Browsing HMS Scholarly Articles by Title
Now showing items 8238-8257 of 17922
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Imaging leukocyte trafficking in vivo with two-photon-excited endogenous tryptophan fluorescence
(Optical Society of America, 2010)We describe a new method for imaging leukocytes in vivo by exciting the endogenous protein fluorescence in the ultraviolet (UV) spectral region where tryptophan is the major fluorophore. Two-photon excitation near 590 nm ... -
Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis
(American Heart Association, 2015)Rationale: Local plaque macrophage proliferation and monocyte production in hematopoietic organs promote progression of atherosclerosis. Therefore, noninvasive imaging of proliferation could serve as a biomarker and monitor ... -
Imaging Neuroinflammation – from Bench to Bedside
(2014)Neuroinflammation plays a central role in a variety of neurological diseases, including stroke, multiple sclerosis, Alzheimer’s disease, and malignant CNS neoplasms, among many other. Different cell types and molecular ... -
Imaging of Nitric Oxide in Nitrergic Neuromuscular Neurotransmission in the Gut
(Public Library of Science, 2009)Background: Numerous functional studies have shown that nitrergic neurotransmission plays a central role in peristalsis and sphincter relaxation throughout the gut and impaired nitrergic neurotransmission has been implicated ... -
Imaging of the unstable plaque: how far have we got?
(Oxford University Press, 2009)Rupture of unstable plaques may lead to myocardial infarction or stroke and is the leading cause of morbidity and mortality in western countries. Thus, there is a clear need for identifying these vulnerable plaques before ... -
Imaging of VSOP Labeled Stem Cells in Agarose Phantoms with Susceptibility Weighted and T2* Weighted MR Imaging at 3T: Determination of the Detection Limit
(Public Library of Science, 2013)Objectives: This study aimed to evaluate the detectability of stem cells labeled with very small iron oxide particles (VSOP) at 3T with susceptibility weighted (SWI) and T2* weighted imaging as a methodological basis for ... -
Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline
(National Institute of Environmental Health Sciences, 2016)Background: Although occupational exposures contribute to a significant proportion of obstructive lung disease, the phenotype of obstructive lung disease associated with work-related organic dust exposure independent of ... -
Imaging Primary Lung Cancers in Mice to Study Radiation Biology
(Elsevier, 2010)Purpose: To image a genetically engineered mouse model of non small-cell lung cancer with micro computed tomography (micro-CT) to measure tumor response to radiation therapy. Methods and Materials: The Cre-loxP system was ... -
Imaging Skeletal Muscle Using Second Harmonic Generation and Coherent Anti-Stokes Raman Scattering Microscopy
(Optical Society of America, 2011-05-01)We describe experimental results on label free imaging of striated skeletal muscle using second harmonic generation (SHG) and coherent anti- Stokes Raman scattering (CARS) microscopy. The complementarity of the SHG and ... -
Imaging Skills for Transthoracic Echocardiography in Cardiology Fellows: The Value of Motion Metrics
(Medknow, 2016)Background: Proficiency in transthoracic echocardiography (TTE) requires an integration of cognitive knowledge and psychomotor skills. Whereas cognitive knowledge can be quantified, psychomotor skills are implied after ... -
Imaging Studies in Focal Dystonias: A Systems Level Approach to Studying a Systems Level Disorder
(Bentham Science Publishers, 2013)Focal dystonias are dystonias that affect one part of the body, and are sometimes task-specific. Brain imaging and transcranial magnetic stimulation techniques have been valuable in defining the pathophysiology of dystonias ... -
Imaging surveillance of gastrointestinal stromal tumour: current recommendation by National Comprehensive Cancer Network and European Society of Medical Oncology-European Reference Network for rare adult solid cancers
(Elsevier BV, 2019-10)Objective: To review the role of imaging in surveillance of gastrointestinal stromal tumor (GIST), in the setting of adjuvant, neoadjuvant or metastatic disease, and to propose practical guidelines for surveillance for ... -
Imaging the Functional Connectivity of the Periaqueductal Gray During Genuine and Sham Electroacupuncture Treatment
(BioMed Central, 2010)Background: Electroacupuncture (EA) is currently one of the most popular acupuncture modalities. However, the continuous stimulation characteristic of EA treatment presents challenges to the use of conventional functional ... -
Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis
(BioMed Central, 2014)The neuroimaging literature of Major Depressive Disorder (MDD) has grown substantially over the last several decades, facilitating great advances in the identification of specific brain regions, neurotransmitter systems ... -
Imaging Therapeutic PARP Inhibition in Vivo through Bioorthogonally Developed Companion Imaging Agents
(Elsevier, 2012)A number of small-molecule poly (ADP-ribose) polymerase (PARP) inhibitors are currently undergoing advanced clinical trials. Determining the distribution and target inhibitory activity of these drugs in individual subjects, ... -
Imaging Tumor Vascularity and Response to Anti-Angiogenic Therapy Using Gaussia Luciferase
(Nature Publishing Group, 2016)We developed a novel approach to assess tumor vascularity using recombinant Gaussia luciferase (rGluc) protein and bioluminescence imaging. Upon intravenous injection of rGluc followed by its substrate coelenterazine, ... -
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish
(Nature Publishing Group, 2016)Cancers contain a wide diversity of cell types that are defined by differentiation states, genetic mutations and altered epigenetic programmes that impart functional diversity to individual cells. Elevated tumour cell ... -
An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models
(Nature Publishing Group, 2014)While it is increasingly recognized that three-dimensional (3D) cell culture models recapitulate drug responses of human cancers with more fidelity than monolayer cultures, a lack of quantitative analysis methods limit ... -
Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma
(BioMed Central, 2016)Background: Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely ... -
An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
(Nature Publishing Group, 2016)Chronic unresolved inflammation plays a causal role in the development of advanced atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain unclear. Here, we use targeted mass spectrometry to ...