Now showing items 13812-13831 of 17917

    • R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids 

      Bishay, Philipp; Schmidt, Helmut; Marian, Claudiu; Häussler, Annett; Wijnvoord, Nina; Ziebell, Simone; Metzner, Julia; Koch, Marco; Myrczek, Thekla; Bechmann, Ingo; Kuner, Rohini; Dehghani, Faramarz; Geisslinger, Gerd; Tegeder, Irmgard; Costigan, Michael (Public Library of Science, 2010)
      Background: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still ...
    • R5 Clade C SHIV Strains with Tier 1 or 2 Neutralization Sensitivity: Tools to Dissect Env Evolution and to Develop AIDS Vaccines in Primate Models 

      Wassermann, Klemens J.; Song, Ruijiang; Wang, Wendy; Kramer, Victor G.; Novembre, Francis J.; Villinger, François; Else, James G.; Montefiori, David C.; Watkins, Jennifer D; Siddappa, Nagadenahalli B.; Lakhashe, Samir; Santosuosso, Michael Robert; Poznansky, Mark; Rasmussen, Robert Anthony; Ruprecht, Ruth Margrit (Public Library of Science, 2010)
      Background: HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but have proved difficult to elicit. Although some current ...
    • The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation 

      Luo, Man-Li; Gong, Chang; Chen, Chun-Hau; Hu, Hai; Huang, Pengyu; Zheng, Min; Yao, Yandan; Wei, Shuo; Wulf, Gerburg; Lieberman, Judy; Zhou, Xiao Zhen; Song, Erwei; Lu, Kun Ping (2015)
      SUMMARY Proline-directed phosphorylation is regulated by the prolyl isomerase Pin1, which plays a fundamental role in driving breast cancer stem-like cells (BCSCs). Rab2A is a small GTPase critical for vesicle trafficking. ...
    • The RAB39B p.G192R mutation causes X-linked dominant Parkinson’s disease 

      Mata, Ignacio F.; Jang, Yongwoo; Kim, Chun-Hyung; Hanna, David S.; Dorschner, Michael O.; Samii, Ali; Agarwal, Pinky; Roberts, John W.; Klepitskaya, Olga; Shprecher, David R.; Chung, Kathryn A.; Factor, Stewart A.; Espay, Alberto J.; Revilla, Fredy J.; Higgins, Donald S.; Litvan, Irene; Leverenz, James B.; Yearout, Dora; Inca-Martinez, Miguel; Martinez, Erica; Thompson, Tiffany R.; Cholerton, Brenna A.; Hu, Shu-Ching; Edwards, Karen L.; Kim, Kwang-Soo; Zabetian, Cyrus P. (BioMed Central, 2015)
      Objective: To identify the causal gene in a multi-incident U.S. kindred with Parkinson’s disease (PD). Methods: We characterized a family with a classical PD phenotype in which 7 individuals (5 males and 2 females) were ...
    • A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair 

      Encarnação, Marisa; Espada, Lília; Escrevente, Cristina; Mateus, Denisa; Ramalho, José; Michelet, Xavier; Santarino, Inês; Hsu, Victor W.; Brenner, Michael B.; Barral, Duarte C.; Vieira, Otília V. (The Rockefeller University Press, 2016)
      Lysosome exocytosis plays a major role in resealing plasma membrane (PM) disruptions. This process involves two sequential steps. First, lysosomes are recruited to the periphery of the cell and then fuse with the damaged ...
    • RabGDI Controls Axonal Midline Crossing by Regulating Robo1 Surface Expression 

      Philipp, Melanie; Niederkofler, Vera; Debrunner, Marc; Alther, Tobias; Kunz, Beat; Stoeckli, Esther T (BioMed Central, 2012)
      Background: Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from ...
    • Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body 

      Piccinotti, Silvia; Whelan, Sean P. J. (Public Library of Science, 2016)
      The single glycoprotein (G) of rabies virus (RABV) dictates all viral entry steps from receptor engagement to membrane fusion. To study the uptake of RABV into primary neuronal cells in culture, we generated a recombinant ...
    • Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6 

      Parkhitko, А.А.; Favorova, О.О.; Henske, Elizabeth Petri (A.I. Gordeyev, 2011)
      The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that in association with Raptor, mLST8, PRAS40 and Deptor forms a complex (mTORC1) playing the key role in the regulation of protein biosynthesis, ...
    • Rac GTPases in Human Diseases 

      Pai, Sung-Yun; Kim, Chaekyun; Williams, David A. (IOS Press, 2010)
      Rho GTPases are members of the Ras superfamily of GTPases that regulate a wide variety of cellular functions. While Rho GTPase pathways have been implicated in various pathological conditions in humans, to date coding ...
    • Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss 

      Cizmecioglu, Onur; Ni, Jing; Xie, Shaozhen; Zhao, Jean J; Roberts, Thomas M (eLife Sciences Publications, Ltd, 2016)
      We aimed to understand how spatial compartmentalization in the plasma membrane might contribute to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110α and p110β. We found that p110β ...
    • Race Differences in the Association between Multivitamin Exposure and Wheezing in Preterm Infants 

      Hibbs, Anna Maria; Babineau, Denise C.; Wang, Xuelei; Redline, Susan (2014)
      Objective: We aimed to determine whether vitamin D exposure, as estimated by use of multivitamins, is positively or negatively associated with recurrent wheezing in infants born preterm. Study Design This prospective cohort ...
    • Race to the Top: evaluation of a novel performance-based financing initiative to promote healthcare delivery in rural Rwanda 

      Nahimana, Evrard; McBain, Ryan; Manzi, Anatole; Iyer, Hari; Uwingabiye, Alice; Gupta, Neil; Muzungu, Gerald; Drobac, Peter; Hirschhorn, Lisa R. (Co-Action Publishing, 2016)
      Background: Performance-based financing (PBF) has demonstrated a range of successes and failures in improving health outcomes across low- and middle-income countries. Evidence indicates that the success of PBF depends, in ...
    • Race-Ethnic Differences in the Association of Genetic Loci with HbA1c levels and Mortality in U.S. Adults: The Third National Health and Nutrition Examination Survey (NHANES III) 

      Grimsby, Jonna L; Porneala, Bianca C; Yang, Quanhe; Dupuis, Josée; Liu, Tiebin; Yesupriya, Ajay; Chang, Man-Huei; Ned, Renee M; Dowling, Nicole F; Khoury, Muin J; Vassy, Jason Lyell; Florez, Jose Carlos; Meigs, James Benjamin (BioMed Central, 2012)
      Background: Hemoglobin A1c (HbA1c) levels diagnose diabetes, predict mortality and are associated with ten single nucleotide polymorphisms (SNPs) in white individuals. Genetic associations in other race groups are not ...
    • Race/Ethnicity, Educational Attainment, and Pregnancy Complications in New York City Women with Pre-existing Diabetes 

      James-Todd, Tamarra; Janevic, Teresa; Brown, Florence M; Savitz, David A (John Wiley & Sons Ltd, 2013)
      Background: More women are entering pregnancy with pre-existing diabetes. Disease severity, glycaemic control, and predictors of pregnancy complications may differ by race/ethnicity or educational attainment, leading to ...
    • Race/ethnicity, socioeconomic status, and ALS mortality in the United States 

      Roberts, Andrea L.; Johnson, Norman J.; Chen, Jarvis T.; Cudkowicz, Merit E.; Weisskopf, Marc G. (Lippincott Williams & Wilkins, 2016)
      Objective: To determine whether race/ethnicity and socioeconomic status are associated with amyotrophic lateral sclerosis (ALS) mortality in the United States. Methods: The National Longitudinal Mortality Study (NLMS), a ...
    • Racial and ethnic variations in phthalate metabolite concentration changes across full-term pregnancies 

      James-Todd, Tamarra; Meeker, John D; Huang, Tianyi; Hauser, Russ B.; Seely, Ellen Wells; Ferguson, Kelly K; Rich-Edwards, Janet Wilson; McElrath, Thomas Frederick (Nature Publishing Group, 2016)
      Higher concentrations of certain phthalate metabolites are associated with adverse reproductive and pregnancy outcomes, as well as poor infant/child health outcomes. In non-pregnant populations, phthalate metabolite ...
    • Racial and Geographic Disparities in Interhospital ICU Transfers 

      Tyler, Patrick; Stone, David J.; Geisler, Benjamin; McLennan, Stuart; Celi, Leo Anthony; Rush, Barret; tyler, patrick (Ovid Technologies (Wolters Kluwer Health), 2018-01)
      Objective—Inter-hospital transfer (IHT), a common intervention, may be subject to healthcare disparities. In mechanically ventilated patients with sepsis, we hypothesize that disparities not disease-related would be found ...
    • Racial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c 

      Edelstein, Leonard C.; Simon, Lukas M.; Montoya, Raúl Teruel; Holinstat, Michael; Chen, Edward S.; Bergeron, Angela; Kong, Xianguo; Nagalla, Srikanth; Mohandas, Narla; Cohen, David E.; Dong, Jing-fei; Shaw, Chad; Bray, Paul F. (2013)
      Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. PAR4 thrombin receptor ...
    • Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins 

      Wang, Liyun; Sacks, Frank M; Furtado, Jeremy D; Ricks, Madia; Courville, Amber B; Sumner, Anne E (BioMed Central, 2014)
      Background: African-Americans have higher HDL, less visceral adipose tissue (VAT) and lower triglyceride (TG) and apoCIII concentrations than whites, despite being more insulin-resistant. We studied in African-American and ...
    • Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study 

      Gupta, Deepak K; Claggett, Brian; Wells, Quinn; Cheng, Susan; Li, Man; Maruthur, Nisa; Selvin, Elizabeth; Coresh, Josef; Konety, Suma; Butler, Kenneth R; Mosley, Thomas; Boerwinkle, Eric; Hoogeveen, Ron; Ballantyne, Christie M; Solomon, Scott D (John Wiley & Sons, Ltd, 2015)
      Background: Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African ...