Now showing items 1564-1583 of 17917

    • Baseline population health conditions ahead of a health system strengthening program in rural Madagascar 

      Miller, Ann; Ramananjato, Ranto H.; Garchitorena, Andres; Rabeza, Victor R.; Gikic, Djordje; Cripps, Amber; Cordier, Laura; Rahaniraka Razanadrakato, Hery-Tiana; Randriamanambintsoa, Marius; Hall, Lara; Murray, Megan Blanche; Safara Razanavololo, Felicite; Rich, Michael Leonard; Bonds, Matthew H (Informa UK Limited, 2017)
    • Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen 

      Thompson, Aaron M.S.; Zanobetti, Antonella; Silverman, Frances; Schwartz, Joel David; Coull, Brent Andrew; Urch, Bruce; Speck, Mary; Brook, Jeffrey R.; Manno, Michael; Gold, Diane R. (National Institute of Environmental Health Sciences, 2009)
      Introduction: Systemic inflammation may be one of the mechanisms mediating the association between ambient air pollution and cardiovascular morbidity and mortality. Interleukin-6 (IL-6) and fibrinogen are biomarkers of ...
    • Baseline Resistance to Nucleoside Reverse Transcriptase Inhibitors Fails to Predict Virologic Response to Combination Therapy in Children (PACTG 338) 

      Fiscus, Susan A; Kovacs, Andrea; Petch, Leslie A; Hu, Chengcheng; Wiznia, Andrew A; Mofenson, Lynne M; Yogev, Ram; McIntosh, Kenneth; Pelton, Stephen I; Napravnik, Sonia; Stanley, Kenneth Earl; Nachman, Sharon A (BioMed Central, 2007)
      Background: The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children. We evaluated drug resistance mutations at 39 codon sites ...
    • Basic and complex emotion recognition in children with autism: cross-cultural findings 

      Fridenson-Hayo, Shimrit; Berggren, Steve; Lassalle, Amandine; Tal, Shahar; Pigat, Delia; Bölte, Sven; Baron-Cohen, Simon; Golan, Ofer (BioMed Central, 2016)
      Background: Children with autism spectrum conditions (ASC) have emotion recognition deficits when tested in different expression modalities (face, voice, body). However, these findings usually focus on basic emotions, using ...
    • Basic Features of a Cell Electroporation Model: Illustrative Behavior for Two Very Different Pulses 

      Son, Reuben S.; Smith, Kyle C.; Gowrishankar, Thiruvallur R.; Vernier, P. Thomas; Weaver, James C. (Springer US, 2014)
      Science increasingly involves complex modeling. Here we describe a model for cell electroporation in which membrane properties are dynamically modified by poration. Spatial scales range from cell membrane thickness (5 nm) ...
    • Basolateral Junction Proteins Regulate Competition for the Follicle Stem Cell Niche in the Drosophila Ovary 

      Kronen, Maria R.; Schoenfelder, Kevin P.; Klein, Allon M.; Nystul, Todd G. (Public Library of Science, 2014)
      Epithelial stem cells are routinely lost or damaged during adult life and must therefore be replaced to maintain homeostasis. Recent studies indicate that stem cell replacement occurs through neutral competition in many ...
    • Battery of behavioral tests in mice to study postoperative delirium 

      Peng, Mian; Zhang, Ce; Dong, Yuanlin; Zhang, Yiying; Nakazawa, Harumasa; Kaneki, Masao; Zheng, Hui; Shen, Yuan; Marcantonio, Edward R.; Xie, Zhongcong (Nature Publishing Group, 2016)
      Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery ...
    • Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis 

      Zong, Wei-Xing; Li, Chi; Hatzivassiliou, Georgia; Lindsten, Tullia; Yu, Qian-Chun; Yuan, Junying; Thompson, Craig B. (Rockefeller University Press, 2003)
      Bax and Bak play a redundant but essential role in apoptosis initiated by the mitochondrial release of apoptogenic factors. In addition to their presence at the mitochondrial outer membrane, Bax and Bak can also localize ...
    • A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway 

      Zamorano, Sebastián; Rojas-Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero, Sergio; Hetz, Claudio (Public Library of Science, 2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Bayesian characterization of uncertainty in intra-subject non-rigid registration 

      Risholm, Petter; Janoos, Firdaus; Norton, Isaiah Hakim; Golby, Alexandra Jacqueline; Wells, William Mercer (Elsevier BV, 2013)
      In settings where high-level inferences are made based on registered image data, the registration uncertainty can contain important information. In this article, we propose a Bayesian non-rigid registration framework where ...
    • Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins 

      Tonikian, Raffi; Xin, Xiaofeng; Toret, Christopher P.; Gfeller, David; Landgraf, Christiane; Panni, Simona; Paoluzi, Serena; Castagnoli, Luisa; Currell, Bridget; Seshagiri, Somasekar; Winsor, Barbara; Gerstein, Mark B.; Bader, Gary D.; Volkmer, Rudolf; Cesareni, Gianni; Drubin, David G.; Kim, Philip M.; Sidhu, Sachdev S.; Boone, Charles; Yu, Haiyuan; Vidal, Marc (Public Library of Science, 2009)
      SH3 domains are peptide recognition modules that mediate the assembly of diverse biological complexes. We scanned billions of phage-displayed peptides to map the binding specificities of the SH3 domain family in the budding ...
    • Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo 

      Field, Sarah L.; Dasgupta, Tathagata; Cummings, Michele; Savage, Richard S.; Adebayo, Julius; McSara, Hema; Gunawardena, Jeremy; Orsi, Nicolas M. (BioMed Central, 2015)
      Background: Cytokine-hormone network deregulations underpin pathologies ranging from autoimmune disorders to cancer, but our understanding of these networks in physiological/pathophysiological states remains patchy. We ...
    • Bayesian neural networks for detecting epistasis in genetic association studies 

      Beam, Andrew L; Motsinger-Reif, Alison; Doyle, Jon (BioMed Central, 2014)
      Background: Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding ...
    • A Bayesian Translational Framework for Knowledge Propagation, Discovery, and Integration Under Specific Contexts 

      Deng, Michelle Rui; Zollanvari, Amin; Alterovitz, Gil (American Medical Informatics Association, 2012)
      The immense corpus of biomedical literature existing today poses challenges in information search and integration. Many links between pieces of knowledge occur or are significant only under certain contexts—rather than ...
    • BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner 

      Nityanandam, Ramya; Serra-Moreno, Ruth (Public Library of Science, 2014)
      BCA2 (Rabring7, RNF115 or ZNF364) is a RING-finger E3 ubiquitin ligase that was identified as a co-factor in the restriction imposed by tetherin/BST2 on HIV-1. Contrary to the current model, in which BCA2 lacks antiviral ...
    • Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice 

      Lau, Garnet J.; Godin, Nicolas; Maachi, Hasna; Lo, Chao-Sheng; Wu, Shyh-Jong; Zhu, Jian-Xin; Brezniceanu, Marie-Luise; Chénier, Isabelle; Fragasso-Marquis, Joelle; Lattouf, Jean-Baptiste; Ethier, Jean; Filep, Janos G.; Nair, Viji; Kretzler, Matthias; Cohen, Clemens D.; Zhang, Shao-Ling; Chan, John S.D.; Ingelfinger, Julie Rich (American Diabetes Association, 2012)
      This study investigated the mechanisms underlying tubular apoptosis in diabetes by identifying proapoptotic genes that are differentially upregulated by reactive oxygen species in renal proximal tubular cells (RPTCs) in ...
    • BCL11A Enhancer Dissection by Cas9-Mediated in Situ Saturating Mutagenesis 

      Canver, Matthew Charles; Smith, Elenoe; Pinello, Luca; Sanjana, Neville E.; Shalem, Ophir; Chen, Diane; Schupp, Patrick G.; Vinjamur, Divya S.; Garcia, Sara P.; Luc, Sidinh; Kurita, Ryo; Fujiwara, Yuko; Maeda, Takahiro; Yuan, Guo-Cheng; Zhang, Feng; Orkin, Stuart Holland; Bauer, Daniel Evan; Nakamura, Yukio (Nature, 2015-09-16)
    • Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma 

      Stegh, Alexander; Kim, Hyunggee; Bachoo, Robert; Forloney, Kristin; Zhang, Jean; Schulze, Harald; Park, Kevin; Hannon, Gregory; Yuan, Junying; Louis, David; DePinho, Ronald; Chin, Lynda (Cold Spring Harbor Laboratory Press, 2007)
      Glioblastoma ( GBM) is an astrocytic brain tumor characterized by an aggressive clinical course and intense resistance to all therapeutic modalities. Here, we report the identification and functional characterization of ...
    • BDNF Val66Met Polymorphism Influences Visuomotor Associative Learning and the Sensitivity to Action Observation 

      Taschereau-Dumouchel, Vincent; Hétu, Sébastien; Michon, Pierre-Emmanuel; Vachon-Presseau, Etienne; Massicotte, Elsa; De Beaumont, Louis; Fecteau, Shirley; Poirier, Judes; Mercier, Catherine; Chagnon, Yvon C.; Jackson, Philip L. (Nature Publishing Group, 2016)
      Motor representations in the human mirror neuron system are tuned to respond to specific observed actions. This ability is widely believed to be influenced by genetic factors, but no study has reported a genetic variant ...
    • BE-SAFE: Bedside Sonography for Assessment of the Fetus in Emergencies: Educational Intervention for Late-pregnancy Obstetric Ultrasound 

      Shah, Sachita; Adedipe, Adeyinka; Ruffatto, Benjamin; Backlund, Brandon H.; Sajed, Dana; Rood, Kari; Fernandez, Rosemarie (Department of Emergency Medicine, University of California, Irvine School of Medicine, 2014)
      Introduction: Late obstetric emergencies are time critical presentations in the emergency department. Evaluation to ensure the safety of mother and child includes rapid assessment of fetal viability, fetal heart rate (FHR), ...