Now showing items 21-40 of 63

    • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study 

      Perlstein, Todd Steven; Weuve, Jennifer Lynn; Schwartz, Joel David; Sparrow, David; Wright, Robert O.; Litonjua, Augusto Ampil; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007)
      Background: Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
    • Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women 

      Weuve, Jennifer Lynn; Korrick, Susan Abigail; Weisskopf, Marc G.; Ryan, Louise Marie; Schwartz, Joel David; Nie, Huiling; Grodstein, Francine; Hu, Howard (National Institute of Environmental Health Sciences, 2008)
      Background: Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. Objective: We examined biomarkers of lead ...
    • Dark microglia: A new phenotype predominantly associated with pathological states 

      Bisht, Kanchan; Sharma, Kaushik P.; Lecours, Cynthia; Gabriela Sánchez, Maria; El Hajj, Hassan; Milior, Giampaolo; Olmos‐Alonso, Adrián; Gómez‐Nicola, Diego; Luheshi, Giamal; Vallières, Luc; Branchi, Igor; Maggi, Laura; Limatola, Cristina; Butovsky, Oleg; Tremblay, Marie‐Ève (John Wiley and Sons Inc., 2016)
      The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic mechanisms. To study microglial implication ...
    • Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan 

      Lamming, Dudley W; Mihaylova, Maria M; Katajisto, Pekka; Baar, Emma L; Yilmaz, Omer H; Hutchins, Amanda; Gultekin, Yetis; Gaither, Rachel; Sabatini, David M (BlackWell Publishing Ltd, 2014)
      Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice. We recently found that chronic treatment with rapamycin not only inhibits mTOR complex ...
    • Derivation and Validation of a Preoperative Prediction Rule for Delirium After Cardiac Surgery 

      Rudolph, James; Jones, Richard Norman; Levkoff, Sue E.; Rockett, C.; Inouye, Sharon; Sellke, F. W.; Khuri, S. F.; Lipsitz, Lewis Arnold; Ramlawi, B.; Levitsky, Sidney; Marcantonio, Edward Ralph (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background— Delirium is a common outcome after cardiac surgery. Delirium prediction rules identify patients at risk for delirium who may benefit from targeted prevention strategies, early identification, and treatment of ...
    • Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism 

      Moroz, Natalie; Carmona, Juan J; Anderson, Edward; Hart, Anne C; Sinclair, David A; Blackwell, T Keith (BlackWell Publishing Ltd, 2014)
      Interventions that slow aging and prevent chronic disease may come from an understanding of how dietary restriction (DR) increases lifespan. Mechanisms proposed to mediate DR longevity include reduced mTOR signaling, ...
    • Differential effects of motor cortical excitability and plasticity in young and old individuals: a Transcranial Magnetic Stimulation (TMS) study 

      Bashir, Shahid; Perez, Jennifer M.; Horvath, Jared C.; Pena-Gomez, Cleofe; Vernet, Marine; Capia, Anuhya; Alonso-Alonso, Miguel; Pascual-Leone, Alvaro (Frontiers Media S.A., 2014)
      Aging is associated with changes in the motor system that, over time, can lead to functional impairments and contribute negatively to the ability to recover after brain damage. Unfortunately, there are still many questions ...
    • DNA repair in species with extreme lifespan differences 

      MacRae, Sheila L.; Croken, Matthew McKnight; Calder, R.B.; Aliper, Alexander; Milholland, Brandon; White, Ryan R.; Zhavoronkov, Alexander; Gladyshev, Vadim N.; Seluanov, Andrei; Gorbunova, Vera; Zhang, Zhengdong D.; Vijg, Jan (Impact Journals LLC, 2015)
      Differences in DNA repair capacity have been hypothesized to underlie the great range of maximum lifespans among mammals. However, measurements of individual DNA repair activities in cells and animals have not substantiated ...
    • Effects of voice on emotional arousal 

      Loui, Psyche; Bachorik, Justin P.; Li, H. Charles; Schlaug, Gottfried (Frontiers Media S.A., 2013)
      Music is a powerful medium capable of eliciting a broad range of emotions. Although the relationship between language and music is well documented, relatively little is known about the effects of lyrics and the voice on ...
    • Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae 

      Kaya, Alaattin; Lobanov, Alexei V; Gladyshev, Vadim N (BlackWell Publishing Ltd, 2014)
      The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected ...
    • Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology 

      Hedden, Trey; Sperling, Reisa Anne; Johnson, Keith Alan; Buckner, Randy Lee; van Dijk, Koene R. A.; Shire, Emily H. (Oxford University Press, 2012)
      Advanced aging is associated with reduced attentional control and less flexible information processing. Here, the origins of these cognitive effects were explored using a functional magnetic resonance imaging task that ...
    • Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice 

      Reis, Felipe C. G.; Branquinho, Jéssica L. O.; Brandão, Bruna B.; Guerra, Beatriz A.; Silva, Ismael D.; Frontini, Andrea; Thomou, Thomas; Sartini, Loris; Cinti, Saverio; Kahn, C. Ronald; Festuccia, William T.; Kowaltowski, Alicia J.; Mori, Marcelo A. (Impact Journals LLC, 2016)
      Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that ...
    • Fluid intelligence and brain functional organization in aging yoga and meditation practitioners 

      Gard, Tim; Taquet, Maxime; Dixit, Rohan; Hölzel, Britta K.; de Montjoye, Yves-Alexandre; Brach, Narayan; Salat, David H.; Dickerson, Bradford C.; Gray, Jeremy R.; Lazar, Sara W. (Frontiers Media S.A., 2014)
      Numerous studies have documented the normal age-related decline of neural structure, function, and cognitive performance. Preliminary evidence suggests that meditation may reduce decline in specific cognitive domains and ...
    • Gait Variability: Methods, Modeling and Meaning 

      Hausdorff, Jeffrey M. (BioMed Central, 2005)
      The study of gait variability, the stride-to-stride fluctuations in walking, offers a complementary way of quantifying locomotion and its changes with aging and disease as well as a means of monitoring the effects of ...
    • Gene expression defines natural changes in mammalian lifespan 

      Fushan, Alexey A; Turanov, Anton A; Lee, Sang-Goo; Kim, Eun Bae; Lobanov, Alexei V; Yim, Sun Hee; Buffenstein, Rochelle; Lee, Sang-Rae; Chang, Kyu-Tae; Rhee, Hwanseok; Kim, Jong-So; Yang, Kap-Seok; Gladyshev, Vadim N (BlackWell Publishing Ltd, 2015)
      Mammals differ more than 100-fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals ...
    • Generalized Multiscale Entropy Analysis: Application to Quantifying the Complex Volatility of Human Heartbeat Time Series 

      Costa, Madalena D.; Goldberger, Ary L. (2016)
      We introduce a generalization of multiscale entropy (MSE) analysis. The method is termed MSEn, where the subscript denotes the moment used to coarse-grain a time series. MSEμ, described previously, uses the mean value ...
    • Genetic evidence of serum phosphate-independent functions of FGF-23 on bone 

      Sitara, Despina; Kim, Somi; Razzaque, Mohammed Shawkat; Bergwitz, Clemens; Taguchi, Takashi; Schüler, Christiane; Erben, Reinhold G.; Lanske, Beate Klara Maria (Public Library of Science, 2008)
      Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast growth factor-23 (FGF-23) is a master ...
    • Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits 

      Teumer, Alexander; Qi, Qibin; Nethander, Maria; Aschard, Hugues; Bandinelli, Stefania; Beekman, Marian; Berndt, Sonja I.; Bidlingmaier, Martin; Broer, Linda; Cappola, Anne; Ceda, Gian Paolo; Chanock, Stephen; Chen, Ming‐Huei; Chen, Tai C.; Chen, Yii‐Der Ida; Chung, Jonathan; Del Greco Miglianico, Fabiola; Eriksson, Joel; Ferrucci, Luigi; Friedrich, Nele; Gnewuch, Carsten; Goodarzi, Mark O.; Grarup, Niels; Guo, Tingwei; Hammer, Elke; Hayes, Richard B.; Hicks, Andrew A.; Hofman, Albert; Houwing‐Duistermaat, Jeanine J.; Hu, Frank; Hunter, David J.; Husemoen, Lise L.; Isaacs, Aaron; Jacobs, Kevin B.; Janssen, Joop A. M. J. L.; Jansson, John‐Olov; Jehmlich, Nico; Johnson, Simon; Juul, Anders; Karlsson, Magnus; Kilpelainen, Tuomas O.; Kovacs, Peter; Kraft, Peter; Li, Chao; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J. F.; Lorentzon, Mattias; Lu, Yingchang; Maggio, Marcello; Magi, Reedik; Meigs, James; Mellström, Dan; Nauck, Matthias; Newman, Anne B.; Pollak, Michael N.; Pramstaller, Peter P.; Prokopenko, Inga; Psaty, Bruce M.; Reincke, Martin; Rimm, Eric B.; Rotter, Jerome I.; Saint Pierre, Aude; Schurmann, Claudia; Seshadri, Sudha; Sjögren, Klara; Slagboom, P. Eline; Strickler, Howard D.; Stumvoll, Michael; Suh, Yousin; Sun, Qi; Zhang, Cuilin; Svensson, Johan; Tanaka, Toshiko; Tare, Archana; Tönjes, Anke; Uh, Hae‐Won; van Duijn, Cornelia M.; van Heemst, Diana; Vandenput, Liesbeth; Vasan, Ramachandran S.; Völker, Uwe; Willems, Sara M.; Ohlsson, Claes; Wallaschofski, Henri; Kaplan, Robert C. (John Wiley and Sons Inc., 2016)
      Summary The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding protein‐3 (IGFBP‐3) have also been implicated ...
    • Gray matter alterations in early aging: A diffusion magnetic resonance imaging study 

      Rathi, Yogesh; Pasternak, Ofer; Savadjiev, Peter; Michailovich, O.; Bouix, Sylvain; Kubicki, Marek R.; Westin, Carl-Fredrik; Makris, Nikolaos; Shenton, Martha Elizabeth (Wiley-Blackwell, 2013)
      Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior ...
    • Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls 

      Gard, Tim; Taquet, Maxime; Dixit, Rohan; Hölzel, Britta K.; Dickerson, Bradford C.; Lazar, Sara W. (Frontiers Media S.A., 2015)
      There has been a growing interest in understanding how contemplative practices affect brain functional organization. However, most studies have restricted their exploration to predefined networks. Furthermore, scientific ...