Now showing items 8282-8301 of 17918

    • Immunodominance and Viral Ditness in Gag May Contribute to Differential Viral Control in HLA-B*7 Supertype Individuals Acutely Infected with HIV-1C 

      Gounder, K; Leshwedi, M; van der Stok, M; Chonco, F; Padayachee, N; Ndimande, B; Mokgoro, M; Jaggernath, M; Wright, J; Walker, Bruce David; Goulder, Philip J. (BioMed Central, 2012)
    • Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection 

      Ramduth, Danni; Day, Cheryl L.; Thobakgale, Christina F.; Mkhwanazi, Nompumelelo P.; de Pierres, Chantal; Reddy, Sharon; van der Stok, Mary; Mncube, Zenele; Nair, Kriebashne; Moodley, Eshia S.; Coovadia, Hoosen M.; Kiepiela, Photini; Kaufmann, Daniel; Streeck, Hendrik; Goulder, Philip J.; Walker, Bruce David (Public Library of Science, 2009)
      Background: A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This ...
    • Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality 

      Mkhwanazi, Nompumelelo; Thobakgale, Christina F.; van der Stok, Mary; Reddy, Shabashini; Mncube, Zenele; Chonco, Fundisiwe; Walker, Bruce David; Altfeld, Marcus; Goulder, Philip J.; Ndung'u, Thumbi (Academic Press, 2010)
      HIV-1 specific HLA-B-restricted CD8+ T cell responses differ from HLA-C-restricted responses in antiviral effectiveness. To investigate possible reasons for these differences, we characterized the frequency and polyfunctionality ...
    • Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy 

      Pfirschke, Christina; Engblom, Camilla; Rickelt, Steffen; Cortez-Retamozo, Virna; Garris, Christopher; Pucci, Ferdinando; Yamazaki, Takahiro; Colame, Vichnou Poirier; Newton, Andita; Redouane, Younes; Lin, Yi-Jang; Wojtkiewicz, Gregory; Iwamoto, Yoshiko; Mino-Kenudson, Mari; Huynh, Tiffany; Hynes, Richard; Freeman, Gordon; Kroemer, Guido; Zitvogel, Laurence; Weissleder, Ralph; Pittet, Mikael (Elsevier, 2016)
      Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung adenocarcinoma mouse models, including ...
    • Immunogenicity of a Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine, Shanchol, in Haiti 

      Charles, Richelle C.; Hilaire, Isabelle J.; Mayo-Smith, Leslie M.; Teng, Jessica E.; Jerome, J. Gregory; Franke, Molly F.; Saha, Amit; Yu, Yanan; Kováč, Paul; Calderwood, Stephen B.; Ryan, Edward T.; LaRocque, Regina C.; Almazor, Charles P.; Qadri, Firdausi; Ivers, Louise C.; Harris, Jason B. (Public Library of Science, 2014)
      Background: Studies of the immunogenicity of the killed bivalent whole cell oral cholera vaccine, Shanchol, have been performed in historically cholera-endemic areas of Asia. There is a need to assess the immunogenicity ...
    • Immunoglobulin E and Mast Cell Proteases Are Potential Risk Factors of Human Pre-Diabetes and Diabetes Mellitus 

      Wang, Zhen; Zhang, Hong; Shen, Xu-Hui; Jin, Kui-Li; Ye, Guo-fen; Qian, Li; Li, Bo; Zhang, Yong-Hong; Shi, Guo-Ping; Song, Yiqing (Public Library of Science, 2011)
      Background: Recent studies have suggested that mast-cell activation and inflammation are important in obesity and diabetes. Plasma levels of mast cell proteases and the mast cell activator immunoglobulin E (IgE) may serve ...
    • Immunohistochemical characterization of human olfactory tissue 

      Holbrook, Eric Hans; Wu, Enming; Curry, William Thomas; Lin, Derrick T.; Schwob, James E. (Wiley-Blackwell, 2011)
      Objectives/Hypothesis The pathophysiology underlying human olfactory disorders is poorly understood because biopsying the olfactory epithelium (OE) can be unrepresentative and extensive immunohistochemical analysis is ...
    • Immunohistochemical Markers Associated With Brain Metastases in Patients with Nonsmall Cell Lung Carcinoma 

      Saad, Ali G.; Yeap, Beow; Thunnissen, Frederik B. J. M.; Pinkus, Geraldine; Pinkus, Jack; Loda, Massimo; Sugarbaker, David J.; Johnson, Bruce; Chirieac, Lucian (Wiley, 2008-10-15)
      BACKGROUND There are no reliable markers able to identify patients with non-small cell lung cancer (NSCLC) likely to metastasize to the brain. We investigated associations between immunohistochemical markers and development ...
    • Immunoidentification of Type XII Collagen in Embryonic Tissues [Published Erratum Appears in J Cell Biol 1989 Nov;109(5):following 2254] 

      Sugrue, Stephen P.; Gordon, M K; Seyer, Jerome; Dublet, B; van der Rest, Michel; Olsen, Bjorn (Rockefeller University Press, 1989-08-01)
      We have generated a monoclonal antibody against a synthetic peptide whose sequence was derived from the nucleotide sequence of a cDNA encoding alpha 1(XII) collagen. The antibody, 75d7, has been used to identify the alpha ...
    • Immunologic monitoring in kidney transplant recipients 

      Townamchai, Natavudh; Safa, Kassem; Chandraker, Anil (Elsevier, 2013)
      Transplant biopsy has always been the gold standard for assessing the immune response to a kidney allograft (Chandraker A: Diagnostic techniques in the work-up of renal allograft dysfunction—an update. Curr Opin Nephrol ...
    • Immunologic Responses to Vibrio cholerae in Patients Co-Infected with Intestinal Parasites in Bangladesh 

      Bhuiyan, Taufiqur R.; Chowdhury, Fahima; Khan, Ashraful I.; Logvinenko, Tanya; Kendall, Jennifer; Faruque, Abu S. G.; Nagler, Cathryn R.; Qadri, Firdausi; Harris, Jason B.; Podolsky, Michael Jeffrey; Larocque, Regina Celes; Ryan, Edward Thomas; Calderwood, Stephen Beaven (Public Library of Science, 2009)
      Background: Infection with intestinal helminths is common and may contribute to the decreased efficacy of Vibrio cholerae vaccines in endemic compared to non-endemic areas. However, the immunomodulatory effects of concomitant ...
    • Immunological Relevance of the Coevolution of IDO1 and AHR 

      Jaronen, Merja; Quintana, Francisco J. (Frontiers Media S.A., 2014)
      The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to ...
    • Immunology of neuromyelitis optica during pregnancy 

      Davoudi, Vahid; Keyhanian, Kiandokht; Bove, Riley M.; Chitnis, Tanuja (Lippincott Williams & Wilkins, 2016)
      Anti–aquaporin-4 (AQP4) autoantibody plays a key role in the pathogenesis of neuromyelitis optica (NMO). Studies have shown increased relapse rates in patients with NMO during pregnancy and postpartum. High estrogen levels ...
    • Immunology of Vascularized Composite Allografts 

      Brandacher, Gerald; Sachs, David H.; Thomson, Angus W. (Hindawi Publishing Corporation, 2013)
    • Immunomodulation by Mesenchymal Stem Cells A Potential Therapeutic Strategy for Type 1 Diabetes 

      Abdi, Reza; Fiorina, Paolo; Adra, Chaker N.; Atkinson, Mark; Sayegh, Mohamed Hassan (American Diabetes Association, 2008)
      Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have the potential to give rise to cells of diverse lineages. Interestingly, MSCs can be found in virtually all postnatal tissues. The main criteria currently ...
    • Immunomodulatory Drugs Activate NK Cells via Both Zap-70 and Cereblon-Dependent Pathways 

      Hideshima, Teru; Ogiya, Daisuke; Liu, Jiye; Harada, Takeshi; Kurata, Keiji; Bae, Jooeun; Massefski, Walter; Anderson, Kenneth (Springer Science and Business Media LLC, 2020-04-01)
      Immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide show remarkable anti-tumor activity in multiple myeloma (MM) via directly inhibiting MM cell growth in the bone marrow (BM) microenvironment and promoting immune ...
    • Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis 

      Hwang, Ji Sun; Kwon, Ho-Keun; Kim, Jung-Eun; Rho, Jeonghae; Im, Sin-Hyeog (BioMed Central, 2012)
      Background: Complementary and alternative medicine (CAM) is becoming a popular treatment for modulating diverse immune disorders. Phellinus linteus (P. linteus) as one of the CAMs has been used to modulate cancers, ...
    • Immunophenotyping and Efficacy of Low Dose ATG in Non-Sensitized Kidney Recipients Undergoing Early Steroid Withdrawal: A Randomized Pilot Study 

      Grafals, Monica; Smith, Brian; Murakami, Naoka; Trabucco, Agnes; Hamill, Katherine; Marangos, Erick; Gilligan, Hannah; Pomfret, Elizabeth A.; Pomposelli, James J.; Simpson, Mary A.; Azzi, Jamil; Najafian, Nader; Riella, Leonardo V. (Public Library of Science, 2014)
      Rabbit antithymocyte globulin (ATG) is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The purpose ...
    • Immunoproteomic Analysis of Antibody in Lymphocyte Supernatant in Patients with Typhoid Fever in Bangladesh 

      Charles, Richelle C.; Liang, Li; Khanam, Farhana; Sayeed, M. Abu; Hung, Chris; Leung, Daniel T.; Baker, Stephen; Ludwig, Albrecht; Harris, Jason B.; LaRocque, Regina C.; Calderwood, Stephen B.; Qadri, Firdausi; Felgner, Philip L.; Ryan, Edward T. (American Society for Microbiology, 2014)
      We have previously shown that an assay based on detection of anti-Salmonella enterica serotype Typhi antibodies in supernatant of lymphocytes harvested from patients presenting with typhoid fever (antibody in lymphocyte ...
    • Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro 

      Isotani, Shuji; Hara, Kenta; Tokunaga, Chiharu; Inoue, Hitomi; Avruch, Joseph; Yonezawa, Kazuyoshi (American Society for Biochemistry and Molecular Biology, 1999)