Now showing items 8592-8611 of 17918

    • In Vivo High Resolution Three-Dimensional Imaging of Antigen-Specific Cytotoxic T-Lymphocyte Trafficking to Tumors 

      Kircher, Moritz; Allport, Jennifer; Graves, Edward; Love, Victoria; Josephson, Lee; Lichtman, Andrew; Weissleder, Ralph (American Association for Cancer Research, 2003)
      Magnetic resonance imaging (MRI) allows noninvasive and three-dimensional visualization of whole organisms over time, and, therefore, would be ideally suited to monitor cell trafficking in vivo. Until now, systemically ...
    • In Vivo Imaging in Cancer 

      Condeelis, John; Weissleder, Ralph (2010)
      Imaging has become an indispensable tool in the study of cancer biology and in clinical prognosis and treatment. The rapid advances in high resolution fluorescent imaging at single cell level and MR/PET/CT image registration, ...
    • In Vivo Imaging of Cerebral Energy Metabolism with Two-Photon Fluorescence Lifetime Microscopy of NADH 

      Yaseen, Mohammad Abbas; Sakadzic, Sava; Wu, Weicheng; Becker, Wolfgang; Kasischke, Karl A.; Boas, David A. (Optical Society of America, 2013)
      Minimally invasive, specific measurement of cellular energy metabolism is crucial for understanding cerebral pathophysiology. Here, we present high-resolution, in vivo observations of autofluorescence lifetime as a biomarker ...
    • In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single cell resolution 

      Earley, Sarah; Vinegoni, Claudio; Dunham, Joshua; Gorbatov, Rostic; Feruglio, Paolo Fumene; Weissleder, Ralph (American Association for Cancer Research, 2012)
      Observing drug responses in the tumor microenvironment in vivo can be technically challenging. As a result, cellular responses to molecularly targeted cancer drugs are often studied in cell culture, which does not accurately ...
    • In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs 

      Wang, Changning; Schroeder, Frederick A.; Wey, Hsiao-Ying; Borra, Ronald; Wagner, Florence F.; Reis, Surya; Kim, Sung Won; Holson, Edward B.; Haggarty, Stephen J.; Hooker, Jacob M. (American Chemical Society, 2014)
      Epigenetic enzymes are now targeted to treat the underlying gene expression dysregulation that contribute to disease pathogenesis. Histone deacetylases (HDACs) have shown broad potential in treatments against cancer and ...
    • In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor 

      Sprachman, Melissa M.; Laughney, Ashley M.; Kohler, Rainer H.; Weissleder, Ralph (American Chemical Society, 2014)
      Cellular up-regulation of multidrug resistance protein 1 (MDR1) is a common cause for resistance to chemotherapy; development of third generation MDR1 inhibitors several of which contain a common 6,7-dimethoxy-2-phenethy ...
    • In vivo imaging of specific drug target binding at subcellular resolution 

      Dubach, J. M.; Vinegoni, C.; Mazitschek, R.; Feruglio, P. Fumene; Cameron, L. A.; Weissleder, R. (Nature Research (part of Springer Nature), 2014)
      The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely ...
    • In vivo imaging of T cell delivery to tumors after adoptive transfer therapy 

      Pittet, Mikael; Grimm, Jan; Berger, Cedric; Tamura, Takahiko; Wojtkiewicz, Gregory; Nahrendorf, Matthias; Romero, Pedro; Swirski, Filip; Weissleder, Ralph (National Academy of Sciences, 2007)
      Adoptive transfer therapy of in vitro-expanded tumor-specific cytolytic T lymphocytes (CTLs) can mediate objective cancer regression in patients. Yet, technical limitations hamper precise monitoring of posttherapy T cell ...
    • In vivo Kinematics of the Knee after a Posterior Cruciate-Substituting Total Knee Arthroplasty: A Comparison between Caucasian and South Korean Patients 

      Bae, Ji-Hoon; Hosseini, Ali; Nha, Kyung-Wook; Park, Sang-Eun; Tsai, Tsung Yuan; Kwon, Young-Min; Li, Guoan (The Korean Knee Society, 2016)
      Purpose This study compared in vivo kinematic differences between Caucasian and South Korean patients after a posterior-substituting total knee arthroplasty (PS-TKA). Materials and Methods In vivo motions of 9 Caucasian ...
    • In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography 

      Blatter, Cedric; Meijer, Eelco F. J.; Nam, Ahhyun S.; Jones, Dennis; Bouma, Brett E.; Padera, Timothy P.; Vakoc, Benjamin J. (Nature Publishing Group, 2016)
      Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. Optical microscopy techniques provide the resolution required for these measurements, but existing optical ...
    • In vivo Monitoring of Transcriptional Dynamics After Lower-Limb Muscle Injury Enables Quantitative Classification of Healing 

      Aguilar, Carlos A.; Shcherbina, Anna; Ricke, Darrell O.; Pop, Ramona; Carrigan, Christopher T.; Gifford, Casey A.; Urso, Maria L.; Kottke, Melissa A.; Meissner, Alexander (Nature Publishing Group, 2015)
      Traumatic lower-limb musculoskeletal injuries are pervasive amongst athletes and the military and typically an individual returns to activity prior to fully healing, increasing a predisposition for additional injuries and ...
    • In Vivo Morphological Features of Human Lumbar Discs 

      Zhong, Weiye; Driscoll, Sean J.; Wu, Minfei; Wang, Shaobai; Liu, Zhan; Cha, Thomas D.; Wood, Kirkham B.; Li, Guoan (Wolters Kluwer Health, 2014)
      Abstract Recent biomechanics studies have revealed distinct kinematic behavior of different lumbar segments. The mechanisms behind these segment-specific biomechanical features are unknown. This study investigated the in ...
    • An In Vivo MRI Study of Prefrontal Cortical Complexity in First-Episode Psychosis 

      Wiegand, Laura C.; Warfield, Simon Keith; Levitt, James Jonathan; Hirayasu, Yoshio; Salisbury, Dean F.; Heckers, Stephan; Bouix, Sylvain; Schwartz, Daniel; Spencer, Magdalena; Dickey, Chandlee C.; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2005)
      Objective: The purpose of this study was to investigate abnormalities in the surface complexity of the prefrontal cortex and in the hemispheric asymmetry of cortical complexity in first-episode patients with schizophrenia. ...
    • In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene 

      Dunn, Gavin P.; Cheung, Hiu Wing; Agarwalla, Pankaj K.; Thomas, Sapana; Zektser, Yulia; Karst, Alison M.; Boehm, Jesse S.; Weir, Barbara A.; Berlin, Aaron M.; Zou, Lihua; Getz, Gad; Liu, Joyce F.; Hirsch, Michelle; Vazquez, Francisca; Root, David E.; Beroukhim, Rameen; Drapkin, Ronny; Hahn, William C. (National Academy of Sciences, 2014)
      High-grade serous ovarian cancers are characterized by widespread recurrent copy number alterations. Although some regions of copy number change harbor known oncogenes and tumor suppressor genes, the genes targeted by the ...
    • In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice 

      Baron, David M.; Clerte, Maeva; Brouckaert, Peter; Raher, Michael J.; Flynn, Aidan W.; Zhang, Haihua; Carter, Edward Albert; Picard, Michael Howard; Bloch, Kenneth Daniel; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background—Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these ...
    • In Vivo Optical Imaging of Interscapular Brown Adipose Tissue with 18F-FDG via Cerenkov Luminescence Imaging 

      Zhang, Xueli; Kuo, Chaincy; Moore, Anna V.; Ran, Chongzhao (Public Library of Science, 2013)
      Objective: Brown adipose tissue (BAT), a specialized tissue for thermogenesis, plays important roles for metabolism and energy expenditure. Recent studies validated BAT’s presence in human adults, making it an important ...
    • In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light 

      Ran, Chongzhao; Zhang, Zhaoda; Hooker, Jacob M; Moore, Anna V. (Springer Nature, 2011)
      Purpose: The poor tissue penetration of visible light has been a major barrier for optical imaging, photoactivatable conversions, and photodynamic therapy for in vivo targets with depths beyond 10 mm. In this report, as a ...
    • In Vivo Proton Magnetic Resonance Spectroscopy Reveals Region Specific Metabolic Responses to SIV Infection in the Macaque Brain 

      Pilkenton, Sarah J; Greco, Jane B; Bombardier, Jeffrey P; Turk, Katherine W; He, Julian; Lee, Vallent; Lackner, Andrew A; González, R Gilberto; Ratai, Eva-Maria; Lentz, Margaret R.; Joo, Chan-Gyu; Westmoreland, Susan V.; Halpern, Elkan F. (BioMed Central, 2009)
      Background: In vivo proton magnetic resonance spectroscopy (1H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. ...
    • In Vivo Quantification of Mitochondrial Membrane Potential 

      Alpert, Nathaniel; Pelletier-Galarneau, Matthieu; Petibon, Yoann; Normandin, Marc; El Fakhri, Georges (Springer Science and Business Media LLC, 2020-07-08)
      Momcilovic et al1 report mitochondrial metabolism differences amongst various mouse lung cancer subtypes, as measured by positron emission tomography (PET) and a voltage-sensitive tracer. They describe their experiments ...
    • In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila 

      Ji, Jun-Yuan; Miles, Wayne O.; Korenjak, Michael; Zheng, Yani; Dyson, Nicholas J. (Genetics Society of America, 2012)
      The E2F transcription factors are important regulators of the cell cycle whose function is commonly misregulated in cancer. To identify novel regulators of E2F1 activity in vivo, we used Drosophila to conduct genetic ...