Browsing HMS Scholarly Articles by Title

Now showing items 9971-9990 of 17922

    • Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 

      Dutta, Partha; Hoyer, Friedrich Felix; Grigoryeva, Lubov S.; Sager, Hendrik B.; Leuschner, Florian; Courties, Gabriel; Borodovsky, Anna; Novobrantseva, Tatiana; Ruda, Vera M.; Fitzgerald, Kevin; Iwamoto, Yoshiko; Wojtkiewicz, Gregory; Sun, Yuan; Da Silva, Nicolas; Libby, Peter; Anderson, Daniel G.; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (The Rockefeller University Press, 2015)
      Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely ...

    • Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia 

      Ramos, Pedro; Casu, Carla; Gardenghi, Sara; Breda, Laura; Crielaard, Bart J.; Guy, Ella; Marongiu, Maria Franca; Gupta, Ritama; Levine, Ross L.; Abdel-Wahab, Omar; Ebert, Benjamin L.; Van Rooijen, Nico; Ghaffari, Saghi; Grady, Robert W.; Giardina, Patricia J.; Rivella, Stefano (2013)
      Regulation of erythropoiesis is achieved by integration of distinct signals. Among these, macrophages are emerging as erythropoietin-complementary regulators of erythroid development, particularly under stress conditions. ...

    • Madness (Unmāda) 

      Weiss, Mitchell Gralnick (Brill Academic Publishers, 2010)

    • MAFG-Driven Astrocytes Promote CNS Inflammation 

      Wheeler, Michael; Clark, Iain; Tjon, Emily; Li, Zhaorong; Zandee, Stephanie E. J.; Couturier, Charles P.; Watson, Brianna; Scalisi, Giulia; Alkwai, Sarah; Rothhammer, Veit; Rotem, Assaf; Heyman, John; Thaploo, Shravan; Sanmarco, Liliana; Ragoussis, Jiannis; Weitz, David; Petrecca, Kevin; Moffitt, Jeffrey; Becher, Burkhard; Antel, Jack P.; Prat, Alexandre; Quintana, Francisco (Springer Science and Business Media LLC, 2020-02-12)

    • MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens 

      Li, Wei; Xu, Han; Xiao, Tengfei; Cong, Le; Love, Michael I; Zhang, Feng; Irizarry, Rafael A; Liu, Jun S; Brown, Myles; Liu, X Shirley (BioMed Central, 2014)
      We propose the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) method for prioritizing single-guide RNAs, genes and pathways in genome-scale CRISPR/Cas9 knockout screens. MAGeCK demonstrates better ...

    • Magic Angle Spinning Nuclear Magnetic Resonance Characterization of Voltage-Dependent Anion Channel Gating in Two-Dimensional Lipid Crystalline Bilayers 

      Eddy, Matthew T.; Andreas, Loren; Teijido, Oscar; Su, Yongchao; Clark, Lindsay; Noskov, Sergei Y.; Wagner, Gerhard; Rostovtseva, Tatiana K.; Griffin, Robert G. (American Chemical Society, 2014)
      The N-terminus of the voltage-dependent anion channel (VDAC) has been proposed to contain the mechanistically important gating helices that modulate channel opening and closing. In this study, we utilize magic angle spinning ...

    • MAGIC-SPP: A Database-Driven DNA Sequence Processing Package with Associated Management Tools 

      Liang, Chun; Sun, Feng; Wang, Haiming; Qu, Junfeng; Freeman, Robert M; Pratt, Lee H; Cordonnier-Pratt, Marie-Michèle (BioMed Central, 2006)
      Background: Processing raw DNA sequence data is an especially challenging task for relatively small laboratories and core facilities that produce as many as 5000 or more DNA sequences per week from multiple projects in ...

    • Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study 

      Zhang, Xiaoxiao; Giovannucci, Edward L.; Wu, Kunling; Smith-Warner, Stephanie A.; Fuchs, Charles Stewart; Pollak, Martin Russell; Willett, Walter C.; Ma, Jing (Nature Publishing Group, 2012)
      Background: Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. Method: We tested magnesium–colorectal cancer hypothesis in the Nurses' ...

    • Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III 

      Deng, Xinqing; Song, Yiqing; Manson, JoAnn E; Signorello, Lisa B; Zhang, Shumin M; Shrubsole, Martha J; Ness, Reid M; Seidner, Douglas L; Dai, Qi (BioMed Central, 2013)
      Background: Magnesium plays an essential role in the synthesis and metabolism of vitamin D and magnesium supplementation substantially reversed the resistance to vitamin D treatment in patients with magnesium-dependent ...

    • Magnetic Barcode Assay for Genetic Detection of Pathogens 

      Liong, Monty; Hoang, Anh N.; Chung, Jaehoon; Gural, Nil; Ford, Christopher B.; Min, Changwook; Shah, Rupal R.; Ahmad, Rushdy; Fernandez-Suarez, Marta; Fortune, Sarah M.; Toner, Mehmet; Lee, Hakho; Weissleder, Ralph (Nature Research (part of Springer Nature), 2013)
      The task of rapidly identifying patients infected with Mycobacterium tuberculosis in resource-constrained environments remains a challenge. A sensitive and robust platform that does not require bacterial isolation or culture ...

    • Magnetic Ligation Method for Quantitative Detection of MicroRNAs 

      Liong, Monty; Im, Hyungsoon; Majmudar, Maulik D.; Aguirre, Aaron D.; Sebas, Matthew; Lee, Hakho; Weissleder, Ralph (Wiley, 2014)

    • Magnetic Nanoparticle Sensors 

      Koh, Isaac; Josephson, Lee (Molecular Diversity Preservation International (MDPI), 2009)
      Many types of biosensors employ magnetic nanoparticles (diameter = 5–300 nm) or magnetic particles (diameter = 300–5,000 nm) which have been surface functionalized to recognize specific molecular targets. Here we cover ...

    • Magnetic Nanoparticles and MicroNMR for Diagnostic Applications 

      Shao, Huilin; Min, Changwook; Issadore, David Aaron; Liong, Monty; Yoon, Tae-Jong; Weissleder, Ralph; Lee, Hakho (Ivyspring International Publisher, 2012)
      Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy ...

    • Magnetic nanoparticles for biomedical NMR-based diagnostics 

      Shao, Huilin; Yoon, Tae-Jong; Liong, Monty; Weissleder, Ralph; Lee, Hakho (Beilstein-Institut, 2010)
      Rapid and accurate measurements of protein biomarkers, pathogens and cells in biological samples could provide useful information for early disease diagnosis, treatment monitoring, and design of personalized medicine. In ...

    • Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles 

      Rho, Junsung; Chung, Jaehoon; Im, Hyungsoon; Liong, Monty; Shao, Huilin; Castro, Cesar M.; Weissleder, Ralph; Lee, Hakho (American Chemical Society, 2013)
      During the course of their lifespan, erythrocytes actively shed phospholipid-bound microvesicles (MVs). In stored blood, the number of these erythrocyte-derived MVs has been observed to increase over time, suggesting their ...

    • Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities 

      Tsourkas, Andrew; Hofstetter, Oliver; Hofstetter, Heike; Weissleder, Ralph; Josephson, Lee (Wiley, 2004)

    • Magnetic relaxation switches capable of sensing molecular interactions 

      Perez, J. Manuel; Josephson, Lee; O'Loughlin, Terrence; Högemann, Dagmar; Weissleder, Ralph (Nature Research, 2002)
      Highly sensitive, efficient, and high-throughput biosensors are required for genomic and proteomic data acquisition in complex biological samples and potentially for in vivo applications. To facilitate these studies, we ...

    • Magnetic Resonance Characterization of Ischemic Tissue Metabolism 

      Cheung, Jerry S; Wang, Xiaoying; Sun, Phillip Zhe (Bentham Open, 2011)
      Magnetic resonance imaging (MRI) and spectroscopy (MRS) are versatile diagnostic techniques capable of characterizing the complex stroke pathophysiology, and hold great promise for guiding stroke treatment. Particularly, ...

    • Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy 

      Sahani, Dushyant V; Jiang, Tao; Hayano, Koichi; Duda, Dan G; Catalano, Onofrio A; Ancukiewicz, Marek; Jain, Rakesh K; Zhu, Andrew X (BioMed Central, 2013)
      Background: To investigate the hypothesis that MRI derived diffusion-weighted imaging (DWI) and perfusion (MRP) parameters are sensitive image biomarkers for monitoring early antiangiogenic effects and predicting progression ...

    • Magnetic resonance imaging in children: common problems and possible solutions for lung and airways imaging 

      Ciet, Pierluigi; Tiddens, Harm A. W. M.; Wielopolski, Piotr A.; Wild, Jim M.; Lee, Edward Y.; Morana, Giovanni; Lequin, Maarten H. (Springer Berlin Heidelberg, 2015)
      Pediatric chest MRI is challenging. High-resolution scans of the lungs and airways are compromised by long imaging times, low lung proton density and motion. Low signal is a problem of normal lung. Lung abnormalities ...