Browsing HMS Scholarly Articles by Keyword "stem cells"

Now showing items 21-35 of 35

    • Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions 

      Lee, Kian Leong; Lim, Sandy Keat; Orlov, Yuriy Lvovich; Yit, Le Yau; Yang, Henry; Poellinger, Lorenz; Lim, Bing; Ang, Lay Teng (Public Library of Science, 2011)
      Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin ...

    • Immune responses to bioengineered organs 

      Ochando, Jordi; Charron, Dominique; Baptista, Pedro M.; Uygun, Basak E. (Lippincott Williams & Wilkins, 2017)
      Purpose of review Organ donation in the United States registered 9079 deceased organ donors in 2015. This high percentage of donations allowed organ transplantation in 29 851 recipients. Despite increasing numbers of ...

    • Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells 

      Piecewicz, Stephanie M.; Pandey, Ambarish; Roy, Bhaskar; Hua Xiang, Soh; Zetter, Bruce Robert; Sengupta, Shiladitya (Public Library of Science, 2012)
      The ability of embryonic stem cells to differentiate into endothelium and form functional blood vessels has been well established and can potentially be harnessed for therapeutic angiogenesis. However, after almost two ...

    • mTORC1 in the Paneth Cell Niche Couples Intestinal Stem Cell Function to Calorie Intake 

      Katajisto, Pekka; Lamming, Dudley W.; Gültekin, Yetis; Bauer-Rowe, Khristian E.; Sengupta, Shomit; Birsoy, Kivanc; Dursun, Abdulmetin; Yilmaz, V. Onur; Selig, Martin; Nielson, G. Petur; Sabatini, David M.; Yilmaz, Omer Hidir; Mino-Kenudson, Mari; Zukerberg, Lawrence R.; Bhan, Atul Kumar; Deshpande, Vikram (Nature Publishing Group, 2012)
      How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment ...

    • Neoplastic Cells are a Rare Component in Human Glioblastoma Microvasculature 

      Rodriguez, Fausto J.; Orr, Brent A.; Ligon, Keith Lloyd; Eberhart, Charles G. (Impact Journals LLC, 2012)
      Microvascular proliferation is a key biological and diagnostic hallmark of human glioblastoma, one of the most aggressive forms of human cancer. It has recently been suggested that stem-like glioblastoma cells have the ...

    • A Novel SALL4/OCT4 Transcriptional Feedback Network for Pluripotency of Embryonic Stem Cells 

      Yang, Jianchang; Ma, Yupo; Bridger, Joanna Mary; Gao, Chong; Chai, Li (Public Library of Science, 2010)
      Background: SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and ...

    • Oct4-Induced Reprogramming is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons 

      Deleidi, Michela; Cooper, Oliver Jamie; Hargus, Gunnar; Levy, Adam; Isacson, Ole Stefan (Public Library of Science, 2011)
      Neural stem cells (NSCs) lose their competency to generate region-specific neuronal populations at an early stage during embryonic brain development. Here we investigated whether epigenetic modifications can reverse the ...

    • Pax3 Stimulates p53 Ubiquitination and Degradation Independent of Transcription 

      Wang, Xiaodan; Morgan, Sarah C.; Loeken, Mary Rose (Public Library of Science, 2011)
      Background: Pax3 is a developmental transcription factor that is required for neural tube and neural crest development. We previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardiac ...

    • Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study 

      Davies, Benjamin M; Rikabi, Sarah; French, Anna; Pinedo-Villanueva, Rafael; Morrey, Mark E; Wartolowska, Karolina; Judge, Andrew; MacLaren, Robert E; Mathur, Anthony; Williams, David J; Wall, Ivan; Birchall, Martin; Reeve, Brock; Atala, Anthony; Barker, Richard W; Cui, Zhanfeng; Furniss, Dominic; Bure, Kim; Snyder, Evan Y; Karp, Jeffrey M; Price, Andrew; Carr, Andrew; Brindley, David A (SAGE Publications, 2014)
      There has been a large increase in basic science activity in cell therapy and a growing portfolio of cell therapy trials. However, the number of industry products available for widespread clinical use does not match this ...

    • Reconstitution of Mammary Epithelial Morphogenesis by Murine Embryonic Stem Cells Undergoing Hematopoietic Stem Cell Differentiation 

      Lee, Byeong-Chel; Jiang, Shuxian; Fu, Yigong; Avraham, Shalom; Lim, Bing; Avraham, Hava (Public Library of Science, 2010)
      Background: Mammary stem cells are maintained within specific microenvironments and recruited throughout lifetime to reconstitute de novo the mammary gland. Mammary stem cells have been isolated through the identification ...

    • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells 

      Suva, Mario Luca; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel David; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Rivera, Miguel Nicolas; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David N.; Bernstein, Bradley E. (Elsevier BV, 2014)
      Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies ...

    • Self-Assembled Matrix by Umbilical Cord Stem Cells 

      Karamichos, Dimitrios; Rich, Celeste B.; Hutcheon, Audrey E.K.; Ren, Ruiyi; Saitta, Biagio; Trinkaus-Randall, Vickery; Zieske, James D. (MDPI, 2011)
      Corneal integrity is critical for vision. Corneal wounds frequently heal with scarring that impairs vision. Recently, human umbilical cord mesenchymal stem cells (cord stem cells) have been investigated for tissue engineering ...

    • Stem Cell Therapy in Heart Diseases: A Review of Selected New Perspectives, Practical Considerations and Clinical Applications 

      Abdelwahid, Eltyeb; Siminiak, Tomasz; Guarita-Souza, Luiz César; de Carvalho, Katherine Athayde Teixeira; Gallo, Pasquale; Shim, Winston; Condorelli, Gianluigi (Bentham Science Publishers, 2011)
      Degeneration of cardiac tissues is considered a major cause of mortality in the western world and is expected to be a greater problem in the forthcoming decades. Cardiac damage is associated with dysfunction and irreversible ...

    • Strategies in Gene Therapy for Glioblastoma 

      Kwiatkowska, Aneta; Nandhu, Mohan S.; Behera, Prajna; Chiocca, E. Antonio; Viapiano, Mariano S. (MDPI, 2013)
      Glioblastoma (GBM) is the most aggressive form of brain cancer, with a dismal prognosis and extremely low percentage of survivors. Novel therapies are in dire need to improve the clinical management of these tumors and ...

    • Therapeutic potential of targeting microRNA‐10b in established intracranial glioblastoma: first steps toward the clinic 

      Teplyuk, Nadiya M; Uhlmann, Erik J; Gabriely, Galina; Volfovsky, Natalia; Wang, Yang; Teng, Jian; Karmali, Priya; Marcusson, Eric; Peter, Merlene; Mohan, Athul; Kraytsberg, Yevgenya; Cialic, Ron; Chiocca, E Antonio; Godlewski, Jakub; Tannous, Bakhos; Krichevsky, Anna M (John Wiley and Sons Inc., 2016)
      Abstract MicroRNA‐10b (miR‐10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR‐10b inhibition strongly impairs proliferation and survival ...