Browsing HMS Scholarly Articles by Title

Now showing items 1569-1588 of 17922

    • Basolateral Junction Proteins Regulate Competition for the Follicle Stem Cell Niche in the Drosophila Ovary 

      Kronen, Maria R.; Schoenfelder, Kevin P.; Klein, Allon M.; Nystul, Todd G. (Public Library of Science, 2014)
      Epithelial stem cells are routinely lost or damaged during adult life and must therefore be replaced to maintain homeostasis. Recent studies indicate that stem cell replacement occurs through neutral competition in many ...

    • Battery of behavioral tests in mice to study postoperative delirium 

      Peng, Mian; Zhang, Ce; Dong, Yuanlin; Zhang, Yiying; Nakazawa, Harumasa; Kaneki, Masao; Zheng, Hui; Shen, Yuan; Marcantonio, Edward R.; Xie, Zhongcong (Nature Publishing Group, 2016)
      Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to lack of animal model(s). We therefore set out to employ a battery ...

    • Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis 

      Zong, Wei-Xing; Li, Chi; Hatzivassiliou, Georgia; Lindsten, Tullia; Yu, Qian-Chun; Yuan, Junying; Thompson, Craig B. (Rockefeller University Press, 2003)
      Bax and Bak play a redundant but essential role in apoptosis initiated by the mitochondrial release of apoptogenic factors. In addition to their presence at the mitochondrial outer membrane, Bax and Bak can also localize ...

    • A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway 

      Zamorano, Sebastián; Rojas-Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero, Sergio; Hetz, Claudio (Public Library of Science, 2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...

    • Bayesian characterization of uncertainty in intra-subject non-rigid registration 

      Risholm, Petter; Janoos, Firdaus; Norton, Isaiah Hakim; Golby, Alexandra Jacqueline; Wells, William Mercer (Elsevier BV, 2013)
      In settings where high-level inferences are made based on registered image data, the registration uncertainty can contain important information. In this article, we propose a Bayesian non-rigid registration framework where ...

    • Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins 

      Tonikian, Raffi; Xin, Xiaofeng; Toret, Christopher P.; Gfeller, David; Landgraf, Christiane; Panni, Simona; Paoluzi, Serena; Castagnoli, Luisa; Currell, Bridget; Seshagiri, Somasekar; Winsor, Barbara; Gerstein, Mark B.; Bader, Gary D.; Volkmer, Rudolf; Cesareni, Gianni; Drubin, David G.; Kim, Philip M.; Sidhu, Sachdev S.; Boone, Charles; Yu, Haiyuan; Vidal, Marc (Public Library of Science, 2009)
      SH3 domains are peptide recognition modules that mediate the assembly of diverse biological complexes. We scanned billions of phage-displayed peptides to map the binding specificities of the SH3 domain family in the budding ...

    • Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo 

      Field, Sarah L.; Dasgupta, Tathagata; Cummings, Michele; Savage, Richard S.; Adebayo, Julius; McSara, Hema; Gunawardena, Jeremy; Orsi, Nicolas M. (BioMed Central, 2015)
      Background: Cytokine-hormone network deregulations underpin pathologies ranging from autoimmune disorders to cancer, but our understanding of these networks in physiological/pathophysiological states remains patchy. We ...

    • Bayesian neural networks for detecting epistasis in genetic association studies 

      Beam, Andrew L; Motsinger-Reif, Alison; Doyle, Jon (BioMed Central, 2014)
      Background: Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding ...

    • A Bayesian Translational Framework for Knowledge Propagation, Discovery, and Integration Under Specific Contexts 

      Deng, Michelle Rui; Zollanvari, Amin; Alterovitz, Gil (American Medical Informatics Association, 2012)
      The immense corpus of biomedical literature existing today poses challenges in information search and integration. Many links between pieces of knowledge occur or are significant only under certain contexts—rather than ...

    • BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner 

      Nityanandam, Ramya; Serra-Moreno, Ruth (Public Library of Science, 2014)
      BCA2 (Rabring7, RNF115 or ZNF364) is a RING-finger E3 ubiquitin ligase that was identified as a co-factor in the restriction imposed by tetherin/BST2 on HIV-1. Contrary to the current model, in which BCA2 lacks antiviral ...

    • Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice 

      Lau, Garnet J.; Godin, Nicolas; Maachi, Hasna; Lo, Chao-Sheng; Wu, Shyh-Jong; Zhu, Jian-Xin; Brezniceanu, Marie-Luise; Chénier, Isabelle; Fragasso-Marquis, Joelle; Lattouf, Jean-Baptiste; Ethier, Jean; Filep, Janos G.; Nair, Viji; Kretzler, Matthias; Cohen, Clemens D.; Zhang, Shao-Ling; Chan, John S.D.; Ingelfinger, Julie Rich (American Diabetes Association, 2012)
      This study investigated the mechanisms underlying tubular apoptosis in diabetes by identifying proapoptotic genes that are differentially upregulated by reactive oxygen species in renal proximal tubular cells (RPTCs) in ...

    • BCL11A Enhancer Dissection by Cas9-Mediated in Situ Saturating Mutagenesis 

      Canver, Matthew Charles; Smith, Elenoe; Pinello, Luca; Sanjana, Neville E.; Shalem, Ophir; Chen, Diane; Schupp, Patrick G.; Vinjamur, Divya S.; Garcia, Sara P.; Luc, Sidinh; Kurita, Ryo; Fujiwara, Yuko; Maeda, Takahiro; Yuan, Guo-Cheng; Zhang, Feng; Orkin, Stuart Holland; Bauer, Daniel Evan; Nakamura, Yukio (Nature, 2015-09-16)

    • Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma 

      Stegh, Alexander; Kim, Hyunggee; Bachoo, Robert; Forloney, Kristin; Zhang, Jean; Schulze, Harald; Park, Kevin; Hannon, Gregory; Yuan, Junying; Louis, David; DePinho, Ronald; Chin, Lynda (Cold Spring Harbor Laboratory Press, 2007)
      Glioblastoma ( GBM) is an astrocytic brain tumor characterized by an aggressive clinical course and intense resistance to all therapeutic modalities. Here, we report the identification and functional characterization of ...

    • BDNF Val66Met Polymorphism Influences Visuomotor Associative Learning and the Sensitivity to Action Observation 

      Taschereau-Dumouchel, Vincent; Hétu, Sébastien; Michon, Pierre-Emmanuel; Vachon-Presseau, Etienne; Massicotte, Elsa; De Beaumont, Louis; Fecteau, Shirley; Poirier, Judes; Mercier, Catherine; Chagnon, Yvon C.; Jackson, Philip L. (Nature Publishing Group, 2016)
      Motor representations in the human mirror neuron system are tuned to respond to specific observed actions. This ability is widely believed to be influenced by genetic factors, but no study has reported a genetic variant ...

    • BE-SAFE: Bedside Sonography for Assessment of the Fetus in Emergencies: Educational Intervention for Late-pregnancy Obstetric Ultrasound 

      Shah, Sachita; Adedipe, Adeyinka; Ruffatto, Benjamin; Backlund, Brandon H.; Sajed, Dana; Rood, Kari; Fernandez, Rosemarie (Department of Emergency Medicine, University of California, Irvine School of Medicine, 2014)
      Introduction: Late obstetric emergencies are time critical presentations in the emergency department. Evaluation to ensure the safety of mother and child includes rapid assessment of fetal viability, fetal heart rate (FHR), ...

    • BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles 

      Chen, Walter W; Balaj, Leonora; Liau, Linda M; Samuels, Michael L; Kotsopoulos, Steve K; Maguire, Casey A; LoGuidice, Lori; Soto, Horacio; Garrett, Matthew; Zhu, Lin Dan; Sivaraman, Sarada; Chen, Clark; Wong, Eric T; Carter, Bob S; Hochberg, Fred H; Breakefield, Xandra O; Skog, Johan (Nature Publishing Group, 2013)
      Development of biofluid-based molecular diagnostic tests for cancer is an important step towards tumor characterization and real-time monitoring in a minimally invasive fashion. Extracellular vesicles (EVs) are released ...

    • Beating-heart mitral valve chordal replacement 

      Laing, Genevieve; Dupont, Pierre E (IEEE, 2011)
      Replacing open-heart surgical procedures with beating-heart interventions substantially decreases the trauma and risk of a procedure. One of the most challenging procedures to perform on the beating heart is valve repair. ...

    • Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome 

      Liu, Yun; Scirica, Benjamin M.; Stultz, Collin M.; Guttag, John V. (Nature Publishing Group, 2016)
      Frequency domain measures of heart rate variability (HRV) are associated with adverse events after a myocardial infarction. However, patterns in the traditional frequency domain (measured in Hz, or cycles per second) may ...

    • Beat‐to‐Beat Spatiotemporal Variability in the T Vector Is Associated With Sudden Cardiac Death in Participants Without Left Ventricular Hypertrophy: The Atherosclerosis Risk in Communities (ARIC) Study 

      Waks, Jonathan W.; Soliman, Elsayed Z.; Henrikson, Charles A.; Sotoodehnia, Nona; Han, Lichy; Agarwal, Sunil K.; Arking, Dan E.; Siscovick, David S.; Solomon, Scott D.; Post, Wendy S.; Josephson, Mark E.; Coresh, Josef; Tereshchenko, Larisa G. (Blackwell Publishing Ltd, 2015)
      Background: Despite advances in prevention and treatment of cardiovascular disease, sudden cardiac death (SCD) remains a clinical challenge. Risk stratification in the general population is needed. Methods and Results: ...

    • The Bed and the Bugs: Interactions Between the Tumor Microenvironment and Cancer Stem Cells 

      Castaño, Zafira; Fillmore, Christine M.; Kim, Carla; McAllister, Sandra (Elsevier BV, 2012-10)
      Tumors have been increasingly recognized as organs with a complexity that approaches, and may even exceed, that of healthy tissues. When viewed from this perspective, the biology of a tumor can be understood only by studying ...