Now showing items 841-860 of 17918

    • Anion-Sensitive Fluorophore Identifies the Drosophila Swell-Activated Chloride Channel in a Genome-Wide RNA Interference Screen 

      Stotz, Stephanie Christine; Clapham, David Eldon (Public Library of Science, 2012)
      When cells swell in hypo-osmotic solutions, chloride-selective ion channels (\(Cl_{swell}\)) activate to reduce intracellular osmolality and prevent catastrophic cell rupture. Despite intensive efforts to assign a molecular ...
    • Anisotropic light scattering of individual sickle red blood cells 

      Kim, Youngchan; Higgins, John Matthew; Dasari, Ramachandra R.; Suresh, Subra; Park, YongKeun (Society of Photo-Optical Instrumentation Engineers, 2012)
      Abstract. We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped ...
    • Anisotropy of transcallosal motor fibres indicates functional impairment in children with periventricular leukomalacia 

      Koerte, Inga Katharina; Pelavin, Paula; Kirmess, Berit; Fuchs, Teresa; Berweck, Steffen; Laubender, Ruediger P; Borggraefe, Ingo; Schroeder, Sebastian; Danek, Adrian; Rummeny, Caludia; Reiser, Maximilian; Kubicki, Marek R.; Shenton, Martha Elizabeth; Ertl-Wagner, Birgit; Heinen, Florian (Wiley-Blackwell, 2010)
      Aim—In children with bilateral spastic cerebral palsy (CP), periventricular leukomalacia (PVL) is commonly identified on magnetic resonance imaging. We characterized this white matter condition by examining callosal ...
    • Ankle impingement 

      Lavery, Kyle P.; McHale, Kevin J.; Rossy, William H.; Theodore, George (BioMed Central, 2016)
      Ankle impingement is a syndrome that encompasses a wide range of anterior and posterior joint pathology involving both osseous and soft tissue abnormalities. In this review, the etiology, pathoanatomy, diagnostic workup, ...
    • ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3 

      Hoff, Sylvia; Halbritter, Jan; Epting, Daniel; Frank, Valeska; Nguyen, Thanh-Minh T.; van Reeuwijk, Jeroen; Boehlke, Christopher; Schell, Christoph; Yasunaga, Takayuki; Helmstädter, Martin; Mergen, Miriam; Filhol, Emilie; Boldt, Karsten; Horn, Nicola; Ueffing, Marius; Otto, Edgar A.; Eisenberger, Tobias; Elting, Mariet W.; van Wijk, Joanna A.E.; Bockenhauer, Detlef; Sebire, Neil J.; Rittig, Søren; Vyberg, Mogens; Ring, Troels; Pohl, Martin; Pape, Lars; Neuhaus, Thomas J.; Soliman Elshakhs, Neveen A.; Koon, Sarah J.; Harris, Peter C.; Grahammer, Florian; Huber, Tobias B.; Kuehn, E. Wolfgang; Kramer-Zucker, Albrecht; Bolz, Hanno J.; Roepman, Ronald; Saunier, Sophie; Walz, Gerd; Hildebrandt, Friedhelm; Bergmann, Carsten; Lienkamp, Soeren S. (2013)
      Nephronophthisis (NPH) is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most NPHP gene products form molecular networks. We have identified ANKS6 as a new NPHP family ...
    • ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning 

      Czarnecki, Peter G.; Gabriel, George C.; Manning, Danielle K.; Sergeev, Mikhail; Lemke, Kristi; Klena, Nikolai T.; Liu, Xiaoqin; Chen, Yu; Li, You; San Agustin, Jovenal T.; Garnaas, Maija K.; Francis, Richard J.; Tobita, Kimimasa; Goessling, Wolfram; Pazour, Gregory J.; Lo, Cecilia W.; Beier, David R.; Shah, Jagesh V. (2015)
      The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 ...
    • Ankyrin 3: Genetic Association with Bipolar Disorder and Relevance to Disease Pathophysiology 

      Leussis, Melanie P.; Madison, Jon Morrow; Petryshen, Tracey L (BioMed Central, 2012)
      Bipolar disorder (BD) is a multi-factorial disorder caused by genetic and environmental influences. It has a large genetic component, with heritability estimated between 59-93%. Recent genome-wide association studies (GWAS) ...
    • Ankyrin-G Regulates Neurogenesis and Wnt Signaling by Altering the Subcellular Localization of β-catenin 

      Durak, Omer; de Anda, Froylan Calderon; Singh, Karun K.; Leussis, Melanie P.; Petryshen, Tracey L.; Sklar, Pamela; Tsai, Li-Huei (2014)
      Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, ...
    • Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair 

      Leoni, Giovanna; Neumann, Philipp-Alexander; Kamaly, Nazila; Quiros, Miguel; Nishio, Hikaru; Jones, Hefin R.; Sumagin, Ronen; Hilgarth, Roland S.; Alam, Ashfaqul; Fredman, Gabrielle; Argyris, Ioannis; Rijcken, Emile; Kusters, Dennis; Reutelingsperger, Chris; Perretti, Mauro; Parkos, Charles A.; Farokhzad, Omid Cameron; Neish, Andrew S.; Nusrat, Asma (American Society for Clinical Investigation, 2015)
      Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; ...
    • Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics 

      Lundby, Alicia; Rossin, Elizabeth J.; Steffensen, Annette B.; Rav Acha, Moshe; Newton-Cheh, Christopher; Pfeufer, Arne; Lynch, Stacey N.; Olesen, Søren-Peter; Brunak, Søren; Ellinor, Patrick T.; Jukema, J.Wouter; Trompet, Stella; Ford, Ian; Macfarlane, Peter W.; Krijthe, Bouwe P.; Hofman, Albert; Uitterlinden, Andre G.; Stricker, Bruno H.; Nathoe, Hendrik M.; Spiering, Wilko; Daly, Mark J.; Asselbergs, Folkert W.; van der Harst, Pim; Milan, David J.; de Bakker, Paul I.W.; Lage, Kasper; Olsen, Jesper V. (2014)
      Genome-wide association studies (GWAS) have identified thousands of loci associated wtih complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtle association signals. We used ...
    • Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study 

      Hoxha, Mirjam; Dioni, Laura; McCracken, John Patrick; Baccarelli, Andrea; Melly, Steven John; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ...
    • Anomalous origin of the coronary artery arising from the opposite sinus: prevalence and outcomes in patients undergoing coronary CTA 

      Cheezum, Michael; Ghoshhajra, Brian Burns; Bittencourt, Marcio S.; Hulten, Edward A.; Bhatt, Ami Bharat; Mousavi, Negareh; Shah, Nishant; Valente, Anne Marie; Rybicki, Frank; Steigner, Michael L.; Hainer, Jon; MacGillivray, Thomas; Hoffmann, Udo; Abbara, Suhny; Di Carli, Marcelo F.; DeFaria Yeh, Doreen; Landzberg, Michael Job; Liberthson, Richard R.; Blankstein, Ron (Oxford University Press (OUP), 2016)
      Aims The impact of coronary computed tomographic angiography (CTA) on management of anomalous origin of the coronary artery arising from the opposite sinus (ACAOS) remains uncertain. We examined the prevalence, anatomical ...
    • Antagonism Between Smad1 and Smad2 Signaling Determines the Site of Distal Visceral Endoderm Formation in the Mouse Embryo 

      Yamamoto, Masamichi; Beppu, Hideyuki; Takaoka, Katsuyoshi; Meno, Chikara; Li, En; Miyazono, Kohei; Hamada, Hiroshi (Rockefeller University Press, 2009)
      The anterior–posterior axis of the mouse embryo is established by formation of distal visceral endoderm (DVE) and its subsequent migration. The precise mechanism of DVE formation has remained unknown, however. Here we show ...
    • Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function 

      Adler, Gail Kurr; Bonyhay, Istvan; Failing, Hannah; Waring, Elizabeth; Dotson, Sarah; Freeman, Roy Lester (American Diabetes Association, 2009)
      OBJECTIVE—Glycemic control decreases the incidence and progression of diabetic complications but increases the incidence of hypoglycemia. Hypoglycemia can impair hormonal and autonomic responses to subsequent hypoglycemia. ...
    • Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-Resistant Enterococcus 

      Carmeli, Yehuda; Eliopoulos, George Miltiades; Samore, Matthew H. (Centers for Disease Control and Prevention, 2002)
      We conducted a matched case-control study to compare the effect of antecedent treatment with various antibiotics on subsequent isolation of vancomycin-resistant Enterococcus (VRE); 880 in-patients; 233 VRE cases, and 647 ...
    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...
    • Anterior Urethral Stricture Disease Negatively Impacts the Quality of Life of Family Members 

      Weese, Jonathan R.; Raup, Valary T.; Eswara, Jairam R.; Marshall, Stephen D.; Chang, Andrew J.; Vetter, Joel; Brandes, Steven B. (Hindawi Publishing Corporation, 2016)
      Purpose. To quantify the quality of life (QoL) distress experienced by immediate family members of patients with urethral stricture via a questionnaire given prior to definitive urethroplasty. The emotional, social, and ...
    • Anterior uveitis secondary to type II essential cryoglobulinemia 

      Nicholson, Laura; Sobrin, Lucia (Springer, 2013)
      Background: The purpose of this report is to describe the association of severe anterior uveitis with type II essential cryoglobulinemia. Findings: A 40-year-old male with a history of psoriatic arthritis presented with ...
    • Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors 

      Beier, Kevin; Saunders, Arpiar; Oldenburg, Ian; Miyamichi, Kazunari; Akhtar, Nazia; Luo, Liqun; Whelan, Sean; Sabatini, Bernardo; Cepko, Constance (National Academy of Sciences, 2011)
    • Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation 

      Scobie, Heather M.; Marlett, John M.; Rainey, G. Jonah A.; Lacy, D. Borden; Collier, R. John; Young, John A.T. (Public Library of Science, 2007)
      The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound ...