Browsing HMS Scholarly Articles by Title
Now showing items 10752-10771 of 17918
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Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression
(Public Library of Science, 2015)Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and ... -
Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes
(Springer Berlin Heidelberg, 2014)Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to its immunomodulatory effects on both the innate and the adaptive immune ... -
MoH+: A Global, Integrated, and Automated View of Official Outbreak Reporting
(University of Illinois at Chicago Library, 2013)Objective: To introduce MoH+, HealthMap’s (HM) real-time feed of official government sources, and demonstrate its utility in comparing the timeliness of outbreak reporting between official and unofficial sources. Introduction: ... -
MolBioLib: A C++11 Framework for Rapid Development and Deployment of Bioinformatics Tasks
(Oxford University Press, 2012)Summary: We developed MolBioLib to address the need for adaptable next-generation sequencing analysis tools. The result is a compact, portable and extensively tested C++11 software framework and set of applications tailored ... -
Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1
(Public Library of Science, 2013)The prostanoid prostacyclin, or prostaglandin I2, plays an essential role in many aspects of cardiovascular disease. The actions of prostacyclin are mainly mediated through its activation of the prostacyclin receptor or, ... -
A Molecular Approach to the Sexing of the Triple Burial at the Upper Paleolithic Site of Dolní Věstonice
(Public Library of Science, 2016)In the past decades ancient DNA research has brought numerous insights to archaeological research where traditional approaches were limited. The determination of sex in human skeletal remains is often challenging for ... -
Molecular architecture of the complete COG tethering complex
(2016)The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG ... -
Molecular architecture of the vesicular stomatitis virus RNA polymerase
(National Academy of Sciences, 2010)Nonsegmented negative-strand (NNS) RNA viruses initiate infection by delivering into the host cell a highly specialized RNA synthesis machine comprising the genomic RNA completely encapsidated by the viral nucleocapsid ... -
Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival
(American Society for Microbiology, 2002) -
Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism
(2016)Inflammasomes are cytosolic caspase-1 activation complexes that sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic interactions by Pyrin domains (PYD) and ... -
Molecular basis of ion permeability in a voltage‐gated sodium channel
(John Wiley and Sons Inc., 2016)Abstract Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events ... -
Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea
(Public Library of Science, 2013)Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between ... -
Molecular characterization and quantification using state of the art solid-state adiabatic TOBSY NMR in burn trauma
(D.A. Spandidos, 2009)We describe a novel solid-state nuclear magnetic resonance (NMR) method that maximizes the advantages of high-resolution magic-angle-spinning (HRMAS), relative conventional liquid-state NMR approaches, when applied to ... -
Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance
(Elsevier, 2014)Advances in nanotechnology and microfluidics are enabling the analysis of small amounts of human cells. We tested whether recently developed micro-nuclear magnetic resonance (mu NMR) technology could be leveraged for ... -
Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala
(Nature Publishing Group, 2016)Molecular characterization of neuron populations, particularly those controlling threat responses, is essential for understanding the cellular basis of behaviour and identifying pharmacological agents acting selectively ... -
Molecular Cochaperones: Tumor Growth and Cancer Treatment
(Hindawi Publishing Corporation, 2013)Molecular chaperones play important roles in all cellular organisms by maintaining the proteome in an optimally folded state. They appear to be at a premium in cancer cells whose evolution along the malignant pathways ... -
Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome
(American Society of Microbiology, 2015)ABSTRACT Vibrionaceae family members are interesting models for studying DNA replication initiation, as they contain two circular chromosomes. Chromosome II (chrII) replication is governed by two evolutionarily unique yet ... -
Molecular driver alterations and their clinical relevance in cancer of unknown primary site
(Impact Journals LLC, 2016)Cancer of unknown primary (CUP) is defined as metastatic solid malignancy where no primary tumor is detected despite appropriate staging. About 90% of CUP represent adenocarcinoma or undifferentiated carcinoma. Since therapy ... -
Molecular Etiology of Hearing Impairment in Inner Mongolia: Mutations in SLC26A4 Gene and Relevant Phenotype Analysis
(BioMed Central, 2008)Background: The molecular etiology of hearing impairment in Chinese has not been thoroughly investigated. Study of GJB2 gene revealed that 30.4% of the patients with hearing loss in Inner Mongolia carried GJB2 mutations. ...