Now showing items 15148-15167 of 17918

    • SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes 

      Tajima, Ken; Yae, Toshifumi; Javaid, Sarah; Tam, Oliver; Comaills, Valentine; Morris, Robert; Wittner, Ben S.; Liu, Mingzhu; Engstrom, Amanda; Takahashi, Fumiyuki; Black, Joshua C.; Ramaswamy, Sridhar; Shioda, Toshihiro; Hammell, Molly; Haber, Daniel A.; Whetstine, Johnathan R.; Maheswaran, Shyamala (Nature Pub. Group, 2015)
      Expression of the p53-inducible antiproliferative gene BTG2 is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative mechanisms of silencing. Using a shRNA screen targeting 43 ...
    • Setting a research agenda for medical overuse 

      Morgan, Daniel J; Brownlee, Shannon; Leppin, Aaron L; Kressin, Nancy; Dhruva, Sanket S; Levin, Les; Landon, Bruce E; Zezza, Mark A; Schmidt, Harald; Saini, Vikas; Elshaug, Adam G (BMJ Publishing Group Ltd., 2015)
      Although overuse in medicine is gaining increased attention, many questions remain unanswered. Dan Morgan and colleagues propose an agenda for coordinated research to improve our understanding of the problem
    • Setting priorities for development of emerging interventions against childhood pneumonia, meningitis and influenza 

      Rudan, Igor; Theodoratou, Evropi; Zgaga, Lina; Nair, Harish; Chan, Kit Yee; Tomlinson, Mark; Tsai, Alexander Chung-Yu; Biloglav, Zrinka; Huda, Tanvir; El Arifeen, Shams; Chopra, Mickey; Campbell, Harry (Edinburgh University Global Health Society, 2012)
    • Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma 

      Murakami, Naoka; Borges, Thiago J.; Yamashita, Michifumi; Riella, Leonardo V. (Oxford University Press, 2016)
      Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases ...
    • Severe Burns in World War II 

      Hedley-Whyte, John; Milamed, Debra (The Ulster Medical Society, 2017)
    • Severe hyperammonemia from intense skeletal muscle activity 

      Taneja, Vikas; Jasuja, Haneesh (Ovid Technologies (Wolters Kluwer Health), 2019-11)
      Rationale: Adult hyperammonemia is most often the result of hepatic dysfunction. Hyperammonemia in the setting of normal hepatic function is a much less common phenomenon and has usually been associated with medications ...
    • Severe Hypertriglyceridemia With Pancreatitis 

      Sacks, Frank Martin; Stanesa, Maxine; Hegele, Robert A. (American Medical Association (AMA), 2014)
      IMPORTANCE Recurrent pancreatitis is a potentially fatal complication of severe hypertriglyceridemia. Genetic defects and lifestyle risk factors may render this condition unresponsive to current treatments. OBSERVATIONS: ...
    • Severe Sepsis: Variation in Resource and Therapeutic Modality use Among Academic Centers 

      Black, Edgar; Graman, Paul S; Lanken, Paul N; Kahn, Katherine L; Snydman, David R; Parsonnet, Jeffrey; Moore, Richard; Yu, Donghui Tony; Sands, Kenneth Eliot Frederick; Schwartz, J. Sanford; Hibberd, Patricia Lavonne; Platt, Richard; Bates, David Westfall (BioMed Central, 2003)
      Background: Treatment of severe sepsis is expensive, often encompassing a number of discretionary modalities. The objective of the present study was to assess intercenter variation in resource and therapeutic modality use ...
    • Severe, Acute Watery Diarrhea in an Adult 

      Chowdhury, Fahima; Khan, Ashraful Islam; Faruque, Abu Syed Golam; Ryan, Edward Thomas (Public Library of Science, 2010)
    • Severity of Disease Estimation and Risk-Adjustment for Comparison of Outcomes in Mechanically Ventilated Patients Using Electronic Routine Care Data 

      van Mourik, Maaike S. M.; Moons, Karel G. M.; Murphy, Michael V.; Bonten, Marc J. M.; Klompas, Michael (Cambridge University Press, 2015)
      BACKGROUND. Valid comparison between hospitals for benchmarking or pay-for-performance incentives requires accurate correction for underlying disease severity (case-mix). However, existing models are either very simplistic ...
    • Severity of Retinopathy Parallels the Degree of Parasite Sequestration in the Eyes and Brains of Malawian Children With Fatal Cerebral Malaria 

      Barrera, Valentina; Hiscott, Paul Stephenson; Craig, Alister Gordon; White, Valerie Ann; Milner, Danny Arnold; Beare, Nicholas Alexander Venton; MacCormick, Ian James Callum; Kamiza, Steve; Taylor, Terrie Ellen; Molyneux, Malcolm Edward; Harding, Simon Peter (Oxford University Press, 2014)
      Background. Malarial retinopathy (MR) has diagnostic and prognostic value in children with Plasmodium falciparum cerebral malaria (CM). A clinicopathological correlation between observed retinal changes during life and the ...
    • Sex dependent risk factors for mortality after myocardial infarction: individual patient data meta-analysis 

      van Loo, Hanna M; van den Heuvel, Edwin R; Schoevers, Robert A; Anselmino, Matteo; Carney, Robert M; Denollet, Johan; Doyle, Frank; Freedland, Kenneth E; Grace, Sherry L; Hosseini, Seyed H; Parakh, Kapil; Pilote, Louise; Rafanelli, Chiara; Roest, Annelieke M; Sato, Hiroshi; Steeds, Richard P; Kessler, Ronald C; de Jonge, Peter (BioMed Central, 2014)
      Background: Although a number of risk factors are known to predict mortality within the first years after myocardial infarction, little is known about interactions between risk factors, whereas these could contribute to ...
    • Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection 

      Mori, Masahiko; Adland, Emily; Paioni, Paolo; Swordy, Alice; Mori, Luisa; Laker, Leana; Muenchhoff, Maximilian; Matthews, Philippa C.; Tudor-Williams, Gareth; Lavandier, Nora; van Zyl, Anriette; Hurst, Jacob; Walker, Bruce D.; Ndung’u, Thumbi; Prendergast, Andrew; Goulder, Philip; Jooste, Pieter (Public Library of Science, 2015)
      The incidence and severity of infections in childhood is typically greater in males. The basis for these observed sex differences is not well understood, and potentially may facilitate novel approaches to reducing disease ...
    • Sex differences in circumstances and consequences of outdoor and indoor falls in older adults in the MOBILIZE Boston cohort study 

      Duckham, Rachel L; Procter-Gray, Elizabeth; Hannan, Marian T; Leveille, Suzanne G; Lipsitz, Lewis A; Li, Wenjun (BioMed Central, 2013)
      Background: Despite extensive research on risk factors associated with falling in older adults, and current fall prevention interventions focusing on modifiable risk factors, there is a lack of detailed accounts of sex ...
    • Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease 

      Augustine, Erika F.; Pérez, Adriana; Dhall, Rohit; Umeh, Chizoba C.; Videnovic, Aleksandar; Cambi, Franca; Wills, Anne-Marie A.; Elm, Jordan J.; Zweig, Richard M.; Shulman, Lisa M.; Nance, Martha A.; Bainbridge, Jacquelyn; Suchowersky, Oksana (Public Library of Science, 2015)
      Introduction: To improve our understanding of sex differences in the clinical characteristics of Parkinson’s Disease, we sought to examine differences in the clinical features and disease severity of men and women with ...
    • Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction 

      Chartoff, Elena H.; Mavrikaki, Maria (Frontiers Media S.A., 2015)
      Behavioral, biological, and social sequelae that lead to drug addiction differ between men and women. Our efforts to understand addiction on a mechanistic level must include studies in both males and females. Stress, ...
    • Sex Differences in the Neurobiology of Fear Conditioning and Extinction: A Preliminary fMRI Study of Shared Sex Differences with Stress-Arousal Circuitry 

      Lebron-Milad, Kelimer; Milad, Mohammed Ragib; Abbs, Brandon R.; Linnman, Clas; Rougemount-Bücking, Ansgar; Zeidan, Mohammed A.; Holt, Daphne J.; Goldstein, Jill M. (BioMed Central, 2012)
      Background: The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning and extinction, and are brain regions known to be sexually dimorphic. We used functional ...
    • Sex Differences, Gonadal Hormones and the Fear Extinction Network: Implications for Anxiety Disorders 

      Lebron-Milad, Kelimer; Milad, Mohammed Ragib (BioMed Central, 2012)
      Convergent data from rodents and human studies have led to the development of models describing the neural mechanisms of fear extinction. Key components of the now well-characterized fear extinction network include the ...
    • Sex Disparities in the Treatment and Control of Cardiovascular Risk Factors in Type 2 Diabetes 

      Gouni-Berthold, Ioanna; Berthold, Heiner K.; Böhm, Michael; Krone, Wilhelm; Mantzoros, Christos S. (American Diabetes Association, 2008)
      OBJECTIVE—To assess whether sex differences exist in the effective control and medication treatment intensity of cardiovascular disease (CVD) risk factors. RESEARCH DESIGN AND METHODS—We performed a cross-sectional analysis ...
    • Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects 

      Zhao, Shanshan; Chlebowski, Rowan T; Anderson, Garnet L; Kuller, Lewis H; Manson, JoAnn E; Gass, Margery; Patterson, Ruth; Rohan, Thomas E; Lane, Dorothy S; Beresford, Shirley AA; Lavasani, Sayeh; Rossouw, Jacques E; Prentice, Ross L (BioMed Central, 2014)
      Introduction: Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women’s Health Initiative ...