Browsing HMS Scholarly Articles by Title

Now showing items 12907-12926 of 17922

    • Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control 

      Ackerman, Margaret E.; Mikhailova, Anastassia; Brown, Eric P.; Dowell, Karen G.; Walker, Bruce D.; Bailey-Kellogg, Chris; Suscovich, Todd J.; Alter, Galit (Public Library of Science, 2016)
      Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to persistently suppress viremia. Because accumulating evidence suggests ...

    • Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia 

      Ruderfer, Douglas M.; Fanous, Ayman H.; Ripke, Stephan; McQuillin, Andrew; Amdur, Richard L.; Gejman, Pablo V.; O’Donovan, Michael C.; Andreassen, Ole A.; Djurovic, Srdjan; Hultman, Christina M.; Kelsoe, John R.; Jamain, Stephane; Landén, Mikael; Leboyer, Marion; Nimgaonkar, Vishwajit; Nurnberger, John; Smoller, Jordan W.; Craddock, Nick; Corvin, Aiden; Sullivan, Patrick F.; Holmans, Peter; Sklar, Pamela; Kendler, Kenneth S. (2013)
      Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities. Recent studies have demonstrated a large overlap of genetic risk loci between these disorders but diagnostic and molecular ...

    • Polygenic Inheritance of Paclitaxel-Induced Sensory Peripheral Neuropathy Driven by Axon Outgrowth Gene Sets in CALGB 40101 (Alliance) 

      Chhibber, Aparna; Mefford, Joel; Stahl, Eli A.; Pendergrass, Sarah A.; Baldwin, R. Michael; Owzar, Kouros; Li, Megan; Winer, Eric P.; Hudis, Clifford A.; Zembutsu, Hitoshi; Kubo, Michiaki; Nakamura, Yusuke; McLeod, Howard L.; Ratain, Mark J.; Shulman, Lawrence N.; Ritchie, Marylyn D.; Plenge, Robert M.; Witte, John S.; Kroetz, Deanna L. (2014)
      Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals there are no known risk factors that predispose patients to the adverse event, and pathogenesis for ...

    • Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism 

      Aboulaich, Nabila; Chui, Patricia C.; Asara, John M; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (American Diabetes Association, 2011)
      OBJECTIVE: Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilization. ...

    • Polymeric nanoparticle drug delivery technologies for oral delivery applications 

      Pridgen, Eric M; Alexis, Frank; Farokhzad, Omid Cameron (Informa Healthcare, 2015)
      Introduction: Many therapeutics are limited to parenteral administration. Oral administration is a desirable alternative because of the convenience and increased compliance by patients, especially for chronic diseases ...

    • Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques 

      Majmudar, Maulik; Yoo, Jeongsoo; Keliher, Edmund; Truelove, Jessica; Iwamoto, Yoshiko; Sena, Brena; Dutta, Partha; Borodovsky, Anna; Fitzgerald, Kevin; Di Carli, Marcelo; Libby, Peter; Anderson, Daniel; Swirski, Filip; Weissleder, Ralph; Nahrendorf, Matthias (American Heart Association, 2013)
      Rationale: Myeloid cell content in atherosclerotic plaques associates with rupture and thrombosis. Thus, imaging of lesional monocytes and macrophages could serve as a biomarker of disease progression and therapeutic ...

    • Polymorphic Amplified Typing Sequences (PATS) Strain Typing System Accurately Discriminates a Set of Temporally and Spatially Disparate Escherichia coli O157 Isolates Associated with Human Infection 

      Kudva, Indira T.; Smole, Sandra; Griffin, Robert W.; Garren, Jeonifer; Kalia, Nimisha; Murray, Megan; John, Manohar; Timperi, Ralph; Calderwood, Stephen B. (Bentham Open, 2013)
      Polymorphic Amplified Typing Sequences (PATS) is a PCR-based Escherichia coli O157 (O157) strain typing system. Here, we show that PATS compares excellently with Pulsed-Field Gel Electrophoresis (PFGE) in that both methods ...

    • Polymorphic Amplified Typing Sequences and Pulsed-Field Gel Electrophoresis Yield Comparable Results in the Strain Typing of a Diverse Set of Bovine Escherichia coli O157:H7 Isolates 

      Kudva, Indira T.; Davis, Margaret A.; Griffin, Robert; Garren, Jeonifer; Murray, Megan Blanche; John, Manohar; Hovde, Carolyn J.; Calderwood, Stephen Beaven (Hindawi Publishing Corporation, 2012)
      Polymorphic amplified typing sequences (PATS), a PCR-based Escherichia coli O157:H7 (O157) strain typing system, targets insertions-deletions and single nucleotide polymorphisms at XbaI and AvrII restriction enzyme sites, ...

    • Polymorphic Amplified Typing Sequences Provide a Novel Approach to Escherichia coli O157:H7 Strain Typing 

      Kudva, Indira T.; Evans, Peter S.; Perna, Nicole T.; Barrett, Timothy J.; DeCastro, G. Joel; Ausubel, Frederick M.; Blattner, Frederick R.; Calderwood, Stephen B. (American Society for Microbiology, 2002)
      Escherichia coli O157:H7 (O157) strains are commonly typed by pulsed-field gel electrophoresis (PFGE) following digestion of genomic DNA with the restriction enzyme XbaI. We have shown that O157 strains differ from each ...

    • Polymorphic repeat in AIB1 does not alter breast cancer risk 

      Haiman, Christopher A; Hankinson, Susan Elizabeth; Spiegelman, Donna Lynn; Colditz, Graham A.; Willett, Walter C.; Speizer, Frank Erwin; Brown, Myles Avery; Hunter, David J. (BioMed Central, 2000)
      We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association ...

    • A polymorphism in HLA-G modifies statin benefit in asthma 

      Naidoo, Devesh; Wu, Ann C; Brilliant, Murray H; Denny, Joshua; Ingram, Christie; Kitchner, Terrie E; Linneman, James G; McGeachie, Michael J; Roden, Dan M; Shaffer, Christian M; Shah, Anushi; Weeke, Peter; Weiss, Scott T; Xu, Hua; Medina, Marisa W (2014)
      Several reports have shown that statin treatment benefits patients with asthma, however inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress ...

    • A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies 

      Terry, Kathryn Lynne; Vitonis, Allison F.; Hernandez, Dena; Lurie, Galina; Song, Honglin; Ramus, Susan J.; Titus-Ernstoff, Linda; Carney, Michael E.; Wilkins, Lynne R.; Gentry-Maharaj, Aleksandra; Menon, Usha; Gayther, Simon A.; Pharaoh, Paul D.; Goodman, Marc T.; Cramer, Daniel William; Birrer, Michael James (e-Century Publishing, 2010)
      Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer ...

    • Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women 

      McGrath, Monica; Michaud, Dominique; De Vivo, Immaculata (BioMed Central, 2006)
      Background: Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining ...

    • Polymorphisms in IL12A and Cockroach Allergy in Children with Asthma 

      Pistiner, Michael; Hunninghake, Gary Matthew; Soto-Quiros, Manuel E; Avila, Lydiana; Murphy, Amy; Su, Jessica Ann Lasky; Schuemann, Brooke; Klanderman, Barbara Jordan; Raby, Benjamin Alexander; Celedón, Juan C (BioMed Central, 2008)
      Background: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. Methods: We tested for association between four linkage disequilibrium (LD)-tagging SNPs ...

    • Polymorphisms in Nucleotide Excision Repair Genes, Arsenic Exposure, and Non-melanoma Skin Cancer in New Hampshire 

      Applebaum, Katie Lyn; Karagas, Margaret R.; Hunter, David J.; Catalano, Paul J.; Byler, Steven H.; Morris, Steve; Nelson, Heather H. (National Institute of Environmental Health Sciences, 2007)
      Background: Arsenic exposure may alter the efficiency of DNA repair. UV damage is specifically repaired by nucleotide excision repair (NER), and common genetic variants in NER may increase risk for non-melanoma skin cancer ...

    • Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma 

      Litonjua, Augusto Ampil; Tantisira, Kelan; Lake, Stephen; Lazarus, Ross; Richter, Brent G; Gabriel, Stacey; Silverman, Eric S; Weiss, Scott Tillman (BioMed Central, 2005)
      Background: Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in ...

    • POLYMORPHISMS IN THE SERUM- AND GLUCOCORTICOID-INDUCIBLE KINASE 1 GENE ARE ASSOCIATED WITH BLOOD PRESSURE AND RENIN RESPONSE TO DIETARY SALT INTAKE 

      Rao, Ajay D; Sun, Bei; Saxena, Aditi; Hopkins, Paul N; Jeunemaitre, Xavier; Brown, Nancy J; Adler, Gail K; Williams, Jonathan S (2012)
      Serum- and glucocorticoid-inducible kinase 1 (SGK1) plays a central role in epithelial sodium channel (ENaC)-dependent Na+ transport in the distal nephron. We hypothesized that SGK1 gene variants may contribute to the ...

    • Polymorphisms in the Vitamin D Receptor and Risk of Ovarian Cancer in Four Studies 

      Tworoger, Shelley Slate; Gate, M. A.; Lee, I-Min; Buring, Julie Elizabeth; Titus-Ernstoff, L.; Cramer, Daniel William; Hankinson, Susan Elizabeth (American Association for Cancer Research (AACR), 2009)
      Prior studies have suggested that vitamin D may reduce ovarian cancer risk. Thus, we examined whether three single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene (Fok1, Bsm1, Cdx2) were associated ...

    • Polymorphisms of MUC16 (CA125) and MUC1 (CA15.3) in Relation to Ovarian Cancer Risk and Survival 

      Williams, Kristina A.; Terry, Kathryn L.; Tworoger, Shelley S.; Vitonis, Allison F.; Titus, Linda J.; Cramer, Daniel W. (Public Library of Science, 2014)
      Objective: To examine single nucleotide polymorphism (SNPs) in MUC16 (CA125) and MUC1 (CA15.3) in relation to ovarian cancer risk and survival. Methods: We genotyped germline variants of MUC16 (rs2547065, rs1559168, ...

    • Polymyxin P is the active principle in suppressing phytopathogenic Erwinia spp. by the biocontrol rhizobacterium Paenibacillus polymyxa M-1 

      Niu, Ben; Vater, Joachim; Rueckert, Christian; Blom, Jochen; Lehmann, Maik; Ru, Jin-Jiang; Chen, Xiao-Hua; Wang, Qi; Borriss, Rainer (BioMed Central, 2013)
      Background: Nine gene clusters dedicated to nonribosomal synthesis of secondary metabolites with possible antimicrobial action, including polymyxin and fusaricidin, were detected within the whole genome sequence of the ...