Browsing HMS Scholarly Articles by Title

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    • Sirt6 regulates dendritic cell differentiation, maturation, and function 

      Lasigliè, Denise; Boero, Silvia; Bauer, Inga; Morando, Sara; Damonte, Patrizia; Cea, Michele; Monacelli, Fiammetta; Odetti, Paizio; Ballestrero, Alberto; Uccelli, Antonio; Mostoslavsky, Raul; Poggi, Alessandro; Nencioni, Alessio (Impact Journals LLC, 2016)
      Dendritic cells (DCs) are antigen-presenting cells that critically influence decisions about immune activation or tolerance. Impaired DC function is at the core of common chronic disorders and contributes to reduce ...

    • Sirt6 regulates TNFα secretion via hydrolysis of long chain fatty acyl lysine 

      Jiang, Hong; Khan, Saba; Wang, Yi; Charron, Guillaume; He, Bin; Sebastian, Carlos; Du, Jintang; Kim, Ray; Ge, Eva; Mostoslavsky, Raul; Hang, Howard C.; Hao, Quan; Lin, Hening (2013)
      The Sir2 family of enzymes or sirtuins are known as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases1 and have been implicated in the regulation of transcription, genome stability, metabolism, and lifespan2, ...

    • SIRT7 Links H3K18 Deacetylation to Maintenance of Oncogenic Transformation 

      Barber, Matthew F.; Michishita-Kioi, Eriko; Xi, Yuanxin; Tasselli, Luisa; Kioi, Mitomu; Moqtaderi, Zarmik; Tennen, Ruth I.; Paredes, Silvana; Young, Nicolas L.; Chen, Kaifu; Struhl, Kevin; Garcia, Benjamin A.; Gozani, Or; Li, Wei; Chua, Katrin F. (2012)
      Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism, and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets, and physiologic functions have been ...

    • The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia 

      Chen, Xiqun; Wales, Pauline; Quinti, Luisa; Zuo, Fuxing; Moniot, Sébastien; Herisson, Fanny; Rauf, Nazifa Abdul; Wang, Hua; Silverman, Richard B.; Ayata, Cenk; Maxwell, Michelle M.; Steegborn, Clemens; Schwarzschild, Michael A.; Outeiro, Tiago F.; Kazantsev, Aleksey G. (Public Library of Science, 2015)
      Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2) deacetylase as a potential drug target to counteract neurodegeneration. ...

    • Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy 

      Michan, Shaday; Juan, Aimee M.; Hurst, Christian G.; Cui, Zhenghao; Evans, Lucy P.; Hatton, Colman J.; Pei, Dorothy T.; Ju, Meihua; Sinclair, David A.; Smith, Lois E. H.; Chen, Jing (Public Library of Science, 2014)
      Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading ...

    • Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism 

      Jeong, Seung Min; Haigis, Marcia C. (Korean Society for Molecular and Cellular Biology, 2015)
      Genomic instability and altered metabolism are key features of most cancers. Recent studies suggest that metabolic reprogramming is part of a systematic response to cellular DNA damage. Thus, defining the molecules that ...

    • Sirtuins, Metabolism, and Cancer 

      Martinez-Pastor, Barbara; Mostoslavsky, Raul (Frontiers Research Foundation, 2012)
      More than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, ...

    • SiteOut: An Online Tool to Design Binding Site-Free DNA Sequences 

      Estrada, Javier; Ruiz-Herrero, Teresa; Scholes, Clarissa; Wunderlich, Zeba; DePace, Angela H. (Public Library of Science, 2016)
      DNA-binding proteins control many fundamental biological processes such as transcription, recombination and replication. A major goal is to decipher the role that DNA sequence plays in orchestrating the binding and activity ...

    • Sites and Determinants of Early Cleavages in the Proteolytic Processing Pathway of Reovirus Surface Protein σ3 

      Jané-Valbuena, Judit; Breun, Laura A.; Schiff, Leslie A.; Nibert, Max L. (American Society for Microbiology, 2002)
      Entry of mammalian reo-virus virions into target cells requires proteolytic processing of surface protein alpha3. In the virion, sigma3 mostly covers the membrane-penetration protein lit, appearing to keep it in an inactive ...

    • Sitting and Supine Esophageal Pressures in Overweight and Obese Subjects Authors 

      Owens, Robert L.; Campana, Lisa M.; Hess, Lauren; Eckert, Danny J.; Loring, Stephen H.; Malhotra, Atul (2012)
      Esophageal pressure can be used to approximate pleural pressure and might be clinically useful, particularly in the obese e.g to guide mechanical ventilator settings in critical illness. However, mediastinal artifact (the ...

    • Situation of HDV Infection in Adult Hepatitis B Patients at The Outpatient Clinic of Pasteur Institute in Ho Chi Minh City 

      Nguyen, Thi Thu Huong; Dinh, Thoi Van; Nguyen, Minh Ngoc; Nguyen, Phuong Lan Thi; Nguyen, Thu Thuy Thi; Hoang, Tuong Giao; Do, Hai Hoang Hanh; Lam, My Linh; Nguyen, Hoai Thu Mong; Pham, Duy Quang; Tran, Nghi V; Nguyen, Duc; Nguyen, Thach (Tan Tao University, 2023-08-01)
      Hepatitis D virus (HDV) infection, also known as delta virus, has been identified as a crucial risk factor contributing to severe complications among hepatitis B patients. Such complications arise as HDV accelerates the ...

    • SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS 

      Westmoreland, Susan V.; Converse, A. Peter; Hrecka, Kasia; Hurley, Mollie; Knight, Heather; Piatak, Michael; Lifson, Jeffrey; Mansfield, Keith G.; Skowronski, Jacek; Desrosiers, Ronald C. (Public Library of Science, 2014)
      Analysis of rhesus macaques infected with a vpx deletion mutant virus of simian immunodeficiency virus mac239 (SIVΔvpx) demonstrates that Vpx is essential for efficient monocyte/macrophage infection in vivo but is not ...

    • SIVΔnef Vaccination Mobilizes Systemic and Mucosal Natural Killer Cells in Mamu A*01+ Macaques 

      Reeves, Roger Keith; Evans, Tristan Isaac; Gillis, Jacqueline Marie; Connole, Michelle Ann; Wong, F; Yu, Yi; Johnson, R. Paul (BioMed Central, 2012)

    • Six-Nine Year Follow-Up of Deep Brain Stimulation for Obsessive-Compulsive Disorder 

      Fayad, Sarah M.; Guzick, Andrew G.; Reid, Adam M.; Mason, Dana M.; Bertone, Agustina; Foote, Kelly D.; Okun, Michael S.; Goodman, Wayne K.; Ward, Herbert E. (Public Library of Science, 2016)
      Objective: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) region has shown promise as a neurosurgical intervention for adults with severe treatment-refractory obsessive-compulsive disorder ...

    • Sixty years of genome biology 

      Doolittle, W Ford; Fraser, Peter; Gerstein, Mark B; Graveley, Brenton R; Henikoff, Steven; Huttenhower, Curtis; Oshlack, Alicia; Ponting, Chris P; Rinn, John L; Schatz, Michael C; Ule, Jernej; Weigel, Detlef; Weinstock, George M (BioMed Central, 2013)
      Sixty years after Watson and Crick published the double helix model of DNA's structure, thirteen members of Genome Biology's Editorial Board select key advances in the field of genome biology subsequent to that discovery.

    • Sizanani: A Randomized Trial of Health System Navigators to Improve Linkage to HIV and TB Care in South Africa 

      Bassett, Ingrid V.; Coleman, Sharon M.; Giddy, Janet; Bogart, Laura M.; Chaisson, Christine E.; Ross, Douglas; Jacobsen, Margo M.; Robine, Marion; Govender, Tessa; Freedberg, Kenneth A.; Katz, Jeffrey N.; Walensky, Rochelle P.; Losina, Elena (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2016)
      Background: A fraction of HIV-diagnosed individuals promptly initiate antiretroviral therapy (ART). We evaluated the efficacy of health system navigators for improving linkage to HIV and tuberculosis (TB) care among newly ...

    • Size and distribution of the global volume of surgery in 2012 

      Weiser, Thomas G; Haynes, Alex B; Molina, George; Lipsitz, Stuart R; Esquivel, Micaela M; Uribe-Leitz, Tarsicio; Fu, Rui; Azad, Tej; Chao, Tiffany E; Berry, William R; Gawande, Atul A (World Health Organization, 2016)
      Abstract Objective: To estimate global surgical volume in 2012 and compare it with estimates from 2004. Methods: For the 194 Member States of the World Health Organization, we searched PubMed for studies and contacted key ...

    • Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates 

      Veiseh, Omid; Doloff, Joshua C.; Ma, Minglin; Vegas, Arturo J.; Tam, Hok Hei; Bader, Andrew R.; Li, Jie; Langan, Erin; Wyckoff, Jeffrey; Loo, Whitney S.; Jhunjhunwala, Siddharth; Chiu, Alan; Siebert, Sean; Tang, Katherine; Hollister-Lock, Jennifer; Aresta-Dasilva, Stephanie; Bochenek, Matthew; Mendoza-Elias, Joshua; Wang, Yong; Qi, Merigeng; Lavin, Danya M.; Chen, Michael; Dholakia, Nimit; Thakrar, Raj; Lacík, Igor; Weir, Gordon C.; Oberholzer, Jose; Greiner, Dale L.; Langer, Robert; Anderson, Daniel G. (2015)
      The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility ...

    • Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis 

      Zelzer, Elazar; McLean, William; Ng, Yin-Shan; Fukai, Naomi; Reginato, Anthony; Lovejoy, Stephanie; D'Amore, Patricia Ann; Olsen, Bjorn Reino (The Company of Biologists, 2002)
      Angiogenesis is an essential component of skeletal development and VEGF signaling plays an important if not pivotal role in this process. Previous attempts to examine the roles of VEGF in vivo have been largely unsuccessful ...

    • Skeletal improvement in patients with Gaucher disease type 1: a phase 2 trial of oral eliglustat 

      Kamath, Ravi S.; Lukina, Elena; Watman, Nora; Dragosky, Marta; Pastores, Gregory M.; Arreguin, Elsa Avila; Rosenbaum, Hanna; Zimran, Ari; Aguzzi, Rasha; Puga, Ana Cristina; Norfleet, Andrea M.; Peterschmitt, M. Judith; Rosenthal, Daniel I. (Springer Berlin Heidelberg, 2014)
      Objective: Eliglustat is an investigational oral substrate reduction therapy for Gaucher disease type 1 (GD1). Its skeletal effects were evaluated by prospective monitoring of bone mineral density (BMD), fractures, marrow ...