Browsing HMS Scholarly Articles by Title

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    • Antimicrobial Photodynamic Inactivation Inhibits Candida albicans Virulence Factors and ReducesIn VivoPathogenicity 

      Kato, Ilka Tiemy; Prates, Renato Araujo; Sabino, Caetano Padial; Tegos, George P.; Mylonakis, Eleftherios; Ribeiro, Martha Simões; Hamblin, Michael; Fuchs, Beth Burgwyn (American Society for Microbiology, 2012-11-05)
      The objective of this study was to evaluate whether Candida albicans exhibits altered pathogenicity characteristics following sublethal antimicrobial photodynamic inactivation (APDI) and if such alterations are maintained ...

    • Antimicrobial Photodynamic Therapy for Methicillin-Resistant Staphylococcus aureus Infection 

      Fu, Xiu-jun; Fang, Yong; Yao, Min (Hindawi Publishing Corporation, 2013)
      Nowadays methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug resistant bacteria both in hospitals and in the community. In the last two decades, there has been growing concern about the ...

    • Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities 

      Battersby, Anna J.; Khara, Jasmeet; Wright, Victoria J.; Levy, Ofer; Kampmann, Beate (Frontiers Media S.A., 2016)
      While developing adaptive immune responses, young infants are especially vulnerable to serious infections, including sepsis, meningitis, and pneumonia. Antimicrobial proteins and peptides (APPs) are key effectors that ...

    • Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4 

      Nicoludis, John M; Vogt, Bennett E; Green, Anna G; Schärfe, Charlotta PI; Marks, Debora S; Gaudet, Rachelle (eLife Sciences Publications, Ltd, 2016)
      Protocadherins (Pcdhs) are cell adhesion and signaling proteins used by neurons to develop and maintain neuronal networks, relying on trans homophilic interactions between their extracellular cadherin (EC) repeat domains. ...

    • Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate 

      Chang, Hung; Yanachkov, Ivan B.; Dix, Edward J.; Yanachkova, Milka; Li, YouFu; Barnard, Marc R.; Wright, George E.; Michelson, Alan D.; Frelinger, Andrew L. (Public Library of Science, 2014)
      Background: Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We ...

    • Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome 

      Kim, Jayoung; Freeman, Michael R. (Korean Continence Society, 2011)
      A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause ...

    • Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes 

      Stevenson, J M; Reilly, J L; Harris, M S H; Patel, S R; Weiden, P J; Prasad, K M; Badner, J A; Nimgaonkar, V L; Keshavan, M S; Sweeney, J A; Bishop, J R (Nature Publishing Group, 2016)
      Genetic factors may underlie beneficial and adverse responses to antipsychotic treatment. These relationships may be easier to identify among patients early in the course of disease who have limited exposure to antipsychotic ...

    • Antipsychotic Use and Stroke 

      Panucci, Genna; Toh, Sengwee Darren; Huang, Ting-Ying; Taylor, Lockwood; Mosholder, Andrew (Physicians Postgraduate Press, Inc, 2019-06-04)
      Objective: To evaluate stroke risk among users of typical antipsychotics compared to users of atypical antipsychotics in a non-elderly and non-demented US population. Methods: New users of antipsychotics aged 18–64 years ...

    • Antiretroviral pre-exposure prophylaxis implementation in the United States: a work in progress 

      Mayer, Kenneth H; Hosek, Sybil; Cohen, Stephanie; Liu, Albert; Pickett, Jim; Warren, Mitchell; Krakower, Douglas; Grant, Robert (International AIDS Society, 2015)
      Introduction: After the initial approval of the use of tenofovir disoproxil fumarate-emtricitabine (TDF/FTC) by the US Food and Drug Administration in 2012 for anti-HIV pre-exposure prophylaxis (PrEP), uptake was initially ...

    • Antiretroviral Regimen and Suboptimal Medication Adherence Are Associated With Low-Level Human Immunodeficiency Virus Viremia 

      Konstantopoulos, Christina; Ribaudo, Heather; Ragland, Kathleen; Bangsberg, David R.; Li, Jonathan Z. (Oxford University Press, 2015)
      Episodes of human immunodeficiency virus low-level viremia (LLV) are common in the clinical setting, but its association with antiretroviral therapy (ART) regimen and adherence remains unclear. Antiretroviral therapy ...

    • Antiretroviral Therapy to Prevent HIV Acquisition in Serodiscordant Couples in a Hyperendemic Community in Rural South Africa 

      Oldenburg, Catherine E.; Bärnighausen, Till; Tanser, Frank; Iwuji, Collins C.; De Gruttola, Victor; Seage, George R.; Mimiaga, Matthew J.; Mayer, Kenneth H.; Pillay, Deenan; Harling, Guy (Oxford University Press, 2016)
      Background. Antiretroviral therapy (ART) was highly efficacious in preventing human immunodeficiency virus (HIV) transmission in stable serodiscordant couples in the HPTN-052 study, a resource-intensive randomized controlled ...

    • Antiretroviral Therapy-Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase-γ Inhibition 

      Selvaraj, Shanmugapriya; Ghebremichael, Musie; Li, Min; Foli, Yram; Langs-Barlow, Allison; Ogbuagu, Arit; Barakat, Lydia; Tubridy, Elizabeth; Edifor, Regina; Lam, Wing; Cheng, Yung-Chi; Paintsil, Elijah (2014)
      We hypothesized that competition between NRTI-triphosphate and endogenous deoxyribonucleoside triphosphate (dNTP) may lead to depletion of dNTP pools and mitochondrial dysfunction independent of Pol-γ inhibition. We collected ...

    • Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins 

      Furtado, Jeremy Daniel; Wedel, M. K.; Sacks, Frank Martin (American Society for Biochemistry & Molecular Biology (ASBMB), 2012)
      Mipomersen, an antisense oligonucleotide that reduces hepatic production of apoB, has been shown in phase 2 studies to decrease plasma apoB, LDL cholesterol (LDL-C), and triglycerides. ApoC-III inhibits VLDL and LDL ...

    • Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma 

      Tian, Ze; Si, Jianyong; Chang, Qi; Zhou, Liang; Chen, Shilin; Xiao, Peigen; Wu, Erxi (BioMed Central, 2007)
      Background: Medicinal plant is a main source of cancer drug development. Some of the cycloartane triterpenoids isolated from the aerial part of Cimicifuga dahurica showed cytotoxicity in several cancer cell lines. It is ...

    • Antitumor Activity of Crizotinib in Lung Cancers Harboring a MET Exon 14 Alteration 

      Camidge, D. Ross; Solomon, Benjamin J.; Li, Sherry; Drilon, Alexander; Clark, Jeffrey; Weiss, Jared; Ou, Sai-Hong Ignatius; Otterson, Gregory; Villacruz, Liza; Riely, Gregory; Heist, Rebecca; Awad, Mark; Shapiro, Geoffrey; Satouchi, Miyako; Hida, Toyoaki; Hayashi, Hidetoshi; Murphy, Danielle; Wang, Sherry; Usari, Tiziana; Palk, Paul; Wilner, Keith; Solomon, Benjamin (Springer Science and Business Media LLC, 2020-01)
      MET exon 14 alterations are oncogenic drivers of non-small cell lung cancers (NSCLCs).1 These alterations are associated with increased MET activity and preclinical sensitivity to MET inhibition.2 Crizotinib is a multikinase ...

    • Antiviral Resistance and the Control of Pandemic Influenza 

      Lipsitch, Marc; Cohen, Ted; Murray, Megan Blanche; Levin, Bruce R (Public Library of Science, 2007)
      Background: The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest ...

    • Anti–PD-1–Related Pneumonitis during Cancer Immunotherapy 

      Nishino, Mizuki; Sholl, Lynette Marie; Hatabu, Hiroto; Ramaiya, Nikhil; Hodi, Frank Stephen (New England Journal of Medicine (NEJM/MMS), 2015)
      The use of antibodies against programmed cell death 1 (PD-1), which block inhibitory T-cell checkpoints, is a promising new therapy for advanced cancers.1 Recent trials have shown substantial clinical activity of anti–PD-1 ...

    • Aortic stiffening and its impact on left atrial volumes and function in patients after successful coarctation repair: a multiparametric cardiovascular magnetic resonance study 

      Voges, Inga; Kees, Julian; Jerosch-Herold, Michael; Gottschalk, Hannes; Trentmann, Jens; Hart, Christopher; Gabbert, Dominik D.; Pardun, Eileen; Pham, Minh; Andrade, Ana C.; Wegner, Philip; Kristo, Ines; Jansen, Olav; Kramer, Hans-Heiner; Rickers, Carsten (BioMed Central, 2016)
      Background: The increased cardiovascular morbidity of adults with late repair of aortic coarctation (CoA) has been well documented. In contrast, successful CoA repair in early childhood has a generally good prognosis, ...

    • AOSSM Early Sport Specialization Consensus Statement 

      LaPrade, Robert F.; Agel, Julie; Baker, Joseph; Brenner, Joel S.; Cordasco, Frank A.; Côté, Jean; Engebretsen, Lars; Feeley, Brian T.; Gould, Daniel; Hainline, Brian; Hewett, Timothy E.; Jayanthi, Neeru; Kocher, Mininder S.; Myer, Gregory D.; Nissen, Carl W.; Philippon, Marc J.; Provencher, Matthew T. (SAGE Publications, 2016)
      Background: Early sport specialization is not a requirement for success at the highest levels of competition and is believed to be unhealthy physically and mentally for young athletes. It also discourages unstructured free ...

    • Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood 

      Wang, Xiu-Ping; O'Connell, Daniel J.; Lund, Jennifer J.; Saadi, Irfan; Kuraguchi, Mari; Turbe-Doan, Annick; Cavallesco, Resy; Kim, Hyunsoo; Park, Peter J.; Harada, Hidemitsu; Kucherlapati, Raju; Maas, Richard L. (Company of Biologists, 2009)
      The ablation of Apc function or the constitutive activation of beta-catenin in embryonic mouse oral epithelium results in supernumerary tooth formation, but the underlying mechanisms and whether adult tissues retain this ...