Browsing HMS Scholarly Articles by Title

Now showing items 137-156 of 17922

    • A Transposon Screen Identifies Genetic Determinants of Vibrio cholerae Resistance to High-Molecular-Weight Antibiotics 

      Dörr, Tobias; Delgado, Fernanda; Umans, Benjamin; Gerding, Matthew; Davis, Brigid; Waldor, Matthew (American Society for Microbiology, 2016)
      Gram-negative bacteria are notoriously resistant to a variety of high-molecular-weight antibiotics due to the limited permeability of their outer membrane (OM). The basis of OM barrier function and the genetic factors ...

    • A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo 

      Turlure, Fanny; Maertens, Goedele; Rahman, Shaila; Cherepanov, Peter; Engelman, Alan (Oxford University Press, 2006)
      Lens epithelium-derived growth factor p75 (LEDGF/p75) is a DNA-binding, transcriptional co-activator that participates in HIV-1 integration site targeting. Using complementary approaches, we determined the mechanisms of ...

    • A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor 

      Hamdan, Samir M.; Marintcheva, Boriana; Cook, Timothy; Lee, Seung-Joo; Tabor, Stanley; Richardson, Charles C. (National Academy of Sciences, 2005)
      Bacteriophage T7 DNA polymerase (gene 5 protein, gp5) interacts with its processivity factor, Escherichia coli thioredoxin, via a unique loop at the tip of the thumb subdomain. We find that this thioredoxin-binding domain ...

    • A unique loop in the DNA-binding crevice of bacteriophage T7 DNA polymerase influences primer utilization 

      Chowdhury, Kajal; Tabor, Stanley; Richardson, Charles C. (National Academy of Sciences, 2000)
      The three-dimensional structure of bacteriophage T7 DNA polymerase reveals the presence of a loop of 4 aa (residues 401-404) within the DNA-binding groove; this loop is not present in other members of the DNA polymerase I ...

    • A unique strategy for mRNA cap methylation used by vesicular stomatitis virus 

      Li, Jianrong; Wang, Jennifer T.; Whelan, Sean J. (National Academy of Sciences, 2006)
      Nonsegmented negative-sense (nsNS) RNA viruses typically replicate within the host cell cytoplasm and do not have access to the host mRNA capping machinery. These viruses have evolved a unique mechanism for mRNA cap formation ...

    • A Wortmannin-Cetuximab as a Double Drug 

      Smith, R. Adam; Yuan, Hushan; Weissleder, Ralph; Cantley, Lewis C.; Josephson, Lee (American Chemical Society, 2009)
      Double drugs are obtained when two pharmacologically active entities are covalently joined to improve potency. We conjugated the viridin Wm with a self-activating linkage to cetuximab and demonstrated the retention of ...

    • A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility 

      Shepard, Jennifer L.; Amatruda, James F.; Stern, Howard M.; Subramanian, Aravind; Finkelstein, David; Ziai, James; Finley, K. Rose; Pfaff, Kathleen L.; Hersey, Candace; Zhou, Yi; Barut, Bruce; Freedman, Matthew; Lee, Charles; Spitsbergen, Jan; Neuberg, Donna; Weber, Gerhard; Golub, Todd R.; Glickman, Jonathan N.; Kutok, Jeffery L.; Aster, Jon C.; Zon, Leonard I. (National Academy of Sciences, 2005)

    • A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing 

      Gjini, Evisa; Mansour, Marc; Sander, Jeffry; Moritz, Nadine; Nguyen, Ashley; Kesarsing, Michiel; Gans, Emma; He, Shuning; Chen, Si; Ko, Myunggon; Kuang, You-Yi; Yang, Song; Zhou, Yi; Rodig, Scott; Zon, Leonard; Joung, J. Keith; Rao, Anjana; Look, A. Thomas (American Society for Microbiology, 2015)
      The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within ...

    • A ‘Magnetic’ Gram Stain for Bacterial Detection 

      Budin, Ghyslain; Chung, Hyun Jung; Lee, Hakho; Weissleder, Ralph (Wiley, 2012)

    • A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells 

      Duan, Zhenfeng; Zhang, Jianming; Ye, Shunan; Shen, Jacson; Choy, Edwin; Cote, Gregory; Harmon, David; Mankin, Henry; Hua, Yingqi; Zhang, Yu; Gray, Nathanael S; Hornicek, Francis J (BioMed Central, 2014)
      Background: Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR ...

    • A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers 

      Jack, Clifford R.; Bennett, David A.; Blennow, Kaj; Carrillo, Maria C.; Feldman, Howard H.; Frisoni, Giovanni B.; Hampel, Harald; Jagust, William J.; Johnson, Keith A.; Knopman, David S.; Petersen, Ronald C.; Scheltens, Philip; Sperling, Reisa A.; Dubois, Bruno (Lippincott Williams & Wilkins, 2016)
      Biomarkers have become an essential component of Alzheimer disease (AD) research and because of the pervasiveness of AD pathology in the elderly, the same biomarkers are used in cognitive aging research. A number of current ...

    • A20 deficiency causes spontaneous neuroinflammation in mice 

      Guedes, Renata Padilha; Csizmadia, Eva; Moll, Herwig P; Ma, Averil; Ferran, Christiane; da Silva, Cleide Gonçalves (BioMed Central, 2014)
      Background: A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs. ...

    • A20 Modulates Lipid Metabolism and Energy Production to Promote Liver Regeneration 

      Studer, Peter; Longo, Christopher R.; Csizmadia, Eva; Shrikhande, Gautam V.; Scali, Salvatore T.; Bhasin, Manoj K.; Selvarajoo, Kumar; Damrauer, Scott Michael; Da Silva, Cleide Gonsalves; Ramsey, Haley Elizabeth; Libermann, Towia Aron; Ferran, Christiane (Public Library of Science, 2011)
      Background: Liver Regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-\(\kappa\)B inhibitory protein A20 significantly improves ...

    • The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer 

      Cotter, Kristina; Liberman, Rachel; Sun-Wada, GeHong; Wada, Yoh; Sgroi, Dennis; Naber, Stephen; Brown, Dennis; Breton, Sylvie; Forgac, Michael (Impact Journals LLC, 2016)
      The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps that acidify intracellular compartments and transport protons across the plasma membrane. Previous work has demonstrated that plasma membrane ...

    • \(A\beta\) alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo 

      Cao, Luxiang; Schrank, Benjamin R.; Rodriguez, Steven; Benz, Eric G.; Moulia, Thomas W.; Rickenbacher, Gregory T.; Gomez, Alexis C.; Levites, Yona; Edwards, Sarah R.; Golde, Todd E.; Hyman, Bradley Theodore; Barnea, Gilad; Albers, Mark W (Nature Publishing Group, 2012)
      The amyloid beta peptide aggregates into amyloid plaques at presymptomatic stages of Alzheimer's disease, but the temporal relationship between plaque formation and neuronal dysfunction is poorly understood. Here we ...

    • Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 

      Calvo, Jennifer A.; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey W.; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick Terry; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013)
      Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...

    • AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges 

      Gardner, Matthew R.; Kattenhorn, Lisa M.; Kondur, Hema R.; von Schaewen, Markus; Dorfman, Tatyana; Chiang, Jessica J.; Haworth, Kevin G.; Decker, Julie M.; Alpert, Michael D.; Bailey, Charles C.; Neale, Ernest S.; Fellinger, Christoph H.; Joshi, Vinita R.; Fuchs, Sebastian P.; Martinez-Navio, Jose M.; Quinlan, Brian D.; Yao, Annie Y.; Mouquet, Hugo; Gorman, Jason; Zhang, Baoshan; Poignard, Pascal; Nussenzweig, Michel C.; Burton, Dennis R.; Kwong, Peter D.; Piatak, Michael; Lifson, Jeffrey D.; Gao, Guangping; Desrosiers, Ronald C.; Evans, David T.; Hahn, Beatrice H.; Ploss, Alexander; Cannon, Paula M.; Seaman, Michael S.; Farzan, Michael (2015)
      Long-term in vivo expression of a broad and potent entry inhibitor could circumvent the need for a conventional vaccine for HIV-1. Adeno-associated virus (AAV) vectors can stably express HIV-1 broadly neutralizing antibodies ...

    • AAV-Mediated Administration of Myostatin Pro-Peptide Mutant in Adult Ldlr Null Mice Reduces Diet-Induced Hepatosteatosis and Arteriosclerosis 

      Guo, Wen; Wong, Siu; Bhasin, Shalender (Public Library of Science, 2013)
      Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such ...

    • AAV-Mediated Gene Delivery in Adult GM1-Gangliosidosis Mice Corrects Lysosomal Storage in CNS and Improves Survival 

      Baek, Rena C.; Broekman, Marike L. D.; Leroy, Stanley G.; Tierney, Laryssa A.; Sandberg, Michael Arthur; d'Azzo, Alessandra; Seyfried, Thomas N.; Sena-Esteves, Miguel (Public Library of Science, 2010)
      Background: GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid β-galactosidase (βgal), which results in the accumulation of GM1-ganglioside and its asialo-form ...

    • AAV-Mediated Intramuscular Delivery of Myotubularin Corrects the Myotubular Myopathy Phenotype in Targeted Murine Muscle and Suggests a Function in Plasma Membrane Homeostasis 

      Buj-Bello, Anna; Fougerousse, Françoise; Schwab, Yannick; Messaddeq, Nadia; Spehner, Danièle; Pierson, Christopher R.; Durand, Muriel; Kretz, Christine; Danos, Olivier; Douar, Anne-Marie; Schultz, Patrick; Montus, Marie; Denèfle, Patrice; Mandel, Jean-Louis; Beggs, Alan Hendrie (Oxford University Press, 2008)
      Myotubular myopathy (XLMTM, OMIM 310400) is a severe congenital muscular disease due to mutations in the myotubularin gene (MTM1) and characterized by the presence of small myofibers with frequent occurrence of central ...