Browsing HMS Scholarly Articles by Title
Now showing items 1524-1543 of 17922
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Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3
(Public Library of Science, 2011)Infection of host cells by pathogenic microbes triggers signal transduction pathways leading to a multitude of host cell responses including actin cytoskeletal re-arrangements and transcriptional programs. The diarrheagenic ... -
The Bacterial Carbon-Fixing Organelle Is Formed by Shell Envelopment of Preassembled Cargo
(Public Library of Science, 2013)Background: Cyanobacteria play a significant role in the global carbon cycle. In Synechococcuselongatus, the carbon-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is concentrated into polyhedral, ... -
Bacterial endophthalmitis in the age of outpatient intravitreal therapies and cataract surgeries: Host–microbe interactions in intraocular infection
(Elsevier BV, 2012)Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging ... -
Bacterial Endophthalmitis: Epidemiology, Therapeutics, and Bacterium-Host Interactions
(American Society for Microbiology, 2002) -
Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions
(Elsevier BV, 2007)Endophthalmitis is an infection of the posterior segment of the eye that frequently results in loss of vision. This devastating result occurs despite prompt and often aggressive therapeutic and surgical intervention. Over ... -
Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection
(Public Library of Science, 2015)Staphylococcus aureus is capable of infecting nearly every organ in the human body. In order to infiltrate and thrive in such diverse host tissues, staphylococci must possess remarkable flexibility in both metabolic and ... -
Bacterial Metabolic State More Accurately Predicts Antibiotic Lethality Than Growth Rate
(Springer Science and Business Media LLC, 2019-08-26)Growth rate and metabolic state have been separately shown to affect antibiotic efficacy1–3. However, the two are interrelated since bacterial growth inherently imposes a metabolic burden4; thus, determining individual ... -
Bacterial protein translocation requires only one copy of the SecY complex in vivo
(The Rockefeller University Press, 2012)The transport of proteins across the plasma membrane in bacteria requires a channel formed from the SecY complex, which cooperates with either a translating ribosome in cotranslational translocation or the SecA ATPase in ... -
A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals
(eLife Sciences Publications, Ltd, 2012)Bacterially-produced small molecules exert profound influences on animal health, morphogenesis, and evolution through poorly understood mechanisms. In one of the closest living relatives of animals, the choanoflagellate ... -
Bacterial vaginosis and adverse outcomes among full-term infants: a cohort study
(BioMed Central, 2016)Background: Bacterial vaginosis (BV) during pregnancy is a well-established risk factor for preterm birth and other preterm pregnancy complications. Little is known about adverse neonatal outcomes associated with BV exposure ... -
Bacteriophage T7 DNA polymerase – sequenase
(Frontiers Media S.A., 2014)An ideal DNA polymerase for chain-terminating DNA sequencing should possess the following features: (1) incorporate dideoxy- and other modified nucleotides at an efficiency similar to that of the cognate deoxynucleotides; ... -
Bacteriophages and Phage-Inspired Nanocarriers for Targeted Delivery of Therapeutic Cargos
(Elsevier BV, 2016-11)The main goal of drug delivery systems is to target therapeutic cargoes to desired cells and to ensure their efficient uptake. Recently a number of studies have focused on designing bio-inspired nanocarriers, such as ... -
Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo
(American Society for Microbiology, 2016)ABSTRACT We recently showed that human gut Bacteroidales species secrete antimicrobial proteins (BSAPs), and we characterized in vitro the first such BSAP produced by Bacteroides fragilis. In this study, we identified a ... -
Bactobolin Resistance Is Conferred by Mutations in the L2 Ribosomal Protein
(American Society of Microbiology, 2012)Burkholderia thailandensis produces a family of polyketide-peptide molecules called bactobolins, some of which are potent antibiotics. We found that growth of B. thailandensis at 30°C versus that at 37°C resulted in increased ... -
BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8
(American Society for Microbiology, 2013)The BAL1 macrodomain-containing protein and its partner E3 ligase, BBAP, are overexpressed in chemotherapy-resistant lymphomas. BBAP selectively ubiquitylates histone H4 and indirectly promotes early 53BP1 recruitment to ... -
Balancing Antiplatelet and Anticoagulant Therapies in Patients with Cardiovascular Disease
(Springer Healthcare, 2013)Anticoagulation is needed for stroke prevention in patients with atrial fibrillation. Antiplatelet therapy is essential for the prevention of stent thrombosis and the reduction of cardiovascular events in patients who ... -
Balancing Education and Service in Graduate Medical Education: Data From Pediatric Trainees and Program Directors
(Published for the Association of American Medical Colleges by Lippincott Williams & Wilkins, 2014)Purpose To measure pediatric program directors’ (PDs’) and trainees’ perceptions of and expectations for the balance of service and education in their training programs. Method In fall 2011, an electronic survey was sent ... -
Balancing Image Quality and Compression Factor for Special Stains Whole Slide Images
(IOS Press, 2012)The objective is to find a practical balance between quality and performance for daily high volume whole slide imaging. We evaluated whole slide images created by various scanners at different compression factors to determine ... -
Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence
(Public Library of Science, 2013)Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb ...