Browsing HMS Scholarly Articles by Title

Now showing items 850-869 of 17922

    • Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics 

      Lundby, Alicia; Rossin, Elizabeth J.; Steffensen, Annette B.; Rav Acha, Moshe; Newton-Cheh, Christopher; Pfeufer, Arne; Lynch, Stacey N.; Olesen, Søren-Peter; Brunak, Søren; Ellinor, Patrick T.; Jukema, J.Wouter; Trompet, Stella; Ford, Ian; Macfarlane, Peter W.; Krijthe, Bouwe P.; Hofman, Albert; Uitterlinden, Andre G.; Stricker, Bruno H.; Nathoe, Hendrik M.; Spiering, Wilko; Daly, Mark J.; Asselbergs, Folkert W.; van der Harst, Pim; Milan, David J.; de Bakker, Paul I.W.; Lage, Kasper; Olsen, Jesper V. (2014)
      Genome-wide association studies (GWAS) have identified thousands of loci associated wtih complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtle association signals. We used ...

    • Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study 

      Hoxha, Mirjam; Dioni, Laura; McCracken, John Patrick; Baccarelli, Andrea; Melly, Steven John; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ...

    • Anomalous origin of the coronary artery arising from the opposite sinus: prevalence and outcomes in patients undergoing coronary CTA 

      Cheezum, Michael; Ghoshhajra, Brian Burns; Bittencourt, Marcio S.; Hulten, Edward A.; Bhatt, Ami Bharat; Mousavi, Negareh; Shah, Nishant; Valente, Anne Marie; Rybicki, Frank; Steigner, Michael L.; Hainer, Jon; MacGillivray, Thomas; Hoffmann, Udo; Abbara, Suhny; Di Carli, Marcelo F.; DeFaria Yeh, Doreen; Landzberg, Michael Job; Liberthson, Richard R.; Blankstein, Ron (Oxford University Press (OUP), 2016)
      Aims The impact of coronary computed tomographic angiography (CTA) on management of anomalous origin of the coronary artery arising from the opposite sinus (ACAOS) remains uncertain. We examined the prevalence, anatomical ...

    • Antagonism Between Smad1 and Smad2 Signaling Determines the Site of Distal Visceral Endoderm Formation in the Mouse Embryo 

      Yamamoto, Masamichi; Beppu, Hideyuki; Takaoka, Katsuyoshi; Meno, Chikara; Li, En; Miyazono, Kohei; Hamada, Hiroshi (Rockefeller University Press, 2009)
      The anterior–posterior axis of the mouse embryo is established by formation of distal visceral endoderm (DVE) and its subsequent migration. The precise mechanism of DVE formation has remained unknown, however. Here we show ...

    • Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function 

      Adler, Gail Kurr; Bonyhay, Istvan; Failing, Hannah; Waring, Elizabeth; Dotson, Sarah; Freeman, Roy Lester (American Diabetes Association, 2009)
      OBJECTIVE—Glycemic control decreases the incidence and progression of diabetic complications but increases the incidence of hypoglycemia. Hypoglycemia can impair hormonal and autonomic responses to subsequent hypoglycemia. ...

    • Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-Resistant Enterococcus 

      Carmeli, Yehuda; Eliopoulos, George Miltiades; Samore, Matthew H. (Centers for Disease Control and Prevention, 2002)
      We conducted a matched case-control study to compare the effect of antecedent treatment with various antibiotics on subsequent isolation of vancomycin-resistant Enterococcus (VRE); 880 in-patients; 233 VRE cases, and 647 ...

    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...

    • Anterior Urethral Stricture Disease Negatively Impacts the Quality of Life of Family Members 

      Weese, Jonathan R.; Raup, Valary T.; Eswara, Jairam R.; Marshall, Stephen D.; Chang, Andrew J.; Vetter, Joel; Brandes, Steven B. (Hindawi Publishing Corporation, 2016)
      Purpose. To quantify the quality of life (QoL) distress experienced by immediate family members of patients with urethral stricture via a questionnaire given prior to definitive urethroplasty. The emotional, social, and ...

    • Anterior uveitis secondary to type II essential cryoglobulinemia 

      Nicholson, Laura; Sobrin, Lucia (Springer, 2013)
      Background: The purpose of this report is to describe the association of severe anterior uveitis with type II essential cryoglobulinemia. Findings: A 40-year-old male with a history of psoriatic arthritis presented with ...

    • Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors 

      Beier, Kevin; Saunders, Arpiar; Oldenburg, Ian; Miyamichi, Kazunari; Akhtar, Nazia; Luo, Liqun; Whelan, Sean; Sabatini, Bernardo; Cepko, Constance (National Academy of Sciences, 2011)

    • Anthrax Toxin Receptor 2 Determinants that Dictate the pH Threshold of Toxin Pore Formation 

      Scobie, Heather M.; Marlett, John M.; Rainey, G. Jonah A.; Lacy, D. Borden; Collier, R. John; Young, John A.T. (Public Library of Science, 2007)
      The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH ∼6.0 or below when it is bound ...

    • Anthrax Toxin Receptor 2-Dependent Lethal Toxin Killing In Vivo 

      Scobie, Heather M; Wigelsworth, Darran J; Marlett, John M; Thomas, Diane; Rainey, G. Jonah A; Lacy, D. Borden; Manchester, Marianne; Collier, R. John; Young, John A. T (Public Library of Science, 2006)
      Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax ...

    • Anthrax Toxins Regulate Pain Signaling and Can Deliver Molecular Cargoes Into ANTXR2+ DRG Sensory Neurons 

      Yang, Nicole J.; Isensee, Jörg; Neel, Dylan V.; Quadros, Andreza U.; Zhang, Han-Xiong Bear; Lauzadis, Justas; Liu, Sai Man; Shiers, Stephanie; Belu, Andreea; Palan, Shilpa; Marlin, Sandra; Maignel, Jacquie; Kennedy-Curran, Angela; Tong, Victoria S.; Moayeri, Mahtab; Röderer, Pascal; Nitzsche, Anja; Lu, Mike; Pentelute, Bradley L.; Brüstle, Oliver; Tripathi, Vineeta; Foster, Keith A.; Price, Theodore J.; Collier, Robert; Leppla, Stephen H.; Puopolo, Michelino; Bean, Bruce; Cunha, Thiago M.; Hucho, Tim; Chiu, Isaac (Springer Science and Business Media LLC, 2021-12-20)
      Bacterial products can act on neurons to alter signaling and function. In the present study, we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-affinity receptor for anthrax toxins. ...

    • Anthrax Vaccine Design: Strategies to Achieve Comprehensive Protection Against Spore, Bacillus, and Toxin 

      Wang, Jun-Xia; Roehrl, Michael H (BioMed Central, 2005)
      The successful use of Bacillus anthracis as a lethal biological weapon has prompted renewed research interest in the development of more effective vaccines against anthrax. The disease consists of three critical components: ...

    • Anthropology in the Clinic: The Problem of Cultural Competency and How to Fix It 

      Kleinman, Arthur Michael; Benson, Peter (Public Library of Science (PLoS), 2006)

    • Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators 

      Jin, Yiping; Arita, Makoto; Zhang, Qiang; Saban, Daniel R.; Chauhan, Sunil Kumar; Chiang, Nan; Serhan, Charles Nicholas; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      Purpose.Resolvins and lipoxins are lipid mediators generated from essential polyunsaturated fatty acids that are the first dual anti-inflammatory and pro-resolving signals identified in the resolution phase of inflammation. ...

    • Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage 

      Fuchsluger, T A; Jurkunas, Ula V.; Kazlauskas, Andrius; Dana, Reza (Springer Nature, 2011)
      Corneal transplantation is the most common form of grafting performed worldwide. Corneal endothelial cells (EC) form a monolayer in the posterior portion of the cornea and are essential for corneal transparency. EC loss ...

    • Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model 

      Chang, De-Kuan; Peterson, Eric; Sun, Jiusong; Goudie, Calum; Drapkin, Ronny I.; Liu, Joyce F.; Matulonis, Ursula; Zhu, Quan; Marasco, Wayne A. (Taylor & Francis, 2016)
      ABSTRACT Recent studies have demonstrated that regulatory T cells (Tregs) are recruited to tumor sites where they can suppress antitumor immunity. The chemokine receptor CCR4 is expressed at high levels on functional ...

    • Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case–control study 

      Arkema, Elizabeth V; Goldstein, Barbara L; Robinson, William; Sokolove, Jeremy; Wagner, Catriona A; Malspeis, Susan; Rosner, Bernard; Grodstein, Francine; Karlson, Elizabeth W; Costenbader, Karen H (BioMed Central, 2013)
      Introduction: The aim of this study was to characterize anti-citrullinated peptide antibody (ACPA) serostatus in pre-clinical rheumatoid arthritis (RA) with and without Human Leukocyte Antigen-Shared Epitope (HLA-SE) ...

    • An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV 

      Hemashettar, Girish; Wang, Wendy; Novembre, Francis J.; Villinger, Francois; Ibegbu, Chris; Patel, Kalpana; Corti, Davide; Agatic, Gloria; Vanzetta, Fabrizia; Bianchi, Siro; Heeney, Jonathan L.; Sallusto, Federica; Lanzavecchia, Antonio; Watkins, Jennifer D; Siddappa, Nagadenahalli B.; Lakhashe, Samir; Humbert, Michael; Sholukh, Anton M; Wong, Yin Ling; Yoon, John C.; Ruprecht, Ruth Margrit (Public Library of Science, 2011)
      Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer ...