Now showing items 1489-1508 of 15601

    • Blockade of Glioma Proliferation through Allosteric Inhibition of JAK2 

      He, Kunyan; Qi, Qi; Chan, Chi-Bun; Xiao, Ge; Liu, Xia; Tucker-Burden, Carol; Wang, Liya; Mao, Hui; Lu, Xiang; McDonald, Frank E.; Luo, Hongbo; Fan, Qi-Wen; Weiss, William A.; Sun, Shi-Yong; Brat, Daniel J.; Ye, Keqiang (American Association for the Advancement of Science (AAAS), 2013)
      The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the efficacy of EGFR-targeted small-molecule inhibitors or monoclonal ...
    • Blockade of Prolymphangiogenic Vascular Endothelial Growth Factor C in Dry Eye Disease 

      Goyal, Sunali; Chauhan, Sunil Kumar; Dana, Reza (American Medical Association (AMA), 2012)
      Objective To determine if blocking prolymphangiogenic factors like VEGF-C would suppress alloimmunity in dry eye disease (DED) using a murine model. Methods The effects of intraperitoneal injections of 400 μg of ...
    • Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes 

      Kochupurakkal, Nora M.; Kruger, Annie J.; Tripathi, Sudipta; Zhu, Bing; Adams, La Tonya; Rainbow, Daniel B.; Rossini, Aldo; Greiner, Dale L.; Sayegh, Mohamed H.; Wicker, Linda S.; Guleria, Indira (Public Library of Science, 2014)
      Aims/Hypothesis Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular ...
    • Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells 

      Tam, Joshua; Duda, Dan Gabriel; Perentes, Jean Y.; Quadri, Rehan S.; Fukumura, Dai; Jain, Rakesh K. (Public Library of Science, 2009)
      Background: We investigated if new vessel formation in fat involves the contribution of local tissue-derived endothelial cells (i.e., angiogenesis) or bone marrow-derived cells (BMDCs, i.e. vasculogenesis) and if antiangiogenic ...
    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...
    • Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways 

      Gunda, V; Bucur, O; Varnau, J; Vanden Borre, P; Bernasconi, M J; Khosravi-Far, R; Parangi, S (Nature Publishing Group, 2014)
      Current treatment for recurrent and aggressive/anaplastic thyroid cancers is ineffective. Novel targeted therapies aimed at the inhibition of the mutated oncoprotein BRAFV600E have shown promise in vivo and in vitro but ...
    • Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study 

      Stein-Merlob, Ashley F.; Kessinger, Chase W.; Erdem, S. Sibel; Zelada, Henry; Hilderbrand, Scott A.; Lin, Charles P.; Tearney, Guillermo J.; Jaff, Michael R.; Reed, Guy L.; Henke, Peter K.; McCarthy, Jason R.; Jaffer, Farouc A. (Ivyspring International Publisher, 2015)
      Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent ...
    • Blood and War 

      Hedley-Whyte, John; Milamed, Debra R. (The Ulster Medical Society, 2010)
      In 1894 Ulsterman and pathologist Almroth Wright described the citation of blood. Twenty-one years later it was introduced into wartime and clinical practice. Harvard Medical School had a large part in providing Colonel ...
    • Blood Banking in Living Droplets 

      Samot, Josh; Moon, Sangjun; Shao, Lei; Zhang, Xiaohui; Xu, Feng; Song, YoungSeok; Keles, Hasan Onur; Matloff, Laura; Markel, Jordan; Demirci, Utkan (Public Library of Science, 2011)
      Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional ...
    • Blood Donation and Colorectal Cancer Incidence and Mortality in Men 

      Zhang, Xuehong; Ma, Jing; Wu, Kana; Chan, Andrew Tan; Fuchs, Charles Stewart; Giovannucci, Edward L. (Public Library of Science, 2012)
      Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...
    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...
    • Blood Lead Levels and Serum Insulin-Like Growth Factor 1 Concentrations in Peripubertal Boys 

      Fleisch, Abby F.; Burns, Jane S.; Williams, Paige L.; Lee, Mary M.; Sergeyev, Oleg; Korrick, Susan A.; Hauser, Russ (National Institute of Environmental Health Sciences, 2013)
      Background: Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort ...
    • Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder 

      Yoshimi, Noriko; Futamura, Takashi; Kakumoto, Keiji; Salehi, Alireza M.; Sellgren, Carl M.; Holmén-Larsson, Jessica; Jakobsson, Joel; Pålsson, Erik; Landén, Mikael; Hashimoto, Kenji (Elsevier, 2016)
      Background: Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis ...
    • Blood Oxygen Depletion Is Independent of Dive Function in a Deep Diving Vertebrate, the Northern Elephant Seal 

      Meir, Jessica U.; Robinson, Patrick W.; Vilchis, L. Ignacio; Kooyman, Gerald L.; Costa, Daniel P.; Ponganis, Paul J. (Public Library of Science, 2013)
      Although energetics is fundamental to animal ecology, traditional methods of determining metabolic rate are neither direct nor instantaneous. Recently, continuous blood oxygen (O2) measurements were used to assess energy ...
    • Blood pool contrast agents for venous magnetic resonance imaging 

      Oliveira, Irai S.; Hedgire, Sandeep Subhash; Li, Weier; Ganguli, Suvranu; Prabhakar, Anand M (AME Publishing Company, 2016)
      Imaging of the venous system plays a vital role in the diagnosis and management of a wide range of clinically significant disorders. There have been great advances in venous imaging techniques, culminating in the use of ...
    • Blood Pressure Changes in Relation to Arsenic Exposure in a U.S. Pregnancy Cohort 

      Farzan, Shohreh F.; Chen, Yu; Wu, Fen; Jiang, Jieying; Liu, Mengling; Baker, Emily; Korrick, Susan A.; Karagas, Margaret R. (NLM-Export, 2015)
      Background: Inorganic arsenic exposure has been related to the risk of increased blood pressure based largely on cross-sectional studies conducted in highly exposed populations. Pregnancy is a period of particular vulnerability ...
    • Blood Pressure Variability and Closed-Loop Baroreflex Assessment in Adolescent Chronic Fatigue Syndrome During Supine Rest and Orthostatic Stress 

      Wyller, Vegard Bruun; Barbieri, Riccardo; Saul, J. Philip (Springer-Verlag, 2010)
      Hemodynamic abnormalities have been documented in the chronic fatigue syndrome (CFS), indicating functional disturbances of the autonomic nervous system responsible for cardiovascular regulation. The aim of this study was ...
    • Blood RNA biomarker panel detects both left- and right-sided colorectal neoplasms: a case-control study 

      Chao, Samuel; Ying, Jay; Liew, Gailina; Marshall, Wayne; Liew, Choong-Chin; Burakoff, Robert (BioMed Central, 2013)
      Background: Colonoscopy is widely regarded to be the gold standard for colorectal cancer (CRC) detection. Recent studies, however, suggest that the effectiveness of colonoscopy is mostly confined to tumors on the left side ...
    • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort 

      Hou, Lifang; Joyce, Brian Thomas; Gao, Tao; Liu, Lei; Zheng, Yinan; Penedo, Frank J.; Liu, Siran; Zhang, Wei; Bergan, Raymond; Dai, Qi; Vokonas, Pantel; Hoxha, Mirjam; Schwartz, Joel; Baccarelli, Andrea (Elsevier, 2015)
      Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...
    • Blood Transfusion Effects in Kidney Transplantation 

      Carpenter, Charles Bernard (Yale Journal of Biology and Medicine, 1990)
      Within the three decades since the beginnings of the field of clinical renal transplantation there have been four phases in blood transfusion policies, swinging from liberal transfusions to avoidance of transfusions, ...