Now showing items 2144-2163 of 15668

    • A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer 

      Lagerweij, Tonny; Hiddingh, Lotte; Biesmans, Dennis; Crommentuijn, Matheus H.W.; Cloos, Jacqueline; Li, Xiao-Nan; Kogiso, Mari; Tannous, Bakhos A.; Vandertop, W. Peter; Noske, David P.; Kaspers, Gertjan J.L.; Würdinger, Tom; Hulleman, Esther (Impact Journals LLC, 2016)
      Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term ...
    • A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size 

      Kitami, Toshimori; Logan, David J.; Negri, Joseph Michael; Hasaka, Thomas; Tolliday, Nicola J.; Carpenter, Anne E.; Spiegelman, Bruce Michael; Mootha, Vamsi Krishna (Public Library of Science, 2012)
      The cellular content of mitochondria changes dynamically during development and in response to external stimuli, but the underlying mechanisms remain obscure. To systematically identify molecular probes and pathways that ...
    • Chemokine Receptor CCR5 Expression in Conjunctival Epithelium of Patients With Dry Eye Syndrome 

      Gulati, Abha; Saccheti, Marta; Bonini, Stefano; Dana, Reza (American Medical Association (AMA), 2006)
      Objective To characterize chemokine receptor CCR5 expression on the conjunctival epithelium in dry eye syndromes. Methods Conjunctival impression cytology samples were obtained from normal subjects (n = 15) and patients ...
    • Chemokine receptor CXCR3 is important for lung tissue damage and airway remodeling induced by short-term exposure to cigarette smoking in mice 

      Nie, Li; Liu, Zhen-jia; Zhou, Wei-xun; Xiang, Ruo-lan; Xiao, Yu; Lu, Bao; Pang, Bao-sen; Gao, Jin-ming (Nature Publishing Group, 2010)
      Aim: To investigate the role of chemokine receptor CXCR3 in cigarette smoking (CS)-induced pulmonary damage. Methods: CXCR3 knockout (CXCR3-/-) mice were used. Differences in airspace enlargement, mRNA expression of matrix ...
    • Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1) 

      Brennig, Sebastian; Lachmann, Nico; Buchegger, Theresa; Hetzel, Miriam; Schambach, Axel; Moritz, Thomas (BioMed Central, 2015)
      Background: Hematologic toxicity represents a major side effect of cytotoxic chemotherapy frequently preventing adequately dosed chemotherapy application and impeding therapeutic success. Transgenic (over)expression of ...
    • Chemoproteomic profiling of host and pathogen enzymes active in cholera 

      Hatzios, Stavroula K.; Abel, Sören; Martell, Julianne; Hubbard, Troy; Sasabe, Jumpei; Munera, Diana; Clark, Lars; Bachovchin, Daniel A.; Qadri, Firdausi; Ryan, Edward T.; Davis, Brigid M.; Weerapana, Eranthie; Waldor, Matthew K. (2016)
      Activity-based protein profiling (ABPP) is a chemoproteomic tool for detecting active enzymes in complex biological systems. We used ABPP to identify secreted bacterial and host serine hydrolases that are active in animals ...
    • ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation 

      Wang, Andrew Z; Yuet, Kai; Zhang, Liangfang; Gu, Frank X; Huynh-Le, Minh; Radovic-Moreno, Aleksandar F; Kantoff, Philip Wayne; Bander, Neil H; Langer, Robert S.; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Aim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. ...
    • Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway 

      Wu, Qiong; Wang, Rui; Yang, Qingling; Hou, Xin; Chen, Sulian; Hou, Yueyue; Chen, Changjie; Yang, Yan; Miele, Lucio; Sarkar, Fazlul H; Chen, Yuqing; Wang, Zhiwei (Impact Journals LLC, 2013)
      Hepatocellular carcinoma (HCC) is one of the common malignances in the world and has high mortality in part due to development of acquired drug resistance. Therefore, it is urgent to investigate the molecular mechanism of ...
    • Chemosensory Cues to Conspecific Emotional Stress Activate Amygdala in Humans 

      Mujica-Parodi, Lilianne R.; Strey, Helmut H.; Frederick, Blaise DeBonneval; Savoy, Robert L.; Cox, David; Botanov, Yevgeny; Tolkunov, Denis; Rubin, Denis; Weber, Jochen (Public Library of Science, 2009)
      Alarm substances are airborne chemical signals, released by an individual into the environment, which communicate emotional stress between conspecifics. Here we tested whether humans, like other mammals, are able to detect ...
    • Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors 

      Chong, Curtis Robert; Wirth, Lori Julin; Nishino, Mizuki; Chen, Aileen Betty; Sholl, Lynette Marie; Kulke, Matthew H; McNamee, Ciaran; Janne, Pasi Antero; Johnson, Bruce Evan (Elsevier BV, 2014)
      Objectives The optimal management of locally advanced and metastatic pulmonary carcinoid tumors remains to be determined. Materials and methods A retrospective review was conducted on patients with typical and ...
    • CHERISH (collaboration for hospitalised elders reducing the impact of stays in hospital): protocol for a multi-site improvement program to reduce geriatric syndromes in older inpatients 

      Mudge, Alison M.; Banks, Merrilyn D.; Barnett, Adrian G.; Blackberry, Irene; Graves, Nicholas; Green, Theresa; Harvey, Gillian; Hubbard, Ruth E.; Inouye, Sharon K.; Kurrle, Sue; Lim, Kwang; McRae, Prue; Peel, Nancye M.; Suna, Jessica; Young, Adrienne M. (BioMed Central, 2017)
      Background: Older inpatients are at risk of hospital-associated geriatric syndromes including delirium, functional decline, incontinence, falls and pressure injuries. These contribute to longer hospital stays, loss of ...
    • Cherubism: Best Clinical Practice 

      Papadaki, Maria E; Lietman, Steven A; Levine, Michael A.; Olsen, Bjorn Reino; Kaban, Leonard B.; Reichenberger, Ernst J (BioMed Central, 2012)
      Cherubism is a skeletal dysplasia characterized by bilateral and symmetric fibro-osseous lesions limited to the mandible and maxilla. In most patients, cherubism is due to dominant mutations in the SH3BP2 gene on chromosome ...
    • Chiasmal visual loss after retinal detachment 

      Prasad, Sashank; Golby, Alexandra Jacqueline (Ovid Technologies (Wolters Kluwer Health), 2012)
      A 52-year-old man developed severe vision loss in the right eye due to a large retinal detachment. Vitrectomy was performed in that eye, with 15% C3F8 perfluoropropane gas injected into the posterior chamber.1 He transiently ...
    • Child Health Status and Parental Employment 

      Kuhlthau, Karen Alice; Perrin, James Marc (American Medical Association (AMA), 2001)
      Objective: To understand the relationship between several measures of child health status and the employment of parents. Design: A cross-sectional study using 1994 National Health Interview Survey on Disability data. ...
    • Child Neurology: Exaggerated dermal melanocytosis in a hypotonic infant: A harbinger of GM1 gangliosidosis 

      Armstrong-Javors, Amy Elizabeth; Chu, Catherine Jean (Ovid Technologies (Wolters Kluwer Health), 2014)
      Gangliosidoses are a group of rare lysosomal storage diseases (LySD) involving the accumulation of lipids in multiple organ systems, including the central and peripheral nervous systems. These disorders are inherited in ...
    • A Child with Chronic Manganese Exposure from Drinking Water 

      Woolf, Alan David; Wright, Robert O.; Amarasiriwardena, Chitra J.; Bellinger, David C. (U.S. Department of Health and Human Services & National Institute of Environmental Health Sciences, 2002)
      The patient's family bought a home in a suburb, but the proximity of the house to wetlands and its distance from the town water main prohibited connecting the house to town water. The family had a well drilled and they ...
    • Childhood ADHD and Risk for Substance Dependence in Adulthood: A Longitudinal, Population-Based Study 

      Levy, Sharon; Katusic, Slavica K.; Colligan, Robert C.; Weaver, Amy L.; Killian, Jill M.; Voigt, Robert G.; Barbaresi, William J. (Public Library of Science, 2014)
      Background: Adolescents with attention-deficit/hyperactivity disorder (ADHD) are known to be at significantly greater risk for the development of substance use disorders (SUD) compared to peers. Impulsivity, which could ...
    • Childhood adversity and asthma prevalence: evidence from 10 US states (2009–2011) 

      Bhan, Nandita; Glymour, M Maria; Kawachi, Ichiro; Subramanian, S V (BMJ Publishing Group, 2014)
      Background: Existing evidence on stress and asthma prevalence has disproportionately focused on pregnancy and postpregnancy early life stressors, largely ignoring the role of childhood adversity as a risk factor. Childhood ...
    • Childhood Adversity as a Predictor of Non-Adherence to Statin Therapy in Adulthood 

      Korhonen, Maarit Jaana; Halonen, Jaana I.; Brookhart, M. Alan; Kawachi, Ichiro; Pentti, Jaana; Karlsson, Hasse; Kivimäki, Mika; Vahtera, Jussi (Public Library of Science, 2015)
      Purpose To investigate whether adverse experiences in childhood predict non-adherence to statin therapy in adulthood. Methods: A cohort of 1378 women and 538 men who initiated statin therapy during 2008–2010 after responding ...
    • Childhood Adversity Is Associated with Adult Theory of Mind and Social Affiliation, but Not Face Processing 

      Germine, Laura; Dunn, Erin C.; McLaughlin, Katie A.; Smoller, Jordan W. (Public Library of Science, 2015)
      People vary substantially in their ability to acquire and maintain social ties. Here, we use a combined epidemiological and individual differences approach to understand the childhood roots of adult social cognitive ...