Browsing HMS Scholarly Articles by Title
Now showing items 16452-16471 of 17920
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Testing for direct genetic effects using a screening step in family-based association studies
(Frontiers Media S.A., 2013)In genome wide association studies (GWAS), family-based studies tend to have less power to detect genetic associations than population-based studies, such as case-control studies. This can be an issue when testing if genes ... -
Testing Pancreatic Islet Function at the Single Cell Level by Calcium Influx with Associated Marker Expression
(Public Library of Science, 2015)Studying the response of islet cells to glucose stimulation is important for understanding cell function in healthy and disease states. Most functional assays are performed on whole islets or cell populations, resulting ... -
Testing the role of predicted gene knockouts in human anthropometric trait variation
(Oxford University Press, 2016)Although the role of complete gene inactivation by two loss-of-function mutations inherited in trans is well-established in recessive Mendelian diseases, we have not yet explored how such gene knockouts (KOs) could influence ... -
Testosterone deficiency and cardiovascular mortality
(Medknow Publications & Media Pvt Ltd, 2015)New concerns have been raised regarding cardiovascular (CV) risks with testosterone (T) therapy (TTh). These concerns are based primarily on two widely reported retrospective studies. However, methodological flaws and data ... -
Testosterone Therapy and Breast Histopathological Features in Transgender Individuals
(Springer Science and Business Media LLC, 2020-09-16)Testosterone therapy (TT) is administered to enhance masculinization in transgender individuals. The long term effect of exogenous testosterone on breast tissues remains unclear. Our study evaluated the modulation of breast ... -
Tet1 controls meiosis by regulating meiotic gene expression
(2012)Meiosis is a germ cell-specific cell division process through which haploid gametes are produced for sexual reproduction1. Prior to initiation of meiosis, mouse primordial germ cells (PGCs) undergo a series of epigenetic ... -
Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes
(Elsevier BV, 2014)With the exception of imprinted genes and certain repeats, DNA methylation is globally erased during preimplantation development. Recent studies have suggested that Tet3-mediated oxidation of 5-methylcytosine (5mC) and DNA ... -
Tetanic stimulation leads to increased accumulation of Ca2+ calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons
(Society for Neuroscience, 1999)mRNA for the alpha-subunit of CaMKII is abundant in dendrites of neurons in the forebrain (Steward, 1997). Here we show that tetanic stimulation of the Schaffer collateral pathway causes an increase in the concentration ... -
Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure
(2012)Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut ... -
Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis
(Public Library of Science, 2013)Nef is the viral gene product employed by the majority of primate lentiviruses to overcome restriction by tetherin (BST-2 or CD317), an interferon-inducible transmembrane protein that inhibits the detachment of enveloped ... -
Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTCP) via Fusion to a High Affinity, Multimeric βTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors
(Public Library of Science, 2015)Transplantation of freshly-aspirated autologous bone marrow, together with a scaffold, is a promising clinical alternative to harvest and transplantation of autologous bone for treatment of large defects. However, survival ... -
Tetracyclines Promote Survival and Fitness in Mitochondrial Disease Models
(Springer Science and Business Media LLC, 2021-01-18)Mitochondrial diseases (MD) are a heterogeneous group of disorders resulting from genetic mutations in nuclear or mitochondrial DNA (mtDNA) genes encoding for mitochondrial proteins 1,2. MD cause pathologies with severe ... -
Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation
(Nature Publishing Group, 2016)Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved ... -
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma
(2012)Here we provide the first evidence that tetraspanin CD151 can support de novo carcinogenesis. During two-stage mouse skin chemical carcinogenesis, CD151 reduces tumor lag time and increases incidence, multiplicity, size, ... -
Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia
(Molecular Diversity Preservation International (MDPI), 2011)Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, ... -
TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers
(Springer Science and Business Media LLC, 2020-06-08)Mammalian cells maintain a remarkably stable, highly methylated global DNA methylation landscape despite expressing both positive (DNMT3A/B) and negative (TET1-3) regulators. Notably, although embryonic stem cells (ESCs) ... -
Text to Move: A Randomized Controlled Trial of a Text-Messaging Program to Improve Physical Activity Behaviors in Patients With Type 2 Diabetes Mellitus
(JMIR Publications Inc., 2016)Background: Text messages are increasingly being used because of the low cost and the ubiquitous nature of mobile phones to engage patients in self-care behaviors. Self-care is particularly important in achieving treatment ... -
Texting while driving: A study of 1211 U.S. adults with the Distracted Driving Survey
(Elsevier, 2016)Texting and other cell-phone related distracted driving is estimated to account for thousands of motor vehicle collisions each year but studies examining the specific cell phone reading and writing activities of drivers ... -
Texting while driving: the development and validation of the distracted driving survey and risk score among young adults
(Springer International Publishing, 2016)Background: Texting while driving and other cell-phone reading and writing activities are high-risk activities associated with motor vehicle collisions and mortality. This paper describes the development and preliminary ... -
TGF-? Is Required for Vascular Barrier Function, Endothelial Survival and Homeostasis of the Adult Microvasculature
(Public Library of Science (PLoS), 2009)Pericyte-endothelial cell (EC) interactions are critical to both vascular development and vessel stability. We have previously shown that TGF-β signaling between EC and mural cells participates in vessel stabilization in ...