Browsing HMS Scholarly Articles by Title

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    • Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not So Different After All! 

      Sebastiani, Paola; Solovieff, Nadia; Sun, Jenny X. (Frontiers Research Foundation, 2012)
      One of the most popular modeling approaches to genetic risk prediction is to use a summary of risk alleles in the form of an unweighted or a weighted genetic risk score, with weights that relate to the odds for the phenotype ...

    • Naïve-like conversion enhances the difference in innate in vitro differentiation capacity between rabbit ES cells and iPS cells 

      HONSHO, Kimiko; HIROSE, Michiko; HATORI, Masanori; YASMIN, Lubna; IZU, Haruna; MATOBA, Shogo; TOGAYACHI, Sumie; MIYOSHI, Hiroyuki; SANKAI, Tadashi; OGURA, Atsuo; HONDA, Arata (The Society for Reproduction and Development, 2015)
      Quality evaluation of pluripotent stem cells using appropriate animal models needs to be improved for human regenerative medicine. Previously, we demonstrated that although the in vitro neural differentiating capacity of ...

    • The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations 

      Keane, Michael; Craig, Thomas; Alföldi, Jessica; Berlin, Aaron M.; Johnson, Jeremy; Seluanov, Andrei; Gorbunova, Vera; Di Palma, Federica; Lindblad-Toh, Kerstin; Church, George M.; de Magalhães, João Pedro (Oxford University Press, 2014)
      Motivation: The naked mole rat (Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent native to East Africa. Although its genome was previously sequenced, here we report a new assembly sequenced ...

    • The Naked Mole Rat Genome: Understanding Aging through Genome Analysis 

      Gladyshev, Vadim N.; Zhang, Guojie; Wang, Jun (Impact Journals, 2011)

    • NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis 

      Yang, Siyoung; Ryu, Je-Hwang; Oh, Hwanhee; Jeon, Jimin; Kwak, Ji-Sun; Kim, Jin-Hong; Kim, Hyun Ah; Chun, Churl-Hong; Chun, Jang-Soo (BMJ Publishing Group, 2015)
      Objective: Hypoxia-inducible factor 2α (HIF-2α), encoded by Epas1, causes osteoarthritic cartilage destruction by regulating the expression of matrix-degrading enzymes. We undertook this study to explore the role of ...

    • Nanodrug-Enhanced Radiofrequency Tumor Ablation: Effect of Micellar or Liposomal Carrier on Drug Delivery and Treatment Efficacy 

      Moussa, Marwan; Goldberg, S. Nahum; Kumar, Gaurav; Sawant, Rupa R.; Levchenko, Tatyana; Torchilin, Vladimir P.; Ahmed, Muneeb (Public Library of Science, 2014)
      Purpose To determine the effect of different drug-loaded nanocarriers (micelles and liposomes) on delivery and treatment efficacy for radiofrequency ablation (RFA) combined with nanodrugs. Materials/Methods Fischer 344 ...

    • Nanog-Independent Reprogramming to iPSCs with Canonical Factors 

      Carter, Ava C.; Davis-Dusenbery, Brandi N.; Koszka, Kathryn; Ichida, Justin K.; Eggan, Kevin (Elsevier, 2014)
      Summary It has been suggested that the transcription factor Nanog is essential for the establishment of pluripotency during the derivation of embryonic stem cells and induced pluripotent stem cells (iPSCs). However, ...

    • Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury 

      Chung, Hyun Jung; Pellegrini, Kathryn L.; Chung, Jaehoon; Wanigasuriya, Kamani; Jayawardene, Innocent; Lee, Kyungheon; Lee, Hakho; Vaidya, Vishal S.; Weissleder, Ralph (Public Library of Science, 2015)
      The high incidence of acute and chronic kidney injury due to various environmental factors such as heavy metals or chemicals has been a major problem in developing countries. However, the diagnosis of kidney injury in these ...

    • Nanoparticle Imaging of Integrins on Tumor Cells 

      Montet, Xavier; Montet-Abou, Karin; Reynolds, Fred; Weissleder, Ralph; Josephson, Lee (Elsevier, 2006)
      Nanoparticles 10 to 100 nm in size can deliver large payloads to molecular targets, but undergo slow diffusion and/or slow transport through delivery barriers. To examine the feasibility of nanoparticles targeting a marker ...

    • Nanoparticle Mediated Measurement of Target-Drug Binding in Cancer Cells 

      Ullal, Adeeti V.; Reiner, Thomas; Yang, Katherine S.; Gorbatov, Rostic; Min, Changwook; Issadore, David; Lee, Hakho; Weissleder, Ralph (American Chemical Society, 2011)
      Responses to molecularly targeted therapies can be highly variable and depend on mutations, fluctuations in target protein levels In individual cells, and drug delivery. The ability to rapidly quantitate drug response in ...

    • Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy 

      Kunjachan, Sijumon; Detappe, Alexandre; Kumar, Rajiv; Ireland, Thomas; Cameron, Lisa; Biancur, Douglas E.; Motto-Ros, Vincent; Sancey, Lucie; Sridhar, Srinivas; Makrigiorgos, Gerassimos M.; Berbeco, Ross I. (American Chemical Society (ACS), 2015)
      More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using ...

    • Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis 

      Nahrendorf, Matthias; Zhang, Hanwen; Hembrador, Sheena; Panizzi, Peter; Sosnovik, David E.; Aikawa, Elena; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph (American Heart Association, 2008)
      Background-Macrophages participate centrally in atherosclerosis, and macrophage markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation. On the basis of the avidity of lesional macrophages ...

    • Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche 

      Krohn-Grimberghe, Marvin; Mitchell, Michael J.; Schloss, Maximilian J.; Khan, Omar F.; Courties, Gabriel; Guimaraes, Pedro P. G.; Rohde, David; Cremer, Sebastian; Kowalski, Piotr S.; Sun, Yuan; Tan, Mingchee; Webster, Jamie; Wang, Karin; Iwamoto, Yoshiko; Schmidt, Stephen P.; Wojtkiewicz, Gregory R.; Nayar, Ribhu; Frodermann, Vanessa; Hulsmans, Maarten; Chung, Amanda; Hoyer, Friedrich Felix; Swirski, Filip K.; Langer, Robert; Anderson, Daniel G.; Nahrendorf, Matthias (Springer Science and Business Media LLC, 2020-10-05)
      Bone marrow hematopoietic stem and progenitor cells (HSPC) give rise to billions of blood cells every day. Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulates HSC maintenance and blood ...

    • Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice 

      Bogorad, Roman L; Yin, Hao; Zeigerer, Anja; Nonaka, Hidenori; Ruda, Vera; Zerial, Marino; Anderson, Daniel G; Koteliansky, Victor (2014)
      Integrins play an important role during development, regulating cell differentiation, proliferation and survival. Here we show that knockdown of integrin subunits slows down the progression of hepatocellular carcinoma ...

    • Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions 

      Koh, Isaac; Hong, Rui; Weissleder, Ralph; Josephson, Lee (American Chemical Society, 2009)
      Magnetic particles can act as magnetic relaxation switches (MRSVs) when they bind to target analytes, and switch between their dispersed and aggregated states resulting in changes in the spin-spin relaxation time (T(2)) ...

    • Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis 

      Zhang, Xue-Qing; Even-Or, Orli; Xu, Xiaoyang; van Rosmalen, Mariska; Lim, Lucas; Gadde, Suresh; Farokhzad, Omid Cameron; Fisher, Edward A. (Wiley-Blackwell, 2014)
      Liver X receptor (LXR) signaling pathways regulate lipid metabolism and inflammation, which has generated widespread interest in developing synthetic LXR agonists as potential therapeutics for the management of atherosclerosis. ...

    • Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma 

      Verma, Jyoti; Lal, Sumit; Van Noorden, Cornelis JF (Dove Medical Press, 2014)
      Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel ...

    • Nanoparticles for the Optical Imaging of Tumor selectin 

      Funovics, Martin; Montet, Xavier; Reynolds, Fred; Weissleder, Ralph; Josephson, Lee (Elsevier, 2005)

    • Nanoparticles That Sense Thrombin Activity As Synthetic Urinary Biomarkers of Thrombosis 

      Lin, Kevin Y.; Kwong, Gabriel A.; Warren, Andrew D.; Wood, David K.; Bhatia, Sangeeta N. (American Chemical Society, 2013)
      Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with numerous diseases such ...

    • Nanoparticles with photoinduced precipitation for the extraction of pollutants from water and soil 

      Brandl, Ferdinand; Bertrand, Nicolas; Lima, Eliana Martins; Langer, Robert (Nature Pub. Group, 2015)
      Nanotechnology may offer fast and effective solutions for environmental clean-up. Herein, amphiphilic diblock copolymers are used to develop a platform of photosensitive core-shell nanoparticles. Irradiation with ultraviolet ...