Browsing HMS Scholarly Articles by Title
Now showing items 16499-16518 of 17922
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The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza a Virus and Dengue Virus Replication
(American Society for Microbiology, 2013)The interferon-induced transmembrane protein 3 (IFITM3) gene is an interferon-stimulated gene that inhibits the replication of multiple pathogenic viruses in vitro and in vivo. IFITM3 is a member of a large protein ... -
The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation
(Cold Spring Harbor Laboratory Press, 2013)The Drosophila male-specific lethal (MSL) dosage compensation complex increases transcript levels on the single male X chromosome to equal the transcript levels in XX females. However, it is not known how the MSL complex ... -
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity
(American Society for Microbiology, 2016)Senicapoc, a Gardos channel inhibitor, prevented erythrocyte dehydration in clinical trials of patients with sickle cell disease. We tested the hypothesis that senicapoc-induced blockade of the Gardos channel inhibits ... -
The Crystal Structure of PF-8, the DNA Polymerase Accessory Subunit from Kaposi's Sarcoma-Associated Herpesvirus
(American Society for Microbiology, 2009)Kaposi's sarcoma-associated herpesvirus is an emerging pathogen whose mechanism of replication is poorly understood. PF-8, the presumed processivity factor of Kaposi's sarcoma-associated herpesvirus DNA polymerase, acts ... -
The Docosatriene Protectin D1 Is Produced by T H 2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering
(American Society for Biochemistry and Molecular Biology, 2005)Docosahexaenoic acid, a major omega-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain ... -
The Drosophila cytokine Unpaired 2 regulates physiological homeostasis by remotely controlling Insulin secretion
(Elsevier (Cell Press), 2012)In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly brain to release Drosophila ... -
The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway
(SAGE Publications, 2011)Ebola virus (EBOV) has been reported to enter cultured cell lines via a dynamin-2-independent macropinocytic pathway or clathrin-mediated endocytosis. The route(s) of productive EBOV internalization into physiologically ... -
The F-box Protein FBX4 Targets PIN2/TRF1 for Ubiquitin-mediated Degradation and Regulates Telomere Maintenance
(American Society for Biochemistry and Molecular Biology, 2006)Pin2/TRF1 was identified previously as both a protein (TRF1) that binds to telomeric DNA repeats and as a protein (Pin2) that associates with the kinase NIMA and suppresses its mitosis inducing activity. Pin2/TRF1 negatively ... -
The First Γ-carboxyglutamic Acid-containing Contryphan. A Selective L-type Calcium Ion Channel Blocker Isolated From the Venom of Conus Marmoreus
(American Society for Biochemistry and Molecular Biology, 2004) -
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
(National Academy of Sciences, 2009)Innate immunity is an ancient defense system used by both vertebrates and invertebrates. Previously characterized innate immune responses in plants and animals are triggered by detection of pathogens using specific receptors, ... -
The Gla Domain of Factor IXa Binds to Factor VIIIa in the Tenase Complex
(American Society for Biochemistry and Molecular Biology, 2003)During blood coagulation factor IXa binds to factor VIIIa on phospholipid membranes to form an enzymatic complex, the tenase complex. To test whether there is a protein-protein contact site between the gamma-carboxyglutamic ... -
The Glutamate Switch of Bacteriophage T7 DNA Helicase: ROLE IN COUPLING NUCLEOTIDE TRIPHOSPHATE (NTP) AND DNA BINDING TO NTP HYDROLYSIS*
(American Society for Biochemistry and Molecular Biology, 2011)The DNA helicase encoded by gene 4 of bacteriophage T7 forms a hexameric ring in the presence of dTTP, allowing it to bind DNA in its central core. The oligomerization also creates nucleotide-binding sites located at the ... -
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
(Elsevier (Cell Press), 2012)Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a ... -
The Host Proteins Transportin SR2/TNPO3 and Cyclophilin a Exert Opposing Effects on HIV-1 Uncoating
(American Society for Microbiology, 2013)Following entry of the HIV-1 core into target cells, productive infection depends on the proper disassembly of the viral capsid (uncoating). Although much is known regarding HIV-1 entry, the actions of host cell proteins ... -
The Human Cytomegalovirus UL44 Protein Is a Substrate for the UL97 Protein Kinase
(American Society for Microbiology, 2003)The human cytomegalovirus UL97 protein is an unusual protein kinase that is able to autophosphorylate and to phosphorylate certain exogenous substrates, including nucleoside analogs such as ganciclovir. However, no natural ... -
The Human Cytomegalovirus UL97 Protein Kinase, an Antiviral Drug Target, Is Required at the Stage of Nuclear Egress
(American Society for Microbiology, 2003)Human cytomegalovirus encodes an unusual protein kinase, UL97, that activates the established antiviral drug ganciclovir and is specifically inhibited by a new antiviral drug, maribavir. We used maribavir and a UL97 null ... -
The Hydrophilic Amino-Terminal Arm of Reovirus Core Shell Protein λ1 Is Dispensable for Particle Assembly
(American Society for Microbiology, 2002) -
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
(National Academy of Sciences, 2007)The approximate to 80-kb pksX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/nonribosomal peptide synthase that has been linked to the production of the uncharacterized antibiotic bacillaene. Multiple ... -
The impact of diabetes on tuberculosis treatment outcomes: A systematic review
(BMC, 2011)Background: Multiple studies of tuberculosis treatment have indicated that patients with diabetes mellitus may experience poor outcomes. We performed a systematic review and meta-analysis to quantitatively summarize evidence ... -
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
(Elsevier (Cell Press), 2006)To understand the role of human epidermal growth factor receptor (hEGFR) kinase domain mutations in lung tumorigenesis and response to EGFR-targeted therapies, we generated bitransgenic mice with inducible expression in ...