Browsing HMS Scholarly Articles by Title
Now showing items 16601-16620 of 17922
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Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
(Blackwell Publishing Ltd, 2014)The endoplasmic reticulum (ER) is responsible for protein folding, modification, and trafficking. Accumulation of unfolded or misfolded proteins represents the condition of ER stress and triggers the unfolded protein ... -
Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
(John Wiley & Sons, Ltd, 2015)Here, we report a novel mechanism of proteasome inhibition mediated by Thiostrepton (Thsp), which interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. We identified Thsp in a cell-based ... -
Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia
(John Wiley and Sons Inc., 2015)Background: Hydrogen sulfide (H2S) exhibits protective effects in various disease models including cerebral ischemia–reperfusion (I/R) injury. Nonetheless, mechanisms and identity of molecules responsible for neuroprotective ... -
The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach
(Wiley-Blackwell, 2015)"The Third International Meeting on Genetic Disorders in the RAS/MAPK Pathway: Towards a Therapeutic Approach" was held at the Renaissance Orlando at SeaWorld Hotel (August 2-4, 2013). Seventy-one physicians and scientists ... -
Thirty-Day Prevalence ofDSM-IVMental Disorders Among Nondeployed Soldiers in the US Army
(American Medical Association (AMA), 2014)Importance Although high rates of current mental disorder are known to exist in the US Army, little is known about the proportions of these disorders that had onsets prior to enlistment. Objective To estimate the ... -
Thoracic Periaortic and Visceral Adipose Tissue and Their Cross-sectional Associations with Measures of Vascular Function
(2013)Objective: Perivascular fat may have a local adverse effect on the vasculature. We evaluated whether thoracic periaortic adipose tissue (TAT), a type of perivascular fat, and visceral adipose tissue (VAT) are associated ... -
Thoreau, Tolstoy and Walden Woods: The Clintons and Belfast
(The Ulster Medical Society, 2021-09) -
Three Distinct Urethral Fistulae 35 Years After Pelvic Radiation
(Kowsar, 2014)Introduction: While the development of fistulae is a well-known complication of radiotherapy, such fistulae can often be challenging to manage. Case Presentation: We describe the case of a 37 year old male who developed ... -
Three New Genetic Loci (R1210C in CFH, Variants in COL8A1 and RAD51B) Are Independently Related to Progression to Advanced Macular Degeneration
(Public Library of Science, 2014)Objectives: To assess the independent impact of new genetic variants on conversion to advanced stages of AMD, controlling for established risk factors, and to determine the contribution of genes in predictive models. ... -
Three Novel Mutations in KIF21A Highlight the Importance of the Third Coiled-Coil Stalk Domain in the Etiology of CFEOM1
(BioMed Central, 2007)Background: Congenital fibrosis of the extraocular muscles types 1 and 3 (CFEOM1/CFEOM3) are autosomal dominant strabismus disorders that appear to result from maldevelopment of ocular nuclei and nerves. We previously ... -
Three Patients with Full Facial Transplantation
(New England Journal of Medicine (NEJM/MMS), 2012)Unlike conventional reconstruction, facial transplantation seeks to correct severe deformities in a single operation. We report on three patients who received full-face transplants at our institution in 2011 in operations ... -
Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity
(Public Library of Science, 2016)We describe three recombinant engineered antibodies against three recombinant epitope tags, constructed with divalent binding arms to recognize divalent epitopes and so achieve high affinity and specificity. In two versions, ... -
Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy
(Optical Society of America, 2012)We demonstrate a fiber-based, three-color femtosecond source for simultaneous imaging of three fluorescent proteins (FPs) using two-photon fluorescence microscopy (2PM). The three excitation wavelengths at 775 nm, 864 nm ... -
A three-dimensional actuated origami-inspired transformable metamaterial with multiple degrees of freedom
(Nature Publishing Group, 2016)Reconfigurable devices, whose shape can be drastically altered, are central to expandable shelters, deployable space structures, reversible encapsulation systems and medical tools and robots. All these applications require ... -
The Three-Dimensional Architecture of a Bacterial Genome and Its Alteration by Genetic Perturbation
(Elsevier BV, 2011-10-21)We have determined the three-dimensional (3D) architecture of the Caulobacter crescentus genome by combining genome-wide chromatin interaction detection, live-cell imaging, and computational modeling. Using chromosome ... -
Three-dimensional bioprinting using self-assembling scalable scaffold-free “tissue strands” as a new bioink
(Nature Publishing Group, 2016)Recent advances in bioprinting have granted tissue engineers the ability to assemble biomaterials, cells, and signaling molecules into anatomically relevant functional tissues or organ parts. Scaffold-free fabrication has ... -
Three-dimensional chemotaxis-driven aggregation of tumor cells
(Nature Publishing Group, 2015)One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion ... -
Three-Dimensional Computed Tomography for Planning Urologic Surgery
(Elsevier BV, 1998)The development and marketing of new volumetric computed tomography (CT) scanners in 1990 made it possible to perform three-dimensional (3-D) imaging of the abdomen without respiratory artifacts and with clarity similar ... -
Three-Dimensional Genome Architecture Influences Partner Selection for Chromosomal Translocations in Human Disease
(Public Library of Science, 2012)Chromosomal translocations are frequent features of cancer genomes that contribute to disease progression. These rearrangements result from formation and illegitimate repair of DNA double-strand breaks (DSBs), a process ... -
A three-dimensional human neural cell culture model of Alzheimer’s disease
(Nature Publishing Group, 2014)Alzheimer’s disease (AD) is the most common form of dementia, characterized by two pathological hallmarks: β-amyloid plaques and neurofibrillary tangles1. The amyloid hypothesis of AD posits that excessive accumulation of ...