Browsing HMS Scholarly Articles by Title
Now showing items 16539-16558 of 17922
-
The Positively Charged Surface of Herpes Simplex Virus UL42 Mediates DNA Binding
(American Society for Biochemistry and Molecular Biology, 2008)Herpes simplex virus DNA polymerase is a heterodimer composed of UL30, a catalytic subunit, and UL42, a processivity subunit. Mutations that decrease DNA binding by UL42 decrease long chain DNA synthesis by the polymerase. ... -
The Pre-NH2-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication
(American Society for Microbiology, 2012)The catalytic subunit of herpes simplex virus 1 DNA polymerase (HSV-1 Pol) has been extensively studied; however, its full complement of functional domains has yet to be characterized. A crystal structure has revealed a ... -
The Predictive Value of the Fine-needle Aspiration Diagnosis “Suspicious for a Follicular Neoplasm, Hürthle Cell Type” in Patients With Hashimoto Thyroiditis
(2011)A fine-needle aspiration sample composed exclusively of Hurthle cells is interpreted as "suspicious for a follicular neoplasm, Hurthle cell type" (SFNHCT). Because some nonneoplastic Hurthle cell proliferations in Hashimoto ... -
The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome
(Cold Spring Harbor Laboratory Press, 2010)The spliceosome, a dynamic assembly of proteins and RNAs, catalyzes the excision of intron sequences from nascent mRNAs. Recent work has suggested that the activity and composition of the spliceosome are regulated by ... -
The Requirement for Cellular Transportin 3 (TNPO3 or TRN-SR2) during Infection Maps to Human Immunodeficiency Virus Type 1 Capsid and Not Integrase
(American Society for Microbiology, 2010)Recent genome-wide screens have highlighted an important role for transportin 3 in human immunodeficiency virus type 1 (HIV-1) infection and preintegration complex (PIC) nuclear import. Moreover, HIV-1 integrase interacted ... -
The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid
(American Society for Microbiology, 2011)Lentiviruses likely infect nondividing cells by commandeering host nuclear transport factors to facilitate the passage of their preintegration complexes (PICs) through nuclear pore complexes (NPCs) within nuclear envelopes. ... -
The Reticulon and Dp1/Yop1p Proteins Form Immobile Oligomers in the Tubular Endoplasmic Reticulum
(American Society for Biochemistry and Molecular Biology, 2008)We recently identified a class of membrane proteins, the reticulons and DP1/Yop1p, which shape the tubular endoplasmic reticulum ( ER) in yeast and mammalian cells. These proteins are highly enriched in the tubular portions ... -
The RNA Polymerase of Marine Cyanophage Syn5
(American Society for Biochemistry and Molecular Biology, 2013)A single subunit DNA-dependent RNA polymerase was identified and purified to apparent homogeneity from cyanophage Syn5 that infects the marine cyanobacteria Synechococcus. Syn5 is homologous to bacteriophage T7 that infects ... -
The Role of the Zinc Motif in Sequence Recognition by DNA Primases
(American Society for Biochemistry and Molecular Biology, 1996) -
The Scaffold Protein CNK1 Interacts with the Tumor Suppressor RASSF1A and Augments RASSF1A-induced Cell Death
(American Society for Biochemistry and Molecular Biology, 2004)The connector enhancer of KSR (CNK) is a multidomain scaffold protein discovered in Drosophila, where it is necessary for Ras activation of the Raf kinase. Recent studies have shown that CNK1 also interacts with RalA and ... -
The Sensor Kinase KinB Regulates Virulence in Acute Pseudomonas aeruginosa Infection
(American Society for Microbiology, 2011)Two-component sensors are widely used by bacteria to sense and respond to the environment. Pseudomonas aeruginosa has one of the largest sets of two-component sensors known in bacteria, which likely contributes to its ... -
The SET Complex Acts as a Barrier to Autointegration of HIV-1
(Public Library of Science, 2009)Retroviruses and retrotransposons are vulnerable to a suicidal pathway known as autointegration, which occurs when the 3'-ends of the reverse transcript are activated by integrase and then attack sites within the viral ... -
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart
(Cold Spring Harbor Laboratory Press, 2009)The integrity of genomic DNA is continuously challenged by the presence of DNA base lesions or DNA strand breaks. Here we report the identification of a new DNA damage response protein, SMARCAL1 (SWI/SNF-related, matrix ... -
The Stoichiometry of Trimeric SIV Glycoprotein Interaction with CD4 Differs from That of Anti-envelope Antibody Fab Fragments
(American Society for Biochemistry and Molecular Biology, 2001) -
The Structure of the Poliovirus 135S Cell Entry Intermediate at 10-Angstrom Resolution Reveals the Location of an Externalized Polypeptide That Binds to Membranes
(American Society for Microbiology, 2005) -
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
(National Academy of Sciences, 2008)Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited ... -
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
(National Academy of Sciences, 2005)Constitutive expression of telomerase prevents senescence and crisis by maintaining telomere homeostasis. However, recent evidence suggests that telomerase is dynamically regulated in normal cells and also contributes to ... -
The Three Vibrio cholerae Chromosome II-Encoded ParE Toxins Degrade Chromosome I following Loss of Chromosome II
(American Society for Microbiology, 2011)Three homologues of the plasmid RK2 ParDE toxin-antitoxin system are present in the Vibrio cholerae genome within the superintegron on chromosome II. Here we found that these three loci-two of which have identical open ... -
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation
(Genetics Society of America, 2015)To facilitate large-scale functional studies in Drosophila, the Drosophila Transgenic RNAi Project (TRiP) at Harvard Medical School (HMS) was established along with several goals: developing efficient vectors for RNAi that ... -
The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner
(American Society for Microbiology, 2009)The stimulatory effect of insulin on protein synthesis is due to its ability to activate various translation factors. We now show that insulin can increase protein synthesis capacity also by translational activation of TOP ...