Browsing HMS Scholarly Articles by Title

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    • IgG Conformer's Binding to Amyloidogenic Aggregates 

      Phay, Monichan; Welzel, Alfred T.; Williams, Angela D.; McWilliams-Koeppen, Helen P.; Blinder, Veronika; O'Malley, Tiernan T.; Solomon, Alan; Walsh, Dominic M.; O'Nuallain, Brian (Public Library of Science, 2015)
      Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the ...

    • IgG4+ to IgG+ Plasma Cells Ratio of Ampulla Can Help Differentiate Autoimmune Pancreatitis From Other “Mass Forming” Pancreatic Lesions 

      Sepehr, Alireza; Mino-Kenudson, Mari; Ogawa, Fumihiro; Brugge, William Robert; Deshpande, Vikram; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Autoimmune pancreatitis (AIP) shows a unique spectrum of histologic features and commonly presents with an abundant IgG4-positive (IgG4+) plasma cell infiltration. However, differentiating AIP from other mass lesions, ...

    • IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material 

      Deshpande, Vikram; Sainani, Nisha I.; Chung, Raymond Taeyong; Pratt, Daniel S.; Mentha, Gilles; Rubbia-Brandt, Laura; Lauwers, Gregory Y. (Springer Nature, 2009)
      IgG4-associated cholangitis is a steroid-responsive hepatobiliary inflammatory condition associated with autoimmune pancreatitis that clinically and radiologically mimics primary sclerosing cholangitis. In this study, we ...

    • IgG4-Related Disease and Hypertrophic Pachymeningitis 

      Wallace, Zachary S.; Carruthers, Mollie N.; Khosroshahi, Arezou; Carruthers, Robert; Shinagare, Shweta; Stemmer-Rachamimov, Anat; Deshpande, Vikram; Stone, John H. (Wolters Kluwer Health, 2013)
      Abstract Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result from mass effect, nerve compression, or vascular ...

    • IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor 

      Khosroshahi, Arezou; Ayalon, Rivka; Beck, Laurence H.; Salant, David J.; Bloch, Donald Bendit; Stone, John H. (Hindawi Publishing Corporation, 2012)
      Patients with IgG4-related disease (IgG4-RD) share histopathological characteristics that are similar across affected organs. The finding of infiltration with IgG4+ plasma cells in the proper clinical and histopathological ...

    • IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity 

      Avnir, Yuval; Watson, Corey T.; Glanville, Jacob; Peterson, Eric C.; Tallarico, Aimee S.; Bennett, Andrew S.; Qin, Kun; Fu, Ying; Huang, Chiung-Yu; Beigel, John H.; Breden, Felix; Zhu, Quan; Marasco, Wayne A. (Nature Publishing Group, 2016)
      IGHV polymorphism provides a rich source of humoral immune system diversity. One important example is the IGHV1-69 germline gene where the biased use of alleles that encode the critical CDR-H2 Phe54 (F-alleles) to make ...

    • The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling 

      Dzamko, Nicolas; Inesta-Vaquera, Francisco; Zhang, Jiazhen; Xie, Chengsong; Cai, Huaibin; Arthur, Simon; Tan, Li; Choi, Hwanguen; Gray, Nathanael Schiander; Cohen, Philip; Pedrioli, Patrick; Clark, Kristopher; Alessi, Dario R. (Public Library of Science, 2012)
      Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson's disease. LRRK2 is highly expressed in immune cells and recent work points towards a link between LRRK2 ...

    • Ikaros fingers on lymphocyte differentiation 

      Yoshida, Toshimi; Georgopoulos, Katia (Springer Science + Business Media, 2014)
      The Ikaros family of DNA binding proteins are critical regulators of lymphocyte differentiation. In multipotent hematopoietic progenitors, Ikaros supports transcriptional priming of genes promoting lymphocyte differentiation. ...

    • Ikaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia 

      Joshi, Ila; Yoshida, Toshimi; Jena, Nilamani; Qi, Xiaoqing; Zhang, Jiangwen; Van Etten, Richard A.; Georgopoulos, Katia (2014)
      Deletion of the Ikaros (Ikzf1) DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias ...

    • An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities 

      Perotti, Elizabeth A.; Georgopoulos, Katia; Yoshida, Toshimi (Public Library of Science, 2015)
      Ikaros DNA binding factor plays critical roles in lymphocyte development. Changes in Ikaros expression levels during lymphopoiesis are controlled by redundant but also unique regulatory elements of its locus that are ...

    • Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression 

      Lin, Fu-Jung; Shen, Li; Jang, Chuan-Wei; Falnes, Pål Ø.; Zhang, Yi (Public Library of Science, 2013)
      Mouse Ikbkap gene encodes IKAP—one of the core subunits of Elongator—and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains ...

    • IKK\(\beta\) Regulates Essential Functions of the Vascular Endothelium Through Kinase-Dependent and -Independent Pathways 

      Ashida, Noboru; SenBanerjee, Sucharita B.; Kodama, Shohta; Foo, Shi Yin; Coggins, Matthew Peter; Spencer, Joel A.; Zamiri, Parisa; Shen, Dongxiao; Li, Ling; Sciuto, Tracey; Dvorak, Ann Marie; Gerszten, Robert Edgardo; Lin, Charles P.; Karin, Michael; Rosenzweig, Anthony (Nature Publishing Group, 2011)
      Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)- \(\kappa\)B ...

    • IL-10 Transcription is Negatively Regulated by BAF180, a Component of the SWI/SNF Chromatin Remodeling Enzyme 

      Wurster, Andrea L; Precht, Patricia; Becker, Kevin G; Wood, William H; Zhang, Yongqing; Wang, Zhong; Pazin, Michael J (BioMed Central, 2012)
      Background: SWI/SNF chromatin remodeling enzymes play a critical role in the development of T helper lymphocytes, including Th2 cells, and directly program chromatin structure at Th2 cytokine genes. Different versions of ...

    • IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation 

      Mayo, Lior; Cunha, Andre Pires Da; Madi, Asaf; Beynon, Vanessa; Yang, Zhiping; Alvarez, Jorge I.; Prat, Alexandre; Sobel, Raymond A.; Kobzik, Lester; Lassmann, Hans; Quintana, Francisco J.; Weiner, Howard L. (Oxford University Press, 2016)
      See Winger and Zamvil (doi:10.1093/brain/aww121) for a scientific commentary on this article. The innate immune system plays a central role in the chronic central nervous system inflammation that drives neurological ...

    • IL-11 Is a Crucial Determinant of Cardiovascular Fibrosis 

      Schafer, Sebastian; Viswanathan, Sivakumar; Widjaja, Anissa A.; Lim, Wei-Wen; Moreno-Moral, Aida; DeLaughter, Daniel; Ng, Benjamin; Patone, Giannino; Chow, Kingsley; Khin, Ester; Tan, Jessie; Chothani, Sonia P.; Ye, Lei; Rackham, Owen J. L.; Ko, Nicole S. J.; Sahib, Norliza E.; Pua, Chee Jian; Zhen, Nicole T. G.; Xie, Chen; Wang, Mao; Maatz, Henrike; Lim, Shiqi; Saar, Kathrin; Blachut, Susanne; Petretto, Enrico; Schmidt, Sabine; Putoczki, Tracy; Guimarães-Camboa, Nuno; Wakimoto, Hiroko; van Heesch, Sebastiaan; Sigmundsson, Kristmundur; Lim, See L.; Soon, Jia L.; Chao, Victor T. T.; Chua, Yeow L.; Tan, Teing E.; Evans, Sylvia M.; Loh, Yee J.; Jamal, Muhammad H.; Ong, Kim K.; Chua, Kim C.; Ong, Boon-Hean; Chakaramakkil, Mathew J.; Seidman, Jonathan; Seidman, Christine; Hubner, Norbert; Sin, Kenny Y. K.; Cook, Stuart A. (Springer Science and Business Media LLC, 2017-12-07)
      Fibrosis is a common pathology in cardiovascular disease1. In the heart, fibrosis causes mechanical and electrical dysfunction1,2 and in the kidney, it predicts the onset of renal failure3. Transforming growth factor β1 ...

    • IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses 

      Lee, Chang-Min; He, Chuan Hua; Nour, Adel M.; Zhou, Yang; Ma, Bing; Park, Jin Wook; Kim, Kyung Hee; Cruz, Charles Dela; Sharma, Lokesh; Nasr, Mahmoud L.; Modis, Yorgo; Lee, Chun Geun; Elias, Jack A. (Nature Publishing Group, 2016)
      Recent studies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Rα2. However, the mechanism that IL-13Rα2 uses to mediate the effects of Chi3l1 has not been defined. Here, we demonstrate that the ...

    • IL-17 in Systemic Lupus Erythematosus 

      Crispín, José C.; Tsokos, George C. (Hindawi Publishing Corporation, 2010)
      IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, ...

    • IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity 

      Kim, Hye Young; Lee, Hyun Jun; Chang, Ya-Jen; Pichavant, Muriel; Shore, Stephanie A.; Fitzgerald, Katherine A.; Iwakura, Yoichiro; Israel, Elliot; Bolger, Kenneth; Faul, John; DeKruyff, Rosemarie H.; Umetsu, Dale T. (2014)
      Obesity is associated with the development of asthma and considerable asthma-related healthcare utilization. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high fat diet for ...

    • IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders 

      Reed, Michael Douglas; Yim, Yeong Shin; Wimmer, Ralf D.; Kim, Hyunju; Ryu, Changhyeon; Welch, Gwyneth Margaret; Andina, Matias; King, Hunter Oren; Waisman, Ari; Halassa, Michael M.; Huh, Jun; Choi, Gloria B.; Choi (Springer Science and Business Media LLC, 2020-01-09)

    • IL-1\(\beta\) Is Upregulated in the Diabetic Retina and Retinal Vessels: Cell-Specific Effect of High Glucose and IL-1\(\beta\) Autostimulation 

      Liu, Yang; Biarnés Costa, Montserrat; Gerhardinger, Chiara (Public Library of Science, 2012)
      Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1\(\beta\)-driven neuroinflammation in the pathogenesis of diabetic retinopathy. IL-1\(\beta\) is well known for its role in ...