Now showing items 17840-17859 of 17917

    • An X Chromosome Association Scan of the Norfolk Island Genetic Isolate Provides Evidence for a Novel Migraine Susceptibility Locus at Xq12 

      Maher, Bridget H.; Lea, Rod A.; Benton, Miles; Cox, Hannah C.; Bellis, Claire; Carless, Melanie; Dyer, Thomas D.; Curran, Joanne; Charlesworth, Jac C.; Schürks, Markus; Blangero, John; Griffiths, Lyn R.; Buring, Julie Elizabeth; Kurth, Tobias; Chasman, Daniel Ian; Ridker, Paul M. (Public Library of Science, 2012)
      Migraine is a common and debilitating neurovascular disorder with a complex envirogenomic aetiology. Numerous studies have demonstrated a preponderance of women affected with migraine and previous pedigree linkage studies ...
    • X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function 

      Akiyama, Masaru; Liew, Chong Wee; Lu, Shusheng; Hu, Jiang; Martinez, Rachael; Hambro, Ben; Kennedy, Robert T.; Kulkarni, Rohit N. (American Diabetes Association, 2013)
      Patients with type 2 diabetes (T2D) often exhibit hyperglucagonemia despite hyperglycemia, implicating defective α-cell function. Although endoplasmic reticulum (ER) stress has been suggested to underlie β-cell dysfunction ...
    • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription 

      Yildirim, Eda; Sadreyev, Ruslan I.; Pinter, Stefan F.; Lee, Jeannie T. (2013)
      Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that ...
    • X-linked myotubular myopathy in Rottweiler dogs is caused by a missense mutation in Exon 11 of the MTM1 gene 

      Shelton, G Diane; Rider, Branden E; Child, Georgina; Tzannes, Sophia; Guo, Ling T; Moghadaszadeh, Behzad; Troiano, Emily C; Haase, Bianca; Wade, Claire M; Beggs, Alan H (BioMed Central, 2015)
      Background: Congenital and inherited myopathies in dogs are faithful models of human muscle diseases and are being recognized with increasing frequency. In fact, canine models of dystrophin deficient muscular dystrophy and ...
    • X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor 

      Elkins, Jonathan M.; Wang, Jing; Deng, Xianming; Pattison, Michael J.; Arthur, J. Simon C.; Erazo, Tatiana; Gomez, Nestor; Lizcano, Jose M.; Gray, Nathanael S.; Knapp, Stefan (American Chemical Society, 2013)
      The protein kinase ERK5 (MAPK7) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role mediating cell proliferation, survival, epithelial–mesenchymal transition, and ...
    • The X-Trials: Neural Correlates of an Inhibitory Control Task in Children and Adults 

      Davis, Elysia Poggi; Bruce, Jacqueline; Snyder, Kelly; Nelson, Charles A. (MIT Press - Journals, 2003)
      Event-related potentials (ERPs) were used to examine developmental differences between adults and 6-year-old children in the neural processes involved in an inhibitory control task. Twenty adults and 21 children completed ...
    • Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia 

      Fazio, Francesco; Lionetto, Luana; Curto, Martina; Iacovelli, Luisa; Cavallari, Michele; Zappulla, Cristina; Ulivieri, Martina; Napoletano, Flavia; Capi, Matilde; Corigliano, Valentina; Scaccianoce, Sergio; Caruso, Alessandra; Miele, Jessica; De Fusco, Antonio; Di Menna, Luisa; Comparelli, Anna; De Carolis, Antonella; Gradini, Roberto; Nisticò, Robert; De Blasi, Antonio; Girardi, Paolo; Bruno, Valeria; Battaglia, Giuseppe; Nicoletti, Ferdinando; Simmaco, Maurizio (Nature Publishing Group, 2015)
      The kynurenine pathway of tryptophan metabolism has been implicated in the pathophysiology of psychiatric disorders, including schizophrenia. We report here that the kynurenine metabolite, xanturenic acid (XA), interacts ...
    • The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy 

      Kim, Rosa S.; Hasegawa, Daisuke; Goossens, Nicolas; Tsuchida, Takuma; Athwal, Varinder; Sun, Xiaochen; Robinson, Christopher L.; Bhattacharya, Dipankar; Chou, Hsin-I; Zhang, David Y.; Fuchs, Bryan C.; Lee, Youngmin; Hoshida, Yujin; Friedman, Scott L. (Nature Publishing Group, 2016)
      Autophagy and the unfolded protein response (UPR) both promote activation of hepatic stellate cells (HSC), however the link between the two stimuli remains unclear. Here we have explored the role of X-box binding protein ...
    • XBP1 Governs Late Events in Plasma Cell Differentiation and Is not Required for Antigen-Specific Memory B Cell Development 

      McHeyzer-Williams, Louise J.; Kowal, Czeslawa; Lee, Ann-Hwee; Volpe, Bruce T.; Diamond, Betty; McHeyzer-Williams, Michael G.; Todd, Derrick James; Glimcher, Laurie Hollis (Rockefeller University Press, 2009)
      The unfolded protein response (UPR) is a stress response pathway that is driven by the increased load of unfolded proteins in the endoplasmic reticulum of highly secretory cells such as plasma cells (PCs). X box binding ...
    • XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway 

      Chen, Xi; Iliopoulos, Dimitrios; Zhang, Qing; Tang, Qianzi; Greenblatt, Matthew B.; Hatziapostolou, Maria; Lim, Elgene; Tam, Wai Leong; Ni, Min; Chen, Yiwen; Mai, Junhua; Shen, Haifa; Hu, Dorothy Z.; Adoro, Stanley; Hu, Bella; Song, Minkyung; Tan, Chen; Landis, Melissa D.; Ferrari, Mauro; Shin, Sandra J.; Brown, Myles; Chang, Jenny C.; Liu, X. Shirley; Glimcher, Laurie H. (2014)
      Cancer cells induce a set of adaptive response pathways to survive in the face of stressors due to inadequate vascularization1. One such adaptive pathway is the unfolded protein (UPR) or endoplasmic reticulum (ER) stress ...
    • XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease 

      Cameron, Trevor L.; Bell, Katrina M.; Gresshoff, Irma L.; Sampurno, Lisa; Mullan, Lorna; Ermann, Joerg; Glimcher, Laurie H.; Boot-Handford, Raymond P.; Bateman, John F. (Public Library of Science, 2015)
      Schmid metaphyseal chondrodysplasia (MCDS) involves dwarfism and growth plate cartilage hypertrophic zone expansion resulting from dominant mutations in the hypertrophic zone collagen, Col10a1. Mouse models phenocopying ...
    • Xenobiotic Metabolizing Enzyme Gene Polymorphisms Predict Response to Lung Volume Reduction Surgery 

      Hersh, Craig Palmer; Demeo, Dawn Lisa; Reilly, John J.; Silverman, Edwin Kepner (BioMed Central, 2007)
      Background: In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences which may explain some of this ...
    • Xenon Impairs Reconsolidation of Fear Memories in a Rat Model of Post-Traumatic Stress Disorder (PTSD) 

      Meloni, Edward G.; Gillis, Timothy E.; Manoukian, Jasmine; Kaufman, Marc J. (Public Library of Science, 2014)
      Xenon (Xe) is a noble gas that has been developed for use in people as an inhalational anesthestic and a diagnostic imaging agent. Xe inhibits glutamatergic N-methyl-D-aspartate (NMDA) receptors involved in learning and ...
    • Xenotransplantation-associated infectious risk: a WHO consultation 

      Fishman, Jay Alan; Scobie, Linda; Takeuchi, Yasuhiro (Wiley-Blackwell, 2012)
      Xenotransplantation carries the potential risk of the transmission of infection with the cells or tissues of the graft. The degree of risk is unknown in the absence of clinical trials. The clinical application of ...
    • Xio is a Component of the Drosophila Sex Determination Pathway and RNA N6-Methyladenosine Methyltransferase Complex 

      Guo, Jian; Tang, Hong-Wen; Li, Jing; Perrimon, Norbert; Yan, Dong (National Academy of Sciences, 2018-04-03)
      N6-methyladenosine (m6A), the most abundant chemical modification in eukaryotic mRNA, has been implicated in Drosophila sex determination by modifying Sex-lethal (Sxl) pre-mRNA and facilitating its alternative splicing. ...
    • The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3 

      McHugh, Colleen A.; Chen, Chun-Kan; Chow, Amy; Surka, Christine F.; Tran, Christina; McDonel, Patrick; Pandya-Jones, Amy; Blanco, Mario; Burghard, Christina; Moradian, Annie; Sweredoski, Michael J.; Shishkin, Alexander A.; Su, Julia; Lander, Eric S.; Hess, Sonja; Plath, Kathrin; Guttman, Mitchell (2015)
      Many long non-coding RNAs (lncRNAs) affect gene expression1, but the mechanisms by which they act are still largely unknown2. One of the best-studied lncRNAs is Xist, which is required for transcriptional silencing of one ...
    • XY and ZW: Is Meiotic Sex Chromosome Inactivation the Rule in Evolution? 

      Namekawa, Satoshi H.; Malik, Harmit S.; Lee, Jeannie T. (Public Library of Science, 2009)
    • Y Chromosome Haplogroups and Prostate Cancer in Populations of European and Ashkenazi Jewish Ancestry 

      Wang, Zhaoming; Parikh, Hemang; Jia, Jinping; Yeager, Meredith; Jacobs, Kevin B.; Hutchinson, Amy; Burdett, Laurie; Ghosh, Arpita; Thun, Michael J.; Gapstur, Susan M.; Virtamo, Jarmo; Albanes, Demetrius; Cancel-Tassin, Geraldine; Valeri, Antoine; Cussenot, Olivier; Offit, Kenneth; Dutra-Clarke, Ana; Kirchhoff, Tomas; Alavanja, Michael; Freeman, Laura B.; Koutros, Stella; Hoover, Robert; Berndt, Sonja I.; Hayes, Richard B.; Agalliu, Ilir; Burk, Robert D.; Wacholder, Sholom; Thomas, Gilles; Amundadottir, Laufey; Myers, Timothy; Giovannucci, Edward L.; Ma, Jing; Stampfer, Meir; Gaziano, John Michael; Hunter, David J.; Diver, W. Ryan (Springer-Verlag, 2012)
      Genetic variation on the Y chromosome has not been convincingly implicated in prostate cancer risk. To comprehensively analyze the role of inherited Y chromosome variation in prostate cancer risk in individuals of European ...
    • YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells 

      Hua, Guohua; Lv, Xiangmin; He, Chunbo; Remmenga, Steven W.; Rodabough, Kerry J.; Dong, Jixin; Yang, Liguo; Lele, Subodh M.; Yang, Peixin; Zhou, Jin; Karst, Alison; Drapkin, Ronny I.; Davis, John S.; Wang, Cheng (2015)
      Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from Fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression ...
    • Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth 

      Cox, Andrew G.; Hwang, Katie L.; Brown, Kristin K.; Evason, Kimberley; Beltz, Sebastian; Tsomides, Allison; O'Connor, Keelin; Galli, Giorgio G.; Yimlamai, Dean; Chhangawala, Sagar; Yuan, Min; Lien, Evan C.; Wucherpfennig, Julia; Nissim, Sahar; Minami, Akihiro; Cohen, David E.; Camargo, Fernando D.; Asara, John M.; Houvras, Yariv; Stainier, Didier Y.R.; Goessling, Wolfram (2016)
      The Hippo pathway is an important regulator of organ size and tumorigenesis. It is unclear, however, how Hippo signaling provides the cellular building blocks required for rapid growth. Here, we demonstrate that transgenic ...