Browsing HMS Scholarly Articles by Title

Now showing items 11142-11161 of 17922

    • Myelin: Dynamic or Stable? 

      Uzman, Betty G.; Hedley-Whyte, E. Tessa (Rockefeller University Press, 1968)

    • Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance 

      Mauer, Jan; Chaurasia, Bhagirath; Plum, Leona; Quast, Thomas; Hampel, Brigitte; Blüher, Matthias; Kolanus, Waldemar; Kahn, C. Ronald; Brüning, Jens C. (Public Library of Science, 2010)
      A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory ...

    • Myeloid Zinc Finger 1 (Mzf1) Differentially Modulates Murine Cardiogenesis by Interacting with an Nkx2.5 Cardiac Enhancer 

      Doppler, Stefanie A.; Werner, Astrid; Barz, Melanie; Lahm, Harald; Deutsch, Marcus-André; Dreßen, Martina; Schiemann, Matthias; Voss, Bernhard; Gregoire, Serge; Kuppusamy, Rajarajan; Wu, Sean M.; Lange, Rüdiger; Krane, Markus (Public Library of Science, 2014)
      Vertebrate heart development is strictly regulated by temporal and spatial expression of growth and transcription factors (TFs). We analyzed nine TFs, selected by in silico analysis of an Nkx2.5 enhancer, for their ability ...

    • Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial 

      Morrow, David Andrew; Wang, Yunmei; Croce, Kevin James; Sakuma, Masashi; Sabatine, Marc Steven; Gao, Huiyun; Pradhan, Aruna Das; Healy, Aileen M.; Buros, Jacki; McCabe, Carolyn; Libby, Peter; Cannon, Christopher Paul; Braunwald, Eugene; Simon, Daniel I. (Elsevier BV, 2008)
      Background Using a transcriptional profiling approach, we recently identified myeloid-related protein 8/14 (MRP-8/14) to be expressed by platelets during acute myocardial infarction (MI). Elevated concentrations of MRP-8/14 ...

    • Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation 

      Sarraj, Bara; Massberg, Steffen; Li, Yitang; Kasorn, Anongnard; Subramanian, Kulandayan; Loison, Fabien; Silberstein, Leslie E.; von Andrian, Ulrich H.; Luo, Hongbo (American Association of Immunologists, 2014-11-04)
      Phosphatidylinositol 3,4,5-trisphosphate \((PIP_3)\) is a second messenger that is involved in a number of cell activities including cell growth, proliferation, and motility. \(PIP_3\) is produced by PI3K and regulated by ...

    • Myeloperoxidase to Risk Stratify Emergency Department Patients with Chest Pain 

      Manini, Alex F.; McAfee, Andrew T.; Noble, Vicki E.; Bohan, J. Stephen (Master Publishing Group, 2009)
      Previous studies suggest that serum myeloperoxidase (MPO) is a potentially useful biomarker to risk stratify troponin-negative patients with suspected myocardial ischemia. We hypothesized that the relationship between ...

    • Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice 

      Swirski, Filip K.; Wildgruber, Moritz; Ueno, Takuya; Figueiredo, Jose-Luiz; Panizzi, Peter; Iwamoto, Yoshiko; Zhang, Elizabeth; Stone, James R.; Rodriguez, Elisenda; Chen, John W.; Pittet, Mikael J.; Weissleder, Ralph; Nahrendorf, Matthias (American Society for Clinical Investigation, 2010)
      Rates of graft rejection are high among recipients of heart transplants. The onset and progression of clinically significant heart transplant rejection are currently monitored by serial biopsy, but this approach is highly ...

    • Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study 

      Derumeaux, G.; Ichinose, Fumito; Raher, M. J.; Morgan, J. G.; Coman, T.; Lee, C.; Cuesta, J. M.; Thibault, H.; Bloch, K. D.; Picard, Michael Howard; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background: Aging is accompanied by an alteration in myocardial contractility. However, its noninvasive detection is difficult. The effect of chronic exercise on this decrease is unknown. Murine models of senescence are ...

    • Myocardial clearance of technetium-99m-teboroxime in reperfused injured canine myocardium 

      Okada, David R; Johnson, Gerald; Okada, Robert D (Springer, 2014)
      Background: Recent technical developments using solid-state technology have enabled rapid image acquisition with single photon emission computed tomography (SPECT) and have led to a renewed interest in technetium-99m-teboroxime ...

    • Myocardial Defect Detection Using PET-CT: Phantom Studies 

      Mananga, Eugene S.; El Fakhri, Georges; Schaefferkoetter, Joshua; Bonab, Ali A.; Ouyang, Jinsong (Public Library of Science, 2014)
      It is expected that both noise and activity distribution can have impact on the detectability of a myocardial defect in a cardiac PET study. In this work, we performed phantom studies to investigate the detectability of a ...

    • Myocardial Hypertrophy Overrides the Angiogenic Response to Hypoxia 

      Choi, Yeong-Hoon; Poutias, Dimitrios; Stamm, Christof; Cowan, Douglas Burr; Nathan, Meena; Del Nido, Pedro J.; McGowan, Francis Xavier (Public Library of Science, 2008)
      Background: Cyanosis and myocardial hypertrophy frequently occur in combination. Hypoxia or cyanosis can be potent inducers of angiogenesis, regulating the expression of hypoxia-inducible factors (HIF), vascular endothelial ...

    • Myocardial infarct delineation in vivo using diffusion tensor MRI and the tractographic propagation angle 

      Mekkaoui, Choukri; Huang, Shuning; Dai, Guangping; Reese, Timothy G.; Ruskin, Jeremy Neil; Hoffmann, Udo; Jackowski, Marcel P; Sosnovik, David E. (BioMed Central, 2013)

    • Myocardial Infarction Accelerates Atherosclerosis 

      Leuschner, Florian; Robbins, Clinton; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T.; Chicoine, Adam T.; van der Laan, Anja M.; Niessen, Hans W.M.; Piek, Jan J.; Rubin, Barry B.; Butany, Jagdish; Katus, Hugo A.; Murphy, Sabina A.; Pittet, Mikael J.; Lin, Charles P.; Dutta, Partha; Courties, Gabriel P; Wei, Ying; Gorbatov, Rostic; Majmudar, Maulik D; Stone, James Robert; Morrow, David Andrew; Sabatine, Marc Steven; Vinegoni, Claudio; Moskowitz, Michael Arthur; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Nature Publishing Group, 2012)
      During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...

    • Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells 

      Dutta, Partha; Sager, Hendrik B; Stengel, Kristy R.; Naxerova, Kamila; Courties, Gabriel P; Saez, Borja; Silberstein, Lev; Heidt, Timo; Sebas, Matthew; Sun, Yuan; Wojtkiewicz, Gregory; Feruglio, Paolo Fumene; King, Kevin Robert; Baker, Joshua N.; van der Laan, Anja M.; Borodovsky, Anna; Fitzgerald, Kevin; Hulsmans, Maarten; Hoyer, Friedrich Felix; Iwamoto, Yoshiko; Vinegoni, Claudio; Brown, Dennis; Di Carli, Marcelo; Libby, Peter; Hiebert, Scott W.; Scadden, David Thomas; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Elsevier BV, 2015)
      Following myocardial infarction (MI), myeloid cells derived from the hematopoietic system drive a sharp increase in systemic leukocyte levels that correlates closely with mortality. The origin of these myeloid cells, and ...

    • Myocardial Tissue Remodeling in Adolescent Obesity 

      Shah, Ravi V.; Abbasi, Siddique A.; Neilan, Tomas G.; Hulten, Edward; Coelho‐Filho, Otavio; Hoppin, Alison; Levitsky, Lynne; de Ferranti, Sarah; Rhodes, Erinn T.; Traum, Avram; Goodman, Elizabeth; Feng, Henry; Heydari, Bobak; Harris, William S.; Hoefner, Daniel M.; McConnell, Joseph P.; Seethamraju, Ravi; Rickers, Carsten; Kwong, Raymond Y.; Jerosch‐Herold, Michael (Blackwell Publishing Ltd, 2013)
      Background: Childhood obesity is a significant risk factor for cardiovascular disease in adulthood. Although ventricular remodeling has been reported in obese youth, early tissue‐level markers within the myocardium that ...

    • Myocarditis in CD8-Depleted SIV-Infected Rhesus Macaques after Short-Term Dual Therapy with Nucleoside and Nucleotide Reverse Transcriptase Inhibitors 

      Annamalai, Lakshmanan; Westmoreland, Susan V.; Domingues, Heber; Walsh, Dennis G.; Gonzalez, Ramon Gilberto; O'Neil, Shawn P. (Public Library of Science, 2010)
      Background: Although highly active antiretroviral therapy (HAART) has dramatically reduced the morbidity and mortality associated with HIV infection, a number of antiretroviral toxicities have been described, including ...

    • Myofibroblast-Derived SFRP1 as Potential Inhibitor of Colorectal Carcinoma Field Effect 

      Valcz, Gábor; Patai, Árpád V.; Kalmár, Alexandra; Péterfia, Bálint; Fűri, István; Wichmann, Barnabás; Műzes, Györgyi; Sipos, Ferenc; Krenács, Tibor; Mihály, Emese; Spisák, Sándor; Molnár, Béla; Tulassay, Zsolt (Public Library of Science, 2014)
      Epigenetic changes of stromal-epithelial interactions are of key importance in the regulation of colorectal carcinoma (CRC) cells and morphologically normal, but genetically and epigenetically altered epithelium in normal ...

    • Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma 

      Tenente, Inês M; Hayes, Madeline N; Ignatius, Myron S; McCarthy, Karin; Yohe, Marielle; Sindiri, Sivasish; Gryder, Berkley; Oliveira, Mariana L; Ramakrishnan, Ashwin; Tang, Qin; Chen, Eleanor Y; Petur Nielsen, G; Khan, Javed; Langenau, David M (eLife Sciences Publications, Ltd, 2017)
      Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely ...

    • Myosin Va Plays a Role in Nitrergic Smooth Muscle Relaxation in Gastric Fundus and Corpora Cavernosa of Penis 

      Chaudhury, Arun; Cristofaro, Vivian; Carew, Josephine A.; Goyal, Raj K.; Sullivan, Maryrose P. (Public Library of Science, 2014)
      The intracellular motor protein myosin Va is involved in nitrergic neurotransmission possibly by trafficking of neuronal nitric oxide synthase (nNOS) within the nerve terminals. In this study, we examined the role of myosin ...

    • Myosin-II controls cellular branching morphogenesis and migration in 3D by minimizing cell surface curvature 

      Elliott, Hunter; Fischer, Robert A.; Myers, Kenneth A.; Desai, Ravi A.; Gao, Lin; Chen, Christopher S.; Adelstein, Robert; Waterman, Clare M.; Danuser, Gaudenz (2014)
      In many cases cell function is intimately linked to cell shape control. We utilized endothelial cell branching morphogenesis as a model to understand the role of myosin-II in shape control of invasive cells migrating in ...