Browsing HMS Scholarly Articles by Issue Date
Now showing items 61-80 of 17918
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Discovery of bioactive microbial gene products in inflammatory bowel disease
(Springer Science and Business Media LLC, 2022-05-25)Microbial communities and their associated bioactive compounds are often disrupted in conditions such as the inflammatory bowel diseases (IBD). However, even in well-characterized environments (e.g. the human gastrointestinal ... -
Effectiveness of CoronaVac Among Children 3 to 5 During the Omicron SARS-CoV-2 Outbreak
(Research Square Platform LLC, 2022-05-23)<jats:title>Abstract</jats:title> <jats:p>The outbreak of the B.1.1.529 lineage of SARS-CoV-2 (omicron) has caused an unprecedented number of Covid-19 cases, including pediatric hospital admissions. Policymakers ... -
Compatibility rules of human enhancer and promoter sequences
(Springer Science and Business Media LLC, 2022-05-20) -
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
(Springer Science and Business Media LLC, 2022-05-11)Non-coding genetic variants may cause disease by modulating gene expression. However, identifying these expression quantitative trait loci (eQTLs) is complicated by gene-regulation differences across fluid functional cell ... -
Sub-3 Å Cryo-EM Structure of RNA Enabled by Engineered Homomeric Self-Assembly
(Nature Portfolio, 2022-05-02)Though many functional RNAs fold into intricate and precise 3D architectures, it is difficult to acquire their high-resolution structures. Herein, we present a nanoarchitectural strategy for efficient structural determination ... -
(PO-176) Suicidal Ideation and Behavior During the COVID-19 Pandemic: A Retrospective, Single-Center Case Series
(Elsevier BV, 2022-05)Objective: In the few months since the first cases were reported, the coronavirus disease 2019 (COVID-19) has emerged as a global pandemic and significant source of morbidity and mortality. Case reports from early-hit ... -
Use of Palliative Care Among Commercially Insured Patients With Metastatic Cancer Between 2001 and 2016
(American Society of Clinical Oncology (ASCO), 2022-05)PURPOSE: Early palliative care, concomitant with disease-directed treatments, is recommended for all patients with advanced cancer. This study assesses population-level trends in palliative care use among a large cohort ... -
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair
(Springer Science and Business Media LLC, 2022-05)The HMCES protein forms a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in ssDNA, and the resulting HMCES-DPC is thought to suppress double-strand break formation in S phase. However, the dynamics of HMCES ... -
Identifying Pediatric Mood Disorders From Transdiagnostic Polygenic Risk Scores: A Study of Children and Adolescents
(Physicians Postgraduate Press, Inc, 2022-04-20) -
Identifying Pediatric Mood Disorders From Transdiagnostic Polygenic Risk Scores
(Physicians Postgraduate Press, Inc, 2022-04-20)Objective: Mood disorders often co-occur with attention deficit-hyperactive disorder (ADHD), disruptive behavior disorders (DBD), and aggression. We aimed to determine if polygenic risk scores (PRSs) based on external ... -
Neurocognitive Impairment Associated With Traditional and Novel Androgen Receptor Signaling Inhibitors ± Androgen Deprivation Therapy: A Pharmacovigilance Study
(Springer Science and Business Media LLC, 2022-04-18)Background Conflicting evidence exists regarding whether hormone therapy for prostate cancer is associated with neurotoxicity. Thus, we aim to characterize the association between different types of hormone therapy and ... -
Decreased thermal niche breadth as a trade-off of antibiotic resistance
(Springer Science and Business Media LLC, 2022-04-14)Evolutionary theory predicts that adaptations, including antibiotic resistance, should come with associated fitness costs; yet, many resistance mutations seemingly contradict this prediction by inducing no growth rate ... -
What Is the Role of Digital Medicine for Adherence Monitoring in Patients With Serious Mental Illness?
(Physicians Postgraduate Press, Inc, 2022-04-11) -
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity
(Springer Science and Business Media LLC, 2022-04-08)The cyclic oligonucleotide-based antiphage signalling system (CBASS) and the pyrimidine cyclase system for antiphage resistance (Pycsar) are antiphage defence systems in diverse bacteria that use cyclic nucleotide signals ... -
Identification and Validation of Ecto-5' Nucleotidase as an Immunotherapeutic Target in Multiple Myeloma
(Springer Science and Business Media LLC, 2022-04-01)Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces tumor cell growth, as well as inhibits innate and adaptive immune ... -
Spotlighting Parmit Kumar Singh: a Q&A
(Harvard University Center for AIDS Research, 2022-04-01) -
A large-scale investigation of white matter microstructural associations with reading ability
(Elsevier BV, 2022-04)Reading involves the functioning of a widely distributed brain network, and white matter tracts are responsible for transmitting information between constituent network nodes. Several studies have analyzed fiber bundle ... -
Antigen identification and high-throughput interaction mapping by reprogramming viral entry
(Springer Science and Business Media LLC, 2022-04)Deciphering immune recognition is critical to understanding a broad range of diseases, and to develop effective vaccines and immunotherapies. Efforts to do so are limited by a lack of technologies capable of simultaneously ... -
Real-Time Diagnosis and Gleason Grading of Prostate Core Needle Biopsies Using Nonlinear Microscopy
(Elsevier BV, 2022-04) -
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
(Springer Science and Business Media LLC, 2022-03-23)Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator, and stimuli sensor. The large-scale generation of human skin with these appendages would ...