Now showing items 2167-2186 of 17096

    • CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation 

      Hayakawa, Kazuhide; Pham, Loc-Duyen; Seo, Ji-Hae; Miyamoto, Nobukazu; Maki, Takakuni; Sakadzic, Sava; Boas, David A.; van Leyen, Klaus J.; Waeber, Christian; Kim, Kyu-Won; Arai, Ken; Lo, Eng H. (SAGE Publications, 2016)
      There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ...
    • CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2 

      Soberman, Roy Jason; MacKay, Christopher R.; Vaine, Christine Adele; Ryan, Glennice Bowen; Cerny, Anna M.; Thompson, Mikayla R.; Nikolic, Boris; Primo, Valeria; Christmas, Peter; Sheiffele, Paul; Aronov, Lisa; Knipe, David Mahan; Kurt-Jones, Evelyn A. (Public Library of Science, 2012)
      The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1−/− mice and employed them to explore ...
    • CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing 

      Butte, Manish J.; Lee, Sun Jung; Jesneck, Jonathan Lee; Keir, Mary E.; Haining, William Nicholas; Sharpe, Arlene Helen (Public Library of Science, 2012)
      CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing ...
    • CD28 Ligation Increases Macrophage Suppression of T Cell Proliferation 

      Silberman, Daniel; Bucknum, Amanda; Bartlett, Thomas; Composto, Gabriella; Kozlowski, Megan; Walker, Amanda; Werda, Amy; Cua, Jackelyn; Somerville, John E.; Riggs, James E.; Sharpe, Arlene Helen (Nature Publishing Group, 2012)
      When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T cell activation in vitro. The greater proportional representation of macrophages in this cell source has been shown to ...
    • CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology 

      Bradshaw, Elizabeth M; Chibnik, Lori B; Keenan, Brendan T; Ottoboni, Linda; Raj, Towfique; Tang, Anna; Rosenkrantz, Laura L; Imboywa, Selina; Lee, Michelle; Von Korff, Alina; Morris, Martha C; Evans, Denis A; Johnson, Keith; Sperling, Reisa A; Schneider, Julie A; Bennett, David A; De Jager, Philip L (2013)
      In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) ...
    • CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation 

      Sheedy, Frederick J.; Grebe, Alena; Rayner, Katey J.; Kalantari, Parisa; Ramkhelawon, Bhama; Carpenter, Susan B.; Becker, Christine E.; Ediriweera, Hasini N.; Mullick, Adam E.; Golenbock, Douglas T.; Stuart, Lynda M.; Latz, Eicke; Fitzgerald, Katherine A.; Moore, Kathryn J. (2013)
      Particulate ligands including cholesterol crystals and amyloid fibrils induce NLRP3-dependent production of interleukin-1β (IL-1β) in atherosclerosis, Alzheimer's disease and diabetes. Soluble endogenous ligands including ...
    • CD39 and Control of Cellular Immune Responses 

      Dwyer, Karen M.; Deaglio, Silvia; Gao, Wenda; Friedman, David J.; Strom, Terry Barton; Robson, Simon Christopher (Springer Verlag, 2007)
      CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic ...
    • CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection 

      Yoshida, Osamu; Dou, Lei; Kimura, Shoko; Yokota, Shinichiro; Isse, Kumiko; Robson, Simon C.; Geller, David A.; Thomson, Angus W. (2015)
      Adenosine triphosphate (ATP), an essential metabolic energy source, is released following cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate innate immune cells. The ectonucleotidase ...
    • CD39 Expression Identifies Terminally Exhausted CD8+ T Cells 

      Gupta, Prakash K.; Godec, Jernej; Wolski, David; Adland, Emily; Yates, Kathleen; Pauken, Kristen E.; Cosgrove, Cormac; Ledderose, Carola; Junger, Wolfgang G.; Robson, Simon C.; Wherry, E. John; Alter, Galit; Goulder, Philip J. R.; Klenerman, Paul; Sharpe, Arlene H.; Lauer, Georg M.; Haining, W. Nicholas (Public Library of Science, 2015)
      Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially ...
    • CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease 

      Sakai, Shunsuke; Kauffman, Keith D.; Sallin, Michelle A.; Sharpe, Arlene H.; Young, Howard A.; Ganusov, Vitaly V.; Barber, Daniel L. (Public Library of Science, 2016)
      IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, ...
    • CD4+ and viral load outcomes of antiretroviral therapy switch strategies after virologic failure of combination antiretroviral therapy in perinatally HIV-infected youth in the United States 

      Fairlie, Lee; Karalius, Brad; Patel, Kunjal; van Dyke, Russell B.; Hazra, Rohan; Hernán, Miguel A.; Siberry, George K.; Seage, George R.; Agwu, Allison; Wiznia, Andrew (Lippincott Williams & Wilkins, 2015)
      Objective: This study compared 12-month CD4+ and viral load outcomes in HIV-infected children and adolescents with virological failure, managed with four treatment switch strategies. Design: This observational study included ...
    • CD4+CD62L+ Central Memory T Cells Can Be Converted to Foxp3+ T Cells 

      Zhang, Xiaolong; Chang Li, Xian; Xiao, Xiang; Sun, Rui; Tian, Zhigang; Wei, Haiming (Public Library of Science, 2013)
      The peripheral Foxp3+ Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4+ T cells can be readily converted to Foxp3+ iTreg in vitro, and memory CD4+ T cells ...
    • CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells 

      Naito, Masayasu; Hainz, Ursula; Burkhardt, Ute E.; Fu, Buyin; Ahove, Deborah; Stevenson, Kristen E.; Rajasagi, Mohini; Zhu, Baogong; Alonso, Anselmo; Witten, Elizabeth; Matsuoka, Ken-ichi; Neuberg, Donna; Duke-Cohan, Jonathan S.; Wu, Cathy Ju-Ying; Freeman, Gordon James (Springer-Verlag, 2012)
      CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available. Like other TNF family members, in ...
    • CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA 

      Farokhzad, Omid Cameron (Oxford University Press (OUP), 2000)
      CD43 is a leukocyte-specific surface molecule which plays an important role both in adhesion and signal transduction. We have identified a site spanning nucleotides +18 to +39 within the human CD43 gene promoter which in ...
    • CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma 

      Gao, Yan; Feng, Yong; Shen, Jacson K.; Lin, Min; Choy, Edwin; Cote, Gregory M.; Harmon, David C.; Mankin, Henry J.; Hornicek, Francis J.; Duan, Zhenfeng (Nature Publishing Group, 2015)
      Osteosarcoma is the most common primary bone malignancy in children and adolescents. Herein, we investigated the role of cluster of differentiation 44 (CD44), a cell-surface glycoprotein involved in cell-cell interactions, ...
    • CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis 

      Sosulski, Amanda; Horn, Heiko; Zhang, Lihua; Coletti, Caroline; Vathipadiekal, Vinod; Castro, Cesar M.; Birrer, Michael J.; Nagano, Osamu; Saya, Hideyuki; Lage, Kasper; Donahoe, Patricia K.; Pépin, David (Public Library of Science, 2016)
      CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other ...
    • CD46 Protects Against Chronic Obstructive Pulmonary Disease 

      Grumelli, Sandra; Lu, Bao; Peterson, Leif; Maeno, Toshitaka; Gerard, Craig John (Public Library of Science, 2011)
      Background: Chronic obstructive pulmonary disease and emphysema develops in 15% of ex-smokers despite sustained quitting, while 10% are free of emphysema or severe lung obstruction. The cause of the incapacity of the immune ...
    • CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer 

      Li, Chong; Liu, Shengwu; Yan, Ruping; Han, Ning; Wong, Kwok-Kin; Li, Lei (Ivyspring International Publisher, 2017)
      Cancer stem cells (CSCs) are considered one of the key contributors to chemoresistance and tumor recurrence. Therefore, the precise identification of reliable CSC markers and clarification of the intracellular signaling ...
    • CD8 T Cell Response and Evolutionary Pressure to HIV-1 Cryptic Epitopes Derived from Antisense Transcription 

      Bansal, Anju; Yan, Jiyu; Akinsiku, Olusimidele T.; Schaefer, Malinda; Sabbaj, Steffanie; Bet, Anne; Levy, David N.; Heath, Sonya; Tang, Jianming; Kaslow, Richard A.; Ndung’u, Thumbi; Heckerman, David; Hunter, Eric; Goepfert, Paul A.; Carlson, Jonathan Courtland; Walker, Bruce David; Goulder, Philip J. (The Rockefeller University Press, 2010)
      Retroviruses pack multiple genes into relatively small genomes by encoding several genes in the same genomic region with overlapping reading frames. Both sense and antisense HIV-1 transcripts contain open reading frames ...
    • CD8+ Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells 

      Klatt, Nichole R.; Shudo, Emi; Ortiz, Alex M.; Engram, Jessica C.; Paiardini, Mirko; Lawson, Benton; Else, James; Pandrea, Ivona; Estes, Jacob D.; Apetrei, Cristian; Ribeiro, Ruy M.; Perelson, Alan S.; Silvestri, Guido; Miller, Michael D.; Schmitz, Joern Engelbert (Public Library of Science, 2010)
      While CD8+ T cells are clearly important in controlling virus replication during HIV and SIV infections, the mechanisms underlying this antiviral effect remain poorly understood. In this study, we assessed the in vivo ...