Browsing HMS Scholarly Articles by Title
Now showing items 16412-16431 of 17922
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Template Recognition and Ribonucleotide Specificity of the DNA Primase of Bacteriophage T7
(American Society for Biochemistry and Molecular Biology, 1997) -
Template-Cut: A Pattern-Based Segmentation Paradigm
(Nature Publishing Group, 2012)We present a scale-invariant, template-based segmentation paradigm that sets up a graph and performs a graph cut to separate an object from the background. Typically graph-based schemes distribute the nodes of the graph ... -
Temporal and Spatial Expression of Tissue Inhibitors of Metalloproteinases 1 and 2 (TIMP-1 and -2) in the Bovine Corpus Luteum
(BioMed Central, 2003)The matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), may mediate the dramatic structural and functional changes in the corpus luteum (CL) over the course ... -
Temporal and Spatial Requirements of unplugged/MuSK Function during Zebrafish Neuromuscular Development
(Public Library of Science, 2010)One of the earliest events in neuromuscular junction (NMJ) development is the accumulation of acetylcholine receptor (AChR) at the center of muscle cells. The unplugged/MuSK (muscle specific tyrosine kinase) gene is essential ... -
Temporal Course of the Tourette Syndrome Clinical Triad
(Columbia University Libraries/Information Services, 2014)Background: Tourette syndrome (TS) is a disorder characterized by childhood onset of motor and phonic tics, often with improvement of tic symptoms by young adult years. The temporal course of tics and commonly comorbid ... -
Temporal Discrimination Learning in Abstinent Chronic Alcoholics
(Wiley, 2002-06)Background: Converging evidence from varied experimental paradigms has demonstrated that the cerebellum is involved in the timing of learned behavior. Given the documented neurological changes secondary to chronic alcoholism, ... -
Temporal Dissection of K-ras\(^{G12D}\) Mutant In Vitro and In Vivo Using a Regulatable K-ras\(^{G12D}\) Mouse Allele
(Public Library of Science, 2012)Animal models which allow the temporal regulation of gene activities are valuable for dissecting gene function in tumorigenesis. Here we have constructed a conditional inducible estrogen receptor-K-ras\(^{G12D}\) ... -
Temporal dynamics of a homeostatic pathway controlling neural network activity
(Frontiers Media S.A., 2013)Neurons use a variety of mechanisms to homeostatically regulate neural network activity in order to maintain firing in a bounded range. One such process involves the bi-directional modulation of excitatory synaptic drive ... -
Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development
(PeerJ Inc., 2016)To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory ... -
Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection
(BioMed Central, 2013)Background: HLA-B alleles are associated with viral control in chronic HIV-1 infection, however, their role in primary HIV-1 disease is unclear. This study sought to determine the role of HLA-B alleles in viral control ... -
Temporal Lobe Cortical Electrical Stimulation during the Encoding and Retrieval Phase Reduces False Memories
(Public Library of Science, 2009)A recent study found that false memories were reduced by 36% when low frequency repetitive transcranial magnetic stimulation (rTMS) was applied to the left anterior temporal lobe after the encoding (study) phase. Here we ... -
Temporal modulation of collective cell behavior controls vascular network topology
(eLife Sciences Publications, Ltd, 2016)Vascular network density determines the amount of oxygen and nutrients delivered to host tissues, but how the vast diversity of densities is generated is unknown. Reiterations of endothelial-tip-cell selection, sprout ... -
Temporal Network Based Analysis of Cell Specific Vein Graft Transcriptome Defines Key Pathways and Hub Genes in Implantation Injury
(Public Library of Science, 2012)Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft ... -
Temporal Patterns of Medications Dispensed to Children and Adolescents in a National Insured Population
(Public Library of Science, 2012)This study aimed to comprehensively describe prevalence and temporal dispensing patterns for medications prescribed to children and adolescents in the United States. Participants were 1.6 million children (49% female) under ... -
Temporal Properties of Liquid Crystal Displays: Implications for Vision Science Experiments
(Public Library of Science, 2012)Liquid crystal displays (LCD) are currently replacing the previously dominant cathode ray tubes (CRT) in most vision science applications. While the properties of the CRT technology are widely known among vision scientists, ... -
Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells
(Impact Journals LLC, 2015)Regulations between NF-κB and HIF-1 have not been adequately addressed in previous research. Here, we report that hypoxia increased NF-κB in hepatocellular carcinoma cells. The HIF-1 protein level was rapidly induced by ... -
Temporal retinal transcriptome and systems biology analysis identifies key pathways and hub genes in Staphylococcus aureus endophthalmitis
(Nature Publishing Group, 2016)Bacterial endophthalmitis remains a devastating inflammatory condition associated with permanent vision loss. Hence, assessing the host response in this disease may provide new targets for intervention. Using a mouse model ... -
Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease
(Springer Nature, 2016)The concept of the 'vulnerable plaque' originated from pathological observations in patients who died from acute coronary syndrome. This recognition spawned a generation of research that led to greater understanding of how ... -
Temporal stability of visually selective responses in intracranial field potentials recorded from human occipital and temporal lobes
(American Physiological Society, 2012)The cerebral cortex needs to maintain information for long time periods while at the same time being capable of learning and adapting to changes. The degree of stability of physiological signals in the human brain in ... -
A Temporal Switch in DER Signaling Controls the Specification and Differentiation of Veins and Interveins in the Drosophila Wing
(The Company of Biologists, 1999-12-15)The Drosophila EGF receptor (DER) is required for the specification of diverse cell fates throughout development. We have examined how the activation of DER controls the development of vein and intervein cells in the ...