Now showing items 2148-2167 of 15718

    • Charting health system reconstruction in post-war Liberia: a comparison of rural vs. remote healthcare utilization 

      Kentoffio, Katherine; Kraemer, John D.; Griffiths, Thomas; Kenny, Avi; Panjabi, Rajesh; Sechler, G. Andrew; Selinsky, Stephen; Siedner, Mark J. (BioMed Central, 2016)
      Background: Despite a growing global emphasis on universal healthcare, access to basic primary care for remote populations in post-conflict countries remains a challenge. To better understand health sector recovery in ...
    • Charting oxidized methylcytosines at base resolution 

      Yardimci, Hasan; Zhang, Yi (Nature Publishing Group, 2015)
      DNA cytosine methylation is a key epigenetic mark that is required for normal mammalian development. Iterative oxidation of 5-methylcytosine (5mC) by the TET family of DNA dioxygenases generates three oxidized nucleotides: ...
    • The CHC22 Clathrin-GLUT4 Transport Pathway Contributes to Skeletal Muscle Regeneration 

      Hoshino, Sachiko; Sakamoto, Kazuho; Vassilopoulos, Stéphane; Camus, Stéphane M.; Griffin, Christine A.; Esk, Christopher; Torres, Jorge A.; Ohkoshi, Norio; Ishii, Akiko; Tamaoka, Akira; Funke, Birgit H.; Kucherlapati, Raju; Margeta, Marta; Rando, Thomas A.; Brodsky, Frances M. (Public Library of Science, 2013)
      Mobilization of the GLUT4 glucose transporter from intracellular storage vesicles provides a mechanism for insulin-responsive glucose import into skeletal muscle. In humans, clathrin isoform CHC22 participates in formation ...
    • Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens 

      Gubin, Matthew M.; Zhang, Xiuli; Schuster, Heiko; Caron, Etienne; Ward, Jeffrey P.; Noguchi, Takuro; Ivanova, Yulia; Hundal, Jasreet; Arthur, Cora D.; Krebber, Willem-Jan; Mulder, Gwenn E.; Toebes, Mireille; Vesely, Matthew D.; Lam, Samuel S.K.; Korman, Alan J.; Allison, James P.; Freeman, Gordon J.; Sharpe, Arlene H.; Pearce, Erika L.; Schumacher, Ton N.; Aebersold, Ruedi; Rammensee, Hans-Georg; Melief, Cornelis J. M.; Mardis, Elaine R.; Gillanders, William E.; Artyomov, Maxim N.; Schreiber, Robert D. (2014)
      The immune system plays key roles in determining the fate of developing cancers by not only functioning as a tumour promoter facilitating cellular transformation, promoting tumour growth and sculpting tumour cell ...
    • A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation 

      Nelson, Erik A.; Sharma, Sreenath V.; Settleman, Jeffrey; Frank, David Alan (Impact Journals LLC, 2011)
      STAT transcription factors transduce signals from the cell surface to the nucleus, where they regulate the expression of genes that control proliferation, survival, self-renewal, and other critical cellular functions. Under ...
    • A Chemical Genetic Approach Reveals Distinct Mechanisms of EphB Signaling During Brain Development 

      Soskis, Michael J.; Ho, Hsin-Yi Henry; Bloodgood, Brenda L.; Robichaux, Michael A.; Malik, Athar N.; Ataman, Bulent; Rubin, Alex A.; Zieg, Janine; Zhang, Chao; Shokat, Kevan M.; Sharma, Nikhil; Cowan, Christopher W.; Greenberg, Michael E. (2012)
      EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, as EphBs ...
    • Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease 

      Bradner, James Elliott; Mak, Raymond Heungwing; Tanguturi, Shyam Kumar; Mazitschek, Ralph; Haggarty, Stephen John; Ross, Kenneth N; Chang, Cindy Y.; Bosco, Jocelyn; West, Nathan; Morse, Elizabeth; Lin, Katherine; Shen, John Paul; Kwiatkowski, Nicholas Paul; Gheldof, Nele; Dekker, Job; DeAngelo, Daniel J.; Carr, Steven A.; Schreiber, Stuart L.; Golub, Todd Robert; Ebert, Benjamin L. (Proceedings of the National Academy of Sciences, 2010)
      The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications ...
    • Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target 

      Chen, Ting; Ozel, Duygu; Qiao, Yuan; Harbinski, Fred; Chen, Limo; Denoyelle, Séverine; He, Xiaoying; Zvereva, Nela; Supko, Jeffrey G.; Chorev, Michael; Halperin, Jose A.; Aktas, Bertal H. (2013)
      Translation initiation plays a critical role in cellular homeostasis, proliferation, differentiation and malignant transformation. Consistently, increasing the abundance of the eIF2·GTP·Met-tRNAi translation initiation ...
    • A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer 

      Lagerweij, Tonny; Hiddingh, Lotte; Biesmans, Dennis; Crommentuijn, Matheus H.W.; Cloos, Jacqueline; Li, Xiao-Nan; Kogiso, Mari; Tannous, Bakhos A.; Vandertop, W. Peter; Noske, David P.; Kaspers, Gertjan J.L.; Würdinger, Tom; Hulleman, Esther (Impact Journals LLC, 2016)
      Treatment of medulloblastoma in children fails in approximately 30% of patients, and is often accompanied by severe late sequelae. Therefore, more effective drugs are needed that spare normal tissue and diminish long-term ...
    • A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size 

      Kitami, Toshimori; Logan, David J.; Negri, Joseph Michael; Hasaka, Thomas; Tolliday, Nicola J.; Carpenter, Anne E.; Spiegelman, Bruce Michael; Mootha, Vamsi Krishna (Public Library of Science, 2012)
      The cellular content of mitochondria changes dynamically during development and in response to external stimuli, but the underlying mechanisms remain obscure. To systematically identify molecular probes and pathways that ...
    • Chemokine Receptor CCR5 Expression in Conjunctival Epithelium of Patients With Dry Eye Syndrome 

      Gulati, Abha; Saccheti, Marta; Bonini, Stefano; Dana, Reza (American Medical Association (AMA), 2006)
      Objective To characterize chemokine receptor CCR5 expression on the conjunctival epithelium in dry eye syndromes. Methods Conjunctival impression cytology samples were obtained from normal subjects (n = 15) and patients ...
    • Chemokine receptor CXCR3 is important for lung tissue damage and airway remodeling induced by short-term exposure to cigarette smoking in mice 

      Nie, Li; Liu, Zhen-jia; Zhou, Wei-xun; Xiang, Ruo-lan; Xiao, Yu; Lu, Bao; Pang, Bao-sen; Gao, Jin-ming (Nature Publishing Group, 2010)
      Aim: To investigate the role of chemokine receptor CXCR3 in cigarette smoking (CS)-induced pulmonary damage. Methods: CXCR3 knockout (CXCR3-/-) mice were used. Differences in airspace enlargement, mRNA expression of matrix ...
    • Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1) 

      Brennig, Sebastian; Lachmann, Nico; Buchegger, Theresa; Hetzel, Miriam; Schambach, Axel; Moritz, Thomas (BioMed Central, 2015)
      Background: Hematologic toxicity represents a major side effect of cytotoxic chemotherapy frequently preventing adequately dosed chemotherapy application and impeding therapeutic success. Transgenic (over)expression of ...
    • Chemoproteomic profiling of host and pathogen enzymes active in cholera 

      Hatzios, Stavroula K.; Abel, Sören; Martell, Julianne; Hubbard, Troy; Sasabe, Jumpei; Munera, Diana; Clark, Lars; Bachovchin, Daniel A.; Qadri, Firdausi; Ryan, Edward T.; Davis, Brigid M.; Weerapana, Eranthie; Waldor, Matthew K. (2016)
      Activity-based protein profiling (ABPP) is a chemoproteomic tool for detecting active enzymes in complex biological systems. We used ABPP to identify secreted bacterial and host serine hydrolases that are active in animals ...
    • ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation 

      Wang, Andrew Z; Yuet, Kai; Zhang, Liangfang; Gu, Frank X; Huynh-Le, Minh; Radovic-Moreno, Aleksandar F; Kantoff, Philip Wayne; Bander, Neil H; Langer, Robert S.; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Aim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. ...
    • Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway 

      Wu, Qiong; Wang, Rui; Yang, Qingling; Hou, Xin; Chen, Sulian; Hou, Yueyue; Chen, Changjie; Yang, Yan; Miele, Lucio; Sarkar, Fazlul H; Chen, Yuqing; Wang, Zhiwei (Impact Journals LLC, 2013)
      Hepatocellular carcinoma (HCC) is one of the common malignances in the world and has high mortality in part due to development of acquired drug resistance. Therefore, it is urgent to investigate the molecular mechanism of ...
    • Chemosensory Cues to Conspecific Emotional Stress Activate Amygdala in Humans 

      Mujica-Parodi, Lilianne R.; Strey, Helmut H.; Frederick, Blaise DeBonneval; Savoy, Robert L.; Cox, David; Botanov, Yevgeny; Tolkunov, Denis; Rubin, Denis; Weber, Jochen (Public Library of Science, 2009)
      Alarm substances are airborne chemical signals, released by an individual into the environment, which communicate emotional stress between conspecifics. Here we tested whether humans, like other mammals, are able to detect ...
    • Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors 

      Chong, Curtis Robert; Wirth, Lori Julin; Nishino, Mizuki; Chen, Aileen Betty; Sholl, Lynette Marie; Kulke, Matthew H; McNamee, Ciaran; Janne, Pasi Antero; Johnson, Bruce Evan (Elsevier BV, 2014)
      Objectives The optimal management of locally advanced and metastatic pulmonary carcinoid tumors remains to be determined. Materials and methods A retrospective review was conducted on patients with typical and ...
    • CHERISH (collaboration for hospitalised elders reducing the impact of stays in hospital): protocol for a multi-site improvement program to reduce geriatric syndromes in older inpatients 

      Mudge, Alison M.; Banks, Merrilyn D.; Barnett, Adrian G.; Blackberry, Irene; Graves, Nicholas; Green, Theresa; Harvey, Gillian; Hubbard, Ruth E.; Inouye, Sharon K.; Kurrle, Sue; Lim, Kwang; McRae, Prue; Peel, Nancye M.; Suna, Jessica; Young, Adrienne M. (BioMed Central, 2017)
      Background: Older inpatients are at risk of hospital-associated geriatric syndromes including delirium, functional decline, incontinence, falls and pressure injuries. These contribute to longer hospital stays, loss of ...
    • Cherubism: Best Clinical Practice 

      Papadaki, Maria E; Lietman, Steven A; Levine, Michael A.; Olsen, Bjorn Reino; Kaban, Leonard B.; Reichenberger, Ernst J (BioMed Central, 2012)
      Cherubism is a skeletal dysplasia characterized by bilateral and symmetric fibro-osseous lesions limited to the mandible and maxilla. In most patients, cherubism is due to dominant mutations in the SH3BP2 gene on chromosome ...