Now showing items 11440-11459 of 15601

    • Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes 

      Poutiainen, Pekka; Jaronen, Merja; Quintana, Francisco J.; Brownell, Anna-Liisa (Frontiers Media S.A., 2016)
      Non-invasive molecular imaging techniques can enhance diagnosis to achieve successful treatment, as well as reveal underlying pathogenic mechanisms in disorders such as multiple sclerosis (MS). The cooperation of advanced ...
    • The Precision of Axon Targeting of Mouse Olfactory Sensory Neurons Requires the BACE1 Protease 

      Cao, Luxiang; Rickenbacher, Gregory T.; Rodriguez, Steven; Moulia, Thomas W.; Albers, Mark W. (Nature Publishing Group, 2012)
      The \(\beta\)-site amyloid precursor protein cleaving enzyme 1 (BACE1) is necessary to generate the A\(\beta\) peptide, which is implicated in Alzheimer's disease pathology. Studies show that the expression of BACE1 and ...
    • Precision of radiostereometric analysis (RSA) of acetabular cup stability and polyethylene wear improved by adding tantalum beads to the liner 

      Nebergall, Audrey K; Rader, Kevin; Palm, Henrik; Malchau, Henrik; Greene, Meridith E (Informa Healthcare, 2015)
      Background and purpose In traditional radiostereometric analysis (RSA), 1 segment defines both the acetabular shell and the polyethylene liner. However, inserting beads into the polyethylene liner permits employment of the ...
    • Preclinical activity of selinexor, an inhibitor of XPO1, in sarcoma 

      Nakayama, Robert; Zhang, Yi-Xiang; Czaplinski, Jeffrey T.; Anatone, Alex J.; Sicinska, Ewa T.; Fletcher, Jonathan A.; Demetri, George D.; Wagner, Andrew J. (Impact Journals LLC, 2016)
      Selinexor is an orally bioavailable selective inhibitor of nuclear export that has been demonstrated to have preclinical activity in various cancer types and that is currently in Phase I and II clinical trials for advanced ...
    • The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder 

      Sahli, Zeyad T.; Banerjee, Pradeep; Tarazi, Frank I. (Taylor & Francis, 2016)
      ABSTRACT Introduction:: Major depressive disorder (MDD) is the leading cause of disability worldwide, and according to the STAR*D trial, only 33% of patients with MDD responded to initial drug therapy. Augmentation of the ...
    • Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection 

      Li, Xue; Wang, Xiaogang; Thompson, Christopher D.; Park, Saeyoung; Park, Wan Beom; Lee, Jean C. (American Society of Microbiology, 2016)
      ABSTRACT Treatment of Staphylococcus aureus infections has become increasingly difficult because of the emergence of multidrug-resistant isolates. Development of a vaccine to prevent staphylococcal infections remains a ...
    • Preclinical Evaluation of Efficacy and Safety of an Improved Lentiviral Vector for the Treatment of β-Thalassemia and Sickle Cell Disease 

      Negre, Olivier; Bartholomae, Cynthia; Beuzard, Yves; Cavazzana, Marina; Christiansen, Lauryn; Courne, Céline; Deichmann, Annette; Denaro, Maria; de Dreuzy, Edouard; Finer, Mitchell; Fronza, Raffaele; Béatrix, Gillet-Legrand; Joubert, Christophe; Kutner, Robert; Leboulch, Philippe; Maouche, Leïla; Paulard, Anaïs; Pierciey Jr., Francis J.; Rothe, Michael; Ryu, Byoung; Schmidt, Manfred; von Kalle, Christof; Payen, Emmanuel; Veres, Gabor (Bentham Science Publishers, 2015)
      A previously published clinical trial demonstrated the benefit of autologous CD34+ cells transduced with a self-inactivating lentiviral vector (HPV569) containing an engineered β-globin gene (βA-T87Q globin) in a subject ...
    • Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML 

      Huang, Ju; Liu, Yuanfeng; Au, Bryan C; Barber, Dwayne L; Arruda, Andrea; Schambach, Axel; Rothe, Michael; Minden, Mark D; Paige, Christopher J; Medin, Jeffrey A (Nature Publishing Group, 2016)
      Interleukin-12 (IL-12) is a potent cytokine that may be harnessed to treat cancer. To date, nearly 100 IL-12-based clinical trials have been initiated worldwide. Yet systemic administration of IL-12 is toxic. Different ...
    • Preconditioning of skeletal myoblast-based engineered tissue constructs enables functional coupling to myocardium in vivo 

      Treskes, Philipp; Neef, Klaus; Srinivasan, Sureshkumar Perumal; Halbach, Marcel; Stamm, Christof; Cowan, Douglas Burr; Scherner, Maximilian; Madershahian, Navid; Wittwer, Thorsten; Hescheler, Jürgen; Wahlers, Thorsten; Choi, Yeong-Hoon (Elsevier BV, 2015)
      Objective Skeletal myoblasts fuse to form functional syncytial myotubes as an integral part of the skeletal muscle. During this differentiation process, expression of proteins for mechanical and electrical integration is ...
    • Precordial S-T segment elevation mapping: An atraumatic method for assessing alterations in the extent of myocardial ischemic injury 

      Maroko, Peter R.; Libby, Peter; Covell, James W.; Sobel, Burton E.; Ross, John; Braunwald, Eugene (Elsevier BV, 1972)
      A noninvasive technique for evaluating the extent of myocardial ischemic injury after experimental coronary artery occlusion was devised and applied to study alterations in the extent of injury produced by hemodynamic and ...
    • Predicted neoantigen load in non-hypermutated endometrial cancers: Correlation with outcome and tumor-specific genomic alterations 

      Shukla, Sachet A.; Howitt, Brooke E.; Wu, Catherine J.; Konstantinopoulos, Panagiotis A. (Elsevier, 2017)
      Elevated neoantigen load has been previously correlated with improved outcome and response to immune checkpoint blockade in various tumor types. In endometrial cancer, previous studies of neoantigen load prediction have ...
    • Predicting ADHD by Assessment of Rutter’s Indicators of Adversity in Infancy 

      Østergaard, Søren D.; Larsen, Janne T.; Dalsgaard, Søren; Wilens, Timothy E.; Mortensen, Preben B.; Agerbo, Esben; Mors, Ole; Petersen, Liselotte (Public Library of Science, 2016)
      Background: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with early onset. ADHD is associated with significant morbidity and mortality, partly due to delayed diagnosis. ...
    • Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity 

      Majumder, Biswanath; Baraneedharan, Ulaganathan; Thiyagarajan, Saravanan; Radhakrishnan, Padhma; Narasimhan, Harikrishna; Dhandapani, Muthu; Brijwani, Nilesh; Pinto, Dency D.; Prasath, Arun; Shanthappa, Basavaraja U.; Thayakumar, Allen; Surendran, Rajagopalan; Babu, Govind K.; Shenoy, Ashok M.; Kuriakose, Moni A.; Bergthold, Guillaume; Horowitz, Peleg; Loda, Massimo; Beroukhim, Rameen; Agarwal, Shivani; Sengupta, Shiladitya; Sundaram, Mallikarjun; Majumder, Pradip K. (Nature Pub. Group, 2015)
      Predicting clinical response to anticancer drugs remains a major challenge in cancer treatment. Emerging reports indicate that the tumour microenvironment and heterogeneity can limit the predictive power of current ...
    • Predicting DNA methylation level across human tissues 

      Ma, Baoshan; Wilker, Elissa H.; Willis-Owen, Saffron A. G.; Byun, Hyang-Min; Wong, Kenny C. C.; Motta, Valeria; Baccarelli, Andrea A.; Schwartz, Joel; Cookson, William O. C. M.; Khabbaz, Kamal; Mittleman, Murray A.; Moffatt, Miriam F.; Liang, Liming (Oxford University Press, 2014)
      Differences in methylation across tissues are critical to cell differentiation and are key to understanding the role of epigenetics in complex diseases. In this investigation, we found that locus-specific methylation ...
    • Predicting episodic memory formation for movie events 

      Tang, Hanlin; Singer, Jed; Ison, Matias J.; Pivazyan, Gnel; Romaine, Melissa; Frias, Rosa; Meller, Elizabeth; Boulin, Adrianna; Carroll, James; Perron, Victoria; Dowcett, Sarah; Arellano, Marlise; Kreiman, Gabriel (Nature Publishing Group, 2016)
      Episodic memories are long lasting and full of detail, yet imperfect and malleable. We quantitatively evaluated recollection of short audiovisual segments from movies as a proxy to real-life memory formation in 161 subjects ...
    • Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: A combined ERP and DTI study 

      Whitford, Thomas; Kubicki, Marek R.; Ghorashi, Shahab; Schneiderman, Jason S.; Hawley, Kathryn J.; McCarley, Robert William; Shenton, Martha Elizabeth; Spencer, Kevin M. (Elsevier BV, 2011)
      Background—Several theories of schizophrenia have emphasized the role of aberrant neural timing in the etiology of the disease, possibly as a consequence of conduction delays caused by structural damage to the white-matter ...
    • Predicting Ligand-Binding Function in Families of Bacterial Receptors 

      Johnson, JM; Church, George McDonald (Proceedings of the National Academy of Sciences, 2000)
      The three-dimensional fold of a new protein sequence can often be inferred directly from sequence homology to a protein of known structure. The function of a new protein sequence is more difficult to predict, however, since ...
    • Predicting Mortality in Low-Income Country ICUs: The Rwanda Mortality Probability Model (R-MPM) 

      Riviello, Elisabeth D.; Kiviri, Willy; Fowler, Robert A.; Mueller, Ariel; Novack, Victor; Banner-Goodspeed, Valerie M.; Weinkauf, Julia L.; Talmor, Daniel S.; Twagirumugabe, Theogene (Public Library of Science, 2016)
      Introduction: Intensive Care Unit (ICU) risk prediction models are used to compare outcomes for quality improvement initiatives, benchmarking, and research. While such models provide robust tools in high-income countries, ...
    • Predicting Outcomes Over Time in Patients With Heart Failure, Left Ventricular Systolic Dysfunction, or Both Following Acute Myocardial Infarction 

      Lopes, Renato D.; Pieper, Karen S.; Stevens, Susanna R.; Solomon, Scott D.; McMurray, John J.V.; Pfeffer, Marc A.; Leimberger, Jeffrey D.; Velazquez, Eric J. (John Wiley and Sons Inc., 2016)
      Background: Most studies of risk assessment or stratification in patients with myocardial infarction (MI) have been static and fail to account for the evolving nature of clinical events and care processes. We sought to ...
    • Predicting Peptides Binding to MHC Class II Molecules Using Multi-objective Evolutionary Algorithms 

      Rajapakse, Menaka; Schmidt, Bertil; Feng, Lin; Brusic, Vladimir (BioMed Central, 2007)
      Background: Peptides binding to Major Histocompatibility Complex (MHC) class II molecules are crucial for initiation and regulation of immune responses. Predicting peptides that bind to a specific MHC molecule plays an ...