Browsing HMS Scholarly Articles by Title
Now showing items 9743-9762 of 17922
-
Localization of Collagen XVIII and the Endostatin Portion of Collagen XVIII in Aged Human Control Eyes and Eyes with Age-Related Macular Degeneration
(Association for Research in Vision and Ophthalmology (ARVO), 2004-05-01)purpose. Endostatin, a C-terminal fragment of collagen XVIII (coll XVIII) formed by proteolysis, specifically inhibits endothelial cell migration and proliferation in vitro and potently inhibits angiogenesis and tumor ... -
Localization of Eosinophilic Esophagitis from H&E Stained Images Using Multispectral Imaging
(BioMed Central, 2011)This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and other eosin ... -
Localization of Mammalian Orthoreovirus Proteins to Cytoplasmic Factory-Like Structures via Nonoverlapping Regions of μNS
(American Society for Microbiology, 2010) -
Localization of the Epileptogenic Foci in Tuberous Sclerosis Complex: A Pediatric Case Report
(Frontiers Media S.A., 2014)Tuberous sclerosis complex (TSC) is a rare disorder of tissue growth and differentiation, characterized by benign hamartomas in the brain and other organs. Up to 90% of TSC patients develop epilepsy and 50% become medically ... -
Localization to the Proteasome is Sufficient for Degradation
(Elsevier BV, 2004-05-14)The majority of unstable proteins in eukaryotic cells are targeted for degradation through the ubiquitin-proteasome pathway. Substrates for degradation are recognized by the E1, E2, and E3 ubiquitin conjugation machinery ... -
Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study
(Elsevier, 2014)The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a ... -
Localized attacks on spatially embedded networks with dependencies
(Nature Publishing Group, 2015)Many real world complex systems such as critical infrastructure networks are embedded in space and their components may depend on one another to function. They are also susceptible to geographically localized damage caused ... -
Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly
(Public Library of Science, 2013)Multiple epigenetic marks have been proposed to contribute to the regulation of antigen receptor gene assembly via V(D)J recombination. Here we provide a comprehensive view of DNA methylation at the immunoglobulin heavy ... -
Localized Epigenetic Changes Induced by DH Recombination Restricts Recombinase to DJH Junctions
(2013)Immunoglobulin heavy chain (Igh) genes are assembled by sequential rearrangements of diversity (DH) and variable (VH) gene segments. Three critical constraints govern VH recombination. These include timing (VH recombination ... -
Location and Dynamics of the Immunodominant CD8 T Cell Response to SIVΔnef Immunization and SIVmac251 Vaginal Challenge
(Public Library of Science, 2013)Live-attenuated SIV vaccines (LAVs) have been the most effective to date in preventing or partially controlling infection by wild-type SIV in non-human primate models of HIV-1 transmission to women acting by mechanisms of ... -
The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study
(Public Library of Science, 2012)Firefly luciferase is one of the few soluble proteins that is acted upon by a wide variety of general anesthetics and alcohols; they inhibit the ATP–driven production of light. We have used time–resolved photolabeling to ... -
Location of Procollagen in Chick Corneal and Tendon Fibroblasts With Ferritin-Conjugated Antibodies
(Rockefeller University Press, 1975-04-01)Three distinct antiprocollagen preparations were characterized and used in immunocytochemical staining of chick embryo corneal and tendon cells. The several ferritin-conjugated antibody preparations permitted similar ... -
Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study
(BMJ Publishing Group, 2015)Objectives: A recent study identified 16 genetic variants associated with N-glycosylation of human IgG. Several of the genomic regions where these single nucleotide polymorphisms (SNPs) reside have also been associated ... -
Locus-specific editing of histone modifications at endogenous enhancers using programmable TALE-LSD1 fusions
(2013)Mammalian gene regulation is dependent on tissue-specific enhancers that can act across large distances to influence transcriptional activity1-3. Mapping experiments have identified hundreds of thousands of putative enhancers ... -
Logarithm Odds Maps for Shape Representation
(Springer Science + Business Media, 2006)The concept of the Logarithm of the Odds (LogOdds) is frequently used in areas such as artificial neural networks, economics, and biology. Here, we utilize LogOdds for a shape representation that demonstrates desirable ... -
The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data
(Public Library of Science, 2009)The epidermal growth factor receptor (EGFR) signaling pathway is probably the best-studied receptor system in mammalian cells, and it also has become a popular example for employing mathematical modeling to cellular signaling ... -
Logic-Based Models for the Analysis of Cell Signaling Networks
(American Chemical Society, 2010)Computational models are increasingly used to analyze the operation of complex biochemical networks, including those involved in cell signaling networks. Here we review recent advances in applying logic-based modeling to ... -
Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems
(Oxford University Press, 2016)Selenocysteine (Sec) is the 21st amino acid in the genetic code, inserted in response to UGA codons with the help of RNA structures, the SEC Insertion Sequence (SECIS) elements. The three domains of life feature distinct ... -
The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle
(Ovid Technologies (Wolters Kluwer Health), 2017)Background—The discovery of functional classes of long noncoding RNAs (lncRNAs) has expanded our understanding of the variety of RNA species that exist in cells. In the heart, lncRNAs have been implicated in the regulation ... -
Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins
(BioMed Central, 2016)Background: Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Long ...