Browsing HMS Scholarly Articles by Title
Now showing items 16728-16747 of 17922
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Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study
(Blackwell Publishing Ltd, 2014)The relationship between tobacco smoking and prostate cancer (PCa) remains inconclusive. This study examined the association between tobacco smoking and PCa risk taking into account polymorphisms in carcinogen metabolism ... -
Tocotrienol-Rich Fraction (TRF) Suppresses the Growth of Human Colon Cancer Xenografts in Balb/C Nude Mice by the Wnt Pathway
(Public Library of Science, 2015)Tocotrienols have been shown many biologic functions such as antioxidant, anti-cancer, maintaining fertility and regulating the immune system and so on. In this study, after feeding with tocotrienol-rich fraction from palm ... -
Toddler temperament and prenatal exposure to lead and maternal depression
(BioMed Central, 2016)Background: Temperament is a psychological construct that reflects both personality and an infant’s reaction to social stimuli. It can be assessed early in life and is stable over time Temperament predicts many later life ... -
Toenail Selenium and Incidence of Type 2 Diabetes in U.S. Men and Women
(American Diabetes Association, 2012)OBJECTIVE Compelling biological pathways suggest that selenium (Se) may lower onset of type 2 diabetes mellitus (T2DM), but very few studies have evaluated this relationship, with mixed results. We examined the association ... -
Tolerance Induction after Organ Transplantation, “Delayed Tolerance,” Via the Mixed Chimerism Approach: Planting Flowers in a Battle Field
(Landes Bioscience, 2012)We have previously reported that peri-transplant conditioning leads to successful induction of renal allograft tolerance via the mixed chimerism approach in nonhuman primates (NHP) and humans. However, this strategy requires ... -
Tolerance Induction to Cytoplasmic \(\beta\)-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity
(Public Library of Science, 2009)Background: Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of ... -
Toll Like Receptor 2, 4, and 9 Signaling Promotes Autoregulative Tumor Cell Growth and VEGF/PDGF Expression in Human Pancreatic Cancer
(MDPI, 2016)Toll like receptor (TLR) signaling has been suggested to play an important role in the inflammatory microenvironment of solid tumors and through this inflammation-mediated tumor growth. Here, we studied the role of tumor ... -
The toll of cascading crises on Lebanon's health workforce
(Elsevier BV, 2022-02) -
The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets
(Public Library of Science, 2016)Deposition of crystallized monosodium urate (MSU) in joints as a result of hyperuricemia is a central risk factor for gout. However other factors must exist that control the progression from hyperuricaemia to gout. A ... -
Toll-like Receptor 4 Signaling Confers Cardiac Protection against Ischemic Injury via Inducible Nitric Oxide Synthase- and Soluble Guanylate Cyclase-dependent Mechanisms
(Ovid Technologies (Wolters Kluwer Health), 2011)Background: Prior administration of a small dose of lipopolysaccharide confers a cardiac protection against ischemia-reperfusion injury. However, the signaling mechanisms that control the protection are incompletely ... -
Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation
(WILEY-VCH Verlag, 2013)Although specialized pro-resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain ... -
Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages
(John Wiley & Sons, Ltd, 2009)Vasoactive intestinal peptide (VIP) was originally isolated as a vasodilator intestinal peptide, then as a neuropeptide. In the immune system, VIP is described as an endogenous macrophage-deactivating factor. VIP exerts ... -
Tomographic fluorescence mapping of tumor targets
(American Association for Cancer Research, 2005)Methods that allow robust imaging of specific molecular targets and biological processes in vivo should have widespread applications in biology and clinical medicine. Here we use a quantitative, three-dimensional ... -
Tongue-tie Repair: Z-Plasty Vs Simple Release
(Mashhad University of Medical Sciences, 2015)Introduction: Ankyloglossia is a congenital anomaly in which the lingual frenulum is unusually short and thick, thus decreasing tongue mobility. In the context of the newborn or young infant it is a subject of ongoing ... -
Tonic inhibition of chemotaxis in human plasma
(National Academy of Sciences, 2008)We found exaggerated chemotaxis in plasma treated with EDTA and thought that the EDTA might itself be inhibiting a tonic inhibitor(s) of chemotaxis. Our plasma fractionations suggested that evidence should be sought for a ... -
A Tool to Utilize Adverse Effect Profiles to Identify Brain-Active Medications for Repurposing
(Oxford University Press, 2015)Background: To shorten the time required to bring new treatments to clinics, recent efforts have focused on repurposing existing Food and Drug Administration (FDA)-approved drugs with established safety data for new ... -
A Toolbox for Spatiotemporal Analysis of Voltage-Sensitive Dye Imaging Data in Brain Slices
(Public Library of Science, 2014)Voltage-sensitive dye imaging (VSDI) can simultaneously monitor the spatiotemporal electrical dynamics of thousands of neurons and is often used to identify functional differences in models of neurological disease. While ... -
Tools to Detect Delirium Superimposed on Dementia: A Systematic Review
(Wiley-Blackwell, 2012) -
Top 100 cited articles in cardiovascular magnetic resonance: a bibliometric analysis
(BioMed Central, 2016)Background: With limited health care resources, bibliometric studies can help guide researchers and research funding agencies towards areas where reallocation or increase in research activity is warranted. Bibliometric ... -
Top-down modulation of visual processing and knowledge after 250 ms supports object constancy of category decisions
(Frontiers Media S.A., 2015)People categorize objects more slowly when visual input is highly impoverished instead of optimal. While bottom-up models may explain a decision with optimal input, perceptual hypothesis testing (PHT) theories implicate ...