Now showing items 12319-12338 of 15603

    • Reconstitution of Peptidoglycan Cross-Linking Leads to Improved Fluorescent Probes of Cell Wall Synthesis 

      Lebar, Matthew D.; May, Janine M.; Meeske, Alexander J.; Leiman, Sara A.; Lupoli, Tania J.; Tsukamoto, Hirokazu; Losick, Richard; Rudner, David Z.; Walker, Suzanne; Kahne, Daniel (American Chemical Society, 2014)
      The peptidoglycan precursor, Lipid II, produced in the model Gram-positive bacterium Bacillus subtilis differs from Lipid II found in Gram-negative bacteria such as Escherichia coli by a single amidation on the peptide ...
    • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells 

      Suva, Mario Luca; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel David; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Rivera, Miguel Nicolas; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David N.; Bernstein, Bradley E. (Elsevier BV, 2014)
      Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies ...
    • Reconstructing Austronesian population history in Island Southeast Asia 

      Lipson, Mark; Loh, Po-Ru; Patterson, Nick; Moorjani, Priya; Ko, Ying-Chin; Stoneking, Mark; Berger, Bonnie; Reich, David (Nature Pub. Group, 2014)
      Austronesian languages are spread across half the globe, from Easter Island to Madagascar. Evidence from linguistics and archaeology indicates that the ‘Austronesian expansion,’ which began 4,000–5,000 years ago, likely ...
    • Reconstructing Native American Population History 

      Reich, David Emil; Patterson, Nick; Campbell, Desmond; Tandon, Arti; Mazieres, Stéphane; Ray, Nicolas; Parra, Maria V.; Rojas, Winston; Duque, Constanza; Mesa, Natalia; García, Luis F.; Triana, Omar; Blair, Silvia; Maestre, Amanda; Dib, Juan C.; Bravi, Claudio M.; Bailliet, Graciela; Corach, Daniel; Hünemeier, Tábita; Bortolini, Maria-Cátira; Salzano, Francisco M.; Petzl-Erler, María Luiza; Acuña-Alonzo, Victor; Aguilar-Salinas, Carlos; Canizales-Quinteros, Samuel; Tusié-Luna, Teresa; Riba, Laura; Rodríguez-Cruz, Maricela; Lopez-Alarcón, Mardia; Coral-Vazquez, Ramón; Canto-Cetina, Thelma; Silva-Zolezzi, Irma; Fernandez-Lopez, Juan Carlos; Contreras, Alejandra V.; Jimenez-Sanchez, Gerardo; Gómez-Vázquez, María José; Molina, Julio; Carracedo, Ángel; Salas, Antonio; Gallo, Carla; Poletti, Giovanni; Witonsky, David B.; Alkorta-Aranburu, Gorka; Sukernik, Rem I.; Osipova, Ludmila; Fedorova, Sardana; Vasquez, René; Villena, Mercedes; Moreau, Claudia; Barrantes, Ramiro; Pauls, David L.; Excoffier, Laurent; Bedoya, Gabriel; Rothhammer, Francisco; Dugoujon, Jean Michel; Larrouy, Georges; Klitz, William; Labuda, Damian; Kidd, Judith; Kidd, Kenneth; Rienzo, Anna Di; Freimer, Nelson B.; Price, Alkes; Ruiz-Linares, Andrés (2013)
      The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved1–5. One contentious issue is whether the settlement occurred via ...
    • Reconstructing Roma History from Genome-Wide Data 

      Moorjani, Priya; Patterson, Nick; Loh, Po-Ru; Lipson, Mark; Kisfali, Péter; Melegh, Bela I.; Bonin, Michael; Kádaši, Ľudevít; Rieß, Olaf; Berger, Bonnie; Reich, David Emil; Melegh, Béla (Public Library of Science, 2013)
      The Roma people, living throughout Europe and West Asia, are a diverse population linked by the Romani language and culture. Previous linguistic and genetic studies have suggested that the Roma migrated into Europe from ...
    • Reconstruction and Validation of a Genome-Scale Metabolic Model for the Filamentous Fungus Neurospora crassa Using FARM 

      Dreyfuss, Jonathan M.; Zucker, Jeremy D.; Hood, Heather M.; Ocasio, Linda R.; Sachs, Matthew S.; Galagan, James E. (Public Library of Science, 2013)
      The filamentous fungus Neurospora crassa played a central role in the development of twentieth-century genetics, biochemistry and molecular biology, and continues to serve as a model organism for eukaryotic biology. Here, ...
    • Reconstruction of malunited diaphyseal fractures of the forearm 

      Jayakumar, Prakash; Jupiter, Jesse B (Springer US, 2014)
      The forearm is a complex anatomical and functional unit with unique osseous, soft tissue and articular relationships. Disruption of these important relations can have a significant impact, leading to pain, instability of ...
    • Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography 

      Chen, Zhenrui; Tie, Yanmei; Olubiyi, Olutayo; Rigolo, Laura; Mehrtash, Alireza; Norton, Isaiah; Pasternak, Ofer; Rathi, Yogesh; Golby, Alexandra J.; O'Donnell, Lauren J. (Elsevier, 2015)
      Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema ...
    • Recovery and verification of memories of childhood sexual trauma. 

      Herman, Judith Lewis; Schatzow, Emily (American Psychological Association (APA), 1987)
      Fifty-three women outpatients participated in short-term therapy groups for incest survivors. This treatment modality proved to be a powerful stimulus for recovery of previously repressed traumatic memories. A relationship ...
    • Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome 

      Whitney, James B.; Wainberg, Mark A (BioMed Central, 2007)
      We have analyzed a SIV deletion mutant that was compromised both in viral replication and RNA packaging. Serial passage of this variant in two different T-cell lines resulted in compensatory reversion and the generation ...
    • RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability 

      Chen, Edwin; Ahn, Jong Sook; Sykes, David Brian; Breyfogle, Lawrence J.; Godfrey, Anna L.; Nangalia, Jyoti; Ko, Amy; DeAngelo, Daniel J.; Green, Alexander Robert; Mullally, Ann (Elsevier BV, 2015)
      JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPNs). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPNs are nevertheless characterized by genomic stability. ...
    • Recruitment and retention of participants in a pragmatic randomized intervention trial at three community health clinics: Results and lessons learned 

      Warner, Erica; Glasgow, Russell E; Emmons, Karen Maria; Bennett, Gary G; Askew, Sandy; Rosner, Bernard Alfred; Colditz, Graham A. (BioMed Central, 2013)
      Background: Obesity and hypertension and their associated health complications disproportionately affect communities of color and people of lower socioeconomic status. Recruitment and retention of these populations in ...
    • Recruitment to Multicentre Trials—Lessons from UKCTOCS: Descriptive Study 

      Menon, Usha; Gentry-Maharaj, Aleksandra; Ryan, Andy; Sharma, Aarti; Burnell, Matthew; Hallett, Rachel; Lopez, Alberto; Godfrey, Keith; Oram, David; Herod, Jonathan; Williamson, Karin; Seif, Mourad; Scott, Ian; Mould, Tim; Woolas, Robert; Murdoch, John; Dobbs, Stephen; Amso, Nazar; Leeson, Simon; Cruickshank, Derek; McGuire, Ali; Campbell, Stuart; Fallowfield, Lesley; Parmar, Mahesh; Jacobs, Ian; Lewis, Sarah Catherine; Skates, Steven J. (BMJ Publishing Group, 2008)
      Objective: To describe the factors that contributed to successful recruitment of more than 200,000 women to the UK Collaborative Trial of Ovarian Cancer Screening, one of the largest ever randomised controlled trials. ...
    • Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression 

      Romas, Laura; Birse, Kenzie; Mayer, Kenneth H.; Abou, Max; Westmacott, Garrett; Giguere, Rebecca; Febo, Irma; Cranston, Ross D.; Carballo-Diéguez, Alex; McGowan, Ian; Burgener, Adam (Mary Ann Liebert, Inc., 2016)
      Abstract Rectal use of a 1% tenofovir (TFV) gel is currently being evaluated for HIV prevention. While careful assessment of mucosal safety of candidate microbicides is a primary concern, tools to assess mucosal toxicity ...
    • Rectal mucosal dysplasia in Crohn's disease. 

      Korelitz, B I; Lauwers, Gregory Y.; Sommers, S C (BMJ, 1990)
      Serial sections of 812 rectal biopsy specimens from 356 Crohn's disease patients were analysed for mucosal epithelial dysplasia. Dysplasia was found in 18 patients (5%), with four showing dysplasia on repeat biopsy specimen. ...
    • The Rectal Tonsil: A Reactive Lymphoid Proliferation That May Mimic Lymphoma 

      Farris, Alton B.; Lauwers, Gregory Y.; Ferry, Judith Ann; Zukerberg, Lawrence R. (Ovid Technologies (Wolters Kluwer Health), 2008)
      The rectal tonsil (RT), a localized reactive proliferation of lymphoid tissue occurring in the rectum, can cause diagnostic difficulty; and awareness of this entity can prevent a misdiagnosis of lymphoma. A clinicopathologic ...
    • Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature 

      Christman, Mitalee P.; Turbett, Sarah E.; Sengupta, Soma; Bakhadirov, Khamidulla U.; Williamson, Craig A.; Nayak, Lakshmi; Milligan, Tracey; Katz, Joel T. (Oxford University Press, 2014)
      Although herpes simplex encephalitis is not classically considered an opportunistic infection, reactivation of herpes simplex is being seen increasingly in patients with cancer or immunosuppression. The authors present a ...
    • Recurrent 8q13.2-13.3 microdeletions associated with Branchio-oto-renal syndrome are mediated by human endogenous retroviral (HERV) sequence blocks 

      Chen, Xiaoli; Wang, Jun; Mitchell, Elyse; Guo, Jin; Wang, Liwen; Zhang, Yu; Hodge, Jennelle C; Shen, Yiping (BioMed Central, 2014)
      Background: Human endogenous retroviral (HERV) sequences are the remnants of ancient retroviral infection and comprise approximately 8% of the human genome. The high abundance and interspersed nature of homologous HERV ...
    • Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas 

      Le, Long Phi; Nielsen, Gunnlaugur Petur; Rosenberg, Andrew Eric; Thomas, Dafydd; Batten, Julie M.; Deshpande, Vikram; Schwab, Joseph H; Duan, Zhenfeng; Xavier, Ramnik; Hornicek, Francis John; Iafrate, Anthony John (Public Library of Science, 2011)
      The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes. Understanding copy number alterations in chordoma may reveal critical disease mechanisms that ...
    • Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth 

      Holst, Frederik; Hoivik, Erling A.; Gibson, William J.; Taylor-Weiner, Amaro; Schumacher, Steven E.; Asmann, Yan W.; Grossmann, Patrick; Trovik, Jone; Necela, Brian M.; Thompson, E. Aubrey; Meyerson, Matthew; Beroukhim, Rameen; Salvesen, Helga B.; Cherniack, Andrew D. (Nature Publishing Group, 2016)
      The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be ...