Browsing HMS Scholarly Articles by Title
Now showing items 15148-15167 of 17918
-
SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes
(Nature Pub. Group, 2015)Expression of the p53-inducible antiproliferative gene BTG2 is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative mechanisms of silencing. Using a shRNA screen targeting 43 ... -
Setting a research agenda for medical overuse
(BMJ Publishing Group Ltd., 2015)Although overuse in medicine is gaining increased attention, many questions remain unanswered. Dan Morgan and colleagues propose an agenda for coordinated research to improve our understanding of the problem -
Setting priorities for development of emerging interventions against childhood pneumonia, meningitis and influenza
(Edinburgh University Global Health Society, 2012) -
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma
(Oxford University Press, 2016)Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases ... -
Severe Burns in World War II
(The Ulster Medical Society, 2017) -
Severe hyperammonemia from intense skeletal muscle activity
(Ovid Technologies (Wolters Kluwer Health), 2019-11)Rationale: Adult hyperammonemia is most often the result of hepatic dysfunction. Hyperammonemia in the setting of normal hepatic function is a much less common phenomenon and has usually been associated with medications ... -
Severe Hypertriglyceridemia With Pancreatitis
(American Medical Association (AMA), 2014)IMPORTANCE Recurrent pancreatitis is a potentially fatal complication of severe hypertriglyceridemia. Genetic defects and lifestyle risk factors may render this condition unresponsive to current treatments. OBSERVATIONS: ... -
Severe Sepsis: Variation in Resource and Therapeutic Modality use Among Academic Centers
(BioMed Central, 2003)Background: Treatment of severe sepsis is expensive, often encompassing a number of discretionary modalities. The objective of the present study was to assess intercenter variation in resource and therapeutic modality use ... -
Severe, Acute Watery Diarrhea in an Adult
(Public Library of Science, 2010) -
Severity of Disease Estimation and Risk-Adjustment for Comparison of Outcomes in Mechanically Ventilated Patients Using Electronic Routine Care Data
(Cambridge University Press, 2015)BACKGROUND. Valid comparison between hospitals for benchmarking or pay-for-performance incentives requires accurate correction for underlying disease severity (case-mix). However, existing models are either very simplistic ... -
Severity of Retinopathy Parallels the Degree of Parasite Sequestration in the Eyes and Brains of Malawian Children With Fatal Cerebral Malaria
(Oxford University Press, 2014)Background. Malarial retinopathy (MR) has diagnostic and prognostic value in children with Plasmodium falciparum cerebral malaria (CM). A clinicopathological correlation between observed retinal changes during life and the ... -
Sex dependent risk factors for mortality after myocardial infarction: individual patient data meta-analysis
(BioMed Central, 2014)Background: Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is known about interactions between risk factors, whereas these could contribute to ... -
Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection
(Public Library of Science, 2015)The incidence and severity of infections in childhood is typically greater in males. The basis for these observed sex differences is not well understood, and potentially may facilitate novel approaches to reducing disease ... -
Sex differences in circumstances and consequences of outdoor and indoor falls in older adults in the MOBILIZE Boston cohort study
(BioMed Central, 2013)Background: Despite extensive research on risk factors associated with falling in older adults, and current fall prevention interventions focusing on modifiable risk factors, there is a lack of detailed accounts of sex ... -
Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease
(Public Library of Science, 2015)Introduction: To improve our understanding of sex differences in the clinical characteristics of Parkinson’s Disease, we sought to examine differences in the clinical features and disease severity of men and women with ... -
Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction
(Frontiers Media S.A., 2015)Behavioral, biological, and social sequelae that lead to drug addiction differ between men and women. Our efforts to understand addiction on a mechanistic level must include studies in both males and females. Stress, ... -
Sex Differences in the Neurobiology of Fear Conditioning and Extinction: A Preliminary fMRI Study of Shared Sex Differences with Stress-Arousal Circuitry
(BioMed Central, 2012)Background: The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning and extinction, and are brain regions known to be sexually dimorphic. We used functional ... -
Sex Differences, Gonadal Hormones and the Fear Extinction Network: Implications for Anxiety Disorders
(BioMed Central, 2012)Convergent data from rodents and human studies have led to the development of models describing the neural mechanisms of fear extinction. Key components of the now well-characterized fear extinction network include the ... -
Sex Disparities in the Treatment and Control of Cardiovascular Risk Factors in Type 2 Diabetes
(American Diabetes Association, 2008)OBJECTIVE—To assess whether sex differences exist in the effective control and medication treatment intensity of cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS—We performed a cross-sectional analysis ... -
Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects
(BioMed Central, 2014)Introduction: Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women’s Health Initiative ...