Browsing HMS Scholarly Articles by Issue Date

Now showing items 81-100 of 17922

    • A large-scale investigation of white matter microstructural associations with reading ability 

      Meisler, Steven; Gabrieli, John (Elsevier BV, 2022-04)
      Reading involves the functioning of a widely distributed brain network, and white matter tracts are responsible for transmitting information between constituent network nodes. Several studies have analyzed fiber bundle ...

    • Antigen identification and high-throughput interaction mapping by reprogramming viral entry 

      Dobson, Connor; Reich, Anna; Gaglione, Stephanie; Smith, Blake; Kim, Ellen; Dong, Jiayi; Ronsard, Larance; Okonkwo, Vintus; Lingwood, Daniel; Dougan, Michael; Dougan, Stephanie; Brinbaum, Michael (Springer Science and Business Media LLC, 2022-04)
      Deciphering immune recognition is critical to understanding a broad range of diseases, and to develop effective vaccines and immunotherapies. Efforts to do so are limited by a lack of technologies capable of simultaneously ...

    • Real-Time Diagnosis and Gleason Grading of Prostate Core Needle Biopsies Using Nonlinear Microscopy 

      Cahill, Lucas; Rosen, Seymour; Yoshitake, Tadayuki; Wu, Yubo; York, Linda; Tsai, Leo; Gershman, Boris; Fujimoto, James; Sun, Yue (Elsevier BV, 2022-04)

    • Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells 

      Lee, Jiyoon; van der Valk, Wouter H.; Serdy, Sara A.; Deakin, CiCi; Kim, Jin; Le, Anh Phoung; Koehler, Karl R.; van der Valk (Springer Science and Business Media LLC, 2022-03-23)
      Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator, and stimuli sensor. The large-scale generation of human skin with these appendages would ...

    • A genome-wide mutational constraint map quantified from variation in 76,156 human genomes 

      Chen, Siwei; Francioli, Laurent C.; Goodrich, Julia K.; Collins, Ryan L.; Kanai, Masahiro; Wang, Qingbo; Alföldi, Jessica; Watts, Nicholas A.; Vittal, Christopher; Gauthier, Laura D.; Poterba, Timothy; Wilson, Michael W.; Tarasova, Yekaterina; Phu, William; Yohannes, Mary T.; Koenig, Zan; Farjoun, Yossi; Banks, Eric; Donnelly, Stacey; Gabriel, Stacey; Gupta, Namrata; Ferriera, Steven; Tolonen, Charlotte; Novod, Sam; Bergelson, Louis; Roazen, David; Ruano-Rubio, Valentin; Covarrubias, Miguel; Llanwarne, Christopher; Petrillo, Nikelle; Wade, Gordon; Jeandet, Thibault; Munshi, Ruchi; Tibbetts, Kathleen; O’Donnell-Luria, Anne; Solomonson, Matthew; Seed, Cotton; Martin, Alicia R.; Talkowski, Michael E.; Rehm, Heidi L.; Daly, Mark J.; Tiao, Grace; Neale, Benjamin M.; MacArthur, Daniel G.; Karczewski, Konrad J. (SpringerNature, 2022-03-21)
      The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders1-4, but attempts to assess constraint for ...

    • Reproducible Brain-Wide Association Studies Require Thousands of Individuals 

      Marek, Scott; Tervo-Clemmens, Brenden; Calabro, Finnegan J.; Montez, David F.; Kay, Benjamin P.; Hatoum, Alexander S.; Donohue, Meghan Rose; Foran, William; Miller, Ryland L.; Hendrickson, Timothy J.; Malone, Stephen M.; Kandala, Sridhar; Feczko, Eric; Miranda-Dominguez, Oscar; Graham, Alice M.; Earl, Eric A.; Perrone, Anders J.; Cordova, Michaela; Doyle, Olivia; Moore, Lucille A.; Conan, Gregory M.; Uriarte, Johnny; Snider, Kathy; Lynch, Benjamin J.; Wilgenbusch, James C.; Pengo, Thomas; Tam, Angela; Chen, Jianzhong; Newbold, Dillan J.; Zheng, Annie; Seider, Nicole A.; Van, Andrew N.; Metoki, Athanasia; Chauvin, Roselyne J.; Laumann, Timothy O.; Greene, Deanna J.; Petersen, Steven E.; Garavan, Hugh; Thompson, Wesley K.; Nichols, Thomas E.; Yeo, B. T. Thomas; Barch, Deanna M.; Luna, Beatriz; Fair, Damien A.; Dosenbach, Nico U. F. (Springer Science and Business Media LLC, 2022-03-16)
      Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions 1–3 (for example, task ...

    • Frontal Neurons Driving Competitive Behaviour and Ecology of Social Groups 

      Williams, Ziv M.; Li, S. William; Zeliger, Omer; Strahs, Leah; Báez-Mendoza, Raymundo; Johnson, Lance; Mcdonald Wojciechowski, Aidan; Williams, Ziv (Springer Science and Business Media LLC, 2022-03-16)

    • High-Deductible Health Plans Paired With Health Savings Accounts Increased Medication Cost Burden Among Individuals With Bipolar Disorder 

      Lu, Christine Y.; Zhang, Fang; Wallace, Jamie; LeCates, Robert; Busch, Alisa; Madden, Jeanne; Callahan, Matthew; Foxworth, Phyllis; Soumerai, Stephen; Ross-Degnan, Dennis; Wharam, James (Physicians Postgraduate Press, Inc, 2022-03-09)
      Objective: High-deductible health plans (HDHPs) paired with health savings accounts (HSAs) require substantial out-of-pocket spending for most services, including medications. We examined effects of HSA-eligible HDHPs on ...

    • The Schizophrenia-Associated Variant in SLC39A8 Alters Protein Glycosylation in the Mouse Brain 

      Mealer, Robert; Williams, Sarah E.; Noel, Maxence; Yang, Bo; D'Souza, Alexandria; Nakata, Toru; Graham, Daniel B.; Creasey, Elizabeth A.; Cetinbas, Murat; Sadreyev, Ruslan; Scolnick, Edward; Woo, Christina; Smoller, Jordan; Xavier, Ramnik; Cummings, Richard (Springer Science and Business Media LLC, 2022-03-08)
      A missense mutation (A391T) in the manganese transporter SLC39A8 is strongly associated with schizophrenia in genomic studies, though the molecular connection to the brain remains hypothetical. Human carriers of A391T have ...

    • MR fingerprinting for semisolid magnetization transfer and chemical exchange saturation transfer quantification 

      Perlman, Or; Farrar, Christian; Heo, Hye‐Young (Wiley, 2022-03-03)

    • Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers 

      Kobayashi, Yoshihisa; Chhoeu, Chhayheng; Li, Jiaqi; Price, Kristin S.; Kiedrowski, Lesli A.; Hutchins, Jamie L.; Hardin, Aaron I.; Wei, Zihan; Hong, Fangxin; Bahcall, Magda; Gokhale, Prafulla C.; Jänne, Pasi A. (Springer Science and Business Media LLC, 2022-03-02)

    • Microscopic structure of three-dimensional charge order in kagome superconductor AV3Sb5 and its tunability 

      Kang, Mingu; Fang, Shiang; Yoo, Jonggyu; Ortiz, Brenden R.; Oey, Yuzki M.; Choi, Jonghyeok; Ryu, Sae Hee; Kim, Jimin; Jozwiak, Chris; Bostwick, Aaron; Rotenberg, Eli; Kaxiras, Efthimios; Checkelsky, Joseph G.; Wilson, Stephen D.; Park, Jae-Hoon; Comin, Riccardo (Research Square Platform LLC, 2022-02-24)
      Correlated electronic systems are naturally susceptible to develop collective, symmetry-breaking electronic phases as observed in Cu- and Fe-based high-temperature superconductors, and twisted Moiré superlattices. The ...

    • Domestication Reprogrammed the Budding Yeast Life Cycle 

      De Chiara, Matteo; Barré, Benjamin; Persson, Karl; Irizar, Agurtzane; Vischioni, Chiara; Khaiwal, Sakshi; Stenberg, Simon; Chioma Amadi, Onyetugo; Zun, Gasper; Dobersek, Katja; Taccioli, Cristian; Schacherer, Joseph; Petrovic, Uros; Warringer, Jonas; Liti, Gianni (Cold Spring Harbor Laboratory, 2022-02-24)

    • Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate 

      Lagattuta, Kaitlyn; Kang, Joyce; Nathan, Aparna; Pauken, Kristen; Jonnson, Anna Helena; Rao, Deepak; Sharpe, Arlene; Ishigaki, Kazuyoshi; Raychaudhuri, Soumya (Springer Science and Business Media LLC, 2022-02-17)
      T cells acquire a regulatory phenotype when their T cell receptors (TCRs) experience an intermediate-high affinity interaction with a self-peptide presented on MHC. Using TCR sequences from FACS-sorted human cells, we ...

    • Spatial and Genomic Correlates of HIV-1 Integration Site Targeting 

      Singh, Parmit; Bedwell, Gregory; Engelman, Alan (MDPI AG, 2022-02-14)
      HIV-1 integrase and capsid proteins interact with host proteins to direct preintegration complexes to active transcription units within gene-dense regions of chromosomes for viral DNA integration. Analyses of spatially-derived ...

    • Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions 

      Pahlevaninezhad, Masoud; Huang, Yao-Wei; Pahlevani, Majid; Bouma, Brett; Suter, Melissa J.; Capasso, Federico; Pahlevaninezhad, Hamid (Springer Science and Business Media LLC, 2022-02-14)

    • Streptococcal Pyrogenic Exotoxin B Cleaves GSDMA and Triggers Pyroptosis 

      Deng, Wanyan; Bai, Yang; Deng, Fan; Pan, Youdong; Mei, Shenglin; Zheng, Zengzhang; Min, Rui; Wu, Zeyu; Li, Wu; Miao, Rui; Zhang, Zhibin; Kupper, Thomas; Lieberman, Judy; Liu, Xing (Springer Science and Business Media LLC, 2022-02-02)

    • The toll of cascading crises on Lebanon's health workforce 

      Kawa, Nisrine; Abisaab, Josyann; Abiad, Firass; Badr, Kamal; El-Kak, Faysal; Alameddine, Mohamad; Balsari, Satchit (Elsevier BV, 2022-02)

    • REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial 

      Fava, Maurizio; Stahl, Stephen; Pani, Luca; De Martin, Sara; Pappagallo, Marco; Guidetti, Clotilde; Alimonti, Andrea; Bettini, Ezio; Mangano, Richard M.; Wessel, Thomas; de Somer, Marc; Caron, Judy; Vitolo, Ottavio V.; DiGuglielmo, Gina R.; Gilbert, Adam; Mehta, Hiren; Kearney, Morgan; Mattarei, Andrea; Gentilucci, Marco; Folli, Franco; Traversa, Sergio; Inturrisi, Charles E.; Manfredi, Paolo L. (American Psychiatric Association Publishing, 2022-02)
      ABSTRACT Objective: The relationship between the duration of major depressive disorder (MDD) and therapeutic response to standard antidepressant treatment (SAT) is unknown. N-methyl-D- aspartate receptor (NMDAR) ...

    • Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer 

      Yi, Yang; Li, Yanqiang; Li, Chao; Wu, Longxiang; Zhao, Dongyu; Li, Fuxi; Fazli, Ladan; Wang, Rui; Wang, Long; Dong, Xuesen; Zhao, Wei; Chen, Kaifu; Cao, Qi (Springer Science and Business Media LLC, 2022-01-29)
      Cell division cycle associated 8 (CDCA8) is a component of chromosomal passenger complex (CPC) that participates in mitotic regulation. Although cancer-related CDCA8 hyperactivation has been widely observed, its molecular ...