.; Zheng, Hui; Wei, Lan; Gudewicz, Thomas; Hoshida, Yujin; Corey, Kathleen E.; Ajayi, Tokunbo; Ufere, Nneka; Baumert, Thomas F.; Chan, Andrew T.; Tanabe, Kenneth K.; Fuchs, Bryan C.; Chung, Raymond T. (Public Library of Science, 2014)
      Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene ...

    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease 

      Jostins, Luke; Ripke, Stephan; Weersma, Rinse K; Duerr, Richard H; McGovern, Dermot P; Hui, Ken Y; Lee, James C; Schumm, L Philip; Sharma, Yashoda; Anderson, Carl A; Essers, Jonah Bryan; Mitrovic, Mitja; Ning, Kaida; Cleynen, Isabelle; Theatre, Emilie; Spain, Sarah L; Raychaudhuri, Soumya; Goyette, Philippe; Wei, Zhi; Abraham, Clara; Achkar, Jean-Paul; Ahmad, Tariq; Amininejad, Leila; Ananthakrishnan, Ashwin N; Andersen, Vibeke; Andrews, Jane M; Baidoo, Leonard; Balschun, Tobias; Bampton, Peter A; Bitton, Alain; Boucher, Gabrielle; Brand, Stephan; Büning, Carsten; Cohain, Ariella; Cichon, Sven; D’Amato, Mauro; De Jong, Dirk; Devaney, Kathy L; Dubinsky, Marla; Edwards, Cathryn; Ellinghaus, David; Ferguson, Lynnette R; Franchimont, Denis; Fransen, Karin; Gearry, Richard; Georges, Michel; Gieger, Christian; Glas, Jürgen; Haritunians, Talin; Hart, Ailsa; Hawkey, Chris; Hedl, Matija; Hu, Xinli; Karlsen, Tom H; Kupcinskas, Limas; Kugathasan, Subra; Latiano, Anna; Laukens, Debby; Lawrance, Ian C; Lees, Charlie W; Louis, Edouard; Mahy, Gillian; Mansfield, John; Morgan, Angharad R; Mowat, Craig; Newman, William; Palmieri, Orazio; Ponsioen, Cyriel Y; Potocnik, Uros; Prescott, Natalie J; Regueiro, Miguel; Rotter, Jerome I; Russell, Richard K; Sanderson, Jeremy D; Sans, Miquel; Satsangi, Jack; Schreiber, Stefan; Simms, Lisa A; Sventoraityte, Jurgita; Targan, Stephan R; Taylor, Kent D; Tremelling, Mark; Verspaget, Hein W; De Vos, Martine; Wijmenga, Cisca; Wilson, David C; Winkelmann, Juliane; Xavier, Ramnik; Zeissig, Sebastian; Zhang, Bin; Zhang, Clarence K; Zhao, Hongyu; Silverberg, Mark S; Annese, Vito; Hakonarson, Hakon; Brant, Steven R; Radford-Smith, Graham; Mathew, Christopher G; Rioux, John D; Schadt, Eric E; Daly, Mark Joseph; Franke, Andre; Parkes, Miles; Vermeire, Severine; Barrett, Jeffrey C; Cho, Judy H (2012)
      Crohn’s disease (CD) and ulcerative colitis (UC), the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry with rising prevalence in other populations1. Genome-wide ...

    • A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia 

      Kaliannan, Kanakaraju; Wang, Bin; Li, Xiang-Yong; Kim, Kui-Jin; Kang, Jing X. (Nature Publishing Group, 2015)
      Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic low grade inflammation that underlies many chronic diseases. Here we show that mice fed a diet high in omega-6 fatty acids exhibit ...

    • Host-Pathogen Interactome Mapping for HTLV-1 and -2 Retroviruses 

      Simonis, Nicolas; Rual, Jean-François; Lemmens, Irma; Boxus, Mathieu; Hirozane-Kishikawa, Tomoko; Gatot, Jean-Stéphane; Dricot, Amélie; Hao, Tong; Vertommen, Didier; Legros, Sébastien; Daakour, Sarah; Klitgord, Niels; Martin, Maud; Willaert, Jean-François; Dequiedt, Franck; Navratil, Vincent; Burny, Arsène; Van Lint, Carine; Tavernier, Jan; Kettmann, Richard; Twizere, Jean-Claude; Cusick, Michael; Hill, David E.; Vidal, Marc (BioMed Central, 2012)
      Background: Human T-cell leukemia virus type 1 (HTLV-1) and type 2 both target T lymphocytes, yet induce radically different phenotypic outcomes. HTLV-1 is a causative agent of Adult T-cell leukemia (ATL), whereas HTLV-2, ...

    • Host-Species Transferrin Receptor 1 Orthologs are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses 

      Abraham, Jonathan; Kwong, Jo Ann; Albariño, César G.; Lu, Jiajie G.; Radoshitzky, Sheli R.; Salazar-Bravo, Jorge; Farzan, Michael Reynolds; Spiropoulou, Christina F.; Choe, Hyeryun (Public Library of Science, 2009)
      The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic ...

    • A Hough Transform Global Probabilistic Approach to Multiple-Subject Diffusion MRI Tractography 

      Aganj, Iman; Lenglet, Christophe; Jahanshad, Neda; Yacoub, Essa; Harel, Noam; Thompson, Paul M.; Sapiro, Guillermo (Elsevier BV, 2011-08)
      A global probabilistic fiber tracking approach based on the voting process provided by the Hough transform is introduced in this work. The proposed framework tests candidate 3D curves in the volume, assigning to each one ...

    • Household and School-Level Influences on Smoking Behavior among Korean Adolescents: A Multilevel Analysis 

      Heo, Jongho; Oh, Juhwan; Subramanian, S. V.; Kawachi, Ichiro (Public Library of Science, 2014)
      Background: Trends in adolescent smoking rates in South Korea have not shown substantial progress due to a lack of effective anti-smoking interventions and policies in school settings. Methods and Findings: We examined ...

    • Household malaria knowledge and its association with bednet ownership in settings without large–scale distribution programs: Evidence from rural Madagascar 

      Krezanoski, Paul J.; Tsai, Alexander C.; Hamer, Davidson H.; Comfort, Alison B.; Bangsberg, David R. (Edinburgh University Global Health Society, 2014)
      Background: Insecticide–treated bednets are effective at preventing malaria. This study focuses on household–level factors that are associated with bednet ownership in a rural area of Madagascar which had not been a recipient ...

    • Household Survey of Pesticide Practice, Deliberate Self-Harm, and Suicide in the Sundarban Region of West Bengal, India 

      Banerjee, Sohini; Chowdhury, Arabinda Narayan; Schelling, Esther; Weiss, Mitchell Gralnick (Hindawi Publishing Corporation, 2013)
      The toxicological impact and intentional ingestion of pesticides are major public health concerns globally. This study aimed to estimate the extent of deliberate self-harm(DSH) and suicides (suicidal behaviour) and document ...

    • Household Transmission of Vibrio cholerae in Bangladesh 

      Sugimoto, Jonathan D.; Koepke, Amanda A.; Kenah, Eben E.; Halloran, M. Elizabeth; Chowdhury, Fahima; Khan, Ashraful I.; LaRocque, Regina C.; Yang, Yang; Ryan, Edward T.; Qadri, Firdausi; Calderwood, Stephen B.; Harris, Jason B.; Longini, Ira M. (Public Library of Science, 2014)
      Background: Vibrio cholerae infections cluster in households. This study's objective was to quantify the relative contribution of direct, within-household exposure (for example, via contamination of household food, water, ...

    • How Accurate Can Genetic Predictions Be? 

      Dreyfuss, Jonathan M; Levner, Daniel; Galagan, James E; Church, George McDonald; Ramoni, Marco F (BioMed Central, 2012)
      Background: Pre-symptomatic prediction of disease and drug response based on genetic testing is a critical component of personalized medicine. Previous work has demonstrated that the predictive capacity of genetic testing ...

    • How and Why Community Hospital Clinicians Document a Positive Screen for Intimate Partner Violence: A Cross-sectional Study 

      Gerber, Megan R; Leiter, Karen S; Hermann, Richard C; Bor, David Harkavy (BioMed Central, 2005)
      Background: This two-part study examines primary care clinicians' chart documentation and attitudes when confronted by a positive waiting room screen for intimate partner violence (IPV). Methods: Patients at community ...

    • How behavioral economics can help to avoid ‘The last mile problem’ in whole genome sequencing 

      Blumenthal-Barby, Jennifer S; McGuire, Amy L; Green, Robert C; Ubel, Peter A (BioMed Central, 2015)
      Editorial summary Failure to consider lessons from behavioral economics in the case of whole genome sequencing may cause us to run into the ‘last mile problem’ - the failure to integrate newly developed technology, on which ...